Against the Grain

About Against the Grain

Host: Samir Kakodkar, MD - specialist in Crohn's disease and ulcerative colitis Medical School: Northwestern Feinberg School of Medicine Internal Medicine Residency: Rush University Medical Center Fellowship in Gastroenterology and Hepatology: Advocate Lutheran General Hospital Advanced Fellowship in Inflammatory Bowel Disease (Crohn's and Colitis): Northwestern Memorial Hospital Practice Location 7900 N Milwaukee Ave Suite 19, Niles, IL 60714 For appointments: 847-318-9595 Contact: samir3@gmail.com YouTube channel: https://www.youtube.com/channel/UCSzuuqUFGgtcwpAbtL5b0xw If interested in scheduling a phone conversation with me, please visit https://calendly.com/samir3/against-the-grain Twitter: @KakodkarSamir

Publisher

Samir Kakodkar

Category

health & fitness

Language

en

Explicit

No

First episode

2 Jan 2018

Latest episode

26 Jun 2026

Latest episodes

1 of 35 episodes have a transcript.

1. 

   26 Jun 2026TRANSCRIPT

   Episode 35: Healing IBD: Biologics, Diet, and the Path to Remission with Dr. Samir Kakodkar and Andrew Kornfeld

   Host Dr. Samir Kakodkar interviews Andrew Kornfeld about the latest advancements in IBD treatment, including biologics and diet, guiding listeners toward remission.

2. 

   27 Feb 2022

   Episode 34: My Unbiased Breakdown of Zeposia (Ozanimod) for Ulcerative Colitis

   This is my review of Zeposia (Ozanimod), a new once a day oral medication for moderate to severe ulcerative colitis. I go over the True North Study (https://www.nejm.org/doi/full/10.1056/NEJMoa2033617) in detail including efficacy and safety data. I have no conflicts of interest with any pharmaceutical companies. These are my opinions regarding Zeposia and other medications based on my personal/clinical experience and review of the literature.

3. 

   30 Jan 2022

   Episode 33: What Do Your Biopsies Mean? The Pathology of Crohn's and Colitis - Shriram Jakate, MD

   Dr. Shriram Jakate is Professor Emeritus in pathology at Rush University Medical Center. He has a particular expertise in GI and liver pathology and has been interpreting slides from patients with Crohn's and colitis for over several decades. I consider him to be the best GI pathologist I have encountered in my career and during this podcast we have a wide ranging discussion about interpretation of IBD pathology. We discuss the pathologic features of Crohn's and ulcerative in detail and also go over IBD mimickers (including NSAID induced inflammation), C diff, pouchitis and rethinking the classification of IBD subtypes.

Inside a recent episode

Episode 35: Healing IBD: Biologics, Diet, and the Path to Remission with Dr. Samir Kakodkar and Andrew Kornfeld

Published 26 Jun 2026 · Transcript excerpt

[…] There's some sort of change in the microbiome. There's some sort of change in the integrity of the gut lining. And please correct me if anything has evolved or changed, but then we see a leakage of bacterial organisms, food particles, other constituents of the microbiome into this inner layer of cells into the lamina propria where there's an immune response. Has anything changed in that mechanism or did I get that right? No, that's about right. I mean, I think overall that's the progression. Now, there is something called early onset inflammatory bowel disease where kids are diagnosed as like babies, like as infants. […]

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Public platform figures. Ratings count people who left a rating, not total listeners.

Apple Podcasts (US)

4.8 / 5

54 ratings

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