Imagine harnessing the power of sound waves to heal the human body–this isn’t science fiction, it’s the reality of focused ultrasound technology. Join the conversation that explores the transformative power of this noninvasive therapy revolutionizing the treatment of nearly 180 diseases and medical conditions and giving hope to patients worldwide. Presented by the Focused Ultrasound Foundation.
Ep63: Focused Ultrasound for Depression and Beyond with Grey Matter Neurosciences
In this episode of Curing with Sound, we speak with Jeffrey Coull, PhD, founder and CEO of Grey Matter Neurosciences, a Toronto-based company developing low-intensity focused ultrasound technology for targeted brain neuromodulation. Building on research led by Dr. Kullervo Hynynen and his team at Sunnybrook Research Institute, the company’s helmet-based system uses an array of more than 2,000 ultrasound transmitters to reach both superficial and deep brain structures.
Dr. Coull discusses why the company chose treatment-resistant depression as its initial clinical application, while also maintaining its interest in Alzheimer’s disease and other age-related neurological conditions. Looking ahead, he shares his perspective on the future of focused ultrasound neuromodulation, including its potential to enable more personalized treatment approaches and, eventually, clinician-supervised care in patients' homes.
Discussion highlights:
A Focus on Treatment-Resistant Depression: Dr. Coull outlines plans for a randomized controlled pilot trial in Toronto, anticipated to begin in early 2027, and explains how the study will evaluate the effects of targeting three brain regions in adults ages 18 to 85.
The Future of Personalized Neuromodulation: This conversation explores how low-intensity focused ultrasound could contribute to more individualized treatment strategies, from improved diagnostic approaches to remotely supervised, home-based care.
EPISODE TRANSCRIPT
----------------------------QUESTIONS?Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.
Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.
FUSF SOCIAL MEDIA
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FUSF WEBSITEhttps://www.fusfoundation.org
FOCUSED ULTRASOUND TREATMENT SITEShttps://www.fusfoundation.org/the-technology/treatment-sites/SIGN UP FOR OUR FREE NEWSLETTERhttps://www.fusfoundation.org/newsletter-signup/READ THE LATEST NEWSLETTERhttps://www.fusfoundation.org/the-foundation/news-media/newsletter/DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK)https://www.fusfoundation.org/read-the-tumor-by-john-grisham/
6 Oct 2026
Ep62: From the Lab to Patient Care: Advancing Histotripsy and Kidney Stone Treatment with Adam Maxwell, PhD
In this episode of Curing with Sound, we speak with Adam Maxwell, PhD, an associate professor of biomedical engineering at Virginia Tech, whose career has literally spanned the focused ultrasound development pathway, from fundamental research and technology development to startups, clinical trials, and FDA-cleared technologies.Dr. Maxwell reflects on his involvement in some of the earliest histotripsy research at the University of Michigan and the technology’s evolution from the laboratory to clinical use. He also discusses his work advancing noninvasive kidney stone treatments for people and companion animals, including co-founding SonoMotion and helping bring its novel Break Wave lithotripsy technology to market.
Discussion highlights:
From Research to Clinical Use: Follow the evolution of focused ultrasound technologies, including histotripsy and burst wave lithotripsy, from research and development to clinical application.
Advancing Kidney Stone Treatment: Learn how new noninvasive approaches are expanding treatment options for kidney stones, including the potential to treat some patients while awake and outside the operating room.
Insights from Veterinary Research: Hear how Foundation-funded studies in cats are informing technology development and generating insights that could help advance treatment approaches for human patients.
EPISODE TRANSCRIPT
----------------------------QUESTIONS?Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.
Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.
FUSF SOCIAL MEDIA
LinkedIn
X
Facebook
Instagram
TikTok
YouTube
FUSF WEBSITEhttps://www.fusfoundation.org
FOCUSED ULTRASOUND TREATMENT SITEShttps://www.fusfoundation.org/the-technology/treatment-sites/SIGN UP FOR OUR FREE NEWSLETTERhttps://www.fusfoundation.org/newsletter-signup/READ THE LATEST NEWSLETTERhttps://www.fusfoundation.org/the-foundation/news-media/newsletter/DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK)https://www.fusfoundation.org/read-the-tumor-by-john-grisham/
22 Sept 2026
Ep61: A Closer Look at Histotripsy for Liver Tumors with Daniel Sheeran, MD
In this episode of Curing with Sound, we speak with Daniel Sheeran, MD, an interventional radiologist at the University of Virginia, about histotripsy, a form of focused ultrasound that mechanically destroys targeted tissue without incisions or heat. In 2023, the US Food and Drug Administration cleared the HistoSonics Edison™ histotripsy system for the noninvasive destruction of liver tumors. Dr. Sheeran, who performed UVA’s first histotripsy procedure in June 2025, explains how the technology works and shares insights from his experience integrating this new treatment option into clinical practice.Dr. Sheeran offers a closer look at the role of histotripsy in the broader treatment landscape for liver tumors and the questions researchers are still working to answer, including its impact on long-term patient outcomes. He also emphasizes the importance of understanding all available treatment options when making decisions about cancer care. Discussion highlights:
A New Noninvasive Option for Liver Tumors: Learn how histotripsy uses focused ultrasound to generate microscopic bubbles that mechanically destroy targeted tissue without incisions or heat—and how the FDA-authorized technology is being incorporated into clinical care.
From Innovation to Patient Impact: Explore why successfully destroying a tumor is only one measure of treatment impact—and why ongoing research is needed to understand histotripsy’s effects on long-term outcomes, quality of life, and survival.
EPISODE TRANSCRIPT
----------------------------QUESTIONS?Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.
Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.
FUSF SOCIAL MEDIA
LinkedIn
X
Facebook
Instagram
TikTok
YouTube
FUSF WEBSITEhttps://www.fusfoundation.org
FOCUSED ULTRASOUND TREATMENT SITEShttps://www.fusfoundation.org/the-technology/treatment-sites/SIGN UP FOR OUR FREE NEWSLETTERhttps://www.fusfoundation.org/newsletter-signup/READ THE LATEST NEWSLETTERhttps://www.fusfoundation.org/the-foundation/news-media/newsletter/DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK)https://www.fusfoundation.org/read-the-tumor-by-john-grisham/
Who has been a guest on Curing with Sound
Names identified in recent episode analyses. Showing up to five guests.
Monica Russell
Shiro Horisawa MD
Bob Palmer
Eve Satterthwaite
Eli Vlaisavljevich
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Podcast Authority Score: 59 / 100
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