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- 2026
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About FitgenesUSA
Join Dr. Sam Shay, DC, FMCP, and co-host Mikayla Wachsmann, MS, CNS, as they decode complex genetics into practical, actionable strategies for health, performance, and longevity. Each episode bridges the gap between clinical data and real-world results, breaking down the specific genes and pathways that actually matter—without the hype or technical noise. Whether you are working to shift your own health trajectory or you're a practitioner seeking clearer communication and better clinical outcomes, this show gives you the frameworks to make DNA truly usable. Stop guessing. Start decoding.
- Publisher
- FitgenesPodcast
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- business
- Language
- en
- Explicit
- No
- First episode
- 23 Jun 2026
- Latest episode
- 13 Oct 2026
Latest episodes
18 episodes in the feed.

13 Oct 2026
Born to Hate Broccoli or Built to Love It? The Genetics of Bitter Taste
Is your DNA the reason you can't stand broccoli? Join host Dr. Sam Shay, DC, FMCP (Genetics Expert & Fitgenes Educator) with co-host Mikayla Wachsmann, MS, CNS, and Lily his "Frenchie". Discover how genes decide bitter sensitivity and shape diet, fullness, and weight. Dr. Sam explains evolutionary bitter detection, "super tasters" vs. "non-tasters," gut/lung receptors, and cooking tricks for vegetables. Key topics covered: Evolution of Bitter Taste: Toxicity avoidance & gag safety mechanism. Bitter Foods & Digestion: Vagus nerve, stomach acid & enzyme activation. TAS2R38 Gene: Super tasters vs. non-tasters. Evolutionary Trade-Offs: Plant protection vs. missing nutrients. Non-Genetic Factors: Age, gender, emotions & sweet crop breeding. Receptors Outside Tongue: Lung & gut immune/satiety roles. Taste Genetics & Weight: Fullness signals & obesity links. Cooking Hacks: Fat, salt, spices & aromatics to cut bitterness. SUBSCRIBE: Loved learning why bitter foods taste different to you? Don't leave your nutrition to guesswork - subscribe and drop us a review to help others decode their DNA. CONNECT: IG: https://www.instagram.com/fitgenesusa/ (https://www.instagram.com/fitgenesusa/) W: https://www.fitgenesusa.com (https://www.fitgenesusa.com) Are you a health practitioner ready to decode your clients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to https://FitgenesUSA.com (https://FitgenesUSA.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. TIME STAMPS 00:00 - Introduction 00:54 - Welcome: Bitter Taste & Genetics 01:21 - 5 Flavor Profiles & Evolution 02:35 - Bitter Reflexes & Safety 03:20 - Vagus Nerve & Enzymes 04:41 - Stomach Acid Triggering 05:10 - Using Bitters Before Meals 06:03 - Lung & Gut Receptors 07:22 - TAS2R38 Genes & RSIDs 08:32 - Super Tasters vs Non-Tasters 09:12 - Sensitivities in Children 10:05 - Genetic Risk-Reward Strategy 14:58 - Sponsor: Fitgenes USA 16:24 - Vegetables & Overconsumption 17:43 - Why Super Tasters Enjoy Greens 18:31 - Age, Gender & Pregnancy 20:02 - Sweeter Agriculture Trends 21:39 - 4 Cooking Hacks for Bitters 24:20 - Sugar, Alcohol & Non-Tasters 26:12 - Carnivore vs Plant Diets 29:13 - Sponsor: Fitgenes Practitioners 30:20 - Key Provider Takeaways 32:06 - Lung Immune & Gut Satiety 33:37 - Gastric Emptying & Appetite 35:15 - Reduced Satiety & Obesity Risk 36:47 - Closing Remarks DISCLAIMER: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. REFERENCES: • Behrens, M., Gunn, H. C., Ramos, P. C., Meyerhof, W., & Wooding, S. P. (2013) (https://doi.org/10.1093/chemse/bjt016) • Ortega, F. J., Aguera, Z., Sabater, M., Moreno- Navarrete, J. M., Alonso-Ledesma, I., Xifra, G., . . . Fernandez-Real, J. M. (2016). (https://doi.org/10.1002/mnfr.201500804) • Pawellek, I., Grote, V., Rzehak, P., Xhonneux, A., Verduci, E., Stolarczyk, A., . . . Koletzko, B. (2016). (https://doi.org/10.1016/j.appet.2016.07.034) • Sandell, M., Hoppu, U., Mikkila, V., Mononen, N., Kahonen, M., Mannisto, S., . . . Raitakari, O. T. (2014). (https://doi.org/10.1007/s12263-014-0433-3) • Tepper, B. J., Koelliker, Y., Zhao, L., Ullrich, N. V., Lanzara, C., d'Adamo, P., . . . Gasparini, P. (2008) (https://doi.org/10.1038/oby.2008.357). • Turner, A., Veysey, M., Keely, S., Scarlett, C., Lucock, M., & Beckett, E. L. (2018). (https://doi.org/10.3390/nu10101336) • Tonic water: https://www.medicinenet.com/side_effects_of_quinine_in_tonic_water/article.htm (https://www.medicinenet.com/side_effects_of_quinine_in_tonic_water/article.htm) accessed June 16, 2026 9:58 am

