- 16
- Episodes
- 2022
- First episode
About One in Two
With one in two of us receiving a cancer diagnosis at some point during our lives, it has never been more important to improve the outcomes for people affected by cancer. This cancer research podcast is brought to you by The University of Manchester in partnership with the Manchester Cancer Research Centre (MCRC). In each episode, our cancer researchers discuss the innovations, discoveries and projects that are changing the landscape of early detection.
- Publisher
- The University of Manchester
- Category
- health & fitness · health & fitness
- Language
- en
- Explicit
- No
- First episode
- 22 Sept 2022
- Latest episode
- 8 Apr 2024
Latest episodes
16 episodes in the feed.
8 Apr 2024
Never-smoking lung cancer with Professor Matt Evison and patient Sally Hayton: Overcoming barriers to early detection in symptomatic lung cancer patients
In the latest episode of One in Two: A Manchester Cancer Research Podcast, we speak to Professor Matt Evison, Professor of Thoracic oncology, and never-smoker ALK+ lung cancer patient, Sally Hayton about: · Never-smoker lung cancer symptoms, demographics, and occurrence · Sally’s experience of receiving her lung cancer diagnosis and the barriers she faced in accessing treatment · Overcoming barriers to early detection in symptomatic lung cancer patients · The Manchester self-referral chest x-ray service and how it is helping in the diagnosis of symptomatic lung cancer patients Show notes: Professor Matt Evison’s profile: https://mft.nhs.uk/wythenshawe/consultants/dr-matthew-evison/ (https://mft.nhs.uk/wythenshawe/consultants/dr-matthew-evison/) Non-small cell lung cancer information from Macmillan: https://www.macmillan.org.uk/cancer-information-and-support/lung-cancer/non-small-cell-lung-cancer (https://www.macmillan.org.uk/cancer-information-and-support/lung-cancer/non-small-cell-lung-cancer) The ALK project: A real-work national network and database: https://christie.openrepository.com/handle/10541/623693 (https://christie.openrepository.com/handle/10541/623693) ALK Positive UK: https://www.alkpositive.org.uk/ (https://www.alkpositive.org.uk/) ALK Positive Org: https://www.alkpositive.org/what-is-alk (https://www.alkpositive.org/what-is-alk) EGFR Positive UK: https://www.egfrpositive.org.uk/ (https://www.egfrpositive.org.uk/) EGFR Registers: https://egfrcancer.org/ (https://egfrcancer.org/) Ruth Strauss Foundation: https://ruthstraussfoundation.com/ (https://ruthstraussfoundation.com/) Rankin shoots campaign to raise awareness of lung cancer in people who have never smoked: https://lbbonline.com/news/rankin-shoots-campaign-to-raise-awareness-of-lung-cancer-in-people-whove-never-smoked (https://lbbonline.com/news/rankin-shoots-campaign-to-raise-awareness-of-lung-cancer-in-people-whove-never-smoked) The ROS1ders: https://www.theros1ders.org/ (https://www.theros1ders.org/) Roy Castle Lung Cancer Foundation: https://roycastle.org/ (https://roycastle.org/) Speaker profiles: Professor Matt Evison Professor Matthew Evison MD MRCP (Respiratory Medicine) MBChB qualified from Manchester University Medical School in 2004. He undertook specialist training in Respiratory Medicine in 2008-2014 including a two-year fellowship in Thoracic Oncology at Wythenshawe Hospital, Manchester University NHS Foundation Trust, completing an MD degree in lung cancer diagnostics. He was appointed as a Consultant in Respiratory Medicine (Thoracic Oncology) at Wythenshawe Hospital in 2014. He was clinical Director for Lung Cancer for Greater Manchester Cancer from 2017-2023 and Appointed as Associate Medical Director for the Greater Manchester Cancer Alliance in 2023. Matt is the Clinical Lead for the Greater Manchester regional tobacco control programme ‘Making Smoking History’. He is a member of the British Thoracic Society Lung Cancer & Mesothelioma Specialist Advisory Group (SAG) & Member of the British Thoracic Oncology Group Steering Committee. He is also MASHC Honorary Clinical Chair, Faculty of Biology, Medicine & Health, The University of