Dr Macrene Alexiades MD PhD Podcast

About Dr Macrene Alexiades MD PhD Podcast

Dr. Macrene Alexiades, MD PhD, dermatologist and scientist, provides education on skin and its aging process. She emphasizes the importance of understanding the skin as an organ and the need to protect, restore, and maintain its health. Dr. Macrene discusses the structure of the skin, including the different types of cells and layers, and explains how UV exposure can cause damage to the skin. She highlights the role of DNA repair and antioxidants in preventing and repairing skin damage. Dr. Macrene also delves into the connection between skin aging and skin cancer, and the importance of a holi

Publisher

Dr Macrene Alexiades MD PhD

Category

health & fitness

Language

en

Explicit

No

First episode

22 Jun 2024

Latest episode

18 Jan 2026

Latest episodes

7 episodes in the feed.

1. 

   18 Jan 2026

   Episode 6: Exosomes: Science vs. Hype in Skincare

   Dr. Macrene Alexiades MD PhD explores exosomes as biological messengers in skincare, differentiating scientific research from marketing claims regarding anti-aging and wound healing.

2. 

   11 Jul 2025

   Episode 5: Sun Damage to Skin Cancer: The Alexiades Scale and Photodynamic Therapy

   Dermatologist Dr. Macrene Alexiades MD PhD explores sun damage and photoaging, explaining her Alexiades Classification Scale and the benefits of photodynamic therapy for treating precancerous lesions and enhancing skin health.

3. 

   19 Mar 2025

   Episode 4: Peptides in Skincare

   In this episode, Dr. Macrene Alexiades MD PhD Dermatologist-Scientist delves into the world of peptides in skincare, explaining their structure, function, and importance in promoting skin health and longevity. She categorizes peptides based on their roles, including dermal regulators, pigment regulators, and neuropeptides, and discusses their clinical benefits, such as reducing fine lines and improving skin elasticity. The episode concludes with practical advice on incorporating peptides into skincare routines for optimal results. Keywords peptides, skincare, anti-aging, dermatology, collagen, elastin, skin health, skincare routine, cosmetic science, skin longevity Takeaways Peptides are small protein fragments made up of amino acids. They play a crucial role in boosting collagen and elastin levels in the skin. Peptides can be classified into various categories based on their function. Amino acid derivatives can prevent collagen degradation. Tripeptides have significant effects on skin health and aging. Tetrapeptides and pentapeptides have unique properties and applications. Hexapeptides can regulate cell senescence and promote skin health. Neuropeptides can provide muscle relaxation effects similar to Botox. Incorporating peptides into skincare routines requires consistency and knowledge of formulation. Peptides have been shown to improve skin tone, elasticity, and reduce inflammation. Chapters 00:00 Introduction to Peptides in Skincare 02:49 Understanding Peptide Structure and Function 06:10 Classification of Peptides and Their Roles 08:59 Amino Acid Derivatives and Their Impact 12:12 Tripeptides: Key Players in Skin Health 14:58 Tetrapeptides and Their Unique Functions 17:55 Exploring Pentapeptides and Their Applications 21:09 Hexapeptides: The Six-Amino Acid Wonders 23:57 Neuropeptides and Their Effects on Skin 27:09 Miscellaneous Peptides and Their Benefits 30:02 Clinical Benefits of Peptides in Skincare 32:54 Incorporating Peptides into Your Routine 36:09 Conclusion and Future Directions

4. 