6 Oct 2026
The "Walking Habit": Why Your Body Was Built to Move, and What Happens When It Doesn't?
Could the world's simplest exercise be the most powerful tool for lowering inflammation and living longer? Join host Genetics Experts & Int'l Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, co-host Mikayla Wachsmann, MS, CNS, and Lily (his Frenchie). From evolutionary survival to modern health, Dr. Sam traces why walking upright was our greatest adaptation - and how science shows it lowers chronic inflammation today. Discover the truth about realistic step targets and simple daily habits to bridge the gap between ancient movement and modern living. Key topics covered: • Inflammation Markers at Rest: How regular walking lowers resting levels of IL-1, 6, 8, 18, TNF-alpha, and CRP - key markers tied to chronic disease. • The Bipedalism Story: 4 evolutionary hypotheses (Thermoregulatory, Provisioning, Postural Feeding, Endurance Running) and anatomical traits that made long travel possible. • Modern Sedentarism by the Numbers: Today's average 1.5 miles/day vs. the 7-10 miles walked by hunter-gatherer populations. • Rethinking the 10,000-Step Rule: Why a 1965 marketing slogan became the standard - and why health benefits actually plateau around 6,000-8,000 steps. • Small Steps, Big Habit: Building up by adding +33 steps a day, plus habit-stacking like hourly 5-minute breaks and under-desk treadmills. • The Power of the Post-Dinner Walk: How an evening walk supports digestion, blood sugar control, circadian rhythm, and neighborhood connection. • Walk Like You Mean It: Why the arm backswing engages the posterior deltoid, supports shoulder health, and naturally lengthens your stride. Loved this episode? Subscribe & leave a review! Are you a health practitioner ready to decode your clients' genetics? Elevate your practice at FitgenesUSA.com (https://FitgenesUSA.com ) to become a certified practitioner and gain access to advanced genetic testing and clinical support. Connect with Dr. Sam: IG:@fitgenesusa (https://www.instagram.com/fitgenesusa/) | W: fitgenesusa.com (https://www.fitgenesusa.com) TIME STAMPS 00:00 - Intro 00:53 - Why Walking on Genetics Show? 02:00 - Lowering Inflammation 03:26 - Bipedalism Evolution 04:52 - Thermoregulatory Hypothesis 06:18 - Provisioning & Feeding 08:11 - Endurance Running 09:53 - Fit Genes USA 11:42 - Brain Stimulation 14:50 - Mating & Trade-Offs 17:35 - 10,000 Steps Slogan 18:33 - Hunter-Gatherer vs Modern 22:35 - Math of Walking 27:13 - Steps & Longevity 30:03 - Hit 7,500 Steps 33:22 - Fit Genes Blueprint 34:35 - Arm Backswing Mechanics 36:52 - Post-Dinner Walks 38:46 - Habit Stacking 40:22 - 33-Step Strategy 41:30 - Community Walking 43:30 - Outro DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. References 1. Harvard Health (2019) (https://www.health.harvard.edu/blog/10000-steps-a-day-or-fewer-2019071117305) 2. Lee I-M. JAMA (2019) (https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2734709) 3. Paluch AE. Lancet (2022) (https://pmc.ncbi.nlm.nih.gov/articles/PMC9289978/) 4. Banach M. Eur J Prev (2023) (https://academic.oup.com/eurjpc/article/30/18/1975/7226309) 5. Lancet Meta-Analysis (2025) (https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(25)00164-1/fulltext) 6. MoTrPAC. Cell (2020) (https://www.cell.com/cell/fulltext/S0092-8674(20)30691-7) 7. Pedersen BK. Phys Rev (2008) (https://journals.physiology.org/doi/full/10.1152/physrev.90100.2007) 8. Exercise & Cytokines (2021) (https://pmc.ncbi.nlm.nih.gov/articles/PMC8740100/) 9. Activity & CRP. JACC (2005) (https://www.jacc.org/doi/10.1016/j.jacc.2004.12.077) 10. Aerobic & Inflam (2019) (https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2019.00098/full) 11. Resistance & TNF (2018) (https://pmc.ncbi.nlm.nih.gov/articles/PMC6230406/) 12. IL-6/IL-10. PLOS (2010) (https://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.1000465) 13. Exercise & IL-10 (2010) ( https://link.springer.com/article/10.1186/ar3064) 14. COX-2 Inhibitor (2014) (https://pmc.ncbi.nlm.nih.gov/articles/PMC4043321/) 15. Chinsomboon J. PNAS (2009) (https://pubmed.ncbi.nlm.nih.gov/19401459/) 16. Genetics & Endurance (2021) (https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.694411/full) 17. MacArthur. ESSR (2007) (https://journals.lww.com/acsm-essr/abstract/2007/01000/actn3__a_genetic_influence_on_muscle_function_and.7.aspx) 18. Bramble. Nature (2004) (https://www.nature.com/articles/nature03052) 19. Wheeler. J Hum Evol (1991) (https://www.sciencedirect.com/science/article/pii/004724849190002D) 20. Ruxton. PNAS (2011) (https://www.pnas.org/doi/10.1073/pnas.1113915108) 21. Lovejoy. Science (1981) (https://www.science.org/doi/10.1126/science.211.4480.341) 22. Hunt. S Afr J Sci (1996) (https://journals.co.za/doi/10.10520/AJA00382353_7777) 23. Sockol. PNAS (2007) (https://www.pnas.org/doi/10.1073/pnas.0703267104) 24. Univ of Arizona (2007) (https://www.sciencedaily.com/releases/2007/07/070716191140.htm) 25. Bravata. JAMA (2007) (https://pubmed.ncbi.nlm.nih.gov/18029834/) 26. Patel. Ann Int Med (2016) (https://www.acpjournals.org/doi/10.7326/M15-1635)

29 Sept 2026
The "Oxygen Genes": Is Your DNA Fueling or Limiting Your VO2 Max?
Could your DNA be the reason you're gasping for air while your training partner cruises right past you? Join host Dr. Sam Shay, DC, FMCP (Genetics Expert), co-host Mikayla Wachsmann, MS, CNS, and Lily - his "Frenchie". Discover the genetics behind VO2 max - one of the most powerful indicators of longevity, measuring how efficiently your body takes in, transports, and uses oxygen. Dr. Sam and Mikayla break down why oxygen is the fuel your mitochondria need to produce energy, what happens when your body can't keep up with that demand, and how four specific genes shape your engine's efficiency.If you enjoyed discovering whether you're built for sprint or endurance in our muscle fiber type episode, this one goes a layer deeper: it's not just which fibers you have, but how well your body actually fuels them with oxygen. Key topics covered in this episode: VO2 Max & Mitochondria: What VO2 max measures, oxygen for ATP production, and anaerobic pathways. Mitochondria as "Guests": Symbiotic organisms with their own DNA powering our cells. AMPD1: Recycles ATP in skeletal muscle; variations affect endurance vs. cardiac protection. VEGFA: Regulates angiogenesis and new capillary creation for oxygen delivery. HIF1A: Low-oxygen emergency sensor & Goldilocks effect. ACSL1: Helps mobilize fatty acids to make ATP for aerobic capacity. Evolutionary Trade-Offs: Variations reflect adaptation, not "broken" genes. The "Non-Responders": Why 40% don't improve VO2 max from Zone 2 alone, and HIIT. Training Smarter: Recovery, biomechanics, and progress by recovery speed from deep muscle burn. Loved learning what your genes reveal about your engine's oxygen efficiency? Don't leave your training to guesswork - subscribe and drop us a review to help others decode their DNA. Connect with Dr. Sam: IG: @fitgenesusa (https://www.instagram.com/fitgenesusa/) | W: fitgenesusa.com (https://www.fitgenesusa.com) Health Practitioners: Ready to offer personalized, root-cause care? Visit FitgenesUSA (https://FitgenesUSA.com) to get certified & access testing TIME STAMPS: 00:00 - Intro 01:26 - What is VO2 Max? 02:20 - VO2 Max & Longevity 04:31 - Oxygen & Mitochondria 07:02 - 4 Key VO2 Max Genes 08:14 - AMPD1: ATP Recycling 16:02 - VEGFA: Capillaries & Oxygen 21:54 - HIF1A: Hypoxia Sensor 26:24 - ACSL1: Fatty Acids & ATP 31:22 - Increasing VO2 Max Safely 33:50 - Why 40% Don't Respond to Zone 2 34:28 - HIIT vs Zone 2 44:23 - Measuring Recovery Speed 47:40 - Outro References (22 Studies): 1. Bouchard et al. (1999) - HERITAGE Family Study (https://pubmed.ncbi.nlm.nih.gov/10484570/) 2. Bouchard et al. (2011) - Genomic predictors of O2 uptake ( https://pubmed.ncbi.nlm.nih.gov/21183627/) 3. Ginevičienė et al. - AMPD1 & athletic performance (https://pmc.ncbi.nlm.nih.gov/articles/PMC4032451/) 4. AMPD1 Deficiency Overview (https://en.wikipedia.org/wiki/Adenosine_monophosphate_deaminase_deficiency_type_1) 5. Rannou et al. (2017) - AMPD1 mutation insights (https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0187266) 6. Smolenski et al. (2014) - AMPD1 & Heart Disease (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955129/) 7. Boidin et al. (2022) - VEGFA & training adaptation (https://pmc.ncbi.nlm.nih.gov/articles/PMC9816297/) 8. Ahmetov et al. - HIF1A in elite endurance athletes (https://pubmed.ncbi.nlm.nih.gov/20299614/) 9. Genetic Polymorphisms & Endurance Meta-Analysis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199302/) 10. Beall et al. (2010) - EPAS1 in Tibetan highlanders ( https://www.pnas.org/doi/10.1073/pnas.1002443107) 11. Lorenzo et al. - EPAS1 & High-Altitude Hypoxia (https://academic.oup.com/mbe/article/34/4/818/2918109) 12. Simonson et al. - Tibetans & hypoxia response (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972739/) 13. Yvert et al. (2012) - ACSL1 & elite endurance status (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041268) 14. ACSL polymorphism among runners (https://www.researchgate.net/publication/330110910_Prevalence_of_ACSL_rs6552828_polymorphism_among_runners) 15. Bailey et al. (2013) - Nitrate supplementation & exercise (https://journals.physiology.org/doi/full/10.1152/japplphysiol.00372.2013) 16. HFE gene H63D polymorphism & endurance (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042188/) 17. Vitamin C & Oxygen Sensing in vivo (https://pmc.ncbi.nlm.nih.gov/articles/PMC3109719/) 18. Gerling et al. (2019) - Omega-3s & mitochondrial membranes (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449797/) 19. Herbst et al. - Omega-3s & mitochondrial respiration (https://pmc.ncbi.nlm.nih.gov/articles/PMC3961091/) 20. Hypoxia Training at High Altitudes (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691031/) 21. HIIT vs MICT on mitochondrial dynamics (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043657/) 22. HIIT vs MICT on VO2 max & blood pressure (https://pmc.ncbi.nlm.nih.gov/articles/PMC7357372/) DISCLAIMER:This podcast is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. Neither Dr. Sam nor the publisher assumes liability for actions taken based on this content. Always consult a qualified healthcare provider before making changes to your diet, supplements, or health plan. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and CarbChoice Advanced