Manchester. Sally Hayton Patient Sally Hayton lives with Frank her partner. She has lived most of her life in Greater Manchester. Sally is a never smoker and was diagnosed with stage 4 lung cancer in 2013 and biomarker testing showed an ALK mutation. She is now being treated at The Christie Hospital. She has always worked in the public sector. After leaving school she trained and worked as an occupational therapist (OT). She then had a career change and worked within NHS Personnel for several years before realising that she wanted to return to her OT career. She has worked within both the NHS and social care, both of which she enjoyed. She is a member of Greater Manchester Cancer Alliance Patient Voices’ and believes it is very important to raise awareness of never smoker lung cancer so that people are diagnosed at earlier stages and have access to the best treatment. Quote “The profile of lung cancer is changing, so I saw it as people who smoked a packet of cigarettes a day for 20, 30 years and then they got to their 70s and 80s and then were diagnosed with stage four lung cancer; that was my rough perception I had in my head. Then now, having been diagnosed with lung cancer and not fitting that group, I realise that never smokers are a totally different group of people. The youngest person I have met with lung cancer was 17 years old. People in their 20s and 30s are also being diagnosed so you can see the profile for never-smoker lung cancer is very different.” ~ Patient Sally Hayton
4 Mar 2024
Breast cancer in Black African women with Professor David Wedge: How analysing genomics can improve our understanding of the aggressiveness of breast cancer
In this episode, we speak to Professor David Wedge, Professor of Cancer Genomics and Data Science, about breast cancer in Black African women, focussing on: · Cancer genomics and what we understand ethnicity to be in the context of genomic research · David’s work within the International Cancer Genome Consortium (https://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/our-research-partnerships/international-cancer-genome-consortium) · The increase in aggressiveness of breast cancer that we see in Black African women compared to White Caucasian women · David’s current research project on genomics of breast cancer progression in Nigerian women · The importance of international research and discuss how this work is driving for health equity. Professor David Wedge: David Wedge is a Professor of Cancer Genomics and Data Science at the Manchester Cancer Research Centre, University of Manchester. He was co-lead of the Evolution and Heterogeneity working group of the ICGC Pan-Cancer Analysis of Whole Genomes (PCAWG) project and is currently one of the leaders of the Pan Prostate Cancer Group. Much of the research in the Wedge lab is focused on tumour evolution, from the initial transformation of normal cells to cancer, through the acquisition of treatment resistance and to the formation of metastatic lesions. The Wedge group have pioneered the development of computational methods to study heterogeneity in primary and metastatic cancers. Recently, the focus of the lab has shifted towards understudied populations, including the genomics of breast cancer in Nigerian women and of lung cancer in non-smokers. Professor David Wedge’s research profile (https://www.crukcentre.manchester.ac.uk/team-members/david-wedge/) Manchester Cancer Research Centre Breast cancer webpage (https://www.mcrc.manchester.ac.uk/research/disease-sites/breast-cancer/) Cancer Research UK Breast cancer webpage (https://www.cancerresearchuk.org/about-cancer/breast-cancer) Etiology and Genomics of Breast Cancer Progression in Women of African Ancestry paper (https://grantome.com/grant/NIH/R01-MD013452-02) Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes nature paper (https://www.nature.com/articles/s41467-021-27079-w%20)
23 Jan 2024
Hereditary cancer predisposition with Dr Emma Woodward and patient Nick Brown: How can the ATLAS study improve cancer early detection in carriers of Li Fraumeni Syndrome?
