A podcast about progress, philosophy, science, education, and the unconstrained human condition.
www.arjunkhemani.com (https://www.arjunkhemani.com?utm_medium=podcast)
Aubrey de Grey: Longevity Escape Velocity, SENS & the End of Aging
My conversation with Aubrey de Grey, a biomedical gerontologist, founder of the LEV Foundation, and author of Ending Aging.
Watch on YouTube (https://youtu.be/o4f9NMxEcz8) or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X (http://x.com/arjunkhemani) for updates on future episodes.
Timestamps
0:00 - SENS vs. the Hallmarks of Aging2:47 - The Robust Mouse Rejuvenation experiment5:48 - Is SENS falsifiable?7:12 - CMLase and extracellular matrix damage10:28 - VEGF and extending lifespan in mice11:37 - Why longevity studies rarely get replicated13:05 - Michael Levin, bioelectricity & aging as information loss15:03 - Is partial reprogramming overhyped?17:32 - The most neglected areas of longevity research18:56 - Longevity escape velocity explained20:28 - Will people alive today live long enough?23:42 - How far are we from dramatically extending mouse lifespan?24:54 - What happens to society if we solve aging?27:20 - How longevity could reshape the global economy28:44 - Does mortality give life meaning?30:00 - Aubrey on the “pro-aging trance”31:34 - What Aubrey would do after solving aging
This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com (https://www.arjunkhemani.com?utm_medium=podcast&utm_campaign=CTA_1)
21 Sept 2026
Michael Levin: Bioelectricity, Aging, and the Future of Medicine
My conversation with Michael Levin, a biologist at Tufts University whose research explores bioelectricity, regeneration, morphogenesis, and how cells collectively process information to build and repair bodies.Topics we discuss are well captured by the timestamps below.
Watch on YouTube (https://youtu.be/BWgJPmeW5g0?si=zhsQ0dwuub2bZQD4) or X (https://x.com/arjunkhemani/status/2102079065096331307). Listen on Apple Podcasts (https://podcasts.apple.com/us/podcast/michael-levin-bioelectricity-aging-and-the/id1624691690?i=1000790969529&itscg=30200&itsct=podcast_box&ls=1&mttnsubad=1000790969529), Spotify (https://open.spotify.com/episode/5Pn6zF5L3ooS4sdzcQ21b8?si=Aq3RMCjTS7iSlfb86lpQTA), or any other podcast platform. Follow me on X (http://x.com/arjunkhemani) for updates on future episodes.
Timestamps
0:00 - Causes and downstream effects of aging3:31 - Bioelectric patterns and memory in regeneration9:30 - Cracking the bioelectric code12:10 - The boredom theory of aging23:11 - The germline is ageless25:45 - Bioelectricity and epigenetic reprogramming27:15 - What experiment could falsify Mike’s ideas?29:13 - The role of aging clocks and biological age31:06 - Top-down control in biological systems39:09 - Consciousness and its implications48:25 - Changing human goals and preferences51:30 - The future of medicine
This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com (https://www.arjunkhemani.com?utm_medium=podcast&utm_campaign=CTA_1)
8 Aug 2026
Karl Pfleger: The Road to Solving Aging
Karl Pfleger is the founder of agingbiotech.info (http://agingbiotech.info) and an investor in several rejuvenation startups.
Topics we discuss are well captured by the timestamps below.
Watch on YouTube (https://youtu.be/jSlcqNaq74E) or X (https://x.com/arjunkhemani/status/2086161216163160484). Listen on Apple Podcasts (https://podcasts.apple.com/ae/podcast/karl-pfleger-the-road-to-solving-aging/id1624691690?i=1000781103963), Spotify (https://open.spotify.com/episode/2fiK8VakSXkSV8rIZtMZz7?si=ZpwRGWLWTmaUblipzVVrJA), or any other podcast platform. Follow me on X (http://x.com/arjunkhemani) for updates on future episodes.
Timestamps
0:00 - Why lifespan is the wrong metric for aging progress
7:28 - Is the hallmarks of aging expanding a problem?
11:36 - Structures vs. processes: the key distinction in aging targets
16:14 - Why Karl favors divide-and-conquer rejuvenation over slowing aging
22:07 - Whole-body replacement and organ/cell-level rejuvenation
26:56 - Is partial epigenetic reprogramming the kill-shot for aging?
35:24 - CMLase and reversing crosslink damage
40:57 - Can AI just solve aging automatically?
46:57 - Funding misallocation and the case for more aging biotech companies/VC
57:28 - Objections to eliminating aging — and why none hold up
1:01:27 - Karl critiques Bryan Johnson’s “Don’t Die”
This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com (https://www.arjunkhemani.com?utm_medium=podcast&utm_campaign=CTA_1)
Who has been a guest on Arjun Khemani Podcast
Names identified in recent episode analyses. Showing up to five guests.
Zooko Wilcox
Josh Swihart
Naval Ravikant
Reach and audience
Public platform figures. Ratings count people who left a rating, not total listeners.
YouTube views
406,494
Score snapshot 15 Sept 2025
Apple Podcasts (US)
5.0 / 5
6 ratings
Spotify
5.0 / 5
27 ratings
Podcast Authority Score: 60 / 100
A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.
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