More than 7 million Americans are living with Alzheimer's, according to the Alzheimer's Association. UC Davis researcher Alyssa Weakley is working on I-Care, a new technology that's helping Alzheimer's patients live longer in their own homes.
At UC Davis, our researchers are working to better understand the causes of dementia, including Alzheimer’s, its most common form, while advancing understanding and improving care for those affected. Through innovative studies, we’re paving the way for new treatments and strategies to slow, prevent and ultimately transform how we approach these complex neurological conditions. Series: "UC Davis News" [Health and Medicine] [Show ID: 41737]
6 Aug 2026
Improving Early Alzheimers Detection in Women by Integrating Multimodal Data Into Clinical Decision Tools with Iris Broce-Diaz Ph.D.
Alzheimer’s disease can begin developing years before memory and thinking problems become noticeable. Iris Broce-Diaz, Ph.D., of UC San Diego is developing accessible, noninvasive, and cost-effective tools to help primary care physicians and neurologists identify people at higher risk earlier. Her models combine information from cognitive assessments, brain imaging, genetics, and PET scans to estimate the likelihood that mild cognitive impairment will progress within five years. Combining multiple measures improves the models’ ability to separate higher- and lower-risk patients. Broce-Diaz also plans to add women-specific factors, including menopause history, hormone therapy, reproductive history, endocrine markers, and symptoms. The goal is to support better referrals, guide monitoring, and help eligible patients consider treatment sooner. Earlier risk assessment could also strengthen clinical trials and make dementia care more useful across different health systems. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 41632]
10 Apr 2026
Alzheimer's and Other Neurodegenerative Diseases: From Mechanisms to (Faltering) Therapies - Shiley Endowed Lecture
Alzheimer’s disease unfolds over many years through a complex interplay of amyloid, tau, genetics, lipid biology, and the brain’s immune response. John Hardy, Ph.D., explains how rare inherited forms of Alzheimer’s disease helped shape current thinking about how the disease begins, then connects those discoveries to broader questions about late onset disease and why it develops differently across people. Hardy shows that amyloid and tau are linked but not identical, and argues that problems with protein buildup and clearance both matter in understanding the disease. He also emphasizes that Alzheimer’s is not a single event but a long process, which makes prediction, diagnosis, and treatment especially difficult. While current amyloid-targeting therapies can help and show measurable benefit, Hardy says they do not stop the disease, underscoring the need for earlier diagnosis, better treatments, and wider access to care Series: "Shiley Endowed Lecture" [Health and Medicine] [Show ID: 41250]
19 Mar 2026
Slowing the Clock: Longevity Science Meets Alzheimer’s Prevention
How fast are you really aging, and what could that mean for brain health? Aladdin H. Shadyab, Ph.D., explores the gap between chronological age and biological age, and why that difference matters for long-term health. Shadyab describes tools that use information from blood to estimate how quickly the body is aging, including approaches that look beyond the body as a whole to consider aging in specific systems. He connects faster biological aging with higher risk for age-related disease and declines in physical and cognitive function, and discusses how blood-based biomarkers may offer earlier signals of processes linked to Alzheimer’s disease. Shadyab also highlights lifestyle and treatment findings that may support healthier aging and longer survival. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41073]
7 Aug 2025
Alzheimer's Disease in Women: Why Sex Differences Matter
Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]
3 Jan 2025
Uncovering Mechanisms of Neurodegenerative Diseases by CRISPR-Based Screens with Martin Kampmann
Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]
9 Sept 2024
Exercise Improves Brain Health?
What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on the effects of exercise on brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40062]
29 Aug 2024
Risk Factors for Alzheimer's What You Can Change
What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, and discover actionable steps you can take to protect your brain health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40061]
21 Aug 2024
Diet's Effect On Cognitive Decline Vascular Risk
What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on diet and cognitive decline. Learn how diet, vascular health and inflammation contributes to cognitive function and discover actionable steps you can take to protect your brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40063]
15 Aug 2024
Delay Cognitive Decline with This Device
What can you do today to improve or maintain your brain health? Sarah Banks, Ph.D., an expert in healthy aging, dementia, and Alzheimer's disease, explores risk factors and corrective tips associated with sleep apnea. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40042]
30 May 2024
Can We Avoid Cognitive Decline with Age?
What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, for an in-depth exploration of the latest research on cognitive decline. This comprehensive program delves into the science behind brain health, covering key factors such as exercise, diet, sleep, social engagement, vascular health, hearing loss, and inflammation. Learn how each of these elements contributes to cognitive function and discover actionable steps you can take to protect your brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39387]
29 Mar 2024
Cognitive Aging In The Oldest Old: Resilience And Risk Revealed
Claudia H. Kawas, M.D., addresses Alzheimer's disease and related conditions in older adults, noting the challenge of accurate diagnosis and the resemblance of other brain conditions to Alzheimer's. She introduces "resistance" and "resilience," explaining how some individuals remain cognitively intact despite brain changes. Kawas suggests declining dementia risk due to improved vascular health management, emphasizing the complexity of cognitive decline and the need for further research. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 39532]
11 Feb 2023
Looking to a Future Without Alzheimer's
Alzheimer’s disease is a major health crisis that is projected to become an even larger threat in the coming decades. According to the National Institute on Aging, the number of Americans 65 and older with Alzheimer’s could rise from 5.8 million in 2020 to 13.8 million by 2050. Given the severity of this health crisis and the toll it takes on patients, their families and society, we must be prepared today to address the needs of tomorrow. Dean Frank LaFerla of UC Irvine's School of Biological Sciences presents an overview of the state of Alzheimer’s disease research. Following his presentation, the panel discusses emerging trends in research, care and the upcoming challenges we will face and how we might mitigate them. [Health and Medicine] [Show ID: 38660]
16 Nov 2022
Modeling Neurological Conditions Using Stem Cell-Derived Neurons: ApoE and APP in Alzheimer's Disease with Thomas C. Südhof - Sanford Stem Cell Symposium 2022
Thomas C. Südhof, M.D., Stanford University, discusses facets of the fundamental cell biology of ApoE and APP analyzed in stem cell-derived human neurons. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38405]
13 Apr 2022
How Changes in Proteins Can Lead to Diseases
Dr. Songi Han, professor in the Department of Chemistry, Biochemistry and Chemical Engineering at UC Santa Barbara, talks about her research into the function of proteins in the body and how changes like protein Tau tangles can lead to neurological diseases like Alzheimer's. Series: "GRIT Talks" [Health and Medicine] [Science] [Show ID: 37869]
20 Nov 2021
Neurostimulation for Cognition in Alzheimer's Dementia and High Risk Populations with Tarek Rajji
Tarek Rajji, MD, shares research from current trials combining brain stimulation with interventions including cognitive remediation. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 37598]
30 Aug 2021
Alzheimer's Disease - The Language Syndrome
Dr. Georges Naasan discusses communication difficulties associated with the language syndrome of Alzheimer's Disease. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 37334]
27 Aug 2021
Alzheimer's Disease - The Frontal/Executive Syndrome
Dr. Georges Naasan describes the symptoms seen in the frontal/executive syndrome of Alzheimer's disease. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 37335]
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