In this episode, we speak to Dr Emma Woodward and patient Nick Brown, about hereditary cancer predisposition, focusing on: · Li Fraumeni Syndrome (LFS), a rare cancer predisposing condition which gives a 70% lifetime risk of developing cancer, caused by germline mutations in the TP53 gene · Nick’s diagnosis with LFS syndrome and the affect this has had on him and his family · The current screening regime for LFS · The ATLAS study run by Dr Emma Woodward in collaboration with Ontario Institute for Cancer Research in Toronto, Canada, which is working to change cancer detection in LFS Show notes: Dr Emma Woodward research profile (https://mft.nhs.uk/saint-marys/consultants/dr-emma-woodward/) The George Pantzirka TP53 Trust (http://www.tp53.co.uk/) Li Fraumeni Syndrome (https://medlineplus.gov/genetics/condition/li-fraumeni-syndrome/) Speaker profiles: Dr Emma R. Woodward: Dr Emma R. Woodward is a Clinical Geneticist specialising in hereditary cancer predisposition. Dr Woodward studied medicine at the University of Cambridge where she also completed a PhD studying familial phaeochromocytoma and familial renal cancer. She then undertook training in adult medicine in London, Lausanne and N. Ireland prior to her higher specialist training in Clinical Genetics in Birmingham. During this time Dr Woodward received an NIHR Clinician Scientist Award and undertook further study of familial renal cancer. She became a consultant at Birmingham Women’s Hospital in 2008 and at Saint Mary’s Hospital in 2015. Dr Woodward’s current research is aimed at improving cancer prevention and early detection strategies for families with a hereditary cancer predisposition. Dr Woodward is an Alliance of Cancer Early Detection (ACED) Director of Research for Trials and Principle Investigator of the ACED-funded study: ELECTRIC (Early Detection of Hereditary Renal Cancer), MAHSC -funded study: PRO-DIRECT (Direct genetic testing for prostate cancer) and a LifeArc-funded project to calculate risk of second primary cancers in hereditary retinoblastoma. Dr Woodward is also joint-PI for the Cancer Research UK/ Ontario Institute for Cancer Research-jointly funded ATLAS study (eArly deTection in Li frAumeni Syndrome). Nick Brown: Patient Nick Brown is married to wife Amanda and has three children aged 25, 23 and 20. He is originally from North Yorkshire and after attending school in Leeds and University at Nottingham, he studied to be a chartered accountant with a big four firm. After qualifying and leaving the profession, Nick spent most of his career in textiles, initially working in carpets and for the last 20 years as finance director at Camira group. In 2019 he retired and remained as a non-exec director and has subsequently taken on a further non-exec role at a worsted suit manufacturer in Leeds. Nick first discovered he had LFS following the passing of his sister who died from multiple cancers in 2015. He was subsequently tested, and it was confirmed he had LFS in 2017. Since then, Nick has been under the care of the genetics team in Manchester and specifically with Dr Emma, Woodward. More recently all of Nick’s children are now in the process of testing to see if they also have LFS. Nick was asked by Emma if he wished to participate in the ATLAS project which he was very happy to do and acted as a lead advocate at a number of patient group feedback sessions. The aim of these sessions was to inform what the Atlas project was about and to obtain patient feedback about the outcomes which may arise from the project.
11 Sept 2023
One in Two - Clinical trials with Professor Corinne Faivre-Finn: How RAPID RT could improve survival rates for lung cancer patients
In this episode, we speak to Corinne Faivre-Finn, a Professor of Thoracic Radiation Oncology about lung cancer clinical trials, focussing on: · Radiotherapy: what it is and how it’s used to treat lung cancers · Clinical trials: what are they, who are they for and how are they set up · The RAPID-RT clinical trial that launched at The Christie in early 2023, and how it could improve survival rates for lung cancer patients · The involvement of AI and rapid learning in this trial, and the benefits this has for data collection · Integrating patient voices into the trial Speaker profile: Corinne Faivre-Finn, FRCR, MD, PhD, is a Professor of Thoracic Radiation Oncology at the Division of Molecular and Cancer Sciences (University of Manchester) and Honorary Consultant Clinical Oncologist (The Christie NHS Foundation Trust, Manchester) with a specialist interest in lung cancer. Prof Faivre-Finn trained in Paris until 1998 and accepted a consultant post at The Christie in 2001. She has numerous professional roles including: Radiotherapy Research Lead and Radiotherapy Big Data Lead for Manchester Cancer Research Centre, Radiotherapy Research Lead for the CRUK