22 Sept 2026
The "Recovery Genes": Is Your DNA Setting You Up for Chronic Inflammation and Slow Healing?
Is your workout helping you heal - or keeping you stuck in a cycle of inflammation? Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily - his "Frenchie" Discover why some bodies bounce back from a hard workout within a day, while others stay sore, swollen, or sidelined for a week - and how a handful of genes tied to inflammation and bone strength may be the reason. Dr. Sam breaks down how exercise-induced micro-damage is actually the first step toward getting stronger, what happens when the body never gets the chance to fully repair, and how to tell whether your training style matches your genetic recovery capacity Key topics covered in this episode: Inflammation 101: Why exercise micro-damage happens - and how it turns chronic when repair fails, leading to fluid retention and lost muscle tone. VDR1 & VDR2: How Vitamin D Receptor gene variations raise bone fracture risk and drive stronger inflammatory responses. IL-6 & TNF-alpha ("Hub Genes"): Why cytokine hub variations prolong the repair response, causing chronic inflammation, oxidative stress, and soreness. Movement vs. Exercise: Why reframing "exercise" as "movement" and "training" improves consistency for those triggered by the word "exercise." Recovery Is Not Optional: Why sleep, anti-inflammatory nutrition, saunas, cold exposure, and light swimming matter as much as the workout. Smarter HIIT: Capping HIIT at 2-3 sessions per week with 45-60 sec bursts of deep muscle burn and keeping total session time under 30 minutes. The Pedometer Advantage: Why step counters are one of the most effective tools for building consistent, low-inflammation movement. Loved learning what your genes reveal about injury and recovery? Don't leave your training to guesswork - subscribe and drop us a review to help others decode their DNA Connect with Dr. Sam: • IG: @fitgenesusa (https://www.instagram.com/fitgenesusa/) • Web: FitgenesUSA.com (https://www.fitgenesusa.com) Health practitioners: Head to FitgenesUSA.com (https://fitgenesusa.com/) to become a certified practitioner and access advanced genetic testing and clinical support. TIME STAMPS: 00:00 - Intro & Overview 00:48 - Host Introductions 01:14 - Exercise-Induced Inflammation Genetics 02:08 - Case Study: Over-Exercising & Fluid Retention 04:17 - Scaffolding Analogy of Inflammation 07:03 - Reversing Hyper-Inflammation 08:06 - Hyper-Inflamers & The Muffin Test 11:42 - Key Inflammatory Genes (IL-6, TNF-Alpha, VDR) 13:28 - DNA Decoded Program 15:32 - VDR Genes & Bone Micro-Fractures 18:21 - TNF-Alpha: Inflammatory Smoke Alarm 19:24 - Personalizing Workout Frequency 22:15 - Effective Recovery Strategies 23:00 - Movement vs. Training vs. Recovery 32:00 - Strains, Sprains & Injury Anatomy 36:40 - Fit Genes USA Practitioner Info 37:54 - Safe Training for High-Risk Genotypes 40:08 - 45-to-60-Second HIIT Protocol 44:26 - Tracking Recovery & Lactate Threshold 49:14 - Modifying Overtraining in CrossFit 51:02 - Outro & Resources DISCLAIMER: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. References: Genetic variation and exercise-induced muscle damage (https://link.springer.com/article/10.1007/s00421-016-3411-1) Vitamin D receptor gene polymorphisms and injuries (https://pmc.ncbi.nlm.nih.gov/articles/PMC4489103/) Vitamin D receptor protein and IL-6 in skeletal muscle (https://pmc.ncbi.nlm.nih.gov/articles/PMC4447580/) Exercise-induced VDR and AR mediate inhibition of IL-6 (https://pubmed.ncbi.nlm.nih.gov/38205185/) VDR gene polymorphisms and fracture healing (https://pubmed.ncbi.nlm.nih.gov/41054574/)

15 Sept 2026
The "Speed Gene": Are You Genetically Built to Sprint, Go the Distance, or Both?
Are you training against your genetics without even knowing it? Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily-his "Frenchie". Discover how a single gene (called ACTN3)-nicknamed the "speed gene"-can reveal whether your body is naturally wired for explosive power, endurance, or a mix of both. Dr. Sam breaks down muscle fiber types, evolutionary history, and injury prevention strategies. Key topics covered in this episode: • ACTN3 Genotypes: RR (power), XX (endurance), and RX (blended) profiles. • Sprint vs. Endurance Genetics: Fast-twitch explosive power vs. slow-twitch aerobic performance. • Evolutionary History: How migration, foraging, and cold survival shaped genetic variants. • Injury Prevention: Training and recovery strategies based on your genetic profile. • Beyond Genetics: The roles of diet, hormones, and mindset in performance. Loved learning the code behind your muscle fibers? Subscribe and drop us a review to help others decode their DNA! Connect with Dr. Sam: IG: @fitgenesusa (https://www.instagram.com/fitgenesusa/) W: fitgenesusa.com (www.fitgenesusa.com) Are you a health practitioner ready to decode your clients' genetics? Elevate your practice today at FitgenesUSA.com (https://FitgenesUSA.com) to become a certified practitioner. DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. References: • Baltazar-Martins G, Gutiérrez-Hellín J, Aguilar-Navarro M, et al. Effect of ACTN3 Genotype on Sports Performance, Exercise-Induced Muscle Damage, and Injury Epidemiology. Sports (Basel). 2020;8(7):99. Published 2020 Jul 13. doi:10.3390/sports8070099. (https://www.mdpi.com/2075-4663/8/7/99) • Eynon N, Hanson ED, Lucia A, et al. Genes for elite power and sprint performance: ACTN3 leads the way. Sports Med. 2013;43(9):803-817. doi:10.1007/s40279-013-0059-4. (https://pubmed.ncbi.nlm.nih.gov/23681449/) • Yang N, MacArthur DG, Gulbin JP, et al. ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet. 2003;73(3):627-631. doi:10.1086/377590. (https://pubmed.ncbi.nlm.nih.gov/12879365/) Alpha-actinin-3 (https://en.wikipedia.org/wiki/Alpha-actinin-3) • Alpha-actinin is an actin (https://en.wikipedia.org/wiki/Actin)-binding protein with multiple roles in different cell types. This gene expression is limited to skeletal muscle. It is localized to the Z-disc (https://en.wikipedia.org/wiki/Sarcomere#Bands) and analogous dense bodies, where it helps to anchor the myofibrillar actin filaments.[7] (https://en.wikipedia.org/wiki/Alpha-actinin-3#cite_note-entrez-7) • Fast versus slow twitch muscle fibers • Skeletal muscle (https://en.wikipedia.org/wiki/Skeletal_muscle) is composed of long cylindrical cells called muscle fibers. There are two types of muscle fibers, slow twitch or muscle contraction (https://en.wikipedia.org/wiki/Muscle_contraction) (type I) and fast twitch (type II). Slow twitch fibers are more efficient in using oxygen to generate energy, while fast twitch fibers are less efficient. However, fast twitch fibers fire more rapidly, allowing them to generate more power than slow twitch (type I) fibers. Fast twitch fibers and slow twitch fibers are also called white muscle fibers and red muscles fibers, respectively. The alpha-actinin-3 protein is found in type II muscle fibers. • It has been speculated that variations in this gene evolved to accommodate the energy expenditure requirements of people in various parts of the world. 8] (https://en.wikipedia.org/wiki/Alpha-actinin-3#cite_note-Epstein_2013-8): 155–156 Over 75% of the persons have one or two copies of ACTN3 577R and have alpha-actinin-3. Homozygous individuals (ACTN3 577XX) have no alpha-actinin-3 (16%-20% of the population), [11] (https://en.wikipedia.org/wiki/Alpha-actinin-3#cite_note-11)[12 (https://en.wikipedia.org/wiki/Alpha-actinin-3#cite_note-12) but they have a high level of alpha-actinin-2. (https://en.wikipedia.org/wiki/Actinin_alpha_2)

