About AoPcasts: Bringing you the latest in medical research
AoPcasts brings together expert voices from across medicine, clinical research, and healthcare innovation to explore the latest developments shaping modern healthcare. Through insightful conversations and specialist interviews, the series highlights emerging research, clinical advances, and the key issues influencing the future of medicine.
Reflecting on a distinguished and wide-ranging career as a clinician scientist, Professor Sir Mark Caulfield shares candid insights into the logistical, political and administrative challenges he has encountered along the way. From his early work in hypertension research to his leadership of the landmark 100,000 Genomes Project, he distils the key lessons learned and the practical toolkit needed to navigate a successful academic career. Offering clear, experience-based advice on planning rese...
2 Feb 2026
Fibromyalgia: New Paradigms in Etiopathogenesis
Fibromyalgia remains a challenging and often misunderstood condition, traditionally viewed through the lens of central sensitisation and chronic pain syndromes. However, emerging evidence is reshaping our understanding of its underlying mechanisms. This webinar will explore exciting new paradigms in fibromyalgia etiopathogenesis, focusing on the roles of immunity, autoimmunity, and small nerve fibre pathology. Cutting-edge research suggests that immune dysregulation and subtle autoimmune phen...
9 Dec 2025
THE CONSULT: Professor Paul Klenerman talks with Professor Christopher Buckley about his recent papers.
These recent papers describe work in the field of stromal cell biology. Fibroblasts were long regarded as simple structural cells and often ignored by immunologists. In these studies of human disease Chris Buckley discusses how recent approaches based on transcriptomics have shone new light on these cells and their role in disease. Given their long lived nature and capacity to remain resident in tissues, they may play particular roles in chronic inflammation. New data allows subsets of such c...
5 Dec 2025
PODCAST: AI in Medicine: Promise and Paradox
Artificial Intelligence is transforming medicine, from diagnostics and drug discovery to personalised treatment and predictive analytics. But alongside its promise come some important challenges: Algorithmic bias, data privacy, accountability and the tension between human judgment and machine intelligence. This webinar brings together medical scientists and academic physicians to explore the realities behind the (potential) hyperbole. An expert faculty will examine how AI can responsibly be i...
28 Nov 2025
THE CONSULT: Rilzabrutinib, Rozanolixizumab, and Beyond: ITP Therapeutics Explored. Professor Paul Klenerman talks to Professor Nichola Cooper about one of her recent papers.
Immune thrombocytopenia (ITP) is a rare autoimmune disease, but also one where a great deal of progress has been made in development of new therapies. Prof Cooper performs clinical trials to understand the impact of new therapies, based upon and also gaining insights into the underlying pathogenesis. The clear readout of platelet count allows for a trial design which can funnel diverse new types of therapy into the translational pathway, and this sort of study has implications more broadly fo...
28 Nov 2025
THE CONSULT: A precision medicine approach to colorectal cancer prevention using the omega (n)-3 polyunsaturated fatty acid (PUFA) EPA
Mark Hull talks about the translational research development of the n-3 PUFA EPA as a cancer prevention agent through to phase 2 and 3 clinical trials, touching on design and delivery of trials of ‘nutraceuticals’ like high-dose n-3 PUFAs, and how such an intervention might impact on cancer. Despite proof of concept from a small, randomised trial of EPA in patients with familial adenomatous polyposis, the same dose and formulation of EPA did not reduce overall colorectal polyp risk in the seA...
13 Nov 2025
PODCAST: Malaria Vaccines in Africa
The Association of Physicians of Great Britain and Ireland presents a discussion with key world leading experts in Malaria vaccines from the World Health Organisation and Oxford. Focusing on how vaccines are transforming Malaria prevention globally. Specifically, looking at the development and implementation of malaria vaccines. Speakers: Malaria vaccine pilot implementation and results (Mary Hamel, WHO)Malaria vaccine introduction - demand, status, challenges and opportunities (Eliane Pellau...
10 Nov 2025
THE CONSULT: Inflammation Across Tissues
Immune Mediated Inflammatory Diseases (IMIDs) are a common and growing problem. Traditional models of research and service delivery silo their management within specific specialities and within adult or paediatric settings. Very often patients with disease in one organ have co-morbid involvement in another, suggesting shared pathogenic pathways. Moreover, IMIDs are often treated in very similar ways (combination therapy) with very similar drugs (steroids and anti TNF biologics). In this semin...
2 Jul 2025
THE CONSULT: Prof. Paul Klenerman talks to Prof. Sir Munir Pirmohamed about two of his recent papers.
Professor Sir Munir Pirmohamed discusses his research on a 12-gene pharmacogenetic panel and preventing adverse drug reactions with Professor Paul Klenerman in this interview.
10 Dec 2024
Diabetes - Painful neuropathy, atrial fibrillation and global health research: An update
Professor Gregory Lip and Professor Solomon Tesfaye explore diabetes complications like neuropathy and atrial fibrillation, discussing research updates and cardiovascular outcomes in an interview with Dr. Uazman Alam.
11 Mar 2021
Infections old and new - has the COVID pandemic made us better prepared for the future?
Vivienne Parry OBE interviews Dr. Rino Rappuoli and Professor Ellie Barnes about the COVID pandemic and its impact on preparing for future infectious disease outbreaks.
11 Mar 2021
Introducing AoPcasts
Science broadcaster Vivienne Parry introduces the AoPcasts podcast series, which explores cutting-edge medical research presented at the Association of Physicians annual meeting, featuring Rino Rappuoli, Chief Scientist of the vaccines division of GSK.
Who has been a guest on AoPcasts: Bringing you the latest in medical research
Names identified in recent episode analyses. Showing up to five guests.
Prof Sir Munir Pirmohamed
Professor Gregory Lip
Professor Solomon Tesfaye
Dr Rino Rappuoli
Professor Ellie Barnes
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