Lung Cancer Centre of Excellence and Early NSCLC Chair of EORTC Lung Group. She is the Co-lead of the Christie/Manchester Cancer Research Centre Patient Reported Outcome Group. Show notes: Professor Corinne Faivre-Finn's research profile (https://www.christie.nhs.uk/patients-and-visitors/your-treatment-and-care/find-your-consultant/faivre-finn-corinne) The Telegraph: AI utilised to help prevent lung cancer patients getting heart disease (https://www.telegraph.co.uk/news/2023/09/10/artificial-intelligence-lung-cancer-heart-radiotherapy/) CRUK clinical trial research website (https://www.cancerresearchuk.org/our-research-by-cancer-topic/our-clinical-trial-research) (https://sites.manchester.ac.uk/rapid-rt/) RAPID RT, The University of Manchester (https://sites.manchester.ac.uk/rapid-rt/) Dr Gareth Price research profile (https://www.crukcentre.manchester.ac.uk/team-members/gareth-price/) We are Vocal home page (https://wearevocal.org/) Using real world data and rapid learning to drive improvements in lung cancer survival (https://research.manchester.ac.uk/en/projects/using-real-world-data-and-rapid-learning-to-drive-improvements-in/publications/)
15 Aug 2023
One in Two Podcast - Lung Cancer in never smokers with Dr Fabio Gomes: The ALK positive mutation in Non-Small Cell Lung Cancer (NSCLC)
In this episode, we speak to Dr Fabio Gomes, a Consultant Medical Oncologist at The Christie NHS Foundation Trust, about lung cancer in never smokers, focusing on: The commonality of lung cancer in never smokers Why never smokers are susceptible to lung cancer, and why you only need lungs to get lung cancer ALK positive mutations in non-small cell lung cancer His research project looking at The UK ALK project The ALK Education programme and educating healthcare professionals through data and case studies Speaker profile: Dr Fabio Gomes is a Consultant Medical Oncologist who specialises in the care of patients with lung cancer, focussing specifically on the ALK positive mutation in Non-small cell lung cancer (NSCLC). He also has a special interest in the care of senior adults with cancer and is the Clinical Director of the multidisciplinary senior adult oncology service launched at The Christie in 2022. Fabio also works with the digital services where he directs the clinical outcomes unit. This unit focuses on the use of clinical data generated as part of the daily practice across the hospital to identify the outcomes of groups of patients and promote improvements. Dr Gomes is an elected board member of the International Society of Geriatric Oncology (SIOG). He is also a Clinical Research Training Fellow alum at The University of Manchester. Show notes: Dr Fabio Gomes’ research profile (https://www.christie.nhs.uk/patients-and-visitors/your-treatment-and-care/find-your-consultant/gomes-fabio) Non-small cell lung cancer information from Macmillan (https://www.macmillan.org.uk/cancer-information-and-support/lung-cancer/non-small-cell-lung-cancer) The ALK project: A real-work national network and database (https://christie.openrepository.com/handle/10541/623693) ALK Positive UK (https://www.alkpositive.org.uk/) ALK Positive Org (https://www.alkpositive.org/what-is-alk) Ruth Strauss Foundation (https://ruthstraussfoundation.com/)
31 Jul 2023
Cancer biomarkers with Professor Caroline Dive: How liquid biopsies could pave the way for lung cancer detection and treatment
In this episode, we speak to Professor Caroline Dive, Professor of Cancer Pharmacology at The University of Manchester, Interim Director of the Cancer Research UK Manchester Institute and Director of the CRUK Cancer Biomarker Centre, about cancer biomarkers in lung cancer, focussing on: Establishing a Cancer Biomarker Centre in Manchester Developing liquid biopsies such as circulating tumour cells (CTCs), circulating free DNA (cfDNA) and circulating tumour DNA (ctDNA) The future of integrating novel biomarkers into the clinic Show notes: About the CRUK MI Cancer Biomarker Centre: https://www.cruk.manchester.ac.uk/Our-Research/Cancer-Biomarker-Centre (https://www.cruk.manchester.ac.uk/Our-Research/Cancer-Biomarker-Centre) Professor Caroline Dive’s research profile: https://www.crukcentre.manchester.ac.uk/team-members/caroline-dive/ (https://www.crukcentre.manchester.ac.uk/team-members/caroline-dive/) cfDNA methylome profiling for detection and subtyping of small cell lung cancers: https://www.nature.com/articles/s43018-022-00415-9 (https://www.nature.com/articles/s43018-022-00415-9) The evolution of lung cancer and impact of subclonal selection in TRACERx: https://scholar.google.com/citations?view_op=view_citation&hl=en&user=3CNlPIMAAAAJ&sortby=pubdate&citation_for_view=3CNlPIMAAAAJ:e84hm74t-eoC (https://scholar.google.com/citations?view_op=view_citation&hl=en&user=3CNlPIMAAAAJ&sortby=pubdate&citation_for_view=3CNlPIMAAAAJ:e84hm74t-eoC) Pulmonary