About Biomedical Frontiers: Stories with Innovators in Healthcare
Welcome to 'Biomedical Frontiers: Stories with Innovators in Healthcare,' a podcast produced by the University of Virginia's Wallace H. Coulter Center for Translational Research.
Biomedical Frontiers is a forum for in-depth discussions at the intersection of healthcare technology and translational research. We feature leading voices from the University of Virginia community and the broader biomedical industry. Each episode explores pivotal research projects and disruptive innovations aimed at translating scientific advancements into tangible healthcare solutions. Rooted in the Coulter Center's mission, this podcast seeks to dissect the methodologies and implications of explicitly translational research, examining their potential to reshape medical practice and patient outcomes.
Join us on this intellectual voyage, where we unravel the complexity of biomedical innovation, fostering a deeper understanding of its impact on healthcare and the broader scientific community. Notable guests of the podcast include Dr. Nathan Price, Chief Science Officer of Thorne Health and co-author of The Age of Scientific Wellness: Why the Future of Medicine is Personalized, Predictive, Data Rich and in Your Hands, Dr. Natasha Sheybani, a pioneering researcher in Focused Ultrasound Immunotherapy and the winner of Forbes 30 under 30 in Science, and Dr. Jennifer West, University of Virginia’s Dean of the School of Engineering.
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Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com (http://www.strat-craft.com)
Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA Coulter Center
Senior Producer: Hannah Moore, Associate Director, UVA Coulter Center
Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com (http://carolynwagnerinc.com)
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Produced by the Wallace H. Coulter Center for Translational Research at University of Virginia.
https://www.engineering.virginia.edu/centers-institutes/coulter-center-translational-research (https://www.engineering.virginia.edu/centers-institutes/coulter-center-translational-research)
Crossing the Valley of Death: How the Manning Institute Will Transform Science into Medicines
Why do so many promising scientific discoveries never become real medicines?
In this episode of Biomedical Frontiers Dr. Mark Esser, Chief Scientific Officer of the Paul and Diane Manning Institute of Biotechnology at the University of Virginia, describes one of the biggest challenges in healthcare innovation: the translational valley of death.
Dr. Esser explains how the Manning Institute is being built to bridge the gap between academic discovery and patient-ready therapies. Drawing on decades of experience in industry, he shares how infrastructure, cross-disciplinary teams, regulatory expertise, and new funding models are essential to turning science into medicine.
The conversation explores:
Why promising biomedical research often stalls before reaching patients
How the Manning Institute’s Accelerate, Create, Educate (ACE) model is designed to overcome these barriers
A real-world case study of a novel sepsis therapy entering clinical trials
What this effort means for the future of drug discovery and Virginia’s growing biotech ecosystem
Follow Dr. Mark Esser on Social Media
LinkedIn: https://www.linkedin.com/in/mark-esser-0b152b2/ (https://www.linkedin.com/in/mark-esser-0b152b2/)
Email: mark.esser@virginia.edu (mailto:mark.esser@virginia.edu)
Paul and Diane Manning Institute of Biotechnology (University of Virginia) https://manninginstitute.virginia.edu (https://manninginstitute.virginia.edu)
UVA Licensing & Ventures https://lvg.virginia.edu/ (https://lvg.virginia.edu/)
Resources:
Recommended Book: “A Practical Guide to Drug Development in Academia” https://catalog.nlm.nih.gov/permalink/01NLM_INST/vdtut1/alma9916234173406676 (https://catalog.nlm.nih.gov/permalink/01NLM_INST/vdtut1/alma9916234173406676)
SPARK Drug Discovery Model (Stanford) https://sparkmed.stanford.edu (https://sparkmed.stanford.edu)
Love this episode? Follow and write to us: 📸 Instagram: @biomedicalfrontiers 🔗 LinkedIn: https://www.linkedin.com/company/uvacoulter (https://www.linkedin.com/company/uvacoulter)📧 Reach us: biomedicalfrontiers@virginia.edu (mailto:biomedicalfrontiers@virginia.edu)
Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com (http://www.strat-craft.com)
Executive Producer: David Chen, Managing Director & Instructor of Engineering Design, UVA
Senior Producer: Hannah Moore, Associate Director, UVA Coulter
Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com (http://carolynwagnerinc.com)
Produced on behalf of Wallace H. Coulter Center for Translational Research at University of Virginia https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research (https://engineering.virginia.edu/centers-institutes/coulter-center-translational-research)
6 Oct 2025
Time to Critical Care: How AI Can Cut Patient Wait Times | Dr. Jamie Wisser & Robert Holton
When every minute counts, inefficiencies in communication and data flow can cost lives. In this episode of Biomedical Frontiers, trauma surgeon Dr. Jamie Wisser and entrepreneur Robert Holton share how they’re using AI and interoperability to accelerate time to critical care.
Dr. Wisser, founder of Actual Healthcare Solutions, describes how his experience performing 26-hour reconstructive surgeries exposed the limits of today’s electronic medical records. Together with Holton, he’s building a platform that connects hospital systems, specialists, and radiologists in real time—using AI to automate referrals, interpret imaging in seconds, and bridge the silos that slow patient care.