   13 Jul 2024

   Episode 3: DNA Repair in Skin Longevity and Skin Aging

   In this episode, Dr. Macrene Alexiades MD PhD discusses the importance of DNA repair in preventing skin damage and aging. She explains how DNA damage occurs due to free radicals and various environmental factors, such as UV radiation and pollution. Dr. Alexiades emphasizes the role of DNA replication and the need for accurate base pairing. She explores different types of DNA repair mechanisms, including direct reversal, excision repair, and post-replication repair. The podcast also delves into the use of DNA repair enzymes in skincare products and the benefits of liposomal delivery. In this conversation, Dr. Macrene Alexiades discusses the importance of DNA repair in skin health and the prevention of skin aging and cancer. She explains the different types of DNA damage and the various mechanisms of DNA repair. Dr. Alexiades also highlights the results of clinical studies that demonstrate the effectiveness of DNA repair enzymes in reducing DNA mutations, oncogene expression, and skin cancer incidence. Additionally, she discusses the impact of DNA repair on skin aging and the potential for ongoing repair even after the application of DNA repair enzymes has ceased. Keywords DNA repair, skin health, free radicals, antioxidants, DNA replication, base pairing, DNA damage, UV radiation, pollution, skincare products, liposomal delivery, DNA repair, skin health, skin aging, skin cancer, UV damage, oncogenes, apoptosis, inflammation, photodynamic therapy, actinic keratosis, animal studies, telomere shortening, matrix metalloprotonases Takeaways ·      DNA repair is crucial for preventing skin damage and aging caused by free radicals and environmental factors. ·      UV radiation, pollution, and chemical agents can cause DNA damage and mutations. ·      Different types of DNA repair mechanisms, such as direct reversal, excision repair, and post-replication repair, help maintain the integrity of the genetic code. ·      Topical products containing DNA repair enzymes, delivered through liposomal encapsulation, can enhance DNA repair in the skin. ·      Understanding DNA repair can lead to the development of effective skincare products for preventing skin cancer and premature aging. DNA repair enzymes can reduce DNA mutations and the incidence of skin cancer. ·      A multi-pronged approach, including DNA repair, is necessary for optimal skin health. ·      DNA repair enzymes can have a cascading effect on cellular responses, including inflammation and immunosuppression. ·      DNA repair can impact past damage and continue to repair DNA even after the application of repair enzymes has ceased. ·      DNA repair enzymes can improve skin aging by reducing wrinkles, laxity, pigmentation, and other signs of photoaging. Chapters 00:00 Introduction and Recap 04:17 Understanding DNA Damage and Aging 08:02 The Role of DNA Repair in Preventing Cancer 14:54 Exploring DNA Repair Mechanisms 27:14 The Benefits of Liposomal Delivery 29:59 The Importance of DNA Repair in Skin Health 34:59 The Need for a Multi-Pronged Approach 41:34 The Potential for Ongoing DNA Repair 45:46 The Impact of DNA Repair on Skin Aging

5. 

   1 Jul 2024

   Episode 2: Skin Aging and Health: Free Radicals and Antioxidants

   In this podcast episode, Dr. Macrene Alexiades MD PhD Dermatologist & Geneticist discusses the damage that occurs to the skin due to free radicals and the importance of antioxidants in protecting and repairing the skin. Free radicals are highly reactive molecules that can cause damage to proteins, lipids, and DNA in the skin. This damage can lead to skin aging and potentially skin cancer. Antioxidants work by neutralizing free radicals and preventing them from causing further damage. Dr. Alexiades emphasizes the importance of a varied diet and the use of topical antioxidants to protect the skin. She also mentions the need for DNA repair enzymes as an additional layer of defense against mutations. Keywords skin, free radicals, antioxidants, damage, protection, repair, skin aging, skin cancer, DNA repair Takeaways Free radicals can cause damage to proteins, lipids, and DNA in the skin, leading to skin aging and potentially skin cancer. Antioxidants play a crucial role in neutralizing free radicals and protecting the skin from damage. A varied diet rich in fruits and vegetables can provide antioxidants to the skin from the inside. Topical application of antioxidants can further enhance the skin's defense against free radicals. In addition to antioxidants, DNA repair enzymes are introduced as the next class of ingredients important for preventing mutations and maintaining skin health. Chapters 00:00 Introduction and Overview 02:26 Understanding Free Radicals 09:06 The Importance of Antioxidants 38:28 The Need for DNA Repair Enzymes 43:10 Conclusion

6. 

   23 Jun 2024

   Episode 1: A Holistic Approach to Skin Health and Beauty

   Summary Dr. Macrene Alexiades, MD PhD, dermatologist and scientist, provides an overview of the skin and its aging process. She emphasizes the importance of understanding the skin as an organ and the need to protect, restore, and maintain its health. Dr. Macrene discusses the structure of the skin, including the different types of cells and layers, and explains how UV exposure can cause damage to the skin. She highlights the role of DNA repair and antioxidants in preventing and repairing skin damage. Dr. Macrene also touches on the connection between skin aging and skin cancer, and the importance of a holistic approach to skin health. Keywords skin, aging, organ, protection, restoration, maintenance, UV exposure, DNA repair, antioxidants, skin cancer Chapters 00:00 Understanding the Skin as an Organ 21:22 The Role of UV Exposure in Skin Aging 32:48 The Importance of DNA Repair and Antioxidants 38:33 Protecting and Restoring the Skin 45:19 Skin Health: Beyond Vanity

7. 

   22 Jun 2024

   Dr Macrene Alexiades MD PhD Podcast (Trailer)

Reach and audience

Public platform figures. Ratings count people who left a rating, not total listeners.

YouTube views

103,805

Score snapshot 15 Sept 2025

Podcast Authority Score: 21 / 100

A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.

Quality

9

Social presence

0

YouTube

82

Engagement

0