venous circulating tumour cell dissemination before tumour resection and disease relapse: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986897/ (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986897/) Speaker profile: Upon completing her PhD studies in Cambridge, Professor Caroline Dive moved to Aston University’s School of Pharmaceutical Sciences in Birmingham where she established her own group studying mechanisms of drug-induced tumour cell death, before moving to The University of Manchester to continue this research. Caroline was awarded a Lister Institute of Preventative Medicine Research Fellowship before joining the Cancer Research UK Manchester Institute (CRUK MI) in 2003. Currently, she is Interim Director of the Institute and Director of its Cancer Biomarker Centre, with research spanning tumour biology, biomarker discovery and preclinical pharmacology alongside regulated laboratories for biomarker assay validation and qualification within clinical trials to Good Clinical Practice standards supporting clinical decision-making. Caroline was awarded the Pasteur-Weizmann/Servier International Prize in 2012 for her Biomarker Research, the AstraZeneca Prize for Women in Pharmacology in 2016 and was presented with the 2019 Heine H. Hansen Lectureship Award by the International Association for the Study of Lung Cancer (IASLC). In 2018, Caroline was awarded Commander of the Order of the British Empire (CBE) for her services to cancer research. Most recently, she became an elected member of EMBO (2020), received the inaugural Johann Anton Merck Award in recognition for exceptional contributions to the field of preclinical oncology (2020) and was the recipient of the Mary J. Matthews Pathology/Translational Distinguished Service Award by IASLC (2021). Caroline was President of the European Association for Cancer Research from 2020 – 2022.
9 Jun 2023
One in Two podcast - The basic biology of lung cancer with Dr Colin Lindsay: Exploring oncogenic drivers such as the KRAS mutation
In this episode, we speak to Dr Colin Lindsay, Clinical Senior Lecturer at The Christie and The University of Manchester about the basic biology of lung cancer, focusing on: The high incidence of lung cancer here in Manchester The differences between non-small cell and small-cell lung cancer Oncogenic drivers in lung cancer such as the KRAS mutation His work on the drug sotorasib which targets KRAS mutant cancer and has now been approved by the FDA and for use in the UK by NICE Colin Lindsay's research profile (https://research.manchester.ac.uk/en/persons/colin.lindsay) EPAC-lung: European pooled analysis of the prognostic value of circulating tumour cells (https://pubmed.ncbi.nlm.nih.gov/34012782/) KRAS: Reasons for optimism in lung cancer (https://pubmed.ncbi.nlm.nih.gov/29894909/) On target: Rational approaches to KRAS inhibition for treatment of non-small cell lung carcinoma (https://pubmed.ncbi.nlm.nih.gov/34417059/) Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG12C mutation: a randomised, open-label, phase 3 trial (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00221-0/fulltext) Molecular characterization of primary and secondary resistance to RET inhibitors in patients (https://www.ejcancer.com/article/S0959-8049(22)00871-1/fulltext) with advanced NSCLC and RET fusions (2022) (https://www.ejcancer.com/article/S0959-8049(22)00871-1/fulltext) https://www.ejcancer.com/article/S0959-8049(22)00871-1/fulltext (https://www.ejcancer.com/article/S0959-8049(22)00871-1/fulltext)
17 Apr 2023
One in Two podcast – Screening access challenges with Dr Jen Davies-Oliveira and Stewart O’Callaghan: How to improve cancer screening uptake in the LGBTQIA+ community and other marginalised groups
In this special episode, we speak to Dr Jen Davies-Oliveira, a researcher and PhD student at The University of Manchester and Stewart O’Callaghan, the Founder and Chief Executive of Live Through This, the UK’s only LGBTQIA+ Cancer charity. We discuss challenges that LGBTQIA+ people face when accessing cancer care in the UK, Jen’s research project in alternative cervical screening which aims to tackle some of these inequalities and Stewart’s experiences as a person living with cancer, how they came to set up their charity and how it is aligned with research. Live through this: https://livethroughthis.co.uk/ (https://livethroughthis.co.uk/) Jo’s Cervical Cancer Trust: https://www.jostrust.org.uk/ (https://www.jostrust.org.uk/) Answer cancer GM: https://www.answercancergm.org.uk/ (https://www.answercancergm.org.uk/) LGBT foundation: https://lgbt.foundation/ (https://lgbt.foundation/) Peaches Womb Cancer Trust: https://peachestrust.org/ (https://peachestrust.org/)
3 Feb 2023
Prostate cancer with Professor Robert Bristow: Is globalisation the future of cancer research?
