About All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit
Started by ACARE in 2023 within the ACARELevelUp program this podcast is an invaluable resource for health care professionals, and anyone interested in learning more about angioedema. Dr. Thomas Buttgereit, Head of the Study Center at Charité Berlin, discusses all forms of angioedema, their pathophysiology, burden and treatment strategies with experts from all over the world. All opinions expressed are those of the faculty. This content should not be taken as medical advice and is for informational purposes only. Learn more about ACARE here: https://acare-network.com/
Publisher
ACARE, the Global Allergy and Asthma Excellence Network for Angioedema
In this episode of All Things Angioedema, Dr. Thomas Buttgereit speaks with Dr. Iván Chérrez and Dr. Carolina Crespo about the SAFE HAE study and an important but under-recognized aspect of hereditary angioedema (HAE): mental health and suicidal ideation. The discussion explores preliminary findings from Latin America and why psychological health should become an integral part of comprehensive HAE care.
They discuss:
🔹 How common are anxiety, depression, and suicidal ideation in patients with HAE?
🔹 What did the preliminary SAFE HAE study reveal?
🔹 How are attack frequency and functional impairment associated with psychological risk?
🔹 Why can even disruptions in everyday life have an important mental health impact?
🔹 Should mental health screening become part of routine HAE management?
🔹 Can findings from Latin America be relevant to HAE patients worldwide?
🔹 What are the next research questions for the SAFE HAE initiative?
The episode emphasizes that HAE management should extend beyond preventing and treating attacks. Recognizing psychological distress and integrating mental health assessment into routine care may help identify vulnerable patients and support more comprehensive, patient-centered management.
Key Learnings from the Episode:
Mental health is an important but under-recognized aspect of HAE care.
Anxiety and depression were common in the preliminary SAFE HAE cohort.
A proportion of patients showed a high risk of suicidal ideation.
Higher attack frequency was associated with increased psychological risk.
Functional impairment and pain can contribute to suicidal ideation.
Mental health risks may not be limited to patients with the most severe physical limitations.
Routine mental health screening could help identify patients at risk.
Validated tools such as SIDAS may support assessment in clinical practice.
Further international research is needed to understand the global relevance of these findings.
Comprehensive HAE care should address both physical disease and psychological wellbeing.
Chapters:
00:00 Introduction to mental health in HAE patients
02:25 Meet the researchers: Dr. Ivan Cherrez-Ojeda and Dr. Carolina Crespo
04:05 Motivation behind studying suicidal ideation in Latin American HAE patients
06:04 Study design: Multi-center cross-sectional survey in Latin America
07:37 Key findings: Prevalence of depression, anxiety, and suicidal risk
09:00 Association between clinical symptoms and mental health risk
10:34 Implications for clinical practice: Routine mental health screening
12:34 Global relevance of findings and future research directions
14:03 Next steps: Comparing Latin America with other regions
16:05 Summary: The importance of mental health assessment in HAE care
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15 Sept 2026
Physician Mental Health in Angioedema Care
In this episode of All Things Angioedema, Dr. Thomas Buttgereit speaks with Dr. Oscar Calderón LLosa from Lima, Peru, about an often-overlooked aspect of angioedema care: the mental burden experienced by physicians. Dr. Calderón introduces the MENPHYS project, which investigates stress, anxiety, burnout, and other psychological challenges among physicians treating patients with recurrent angioedema.
They discuss:
🔹 Why is physician mental health important in angioedema care?
🔹 What did the initial MENPHYS pilot study reveal?
🔹 How does access to HAE treatment influence physician burden?
🔹 Which healthcare system factors contribute to stress?
🔹 How involved are physicians during acute HAE attacks?
🔹 What do early findings show about anxiety, stress, and burnout?
🔹 How could the MENPHYS project improve future angioedema care?
The discussion shows that improving angioedema care is not only about supporting patients and caregivers. Recognizing and addressing the mental burden of healthcare professionals may also be essential for sustainable, high-quality patient care.