8 Sept 2026
Decoding Collagen Genetics: Hypermobility, Injury Prevention, and Soft Tissue Recovery
Is collagen marketing hiding the truth about your joint, skin, and soft tissue health? Join Dr. Sam Shay, DC, FMCP, co-host Mikayla Wachsmann, MS, CNS, and Lily - his "Frenchie". Discover how COL1A1 and COL5A1 genetic variations influence collagen structure, joint hypermobility, and risks for EDS, disc herniations, and hernias. Learn why overuse and chronic inflammation - not age - drive tissue breakdown, plus strategies for safe training, managing histamine, and recovery. Key topics covered in this episode: • Hypermobility: COL5A1 & COL1A1 variants increase risks for EDS and soft tissue injuries. • Overuse vs. Aging: Joint wear-and-tear is driven by cumulative strain and inflammation. • Training & Recovery: Dangers of cold static stretching, dynamic warm-ups, and HIIT recovery. • Nutrition: Support collagen with Vitamin C, Creatine, Inositol; manage histamine. • Movement: Low-impact activities (walking, Qigong) maintain mobility without joint overload. Subscribe and drop us a review to help others decode their DNA! TIME STAMPS 00:00 - Intro 00:53 - Collagen Integrity 01:41 - Collagen Protein & Tryptophan 02:18 - Genetics of Collagen 03:49 - Hypermobility & EDS 04:13 - Age vs. Overuse 06:44 - COL5A1 & COL1A1 07:18 - Injury Prevention 09:50 - Hernias & Osteoporosis 11:04 - Fit Genes USA 12:42 - Collagen Health Variables 14:04 - Static Stretching vs. Warm-ups 15:23 - Post-Exercise Recovery 16:13 - Overtraining & Inflammation 17:29 - Safe HIIT 21:35 - Collagen on Plant-Based Diet 24:29 - Managing Histamine 26:55 - Genetic Reality 28:51 - Dog Rescuing Benefits 29:16 - Staying Active 29:45 - Outro Connect with Dr. Sam: IG: @fitgenesusa (https://www.instagram.com/fitgenesusa/) Website: fitgenesusa.com (https://www.fitgenesusa.com) Health practitioners: Ready to offer personalized, root-cause care? Elevate your practice at FitgenesUSA.com (https://fitgenesusa.com) to become a certified practitioner. DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. REFERENCES • Beck KL, et al. Micronutrients and athletic performance. Food Chem Toxicol. 2021;158:112618. doi:10.1016/j.fct.2021.112618. • de la Puente Yagüe M, et al. Role of Vitamin D in Athletes. Nutrients. 2020;12(2):579. doi:10.3390/nu12020579. • Kaufman MW, et al. Impact of Supplements on Sports Performance. Curr Sports Med Rep. 2022;21(7):232-238. doi:10.1249/JSR.0000000000000972. • Leońska-Duniec A, et al. Genetic variants influencing exercise training programmes. Biol Sport. 2016;33(3):207-214. doi:10.5604/20831862.1201052. • Maffulli N, et al. Genetics of sports injuries. Muscles Ligaments Tendons J. 2013;3(3):173-189. • Petersen AM, Pedersen BK. Role of IL-6 in mediating anti-inflammatory effects of exercise. J Physiol Pharmacol. 2006;57 Suppl 10:43-51. • Type I Collagen (https://en.wikipedia.org/wiki/Type_I_collagen) • Collagen Alpha 1 (https://en.wikipedia.org/wiki/Collagen,_type_I,_alpha_1) • Type V Collagen (https://en.wikipedia.org/wiki/Type_V_collagen) • Collagen Type V Alpha 1 (https://en.wikipedia.org/wiki/Collagen,_type_V,_alpha_1)

1 Sept 2026
What Is Histamine Intolerance? Causes, Genetic Testing & Diet Tips
Ever feel like your "healthy" diet is making you feel worse? Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily - his "Frenchie". In this episode, we dive into the genetics behind histamine metabolism - specifically looking at the AOC1 gene (which codes for the DAO enzyme) and the HNMT gene - and break down what your genetic risk results actually mean for your health. Dr. Sam shares personal experiences and real-life case studies to illustrate how histamine issues manifest, why the histamine load is additive, and how to navigate the frustrating overlap between superfoods and high-histamine triggers. Key topics covered in this episode: • The Genetic Blueprint: How DAO and HNMT genes dictate your body's ability to clear histamine. • The "Healthy Food" Paradox: Why wellness shots, fermented foods (miso, natto, ACV), and aged products can spark unexpected reactions. • Canned vs. Dry Beans: The surprising science behind storage liquids, processing times, and histamine-producing bacteria. • Navigating Dairy & Aged Cheeses: How to manage low-lactose foods that are simultaneously high in histamine. • Flavor Without the Flare-Ups: Practical tips and substitutions for cooking with high-histamine spices like cinnamon, cayenne, and curry powders. • Roadblocks & Protocols: Actionable strategies, nutrigenomic insights, and how practitioners can avoid costly diagnostic pitfalls. If you found this episode eye-opening, don't forget to subscribe, share it with a friend, and leave us a 5-star review to help more people decode their DNA! Connect with Dr. Sam IG: @fitgenesusa/ (https://www.instagram.com/fitgenesusa/) W: fitgenesusa (https://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to FitgenesUSA (https://FitgenesUSA.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. References: • Ayuso, P., García-Martín, E., Martínez, C., & Agúndez, J. A. (2007). Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity. Pharmacogenetics and genomics, 17(9), 687-693. Click Here (https://doi.org/10.1097/FPC.0b013e328012b8e4) • García-Martín, E. et al. (2015). Diamine oxidase rs10156191 and rs2052129 variants are associated with the risk for migraine. Headache, 55(2), 276-286. Click Here (https://doi.org/10.1111/head.12493) • Meza-Velázquez, R. et al. (2017). Association of diamine oxidase and histamine N-methyltransferase polymorphisms with presence of migraine in a group of Mexican mothers of children with allergies. Neurologia, 32(8), 500-507. Click Here (https://doi.org/10.1016/j.nrl.2016.02.025) • Maintz, L. et al. (2011). Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities. Allergy, 66(7), 893-902. Click Here (https://doi.org/10.1111/j.1398-9995.2011.02548.x) • Stevenson, J. et al. (2010). The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms. The American journal of psychiatry, 167(9), 1108-1115. Click Here (https://doi.org/10.1176/appi.ajp.2010.09101529)