This World Cancer Day 2023, we speak to Professor Robert Bristow, the Director of the Manchester Cancer Research Centre, Chief Academic Officer at The Christie NHS Foundation Trust and Professor of Cancer Studies at The University of Manchester about his research in prostate cancer. We also cover the broader cancer research environment in Manchester, the importance of teamwork and team science and research, and delivering impact through internationalisation. Professor Robert Bristow’s profile: https://www.bmh.manchester.ac.uk/about/people/leadership/robert-bistow/ (https://www.bmh.manchester.ac.uk/about/people/leadership/robert-bistow/) Listen to Dr Martin Swinton explain the HYPROGEN trial: CRUK RadNet Manchester. -The HYPROGEN Trial with Dr Martin Swinton (https://youtu.be/QCpfuiLSBxI)
11 Nov 2022
One in Two podcast - Looking outside the cell with Professor Sarah Cartmell: can we see where cancer starts?
In this episode we speak to Professor Sarah Cartmell on her work in bioengineering and ex-vivo modelling which involves studying cancer cells outside of an organism. Specifically, we talk about her team's work developing these models that can analyse, in three dimensions, how non-cancerous lung cancer cells develop into tumours and what the findings from this work could mean for improving patient outcomes. Sarah Cartmell research profile: https://www.research.manchester.ac.uk/portal/sarah.cartmell.html (https://www.research.manchester.ac.uk/portal/sarah.cartmell.html) Sarah Cartmell wikipedia page: https://en.wikipedia.org/wiki/Sarah_Cartmell (https://en.wikipedia.org/wiki/Sarah_Cartmell) Retendon home page: https://retendon.com (https://retendon.com/) Manchester Cancer Research Centre: https://www.mcrc.manchester.ac.uk (https://www.mcrc.manchester.ac.uk/) Professor Angeliki Malliri research profile: https://www.research.manchester.ac.uk/portal/en/researchers/angeliki-malliri(ef02a673-73ab-4434-8e1f-c18400019490).html (https://www.research.manchester.ac.uk/portal/en/researchers/angeliki-malliri(ef02a673-73ab-4434-8e1f-c18400019490).html) Dr Andrew Gilmore research profile: https://www.research.manchester.ac.uk/portal/andrew.gilmore.html (https://www.research.manchester.ac.uk/portal/andrew.gilmore.html) Dr Sean Knight research profile: https://www.research.manchester.ac.uk/portal/sean.knight.html (https://www.research.manchester.ac.uk/portal/sean.knight.html) Dr Kate Finegan research profile: https://www.research.manchester.ac.uk/portal/k.g.finegan.html (https://www.research.manchester.ac.uk/portal/k.g.finegan.html) Miss Emmanouela Mitta research profile: https://www.research.manchester.ac.uk/portal/emmanouela.mitta.html (https://www.research.manchester.ac.uk/portal/emmanouela.mitta.html)
4 Nov 2022
One in Two podcast - Womb cancer and Lynch syndrome with Professor Emma Crosbie: How did we change clinical practice?
In this episode, we speak to Professor Emma Crosbie about her research in womb cancer and the breakthrough she made in discovering a link between Lynch syndrome and womb cancer. We discuss the steps Emma and her team took to change NICE guidance on testing for Lynch syndrome for women with womb cancer, and what this now means for the many women and their families with this disease. Emma Crosbie’s research profile: https://www.research.manchester.ac.uk/portal/emma.crosbie.html (https://www.research.manchester.ac.uk/portal/emma.crosbie.html) Cancer futures: https://www.bmh.manchester.ac.uk/stories/cancer/ (https://www.bmh.manchester.ac.uk/stories/cancer/) Peaches trust: https://peachestrust.org/ (https://peachestrust.org/) What is cervical screening? https://www.nhs.uk/conditions/cervical-screening/ (https://www.nhs.uk/conditions/cervical-screening/) Macmillan Cancer support: https://www.macmillan.org.uk/ (https://www.macmillan.org.uk/) Read more in this blog from the Policy@Manchester Team and hear directly from people who will be affected by this change in healthcare policy: https://www.policy.manchester.ac.uk/activities/lynch-syndrome/ (https://www.policy.manchester.ac.uk/activities/lynch-syndrome/)
28 Oct 2022
One in Two podcast - Nano-omics with Dr Marilena Hadjidemetriou: can nanoparticles help us find early signs of cancer?
