Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. Episodes feature leaders across industry and academia sharing real-world experiences and lessons learned to help the field overcome hurdles on the path to providing individualized treatments for patients.
N1C Fireside Chats Disclaimer
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Lynn Bush, PhD, MS Bioethics, MA
Elizabeth Berry-Kravis, MD, PhD
Emily McCourt, MD
Yael Shiloh-Malawsky, M.D.
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
15 Jan 2026
Inside the Thorny Trench
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Lynn Bush, PhD, MS Bioethics, MA
Wendy Chung, MD, PhD
Gregory Costain, MD, PhD
Austin Larson, M.D.
Olivia Kim-McManus, M.D.
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
11 Dec 2025
The Weight of the Unknown
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Lynn Bush, PhD, MS Bioethics, MA
Annemieke Aartsma-Rus, Ph.D.
Rebecca Schüle, M.D.
Claudio Melo De Gusmao, MD, PhD
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
8 May 2025
It Takes a Village
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Marlen Lauffer, M.D.
Dalila Sabaredzovic
David Silver, PhD
Roxana Redis, Ph.D.
David Fischer, Ph.D.
Tim Yu, M.D., PhD
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
24 Mar 2025
Scaling n-of-1 Therapies: From One to Many
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Steven Ringel
Jeff Milton
Scott Demarest, M.D.
Marlen Lauffer, M.D.
Annemieke Aartsma-Rus, Ph.D.
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
11 Mar 2025
Beyond the Data: Author Insights on N-of-1 Trials in Precision Medicine
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Scott Demarest, M.D.
Tim Yu, M.D., PhD
Olivia Kim-McManus, M.D.
Richard Finkel, M.D.
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
6 Jan 2025
Visionary Science: Charting a Path for Mutation-Based Retinal Interventions
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Rob Collin, Ph.D.
Roger Paxton, Ph.D.
Scott Henry, Ph.D.
Annemieke Aartsma-Rus, Ph.D.
Tim Yu, MD, PhD
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
26 Sept 2024
Molecules and Methods: Reevaluating ASO Biodistribution to the Brain
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Charles Berde, M.D., Ph.D.
Joseph Madsen, M.D.
Bryn Martin, Ph.D.
Kathrin Meyer, Ph.D.
Roxana Redis, Ph.D.
Willeke can Roon-Mom, Ph.D.
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
30 Aug 2024
Behind the Publication: Author Insights on 'How to Pay for Individualized Genetic Medicines'
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, our featured guests discuss the topic of "How to Pay for Individualized Genetic Medicines (https://www.n1collaborative.org/post/how-to-pay-for-individualized-genetic-medicines)"
Timothy Yu, M.D., Ph.D.
Andrew Lo, Ph.D.
Julia Pian, M.D.
Deanna Portero, MPH/MBA Candidate
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
8 Jul 2024
Smarter Ways to Identify Treatment Targets
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Logan Newton, M.S.
Annemieke Aartsma-Rus, Ph.D.
Bush, Lynn, Ph.D., M.S. Bioethics, M.A.
Marlen Lauffer, M.D.
Willeke van Roon-Mom, Ph.D.
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
17 Jun 2024
Finding the Balance: Urgency, Rigor, and Uncertainty in Lead Optimization
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Casey McPherson
Jennifer San Miguel, Ph.D.
Michael Templin, Ph.D., DABT
Roxana Redis, Ph.D.
Willeke van Roon-Mom, Ph.D.
Robert Cabrera, Ph.D.
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
13 Mar 2024
When is Enough Enough?
Fireside Chats in Individual Medicines brings together experts at the forefront of individualized medicines to have candid discussions about relevant topics and practical challenges involved in advancing these pioneering therapies. In this episode, we feature:
Thomas LaRocca, MD, PhD
Annemieke Aartsma-Rus, PhD
Willeke van Roon-Mom, PhD
Marlen Lauffer, MD, PhD
Tim Yu, MD, PhD
Fireside Chats in Individualized Medicines is a podcast hosted by the N=1 Collaborative. This podcast is the work product of the N=1 Collaborative, a group of researchers and practitioners who share their expertise and experience in individualized medicine. This podcast hosts individuals from multiple organizations and is intended to provide information for research and educational purposes only and is expressly not intended to provide legal, clinical, or professional advice which should be sought separately by qualified practitioners. The information and views shared in the podcast are based on the best available knowledge and practice at the time of publication. The N1C reserves the right to update, modify, or withdraw content at any time without prior notice. Listeners of these podcasts should exercise their own judgment and discretion in applying these practices to their specific situations.
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