American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

About American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

Podcasts of the American Journal of Physiology-Gastrointestinal and Liver Physiology

Publisher

ajpgi

Category

science

Language

en

Explicit

No

First episode

28 Mar 2022

Latest episode

8 Sept 2025

Latest episodes

50 episodes in the feed.

1. 

   8 Sept 2025

   Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling

   In this episode, Dr. Aditya Joshi and coauthors discuss their team’s recently published study, “Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling." The study showed that absence of AhR in hepatocytes results in exacerbated metabolic dysfunction-associated steatohepatitis (MASH) in mice subjected to Western-style high-fat high-fructose high-cholesterol diet. Moreover, treatment with a tryptophan catabolite, cinnabarinic acid (CA) mitigated hallmarks of MASH in an AhR-dependent manner. In conclusion, the study delineates the significance of hepatic AhR-dependent AMPK signaling in CA-mediated protection against MASH. Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling. Nikhil Y. Patil, Iulia Rus, Felix Ampadu, Hassan M. Abu Shukair, Sarah Bonvicino, Richard S. Brush, Elena Eaton, Martin-Paul Agbaga, Tae Gyu Oh, Jacob E. Friedman, and Aditya D. Joshi 2025 329:4, G433-G447

2. 

   24 Jul 2025

   Uncovering the Gut-Adipose-Liver Axis: Microbiota Encroachment and Metabolic Dysfunction in MASLD

   In this episode, coauthors Daria Igudesman and Karen D. Corbin discuss their team’s recently published study, "Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease." This first-in-human study explores how changes in the gut microbiota may contribute to metabolic dysfunction through a gut-adipose-liver axis. The researchers found that colonic expression of insulin and lipid-related genes may link microbial encroachment in the colon with adipose tissue insulin resistance and the development of metabolic dysfunction-associated steatotic liver disease (MASLD). Tune in to learn how these findings offer new insights into the complex interplay between the gut microbiome and metabolic health. Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease Daria Igudesman, GongXin Yu, Charlene Dauriat, Torfay Roman, Maryam R. Kashi, Elizabeth Blakley, Benoit Chassaing, and Karen D. Corbin American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 329:1, G201-G214

3. 

   24 Jul 2025

   Modeling Eosinophilic Esophagitis: Insights from Mouse Models into Mechanisms and Therapies

   In this episode, coauthors Jazmyne L. Jackson, Abigail J. Staub, Annie D. Fuller, and Kelly A. Whelan join us to discuss their recently published review, "Mouse models of eosinophilic esophagitis: molecular and translational insights." Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease of the esophagus with growing prevalence and clinical impact, yet many of its underlying mechanisms remain poorly understood. The authors explore how murine models have advanced our knowledge of EoE pathogenesis, highlighting key molecular and translational findings uncovered through in vivo research. This episode delves into the strengths and limitations of existing models, current challenges, and future opportunities for leveraging mouse models to guide diagnosis, monitoring, and therapy development in EoE. Mouse models of eosinophilic esophagitis: molecular and translational insights Jazmyne L. Jackson, Abigail J. Staub, Annie D. Fuller, John M. Crespo, Travis H. Bordner, Courtney Worrell, No’ad Shanas, Danielle Waheed, Tatiana A. Karakasheva, Melanie Ruffner, Amanda B. Muir, and Kelly A. Whelan American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 329:1, G215-G231

Who has been a guest on American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

Names identified in recent episode analyses. Showing up to five guests.

• Gabriela Ribeiro
• Marta P Silvestre
• Harriët Schellekens
• Cristina Cuesta-Marti

Podcast Authority Score: 11 / 100

A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.

Quality

11

Social presence

0

YouTube

0

Engagement

27