Key Learnings from the Episode:
Physicians treating recurrent angioedema can experience substantial mental burden.
Managing potentially life-threatening HAE attacks can create significant stress.
Access to effective treatments varies considerably between countries.
Physician burden appears to be influenced by multiple healthcare system factors.
Many physicians are contacted directly by patients during acute attacks.
Anxiety, perceived stress, burnout, and depersonalization are important areas of concern.
Standardized tools can help quantify physician mental health outcomes.
Education on angioedema classification and treatment remains important.
The MENPHYS study aims to identify strategies that reduce physician burden.
Supporting physicians may ultimately contribute to better and more sustainable patient care.
Chapters:
00:00 Introduction to the MENPHYS study and its focus
02:49 Motivation behind the MENPHYS project
05:09 Key findings from the pilot study
08:19 Main objectives of the MENPHYS study
09:24 Tools used to measure mental health in physicians
10:29 Physicians' involvement during acute attacks
11:26 Early mental health outcomes from MENPHYS
12:24 Next steps for the MENPHYS project
13:28 Final message on physician mental health
14:23 Summary and closing remarks
Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here.
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18 Aug 2026
Facial Swelling: Finding the Diagnosis
In this episode of All Things Angioedema, Dr. Thomas Buttgereit speaks with dermatologist Dr. Natasha Teovska Mitrevska from North Macedonia about one of the biggest challenges in clinical practice: distinguishing angioedema from other conditions that cause facial or tissue swelling. Drawing on her experience in both medical and aesthetic dermatology, she explains common differential diagnoses and discusses how cosmetic procedures can trigger swelling that resembles angioedema.
They discuss:
🔹 Which conditions commonly mimic angioedema?
🔹 How can cosmetic and aesthetic procedures trigger swelling?
🔹 Which forms of chronic inducible urticaria may occur after aesthetic treatments?
🔹 Why is careful patient history essential before cosmetic procedures?
🔹 How can clinicians distinguish inflammatory swelling from true angioedema?
🔹 What should patients and practitioners know about fillers and delayed reactions?
The episode highlights the importance of careful clinical assessment, patient history, and awareness of differential diagnoses to ensure patients receive the correct diagnosis and treatment while safely undergoing dermatological and aesthetic procedures.
Key Learnings from the Episode:
Not every facial swelling is angioedema.
Several skin diseases and infections can mimic angioedema.
A thorough medical history is essential before cosmetic procedures.
Laser treatments, fillers, and other aesthetic procedures can trigger temporary swelling.
Patients with chronic urticaria or inducible urticaria may have a higher risk of procedure-related reactions.
Different types of chronic inducible urticaria can be triggered by physical stimuli during aesthetic treatments.
Delayed inflammatory reactions after fillers require careful evaluation.
Accurate diagnosis helps distinguish true angioedema from cosmetic treatment-related swelling.
Close collaboration between dermatologists and allergy specialists improves patient safety.
Chapters:
00:00 Introduction to the episode and guest
01:08 Guest introduction and practice background
04:20 Common differential diagnoses for facial swelling
06:22 Swelling duration and laser hair removal
07:45 Inflammatory swelling from aesthetic procedures
09:25 Other differential diagnoses: lupus, rosacea, drug reactions
12:22 Impact of chronic conditions and medication on swelling
16:32 Allergic reactions to fillers and aesthetic materials
18:23 Perception of beauty and filler overfilling
21:24 Balancing aesthetic goals with safety considerations
22:22 Closing remarks and contact information
Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here.
Feedback form ATA: https://forms.office.com/e/ZWxx3D4Cmr (https://forms.office.com/e/ZWxx3D4Cmr)
Who has been a guest on All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit
Names identified in recent episode analyses. Showing up to five guests.
Dr Mark Kačar
Dr Vesna Trajkova
Mats de Lange
Dr Alexis Bocquet
Dr Efrem Eren
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