💡 What you’ll learn:
✅ Why healthcare still runs on disconnected “data islands”
✅ How AI-driven radiology can deliver results in under 30 seconds
✅ How interoperability can improve patient outcomes and physician efficiency
✅ Lessons from a trauma surgeon turned health tech founder
📚 Resources:
Actual HealthCare Solutions: https://www.actualhealthcaresolutions.com (https://www.actualhealthcaresolutions.com)
HIT Lab: https://www.hitlab.org (https://www.hitlab.org)
New York Innovation Week: https://www.nyinnovationweek.com (https://www.nyinnovationweek.com)
Follow Biomedical Frontiers for more:
📸 Instagram: @biomedicalfrontiers
🔗 LinkedIn: https://www.linkedin.com/company/uvacoulter (https://www.linkedin.com/company/uvacoulter)
📧 Reach us: biomedicalfrontiers@virginia.edu (mailto:biomedicalfrontiers@virginia.edu)
Love this podcast? Write to us with feedback or guest recommendations!
Production Team:
Director & Host: Dasha Tyshlek, StratCraft, Inc. www.strat-craft.com (http://Inc.www.strat-craft.com)
Executive Producer: David Chen, Managing Director & Instructor of Engineering Design
Senior Producer: Hannah Moore, Associate Director, UVA Coulter
Design Director: Carolyn Wagner, Inc. & Link: carolynwagnerinc.com (http://carolynwagnerinc.com)
Produced on behalf of: Wallace H. Coulter Center for Translational Research at University of Virginia
26 Aug 2025
Reversing Diabetes: The Promise of Lifestyle Medicine With Dr. Meagan Grega
Type 2 diabetes affects over 37 million Americans — but what if our standard treatment paradigm is all wrong?
In this episode, Dr. Meagan Grega shares the science and strategy behind lifestyle medicine, a fast-growing movement that uses food, sleep, movement, stress reduction, and social connection to treat and even reverse chronic disease.
Dr. Grega is the co-author of the first-ever Clinical Practice Guideline on Lifestyle Interventions for Type 2 Diabetes and a lead author of ACLM’s Expert Consensus Statement on lifestyle medicine in primary care. She co-founded the Kellyn Foundation, where she helps families across Pennsylvania access fresh food, grow gardens, change lifestyle and improve their health together.
You’ll learn:
How fat in your muscles causes insulin resistance — and how to reverse it
What makes behavior change stick
Why doctors don’t prescribe lifestyle medicine — and how that’s changing
How community-based programs and school gardens are transforming lives
New Clinical Guidelines and Expert Consensus on treating diabetes with lifestyle interventions
📚 Resources:
Free CME course: https://lifestylemedicine.org/education-certification/course-catalog/ (https://lifestylemedicine.org/education-certification/course-catalog/)
Kellyn Foundation: https://www.kellyn.org/ (https://www.kellyn.org/)
Dr. Grega’s TED Talk: https://www.youtube.com/watch?v=efGa8QD8pU4 (https://www.youtube.com/watch?v=efGa8QD8pU4)
ACLM Clinical Practice Guideline: https://journals.sagepub.com/toc/ajla/19/2_suppl (https://journals.sagepub.com/toc/ajla/19/2_suppl)
ACLM Expert Consensus Statement: Lifestyle Medicine for Optimal Outcomes in Primary Care: https://journals.sagepub.com/doi/full/10.1177/15598276231202970 (https://journals.sagepub.com/doi/full/10.1177/15598276231202970)
Follow Biomedical Frontiers for more:
📸 Instagram: @biomedicalfrontiers
🔗LinkedIn: https://www.linkedin.com/company/uvacoulter (https://www.linkedin.com/company/uvacoulter)
📧 Reach us: biomedicalfrontiers@virginia.edu (mailto:biomedicalfrontiers@virginia.edu)
Love this podcast? Write to us with feedback or guest recommendations!
Production Team:
Director & Host: Dasha Tyshlek, StratCraft www.strat-craft.com (http://www.strat-craft.com)
Executive Producer: David Chen, Managing Director & Instructor of Engineering Design
Senior Producer: Hannah Moore, Associate Director, UVA Coulter Design Director
Produced on behalf of: Wallace H. Coulter Center for Translational Research at University of Virginia
Who has been a guest on Biomedical Frontiers: Stories with Innovators in Healthcare
Names identified in recent episode analyses. Showing up to five guests.
Vinay Patel
Dr Abigail Fahim
Dr Chris Moen
Reach and audience
Public platform figures. Ratings count people who left a rating, not total listeners.
YouTube views
631,972
Score snapshot 15 Sept 2025
Apple Podcasts (US)
5.0 / 5
5 ratings
Spotify
5.0 / 5
3 ratings
Podcast Authority Score: 61 / 100
A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.
Quality
64
Social presence
0
YouTube
86
Engagement
60
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