25 Aug 2026
Decoding Lactose Intolerance: Genetics, Dairy Allergies & Gut Health
Discover how your genes (LCT and MCM6) impact lactose intolerance, lactase persistence, and dairy sensitivities. Uncover the crucial differences between sugar intolerances and protein allergies, plus practical strategies for managing dairy in your diet. Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily - his "Frenchie". In this episode, we dive deep into the science and evolutionary history surrounding dairy digestion. We explore how your DNA dictates your ability to produce the lactase enzyme into adulthood, break down the vital distinctions between non-immune enzyme deficiencies and immune-driven protein allergies, and share actionable tips - from low-lactose swaps to navigating social meals - so you can optimize your gut health with confidence. • The Genetic Switch for Dairy: How variations in the LCT gene and MCM6 control switch (RS4988235) determine lactase persistence, and why "yellow dot" (heterozygous) results still allow for normal lactose digestion. • Evolutionary Context: Why the ability to digest milk evolved as a survival advantage in early pastoral communities, offering a rich source of nutrients during food scarcity. • Lactose Intolerance vs. Dairy Allergy: Clearing up confusion between an enzyme deficiency (lacking the "scissors" to split lactose sugars) and an immune-mediated response (IgE or IgG) to dairy proteins like casein and whey. • Hidden Dairy Symptoms: Why you might genetically process lactose just fine, but still experience bloating, acne, fatigue, or constipation due to dairy protein sensitivities. • Enzymes, Ghee, and Smart Swaps: Practical diet hacks, including utilizing lactase enzyme supplements, choosing naturally low-lactose hard cheeses, and opting for pure-fat options like ghee. • Navigating Social Situations: How to politely handle dining out or hosted meals with gratitude while keeping your digestion protected. If you found this episode eye-opening, don't forget to subscribe, share it with a friend, and leave us a 5-star review to help more people decode their DNA! Connect with Dr. Sam IG: https://www.instagram.com/fitgenesusa/ (https://www.instagram.com/fitgenesusa/) W: www.fitgenesusa.com (https://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to https://FitgenesUSA.com (https://FitgenesUSA.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. TIME STAMPS • 0:00 - Welcome • 1:13 - Why Discuss Lactose Intolerance Genetically? • 3:11 - Decoding LCT Gene & MCM6 Switch • 6:24 - Evolutionary Context • 11:05 - Green vs. Yellow Dots in LCT • 14:15 - Intolerance vs. Allergy • 17:11 - IgE vs. IgG Responses • 24:01 - What Causes Bloating, Gas, & Diarrhea? • 25:32 - Comparing Lactose Levels in Foods • 29:02 - Non-Dairy Alternatives • 33:16 - History of Dairy Industry • 37:54 - Practical Summary • 39:17 - How to Decline Dairy Offers • 41:40 - Final Thoughts DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced.

18 Aug 2026
Decoding Gluten Intolerance: Genetics, Celiac Risk & Hidden Sources
Discover how your genes (HLA DQ genes) impact gluten intolerance, celiac disease risk, and autoimmunity like Hashimoto's. Uncover hidden gluten sources and practical health tips. Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily—his "Frenchie". In this episode, we dive deep into the science and culture surrounding gluten intolerance. We explore how your DNA dictates your risk for celiac disease and autoimmunity, break down the crucial differences between allergies, sensitivities, and intolerances, and expose the hidden sources of gluten sneaking into everyday foods—so you can make informed choices and protect your health long term. • The Power of Genetic Testing: Why understanding your unique DNA offers a lifelong health roadmap to prevent chronic illness before symptoms start. • Allergy vs. Intolerance vs. Sensitivity: Clearing up confusion between IgE/IgG immune-driven reactions and digestive enzyme deficiencies. • Celiac Disease & Autoimmunity: How genetic variations in the HLA-DQA1 and HLA-DQB1 genes interact with leaky gut to trigger autoimmune conditions like Hashimoto's thyroiditis. • Modern Wheat & Glyphosate: How industrial farming practices, dwarf wheat breeding, and heavy pesticide/glyphosate use contribute to non-celiac gluten sensitivity in the U.S. • The "BROWS" Framework: Identifying core gluten-containing grains—Barley, Rye, Oats (via contamination), Wheat, and Spelt. • Hidden Gluten & Cross-Reactivity: Exposing sneaky sources of gluten in everyday items (soy sauce, imitation crab, salad dressings) and non-gluten foods that can mimic gluten reactions in the body (dairy, rice, yeast). If you found this episode eye-opening, make sure to hit the Follow button here on Spotify, share it with a friend, and leave us a 5-star rating to help more people decode their DNA! Connect with Dr. Sam • IG: @fitgenesusa (https://www.instagram.com/fitgenesusa/) • W: www.fitgenesusa.com (http://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to FitgenesUSA.com (https://FitgenesUSA.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. TIME STAMPS • 00:00 - Welcome & Today's Topic • 02:24 - Allergy, Sensitivity & Intolerance Explained • 07:06 - Undetected Celiac Disease & Autoimmunity • 09:40 - Glyphosate & Modern Wheat's Impact • 18:22 - Decoding Genetics (SNPs & HLA Genes) • 26:18 - 3 Components of Autoimmune Disease • 30:57 - Foods with Gluten & The B.R.O.W.S. Rule • 37:13 - Cross-Reactive Foods & Hidden Gluten • 45:54 - Managing Intolerance & Leaky Gut • 50:10 - Gluten, Thyroid Attacks & Inflammation • 54:02 - Gut Testing & Healing Strategies DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. References: • https://pmc.ncbi.nlm.nih.gov/articles/PMC3945755/ (https://pmc.ncbi.nlm.nih.gov/articles/PMC3945755/)