In this episode we speak to Dr Marilena Hadjidemetriou about her research on nano-omics, which aims to integrate nanotechnology to the ‘world of omics’ as well as proteomic biomarker discovery. We find out how nano-omics is being used to isolate molecular biomarkers that highlight the early stages of cancer in patients, making earlier cancer detection possible. Marilena’s research profile: https://nanomedicinelab.com/people/marilena-hadjidemetriou/ (https://nanomedicinelab.com/people/marilena-hadjidemetriou/) Nanomedicine lab 2.0: https://nanomedicinelab.com/research/teams/nano-omics/ (https://nanomedicinelab.com/research/teams/nano-omics/)
14 Oct 2022
One in Two podcast - Health Economics: Is early detection cost effective?
In this episode we speak to Professor Katherine Payne about health economics; what it is, its importance in cancer treatment and early detection strategies and the crucial role it plays in changing healthcare policy. We discuss Katherine’s work evaluating the health and economic benefits of banning sunbeds in England and the effect that a policy intervention would have in reducing the burden of skin cancer on the NHS. CRUK: https://www.cancerresearchuk.org/?gclid=Cj0KCQjw-fmZBhDtARIsAH6H8qgxqXaY3V-t80BG6HPUGwl9XBsoh74Xr7N1rVQObEm6EYHYsEsyBq4aAj99EALw_wcB&gclsrc=aw.ds (https://www.cancerresearchuk.org/?gclid=Cj0KCQjw-fmZBhDtARIsAH6H8qgxqXaY3V-t80BG6HPUGwl9XBsoh74Xr7N1rVQObEm6EYHYsEsyBq4aAj99EALw_wcB&gclsrc=aw.ds) Melanoma Focus: https://melanomafocus.org/ (https://melanomafocus.org/) How can we encourage the UK public to stop indoor tanning?: https://www.mcrc.manchester.ac.uk/how-can-we-encourage-the-uk-public-to-stop-indoor-tanning/ (https://www.mcrc.manchester.ac.uk/how-can-we-encourage-the-uk-public-to-stop-indoor-tanning/) The case for banning sunbeds: https://www.mcrc.manchester.ac.uk/impact-case-studies/the-case-for-banning-sunbeds/ (https://www.mcrc.manchester.ac.uk/impact-case-studies/the-case-for-banning-sunbeds/) Scientists: 'A ban on sunbeds could save lives from skin cancer': https://www.bbc.co.uk/news/newsbeat-61508470 (https://www.bbc.co.uk/news/newsbeat-61508470) Ban on solariums in England would save hundreds of lives from skin cancer, study finds: https://www.theguardian.com/society/2022/may/19/ban-on-solariums-in-england-would-save-hundreds-of-lives-from-skin-cancer-study-finds (https://www.theguardian.com/society/2022/may/19/ban-on-solariums-in-england-would-save-hundreds-of-lives-from-skin-cancer-study-finds)
7 Oct 2022
One in Two podcast - Cervical screening in the LGBTQIA+ community with Dr Jen Davies-Oliveria and Professor Emma Crosbie: how can we make screening more inclusive?
