Explore the world of thrombosis and hemostasis with "Clot Clot, Who's There?", a thought-provoking podcast brought to you by Vasculearn Network in collaboration
with the Thrombosis and Haemostasis Editors (Thieme).
Choosing Advanced PE Therapies: Evidence, Timing, and Technique From Risk Assessment to Treatment
More tools. New evidence. Tough decisions. With the 2026 AHA/ACC pulmonary embolism (PE) guidelines as a backdrop, when is anticoagulation enough, and when is it time to reach for advanced therapy?
Behnood Bikdeli, Jane Leopold, Lisa Moores, and Suresh Vedantham return to take on the treatment questions that follow risk assessment. From fibrinolysis and mechanical thrombectomy to extracorporeal membrane oxygenation (ECMO), the panel weighs what the trials tell us, where uncertainty remains, and what matters at the bedside. Two patient cases put bleeding risk, clot anatomy, clinical trajectory, resources, and patient preferences into the mix.
Episode chapters
00:00 Welcome and the Advanced PE Therapy Toolkit
03:06 Fibrinolysis and Thrombectomy: What the Trials Show
11:25 ECMO and Immediate Priorities in High-Risk PE
16:55 Choosing an Intervention: Bleeding Risk, Anatomy, and Resources
20:09 Case Discussions: Anticoagulation Alone or Advanced Therapy?
27:31 Practical Takeaways
Thank you to our sponsor, Penumbra, for their generous support of this podcast episode. All content was independently developed by Vasculearn Network and the expert panel.
Missed the first conversation? Check out Part 1: PE Risk Stratification to explore the new framework and how to spot patients who may be heading toward trouble.
9 Oct 2026
Reading the Risk: PE Stratification in 2026 A New Era in PE Care
The blood pressure looks reassuring, but is it telling the whole story? In acute pulmonary embolism (PE), the next few hours can matter as much as the first set of vital signs.
Behnood Bikdeli joins experts Jane Leopold, Lisa Moores, and Suresh Vedantham to unpack the 2026 AHA/ACC PE guidelines and put the new risk-stratification framework to work. With two patient cases and practical bedside insights, the panel explores who needs a closer watch, when to mobilize a response team, and how to stay ahead of a patient who may be heading in the wrong direction.
Episode chapters
00:00 The New PE Risk-Stratification Framework
06:21 Assessing Risk: Vital Signs, Biomarkers, Imaging, and Scores
11:22 Turning Risk Assessment Into Action: PERT, Monitoring, and Preparedness
18:47 Timing, Resources, and Transfer Decisions
21:59 Case 1: A Stable Presentation With Signs of RV Strain
27:32 Case 2: Transient Hypotension, Closer Monitoring, and Acute-on-Chronic Clues
Thank you to our sponsor, Penumbra, for their generous support of this podcast episode. All content was independently developed by Vasculearn Network and the expert panel.
What comes after risk assessment? Check out Part 2, where the panel weighs the evidence behind advanced therapies and tackles when—and how—to intervene.
17 Sept 2026
The GLP-1 Question: What About Blood Clots?
GLP-1s are transforming the treatment of diabetes and obesity, but could their benefits extend to venous thromboembolism (VTE)? And what should clinicians tell patients with a history of VTE?
Join host Julia Sandrin Gauer and experts Christian Ruff and Rushad Patell as they discuss:
• What current evidence suggests about GLP-1 therapies and VTE risk
• The limitations of existing clinical trial and observational data
• Whether GLP-1 and multi-incretin therapies may have different effects
• What these findings mean for clinical practice, and the questions that remain
Tune in now to this special collaboration between the ISTH Pulse Podcast and Vasculearn Network's Clot, Clot, Who's There?, for this timely conversation!
Who has been a guest on Clot, Clot, Who's There?
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Bethany Samuelson Bannow
Erik Klok
Geoff Barnes
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