11 Aug 2026
The Science of Alcohol: Genetics, Health Risks & Social Drinking
Discover how genetics (ADH1B & ALDH2 genes) impact alcohol metabolism, toxicity, and addiction risk. Learn CDC drinking limits, social impacts, and strategies for conscious drinking. Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily—his "Frenchie". In this episode, we explore how your genes shape toxicity and addiction risk, unpack social pressures around drinking, and share practical strategies—from CDC guidelines to non-alcoholic alternatives—so you can make informed health choices. Genetics of Alcohol Intolerance & Toxicity: How ADH1B & ALDH2 variations determine acetaldehyde conversion—and why lack of flushing isn't low risk. The "Unholy Trifecta" of Addiction Risk: How combining alcohol-processing genes with sweet/bitter taste preferences elevates consumption risk. Social Pressures & Sober Curious Movement: Alcohol as a social lubricant, regional drinking cultures, and navigating events alcohol-free. CDC Frameworks: Defining binge vs. heavy drinking and assessing dependency through health/relational impact rather than volume alone. Practical Strategies for Change: Needing vs. wanting help, professional interventions, and using non-alcoholic alternatives effectively. If you found this episode eye-opening, please subscribe and share it with someone who loves deep dives into health and wellness! Connect with Dr. Sam IG: https://www.instagram.com/fitgenesusa/ (https://www.instagram.com/fitgenesusa/) W: www.fitgenesusa.com (http://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics? Elevate your practice at https://FitgenesUSA.com (https://FitgenesUSA.com) to become a certified practitioner and access advanced genetic testing and clinical support. TIME STAMPS 0:00 - Introduction & Podcast Overview 0:51 - Why Study Alcohol Intolerance & Genetics? 2:34 - Consumption Trends & Sober Curious 4:52 - Dr. Sam Shay’s Personal History 8:14 - Social Lubricant vs. Digital Isolation 13:08 - Quitting Alcohol & Changing Friendships 20:34 - Understanding Genetic Reports 23:49 - Key Genes: ALDH2, ADH1B & Acetaldehyde 33:05 - Binge Drinking, Heavy Drinking & Addiction 38:26 - Need Help vs. Want Help in Addiction 42:37 - Warning Signs & Historical Context 48:36 - Alcohol’s Effects on Sleep & Snoring 49:30 - Mocktails & Social Strategies 52:18 - Liver Support & Helpful Nutrients 54:19 - Alcoholism Risk & The "Unholy Trifecta" 59:48 - Current Science & Closing Thoughts DISCLAIMER This podcast is for educational purposes only and not medical advice. Always consult a qualified healthcare provider before altering your health routine. Dr. Sam Shay, DC, FMCP has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and CarbChoice Advanced. References • Jorgenson, E., et al. (2017). Genetic contributors to variation in alcohol consumption. Mol Psychiatry, 22(9), 1359-1367. https://doi.org/10.1038/mp.2017.101 (https://doi.org/10.1038/mp.2017.101) • Edenberg, H. J. (2007). The genetics of alcohol metabolism. Alcohol Res Health, 30(1), 5-13. • Bierut, L. J., et al. (2012). ADH1B is associated with alcohol dependence. Mol Psychiatry, 17(4), 445-450. https://doi.org/10.1038/mp.2011.124 (https://doi.org/10.1038/mp.2011.124)

4 Aug 2026
Why You Can’t Lose the Weight: Genetics, Inflammation & "Water Weight" Explained
Ever feel like you’re doing everything right - eating clean, grinding through high-intensity workouts - and yet the scale won't budge or you wake up feeling "puffy"? You might not be dealing with excess fat or calories. Instead, you could be experiencing inflammatory water weight. Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily - his "Frenchie" (who is busy enjoying a studio spa day). In this episode, we dive deep into the fascinating interplay between your DNA, systemic inflammation, and body weight. We break down why the traditional "calories in, calories out" model falls short and how your genes dictate how your body responds to stress, food, and exercise. In this episode, we cover: The 3 Genetic Categories of Weight Weight: Discover why calorie intake is actually the least common driver of excess weight - and how hormonal toxicity and inflammatory water weight dominate. The "Bee Sting" Analogy: Understand how your immune system retains fluid to dilute toxins, leading to sudden, unexplainable weight fluctuations. The Exercise Paradox: Why over-exercising can backfire in genetically vulnerable individuals, triggering systemic inflammation and weight gain instead of fat loss. The "Muffin Test": A simple, real-world metric to help you distinguish between true fat gain and a rapid, hyperinflammatory response. Key Genes Driving Your Symptoms: How variations in CRP, Interleukin (IL-6/IL-10), Vitamin D receptors, and liver detox genes (GSTP1) control your body's alarm systems. Histamine & Salt Vulnerabilities: Why healthy foods like avocados or fermented items might be triggering a histamine response via DAO and HMNT genes, plus how salt-sensitivity genes (ACE, AGTR1) compound fluid retention. Actionable Management Strategies: Practical tips on shifting from stressful "exercise" to gentle movement, customizing your diet using an 80/20 approach, and leveraging targeted supplements like EPA/DHA, sulforaphane, and quercetin. If you learned something new today, hit subscribe, leave us a 5-star review, and remember: next time you wake up puffy, don't blame the scale - blame your genes throwing a histamine party! Connect with Dr. Sam IG: https://www.instagram.com/fitgenesusa/ (https://www.instagram.com/fitgenesusa/) W: www.fitgenesusa.com (https://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to https://FitgenesUSA.com (https://FitgenesUSA.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. TIMESTAMPS 00:00 - Intro & The 3 Genetic Types of Weight Gain 03:32 - The "Bee Sting" Analogy: Size vs. Calories 05:47 - Exercise-Induced Obesity & Overworking 08:35 - The "Muffin Test" & Inflammatory Water Weight 14:38 - Real-Life Case Study: Dropping 4 lbs in 24 Hours 18:20 - Decoding High-Inflamer Genes (CRP, IL-6, VDR, GSTP1) 24:48 - Exercise vs. Gentle Movement for High-Inflamers 28:03 - Salt-Sensitivity Genes & Water Retention 31:56 - Histamines, DAO/HMNT Genes & Swollen Weight 41:08 - Practical Action Steps & The "Top 10" Elimination Strategy 44:28 - Targeted Anti-Inflammatory Supplements & Swaps DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced.

28 Jul 2026
Why You're Always Inflamed (And What Your Genes Have to Do With It)
Do you feel stiff, achy, or completely wiped out by minor daily stressors, poor sleep, or a single less-than-perfect meal? It’s not just a sign of getting older: it’s an evolutionary mismatch hardcoded into your DNA. Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily, his "Frenchie" (who is busy enjoying a studio spa day). In this episode, we break down why being a "hyper-inflamer" was once a literal lifesaver for hunter-gatherers but has become a modern-day recipe for chronic illness. We explore how a core cluster of 16 genes dictates how your body reacts to the modern "inflammatory soup" of processing foods, pollution, and doom scrolling. In this episode, we cover: The Hunter-Gatherer Superpower: Why a hyper-inflammatory response was essential for surviving prehistoric animal wounds, but why that same genetic trait leaves you defenseless against modern environmental insults. The Three Phases of the Fire: How your specific genes control the spark (Initiation via IL-1, IL-6, and TNF-alpha), the bonfire (Propagation via IL-8, IL-18, and COX), and whether you have a fire truck or a squirt gun to put it out (Extinguishing via IL-10). The Inflammatory Weight Loop: Why highly inflammatory genetic profiles cause people to rapidly balloon with inflammatory water weight from eating half a muffin, and the silver lining of how to drop it just as fast. Nutritional vs. Nutrigenomic Dosing: Why standard supplement guidelines fail to move the needle, and how hitting higher therapeutic thresholds (like over 2 grams of combined EPA/DHA fish oil) actually rewrites your cellular machinery instead of just adding a patch. The Ultimate Anti-Inflammatory Levers: The incredible genetic power of Sulforaphane (broccoli sprout extract) and SOD (Superoxide Dismutase) inducers like zinc and curcumin to help douse chronic cellular flames. Subscribe today and share this episode with anyone who feels like they have the joints of an 80-year-old. Every 5-star rating helps others find this show and unlock the power of their own genetic blueprint. Connect with Dr. Sam: IG: https://www.instagram.com/fitgenesusa/ (https://www.instagram.com/fitgenesusa/) W: www.fitgenesusa.com (http://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to https://FitgenesUSA.com (https://FitgenesUSA.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. TIMESTAMPS: 0:00 - Intro: Decoding Your DNA 0:51 - Welcome & Genetics/Inflammation 1:20 - Inflammation: Genetic View 2:02 - Hunter-Gatherers vs Today 3:50 - Survival vs Chronic Illness 6:25 - Environmental Triggers 8:13 - What is Chronic Inflammation? 10:33 - Dr. Sam’s Story 11:38 - Brain & Gut-Brain Axis 13:54 - Top 15-16 Inflammatory Genes 18:24 - Red, Yellow, Green Dots 22:32 - The 3 Fire Stages 25:31 - Risk Profiles 29:05 - Blueprint Data to Action 33:40 - Targeted Interventions 35:38 - Nutrigenomic Dosing 38:51 - Key Compounds 43:01 - Water Weight & Lifestyle 47:09 - Summary & Advice DISCLAIMER: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced.

