Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.
We specialize in:
• Peer to peer interviews, panels & round-tables
• Curated live events & conferences
• Professional in-depth content & research updates
• Interactive learning modules & webinars
• Live & on-demand webcasts & podcasts
HER2-Low & Ultralow Breast Cancer: Testing & T-DXd with Drs. Neil Iyengar & Sunil Badve
Why does accurate HER2 testing matter more than ever for patients with breast cancer?
Dr. Neil Iyengar and Dr. Sunil Badve discuss the evolving understanding of HER2-low and HER2-ultralow breast cancer and how advances in pathology and clinical evidence are expanding the population of patients who may be candidates for trastuzumab deruxtecan (T-DXd).
Drawing on findings from DESTINY-Breast04 and DESTINY-Breast06, they explore how HER2 assessment has moved beyond the traditional amplified versus non-amplified framework, why accurately identifying low levels of HER2 expression matters, and how clinicians and pathologists can work together to reduce the risk of missing potential treatment opportunities.
Topics discussed:
How HER2 testing has evolved from identifying amplification to detecting low levels of protein expression
Defining HER2-low, HER2-ultralow, and HER2-null disease
Limitations of current HER2 assays at very low levels of expression
Pre-analytic and analytic factors that can affect HER2 testing
Key considerations when interpreting HER2 IHC results
How DESTINY-Breast04 established T-DXd as a treatment option in HER2-low metastatic breast cancer
How DESTINY-Breast06 expanded the discussion to HER2-ultralow disease and earlier use of T-DXd
Why repeat biopsy and reassessment of HER2 expression can matter
When archival tissue or a pathology second opinion may be useful
Tumor heterogeneity and changes in HER2 expression over time and across metastatic sites
HER2-low expression in hormone receptor-positive and triple-negative breast cancer
Managing T-DXd-associated nausea, fatigue, ILD, and cardiac considerations
Improving concordance in HER2 assessment through training and standardized testing
The emerging role of AI and quantitative tools in evaluating HER2 expression
What DESTINY-Breast15 could mean for HER2 testing and patients with HER2 IHC 0 disease
▶️ Watch the full CHM Conversation for expert perspectives on HER2 testing, evolving pathology standards, and identifying patients who may benefit from T-DXd.
#NeilIyengar #SunilBadve #CHMConversations #HER2Low #HER2Ultralow #BreastCancer #TDXd #TrastuzumabDeruxtecan #DESTINYBreast04 #DESTINYBreast06 #CommunityHealthMedia
–
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Our podcasts are also available on:
Spotify - https://spotf.fi/chm-podcast (https://spotf.fi/chm-podcast)
Amazon Music - https://amazn.so/chm-podcast (https://amazn.so/chm-podcast)
Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 (https://podcasts.apple.com/us/podcast/community-health-media/id1837428248)
Castbox - https://castbox.fm/vh/6735434 (https://castbox.fm/vh/6735434)
Goodpods - https://goodpods.com/profile/chm-111066 (https://goodpods.com/profile/chm-111066)
iHeartRadio - https://iheart.com/podcast/291542082 (https://iheart.com/podcast/291542082)
Pocket Casts - https://pca.st/3ncdh11o (https://pca.st/3ncdh11o)
–
Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.
We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences.
We specialize in:
Peer to peer interviews, panels & round-tables
Curated live events & conferences
Professional in-depth content & research updates
Interactive learning modules & webinars
Live & on-demand webcasts & podcasts
Learn more about us here - https://communityhealth.media (https://communityhealth.media)
7 Oct 2026
Special CHM Conversation: Second-Line ER+/HER2- mBC with Drs. Seth Wander & Paolo Tarantino
How is the rapidly changing treatment landscape reshaping second-line ER-positive, HER2-negative metastatic breast cancer care?
In this Special CHM Conversation, Dr. Seth Wander and Dr. Paolo Tarantino discuss the growing number of endocrine therapy options and how clinicians can navigate increasingly complex treatment decisions.
They explore what the newly approved combination of imlunestrant plus abemaciclib means for patients with ESR1 mutations, how ctDNA and molecular profiling guide treatment selection, and why sequencing next-generation endocrine therapies remains an open question as new options emerge.
Topics discussed:
EMBER-3 and imlunestrant plus abemaciclib
Treatment options for ESR1-mutated disease
Single-agent vs combination endocrine therapy
ctDNA and molecular profiling
Biomarker-driven treatment selection
Balancing efficacy and tolerability
SERENA-6 and molecular progression
Sequencing next-generation endocrine therapies
Oral SERDs in the adjuvant and first-line settings
Emerging doublet and triplet strategies
▶️ Watch this Special CHM Conversation for expert perspectives on navigating the evolving second-line treatment landscape in ER-positive, HER2-negative metastatic breast cancer.
