Welcome to Chromatography Experts, the podcast dedicated to advancing chromatography through expert insights and real-world applications—brought to you by the #ChromatographyExperts at Tosoh Bioscience – Separation & Purification.
Join us as we explore the science and applications behind chromatography with leading industry professionals. Each episode unpacks key trends and breakthroughs in process media, pre-packed columns, HPLC columns, MALS detection, GPC, Multi-Column Chromatography (MCC), and more.
Whether you’re a Ph.D. student, a scientist, or an industry enthusiast, there’s always something for you!
From Process Development to GMP: Scaling with Pre-Packed Columns
In this episode of Chromatography Experts, Patrick Endres hosts Elena Kumm and Balu Guduri, as they discuss the challenges of moving from process development to GMP manufacturing and the growing demand for large-scale pre-packed chromatography columns.
Topics include:
The challenges of scaling from development to manufacturing
When column packing becomes a business and regulatory risk
The performance data behind the SkillPak™ 1k MAX launch
Chromatographic consistency, robustness, and reproducibility at 1 L scale
The value of pre-packed columns compared to in-house or third-party packing
Early customer feedback and what success looks like for manufacturing-scale chromatography
Whether you're involved in process development, scale-up, or downstream purification, this conversation provides valuable insights into reducing risk and improving confidence in manufacturing-ready chromatography solutions.
11 Aug 2026
Exploring Oligonucleotides
In this episode of Chromatography Experts, Patrick Endres of Tosoh Bioscience is joined by Steffi Stephen and Daniele Addis from Axolabs for an in-depth discussion on oligonucleotides. Together, they explore what oligonucleotides are, how they are produced, and the key steps involved in moving from synthesis to a purified therapeutic product.
The conversation covers emerging applications such as antibody-oligonucleotide conjugates (AOCs), as well as the purification and analytical challenges associated with developing oligonucleotide-based therapies. Steffi and Daniele share insights into the critical role chromatography plays in addressing these challenges.
Whether you're new to oligonucleotides or looking to expand your knowledge of this rapidly growing field, this episode offers valuable perspectives on the technologies, challenges, and partnerships driving the future of nucleic acid therapeutics.
20 Jul 2026
Packed for Success: The Science Behind Pre-Packed Chromatography Columns
In this episode of Chromatography Experts, we take a deep dive into the science and advantages of pre-packed chromatography columns. Our experts discuss how column packing impacts performance, reproducibility, and process efficiency, and why pre-packed solutions continue to gain traction in bioprocessing and pharmaceutical manufacturing.
Topics covered include:
The GMP advantages of pre-packed chromatography columns• What defines a "well-packed" column and why packing quality is critical• The science behind column packing and chromatographic performance• How pre-packed columns help improve consistency, reduce risk, and streamline operations• Key considerations when selecting a chromatography column for your process
Subscribe to Chromatography Experts for more conversations on the science, technologies, and innovations shaping modern chromatography.
16 Jun 2026
Getting Started with MALS – Setup, Performance, Best Practices
Getting started with MALS doesn’t have to be complex.
In this episode of the Chromatography Experts podcast, we break down the fundamentals of Multi-Angle Light Scattering (MALS), from instrumentation and setup to real-world troubleshooting and data interpretation.
You’ll learn:
What MALS is and how it integrates with chromatography systems
The detectors and setup required for accurate measurements
How sample quality impacts your results (and common pitfalls to avoid)
Key troubleshooting strategies when results don’t look right
Best practices for maintaining performance and interpreting data with confidence
Whether you're new to MALS or looking to refine your workflow, this episode is packed with practical insights to help you get consistent, high-quality results.
Interested in learning more about MALS? Find more here: https://www.tosohbioscience.com/US-EN-separations/lens-mals-education?utm_source=social-organic&utm_
6 May 2026
Exploring Multi-Angle Light Scattering
We are back with another episode of Chromatography Experts! This time, we focus on Multi-Angle Light Scattering (MALS) with Corey Meadows and Landry Bennett.
In this episode, we break down the fundamentals of MALS, explore real-world applications, and explain why light scattering remains such a powerful analytical technique.
30 Mar 2026
Inside Pre-Packed Chromatography Columns
Prepacked chromatography columns are changing how scientists approach purification—making scale‑up faster, more consistent, and more reliable than ever before.
In this episode, we explore prepacked chromatography columns… what they are, how they’re manufactured, and why they’ve become a go‑to solution from early process development through GMP production. Our experts Kevin O’Donnell and Phu Duong discuss performance consistency and how pre-packed formats help reduce variability and save time in the lab and manufacturing.
Topics include:
Prepacked vs. batch columns
Scale‑up and reproducibility
Time, cost, and operational efficiencies
Best practices for implementation
Perfect for scientists, engineers, and bioprocessing professionals looking to streamline purification without compromising performance.
Learn more today: https://bit.ly/4bUcROm
23 Feb 2026
Exploring AAVs
Join host Abbie Breton and special guest Yuliya McAnany on Chromatography Experts as we explore AAV purification, cell & gene therapy advancements, and a new method from Tosoh that’s reshaping how researchers separate full and empty AAV capsids.
We break down the science behind our recent paper, ‘Preparative choline-based anion-exchange chromatography for enrichment of full adeno-associated virus capsids’ and reveal the results, up to 90% full capsids with 75% recovery.
You’ll also hear insights on scalability, method adaptation for other viral vectors, and expert advice for improving purification workflows. If you work with AAVs, this is an episode you don’t want to miss.
The paper can be found here: https://www.sciencedirect.com/science/article/pii/S0021967325006636
8 Dec 2025
Episode 6: AAVs - From Basics to Breakthroughs
This episode explores adeno-associated viruses, their revolutionary impact on gene therapy, and breakthrough analytical methods, offering insights into biotech innovation.
23 Sept 2025
Exploring Chromatography Resin Selection
Phu Duong and Anson Lewis examine chromatography resin selection for bioprocessing applications, highlighting key factors, performance comparisons, and real-world case studies in this interview.
22 Jul 2025
Viral Clearance in Bioprocessing: Multi-Column Chromatography Edition
Marissa Heino and Abbie Breton discuss viral clearance in multi-column chromatography, highlighting its importance and how it shapes bioprocessing in this interview episode.
7 Jul 2025
Shedding Light on Multi-Angle Light Scattering (MALS)
Tianyu Li, Ph.D., elucidates the capabilities of Multi-Angle Light Scattering in chromatography and its implementation, in an interview with Phu Duong, Ph.D., for improved analysis.
30 May 2025
Beyond the Beads: Exploring Chromatography Resin
Industry experts examine chromatography resins, discussing key terminology, diverse applications, and unique characteristics that propel the future of purification in biomanufacturing.
21 Apr 2025
Multi-Column Chromatography (MCC): How it Works & What's Next (AUDIO ONLY)
Multi-Column Chromatography (MCC) is changing everything. But what exactly is MCC? How does it compare to traditional batch methods, and where is it taking bioprocessing next? Our #ChromatographyExperts break it all down in this episode.
21 Apr 2025
Multi-Column Chromatography (MCC): How it Works & What's Next
Multi-Column Chromatography (MCC) is changing everything. But what exactly is MCC? How does it compare to traditional batch methods, and where is it taking bioprocessing next? Our #ChromatographyExperts break it all down in this episode.
Who has been a guest on Chromatography Experts
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Phu Duong
Anson Lewis
Marissa Heino
Abbie Breton
Tianyu Li
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Podcast Authority Score: 12 / 100
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