Welcome to "Ageless & Outrageous", the podcast where urogynecologist and hormone and sexual health expert, Dr. Kristin Jackson, shares her 25 years of expertise to guide both men and women on the path to aging amazingly.
Listen as she dives into a spectrum of topics, with an emphasis on hormone optimization, pelvic floor health, and maintaining vibrant sexual experiences as we age. From exploring the intricacies of hormonal balance to discussing strategies for pelvic floor well-being, Dr. Jackson brings you real-life insights rooted in solid scientific knowledge.
Get ready for a podcast that combines the wisdom of years of medical practice with an approach that's relatable and enjoyable. Tune in for a dose of laughter, knowledge, and a rejuvenated perspective on the incredible adventure of growing older.
Beyond Hot Flashes: How Estrogen Shapes Women’s Heart Health
In this episode, I’m talking about one of the most overlooked threats to women’s health—heart disease—and the powerful role estrogen plays in protecting your cardiovascular system. Most people think of estrogen in relation to hot flashes, mood swings, or bone health, but it also keeps your blood vessels healthy and your heart protected. When estrogen levels drop at menopause, that protection fades, and your risk for heart problems can rise quickly.
I break down how estrogen impacts your blood vessels, why heart disease risk skyrockets after menopause, and the surprising reproductive and lifestyle factors that can raise your risk—many of which you’ve probably never heard about from your doctor. I’ll also share the simple, powerful steps you can take right now to protect your heart, improve your longevity, and feel your best as you age.
Here’s what I cover in this episode:
How estrogen protects your arteries, reduces inflammation, and lowers LDL cholesterol
Why heart disease is the number one killer of women—and why most women don’t realize it
Reproductive and hormonal risk factors (PCOS, early menopause, pregnancy complications, persistent hot flashes)
The hidden danger of central obesity and why fat distribution matters
Key lifestyle strategies for heart health: movement, diet, and modifying controllable risks
How hormone replacement therapy (HRT) can benefit both short-term symptoms and long-term heart protection
Practical tips to start improving cardiovascular health in midlife and beyond
This episode is all about giving you the science, the numbers, and the tools you need to protect your heart—because when it comes to longevity, the odds are in your favor if you focus on the right risks.
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9 Jul 2025
Estrogen and Alzheimer’s: What 6 Million Women Taught Us
Let’s talk about something most doctors still aren’t saying clearly enough: estrogen matters for your brain. In this episode, I review what the research actually shows about HRT and long-term brain protection.
Alzheimer’s disease is the leading cause of death for women over 65 in the U.S. and Australia. And it’s not just because we live longer — women are more biologically vulnerable. One major reason? Estrogen loss.
Let's look at a 2023 comprehensive review of over 6 million women that looked at whether hormone therapy helps or harms brain health. Spoiler alert: timing matters. This episode is especially important for women in perimenopause or newly postmenopausal who are being told to “just wait it out.”
The Alzheimer’s crisis in women
Over 2/3 of Alzheimer’s cases are women
Not just about longevity — estrogen plays a direct role in brain protection
Major takeaways from the 2023 neuroscience meta-analysis
Over 6 million women studied
Combined randomized trials + real-world data
Main finding: Timing and type of hormone therapy make all the difference
When hormone therapy helps protect your brain
Estrogen started in midlife (around age 50) reduced Alzheimer’s risk by 32%
Observational studies showed a 22% lower risk of Alzheimer’s and a 19% reduced risk of all-cause dementia
Women on estrogen-only therapy had better cognitive outcomes than those on estrogen + synthetic progestins
Longer duration (>6 years) of HRT use = greater brain benefit
When it may not help — or may even increase risk
Women who start hormone therapy after age 65 or well past menopause may see no benefit or increased risk
This risk mostly applies to oral estrogen and progestins (synthetic, not bioidentical)
Think of it like sunscreen: starting after the damage has been done doesn’t help much
The “Window of Opportunity” Concept
Best brain benefits come from starting HRT during perimenopause or early postmenopause (within 10 years of last period)
Estrogen is neuroprotective during this transition — but less effective if cognitive decline has already started
Why synthetic progestins fall short
Studies consistently show better brain outcomes without progestins
We still lack data on bioidentical progesterone and brain health — more research needed
Bottom line: avoid synthetic versions if possible
If you’re already over 65 — is it too late?
Not necessarily
HRT may still help with other issues like bone, sleep, or quality of life
But brain protection may not be as significant
Requires individualized risk-benefit analysis
Every woman deserves a personalized, balanced discussion about hormone therapy — not one-size-fits-all advice based on outdated studies. If you’re in your 40s or 50s, this is the time to have that conversation — not after problems start.
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Website https://www.foundationsfl.com/ (https://www.foundationsfl.com/)
FB facebook.com/advancedurogynecology (facebook.com/advancedurogynecology)
3 Jul 2025
Still Flashing at 65? You’re Not Too Late for HRT
Kristin Jackson MD discusses the myth that women over 60 are too old for hormone replacement therapy, exploring the origins of this misconception and the latest scientific data.
Reach and audience
Public platform figures. Ratings count people who left a rating, not total listeners.
Apple Podcasts (US)
5.0 / 5
8 ratings
Spotify
5.0 / 5
4 ratings
Podcast Authority Score: 47 / 100
A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.
Quality
67
Social presence
0
YouTube
0
Engagement
71
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