#SethWander #PaoloTarantino #CHMConversations #ESR1 #EMBER3 #EndocrineTherapy #OralSERD #MetastaticBreastCancer #BreastCancer #CommunityHealthMedia
–
Thanks for watching!
Our podcasts are also available on:
• Spotify - https://spotf.fi/chm-podcast (https://spotf.fi/chm-podcast)
• Amazon Music - https://amazn.so/chm-podcast (https://amazn.so/chm-podcast)
• Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 (https://podcasts.apple.com/us/podcast/community-health-media/id1837428248)
• Castbox - https://castbox.fm/vh/6735434 (https://castbox.fm/vh/6735434)
• Goodpods - https://goodpods.com/profile/chm-111066 (https://goodpods.com/profile/chm-111066)
• iHeartRadio - https://iheart.com/podcast/291542082 (https://iheart.com/podcast/291542082)
• Pocket Casts - https://pca.st/3ncdh11o (https://pca.st/3ncdh11o)
–
Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.
We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences.
We specialize in:
Peer to peer interviews, panels & round-tables
Curated live events & conferences
Professional in-depth content & research updates
Interactive learning modules & webinars
Live & on-demand webcasts & podcasts
Learn more about us here - https://communityhealth.media (https://communityhealth.media)
6 Oct 2026
ESR1-Mutated Breast Cancer: Oral SERDs and Vepdegestrant with Drs. Jason Mouabbi & Erika Hamilton
How should clinicians navigate the growing number of treatment options for ESR1-mutated metastatic breast cancer?
Dr. Jason Mouabbi and Dr. Erika Hamilton discuss the evolving treatment landscape for hormone receptor-positive, HER2-negative metastatic breast cancer, with a focus on ESR1 mutations, molecular testing, PROTACs, oral SERDs, and treatment sequencing.
They explore when and how to test for ESR1 mutations, including the role of liquid biopsy and serial testing as resistance emerges. The conversation also examines the differences between a PROTAC and oral SERDs, the clinical data supporting vepdegestrant, and how emerging combination strategies could further reshape endocrine therapy.
Topics discussed:
• Why ESR1 mutations matter in HR-positive/HER2-negative metastatic breast cancer
• When to test and retest for ESR1 mutations
• Tissue NGS vs liquid biopsy for detecting ESR1 mutations
• ESR1 as both a resistance mechanism and a predictive biomarker
• Current treatment options for ESR1-mutated disease
• How PROTACs differ from oral SERDs
• VERITAC-2 and the clinical data supporting vepdegestrant
• Understanding VERITAC-2, EMERALD, and EMBER-3
• Tolerability, GI toxicity, fatigue, and QTc monitoring with vepdegestrant
• Selecting among endocrine monotherapy options
• Retesting ESR1 after progression on an oral SERD
• Sequencing a PROTAC after prior oral SERD therapy
• Imlunestrant plus abemaciclib and emerging combination strategies
• SERENA-6 and switching therapy at molecular progression
• Molecular progression vs radiologic progression
• The future role of PROTAC and CDK4/6 inhibitor combinations
• Why endocrine monotherapy still has an important role
• Preserving endocrine therapy before transitioning to antibody-drug conjugates
• Reconsidering endocrine therapy after treatment with an ADC
• The growing importance of genomic profiling and personalized treatment sequencing
▶️ Watch the full CHM Conversation for expert perspectives on ESR1 testing, endocrine resistance, treatment selection, and the evolving role of oral SERDs and PROTACs in metastatic breast cancer.
#JasonMouabbi #ErikaHamilton #CHMConversations #BreastCancer #MetastaticBreastCancer #ESR1 #HRPositiveBreastCancer #HER2Negative #Vepdegestrant #OralSERD #PROTAC #CommunityHealthMedia
–
Thanks for watching!
Our podcasts are also available on:
• Spotify - https://spotf.fi/chm-podcast
• Amazon Music - https://amazn.so/chm-podcast
• Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248
• Castbox - https://castbox.fm/vh/6735434
• Goodpods - https://goodpods.com/profile/chm-111066
• iHeartRadio - https://iheart.com/podcast/291542082
• Pocket Casts - https://pca.st/3ncdh11o
–
Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.
We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences.
We specialize in:
• Peer to peer interviews, panels & round-tables
• Curated live events & conferences
• Professional in-depth content & research updates
• Interactive learning modules & webinars
• Live & on-demand webcasts & podcasts
Learn more about us here - https://communityhealth.media
Who has been a guest on Community Health Media
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Sonya Reid
Shruti Singh
Senthil Damodaran
Mothaffar Rimawi
Michelina Cairo
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