21 Jul 2026
Why Coffee Makes You Anxious (It Could Be Your Genes)
Do you feel jittery, anxious, or completely wiped out after a single cup of coffee? It’s not just in your head—it’s in your genes. Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-hosts Mikayla Wachsmann, MS, CNS, and Lily—his "Frenchie." We break down the "depression combo punch" of caffeine sensitivity. We explore how specific variations in your ADORA2A, CYP1A2, and COMT genes dictate whether coffee gives you a clean energy boost or traps your brain in a state of exhausting hyperarousal. We’ll look at real-life case studies and provide actionable, nutritional workarounds to help you clear caffeine faster and reclaim your calm. IN THIS EPISODE, WE COVER: The "Sleepy Buttons": How the ADORA2A gene controls your adenosine receptors, and why caffeine jams those signals (leaving the "brakes" off your brain). The Liver's Cleanup Crew: Why the CYP1A2 gene determines if you are a "fast" or "slow" metabolizer—and why slow metabolizers stay wired for 8+ hours. The Stress Pileup: The role of the COMT gene in clearing out adrenaline and dopamine, and how a slow COMT creates the ultimate anxiety storm. Nutritional Hacks: How eating cruciferous vegetables (like broccoli and Brussels sprouts) can speed up your body's caffeine clearance. Practical Q&A: Mikayla asks Dr. Sam how to regulate bowel motility and find pre-workout energy without relying on heavy stimulants. If this episode made you rethink your relationship with coffee, hit subscribe and share it with your favorite caffeine addict. Your genes—and your friends—will thank you. CONNECT WITH DR. SAM IG: @fitgenesusa (https://www.instagram.com/fitgenesusa/) W: FitgenesUSA (https://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to FitgenesUSA.com (https://FitgenesUSA.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. TIME STAMPS 0:00 - Intro 1:03 - The truth about caffeine sensitivity 5:16 - Caffeine-induced anxiety and depression 13:33 - Understanding genetics: The traffic light system 20:26 - ADORA2A: The brain's "sleepy buttons" 24:52 - CYP1A2: The liver's cleanup crew 26:41 - COMT: Adrenaline, dopamine, and the anxiety storm 32:27 - Managing coffee quality, timing, and volume 35:32 - Foods that speed up vs. slow down caffeine detox 43:00 - How Magnesium Threonate calms a slow COMT gene 47:44 - Coffee alternatives and Swiss Water decaf 57:08 - Q&A: Why coffee makes you poop and the "Poop Stack" 1:03:25 - Q&A: Getting pre-workout energy without stimulants 1:09:22 - Delaying morning coffee for better circadian rhythms DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. REFERENCES: World Population Review: Which Country Eats the Most Chocolate? (https://worldpopulationreview.com/country-rankings/which-country-eats-the-most-chocolate) Clinical Study: Association between ADORA2A polymorphisms and caffeine-induced anxiety (https://pubmed.ncbi.nlm.nih.gov/12825092/) Clinical Study: CYP1A2 polymorphism and caffeine metabolism adaptations (https://pubmed.ncbi.nlm.nih.gov/29282363/) Clinical Study: Impact of ADORA2A variations on depression and symptoms (https://pmc.ncbi.nlm.nih.gov/articles/PMC6439088/)

14 Jul 2026
Meet Your Co-Host Mikayla: From Intern to Precision Genomics Expert
What if your genes aren't a scary, fixed destiny, but a highly personalized owner's manual waiting to be decoded? Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-hosts Mikayla Wachsmann, MS, CNS, and Lily—his "Frenchie." Get an inside look into Mikayla's journey from Dr. Sam’s very first intern to running a fully remote telemedicine practice. Long before launching her practice, Mikayla was working side-by-side with Dr. Sam, digitally hand-assembling the complex data that eventually evolved into today's premier Fitgenes Genetic Blueprints. Now, she is stepping out from behind the Zoom screen and into the studio to share how she helps clients transition from standard, frustrating "one-size-fits-all" advice to true precision nutrition and lifestyle optimization. Together, this dynamic clinical duo reunites to break down the cutting-edge world of functional genomics, giving you the ultimate owner's manual for your unique biology. In this episode, we will cover: The Pivot to Precision: Mikayla shares her personal "why"—from losing her father to brain cancer as an infant to navigating her own severe gut issues using the Institute for Functional Medicine (IFM) matrix. Demystifying Functional Genomics: Why the Fitgenes Genetic Blueprint is a tool to uncover your body's unique strengths and vulnerabilities, rather than a deterministic diagnosis. The Histamine Protocol: Why healthy "superfoods" like sauerkraut and avocados can cause an overflow in your "histamine bucket," leading to mysterious midsection water weight, morning congestion, hives, digestive issues and migraines. The 80/20 Solution: A realistic, judgment-free coaching strategy to manage a low-histamine lifestyle without sacrificing your absolute favorite foods. Overcoming "Metabolic Barbed Wire": How secondary, acquired stressors—like gut infections, mold, or nervous system dysregulation—wrap around your genes, block their expression, and cause weight or energy plateaus. Connect with Mikayla: • IG: @mw.clinicalnutrition (https://www.instagram.com/mw.clinicalnutrition) • W: MW-Nutrition.com (https://www.mw-nutrition.com) Connect with Dr. Sam: • IG: @fitgenesusa (https://www.instagram.com/fitgenesusa/) • W: FitgenesUSA.com (https://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to FitgenesUSA.com (https://www.fitgenesusa.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. Subscribe & Review: If you loved this episode, please subscribe, share and leave a review. Every 5-star rating helps others find this show and unlock the power of their own genetic blueprint. We have incredible episodes coming up covering caffeine sensitivity, inflammation management, workout recovery, and so much more. TIME STAMPS 0:00 - Intro: Mikayla Wachsmann 1:33 - Mikayla's Journey & Mentorship 5:47 - Genetics vs Functional Guide 7:30 - Gut Issues & Root Cause Care 10:48 - Remote Telemedicine Practice 13:23 - Histamine Intolerance Signs 16:39 - Gut Infections & DNA Data 21:12 - Acne, Bloating & Carb Choice 24:32 - Wounded Healer & Mold Journey 30:39 - Ideal Clients & Lab Testing 36:17 - Outro & Closing Message DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced.

7 Jul 2026
Carbohydrates: Why Your DNA Holds the Secret to Your Perfect Diet
Ever wonder why your best friend can crush sourdough toast and bananas all day with boundless energy, while you just look at a piece of bread and instantly feel bloated, heavy, and exhausted? Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-hosts Mikayla Wachsmann, MS, CNS, and Lily—his "Frenchie." They crack open the frustrating world of "one-size-fits-none" dieting. If you’ve cycled through Keto, Paleo, and Veganism only to end up more confused than when you started, it’s time to stop the guesswork. Your body isn't working against you—it’s just waiting for the right instructions. Dr. Shay introduces CarbChoice Advanced, a groundbreaking genetic test that analyzes the AMY1 gene to determine exactly how your unique biology handles carbohydrates. Whether you are a health-conscious individual looking for your perfect diet or a healthcare practitioner wanting to upgrade from "a compass and a prayer" to precision medicine, this episode provides the definitive roadmap. In this episode, we cover: The "One-Size-Fits-None" Trap: Why trending diets fail most people and how ignoring your genetics is the missing link in your wellness journey. The AMY1 "Cannons" Analogy: A simple, brilliant way to understand how your mouth produces salivary amylase to fight off carbohydrate "Vikings." The Spectrum of Carbs: How to find your specific "Carb Number" to know if you truly belong on a strict Keto plan, a Mediterranean diet, or somewhere in between. The Practitioner’s Edge: How clinicians can use precision data to eliminate client compliance issues and build long-term lifestyle roadmaps. Subscribe & Review: If you loved this episode, please subscribe, share and leave a review. Every 5-star rating helps others find this show and unlock the power of their own genetic blueprint. We have incredible episodes coming up covering caffeine sensitivity, inflammation management, workout recovery, and so much more. Connect with Dr. Sam IG: https://www.instagram.com/fitgenesusa/ (https://www.instagram.com/fitgenesusa/) W: www.fitgenesusa.com (https://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to https://FitgenesUSA.com (https://FitgenesUSA.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced.