In this episode we speak to Dr Jen Davies-Oliveira and Professor Emma Crosbie about their research into womb cancer and human papilloma virus, commonly known as HPV. We also discuss one of their research projects developing alternative self-sampling methods for HPV. With lower cervical screening uptake in communities such as the LGBTQIA+ community, we explore how addressing barriers to screening can be achieved through greater engagement with these groups and the importance of developing an inclusive approach to screening. Live through this: https://livethroughthis.co.uk/ (https://livethroughthis.co.uk/) Jo’s Cervical Cancer Trust: https://www.jostrust.org.uk/ (https://www.jostrust.org.uk/) Answer cancer GM: https://www.answercancergm.org.uk/ (https://www.answercancergm.org.uk/) LGBT foundation: https://lgbt.foundation/ (https://lgbt.foundation/) Peaches Womb Cancer Trust: https://peachestrust.org/ (https://peachestrust.org/)
29 Sept 2022
One in Two podcast - Breast cancer with Professor Gareth Evans: should all women be screened equally?
In this episode we speak to Professor Gareth Evans about the importance of breast cancer screening, as well as the risk predictors of breast cancer as he answers the question: Should all women be screened equally for breast cancer? He discusses risk prediction, early detection and prevention of breast cancer, highlighting the outputs of trials led by Manchester investigating the best routes for breast cancer screening. Professor Gareth Evans profile: https://www.research.manchester.ac.uk/portal/gareth.d.evans.html (https://www.research.manchester.ac.uk/portal/gareth.d.evans.html) Julia Bradbury: Breast Cancer and Me: https://www.itv.com/hub/julia-bradbury-breast-cancer-and-me/10a1995a0001 (https://www.itv.com/hub/julia-bradbury-breast-cancer-and-me/10a1995a0001) MFT Cancer Professor features in Julia Bradbury breast cancer documentary: https://research.cmft.nhs.uk/news-events/mft-cancer-professor-features-in-julia-bradbury-breast-cancer-documentary (https://research.cmft.nhs.uk/news-events/mft-cancer-professor-features-in-julia-bradbury-breast-cancer-documentary) Saliva test ‘could predict breast cancer risk’: https://www.thetimes.co.uk/article/saliva-test-could-predict-breast-cancer-risk-w9trmkdvx (https://www.thetimes.co.uk/article/saliva-test-could-predict-breast-cancer-risk-w9trmkdvx) Simple saliva test for breast cancer could save thousands of under-50s as breakthrough can spot women at a highest risk years earlier, study shows: https://www.dailymail.co.uk/news/article-10843127/Simple-saliva-test-breast-cancer-save-thousands-50s.html (https://www.dailymail.co.uk/news/article-10843127/Simple-saliva-test-breast-cancer-save-thousands-50s.html) Breast cancer in women: https://www.nhs.uk/conditions/breast-cancer/ (https://www.nhs.uk/conditions/breast-cancer/) Macmillan cancer support: https://www.macmillan.org.uk/ (https://www.macmillan.org.uk/) Prevent Breast Cancer: https://preventbreastcancer.org.uk/ (https://preventbreastcancer.org.uk/) Please be aware, this podcast was recorded on the 7th June 2022 when Sajid Javid was still Secretary of State for Health.
22 Sept 2022
One in Two podcast - Health inequalities with Professors Phil and Emma Crosbie: does going directly to communities improve screening uptake?
In this episode, we speak to Professor Phil Crosbie and Professor Emma Crosbie about their research in the early detection of lung and womb cancer and their work on community screening and addressing health inequalities. With cancer incidence rising, especially amongst the most socially and economically disadvantaged communities, the need for earlier detection interventions has never been more important. We find out how this cancer research power couple are transforming cancer patient outcomes through novel approaches to early detection. Phil Crosbie’s research profile: https://www.research.manchester.ac.uk/portal/philip.crosbie.html (https://www.research.manchester.ac.uk/portal/philip.crosbie.html) Emma Crosbie’s research profile: https://www.research.manchester.ac.uk/portal/emma.crosbie.html (https://www.research.manchester.ac.uk/portal/emma.crosbie.html) Cancer futures: https://www.bmh.manchester.ac.uk/stories/cancer/ (https://www.bmh.manchester.ac.uk/stories/cancer/) Peaches trust: https://peachestrust.org/ (https://peachestrust.org/) What is cervical screening? https://www.nhs.uk/conditions/cervical-screening/ (https://www.nhs.uk/conditions/cervical-screening/) Manchester lung health check: https://mft.nhs.uk/lunghealthcheck/ (https://mft.nhs.uk/lunghealthcheck/) Macmillan Cancer support: https://www.macmillan.org.uk/ (https://www.macmillan.org.uk/)
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