30 Jun 2026
Why Your Genetics Aren't a Fixed Fate (And What to Do About It)
Are you intimidated by the science of genetics? Do you worry that your DNA is a fixed fate you are powerless to change? Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-hosts Mikayla Wachsmann, MS, CNS, and Lily—his "Frenchie." Together, Dr. Sam and Mikayla strip away sterile textbook definitions, replacing them with an intuitive framework you can actually use to reclaim your health. We dive headfirst into the "How" of genetics. Learn why your cells are like tiny encapsulated cities, how your inherited genes operate like pages in a recipe book, and what the universal "traffic light" color-coding system (Green, Yellow, and Red dots) actually means for your daily well-being. Plus, Dr. Sam unpacks the buzzword of the decade—epigenetics—explaining how your lifestyle, mindset, and environment act as a dimmer switch to control how your genes behave. In this episode, we cover: The Traffic Light of DNA (Green, Yellow, and Red Dots): Learn the difference between possessing a flawless "Green dot" copy of a gene, a hybrid "Yellow dot" copy, or a "Red dot" copy based on the fitgenes genetic blueprint system. Why "Bad Genes" Aren't Always Bad: Dr. Sam flips the script on "least beneficial" genes. Using estrogen detoxification as a prime example, he explains how a slow-clearing "Red dot" gene was actually a survival superpower during ancient hunter-gatherer times of starvation, even if it backfires in our modern world of chemical overload. The Epigenetic Dimmer Switch: Your DNA is not an on/off light switch—it’s a dial. Learn how epigenetics empowers you to use targeted actions (like high-quality fish oil, air optimization, and precise recovery protocols) to nudge a default "Red" or "Yellow" gene to behave like a healthy "Green" gene. The Sea of Green Trap: Think good genes make you invincible? Dr. Sam reveals real-life insights from his clinical practice showing how individuals with near-perfect "Green" genetics can still end up chronically ill if subjected to extreme environmental toxicity and poor lifestyle choices. Subscribe & Review: If you loved this episode, please subscribe, share and leave a review. Every 5-star rating helps others find this show and unlock the power of their own genetic blueprint. We have incredible episodes coming up covering caffeine sensitivity, inflammation management, workout recovery, and so much more. Connect with Dr. Sam * IG: https://www.instagram.com/fitgenesusa/ (https://www.instagram.com/fitgenesusa/) * W: www.fitgenesusa.com (https://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to https://FitgenesUSA.com (https://FitgenesUSA.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. DISCLAIMER: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced.

23 Jun 2026
Meet Dr. Sam & Rewrite Your Genetic Story
Welcome to the debut episode of The Fitgenes Podcast! Join your host, Dr. Sam Shay, DC, FMCP—Genetics Expert and Certified Fitgenes Practitioner—and co-host Mikayla Wachsmann, MS, CNS, as they strip away the medical jargon and open up the ultimate user manual for your body. If you’ve ever felt overwhelmed by conflicting health advice, this episode is your breath of fresh air. Dr. Sam and Mikayla break down why your DNA isn't a genetic death sentence, but rather a personalized roadmap to optimal health. In this episode, we cover: • The Power of Genetics (The One-and-Done Test): Why your genetic blueprint is the single highest-value test you can ever take. Unlike other functional tests that require constant re-testing, your DNA stays the same for life. • Functional Genetics vs. The Rest: Dr. Sam breaks down the four types of genetic testing (genealogy, paternity, disease diagnostics, and functional genetics). Discover why Fitgenes focuses on identifying the drivers of wellness rather than just chasing diseases. • Dr. Sam’s Personal Journey: From crippling joint pain, anxiety, and severe digestive issues to vibrant health. Dr. Sam shares how discovering his own hyper-inflammatory genes and Vitamin D absorption issues changed everything, proving his genes weren't "bad"—they were just mismatched for modern society. • Data vs. Wisdom: Why more data isn’t always better data. Learn how the Fit Genes approach helps practitioners prioritize information so clients get clear, actionable steps for diet, inflammation, and lifestyle without the information overload. Key Takeaway: Your genes are not your destiny. They are your blueprint. By understanding your unique functional genetics, you eliminate the guesswork and gain total agency over how you heal, move, and thrive. Subscribe & Review: If you loved this episode, please subscribe, share and leave a review. Every 5-star rating helps others find this show and unlock the power of their own genetic blueprint. We have incredible episodes coming up covering caffeine sensitivity, inflammation management, workout recovery, and so much more. Connect with Dr. Sam: • IG: @fitgenesusa (https://www.instagram.com/fitgenesusa/) • W: www.fitgenesusa.com (https://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to FitgenesUSA.com (https://www.fitgenesusa.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. Episode Chapters: 00:00 — Introduction & Why Genetics is the Ultimate Testing Gap 04:24 — The Four Types of Genetic Testing 07:51 — Dr. Sam's Personal Health Journey 11:06 — Decoding the Results: Hyper-Inflammation and Vitamin D 16:14 — Nutritional Dosing vs. Nutrigenomic Dosing 17:58 — Evolutionary Mismatches & Caffeine-Induced Anxiety 24:42 — Cross-Referencing Blood Work: The Rotating Sushi Tray Analogy 30:06 — Rethinking Data Dumps & Exercise-Induced Obesity 36:19 — How to Get Started & Outro DISCLAIMER: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of Fitgenes USA (https://www.fitgenesusa.com) and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced.

23 Jun 2026
Introducing the Fitgenes Podcast: Stop Guessing, Start Decoding
Join Dr. Sam Shay, DC, FMCP, and co-host Mikayla Wachsmann, MS, CNS, as they decode complex genetics into practical, actionable strategies for health, performance, and longevity. Each episode bridges the gap between clinical data and real-world results, breaking down the specific genes and pathways that actually matter—without the hype or technical noise. Whether you are working to shift your own health trajectory or you're a practitioner seeking clearer communication and better clinical outcomes, this show gives you the frameworks to make DNA truly usable. Learn more, become a practitioner, or find care near you: Western Hemisphere, Europe, & UK: FitgenesUSA.com (https://fitgenesusa.com) Australia & Asia: Fitgenes.com (https://fitgenes.com) New Zealand: Nutriscript.co.nz (https://nutriscript.co.nz) Subscribe & Review: If you loved this episode, please subscribe, share and leave a review. Every 5-star rating helps others find this show and unlock the power of their own genetic blueprint. We have incredible episodes coming up covering caffeine sensitivity, inflammation management, workout recovery, and so much more. Connect with Dr. Sam: IG: https://www.instagram.com/fitgenesusa/ (https://www.instagram.com/fitgenesusa/) W: www.fitgenesusa.com (https://www.fitgenesusa.com) Are you a health practitioner ready to decode your patients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to FitgenesUSA.com (https://fitgenesusa.com) today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced.
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