Flux is a podcast about the pioneers building companies at the frontier of technology. This series of interviews goes beyond the soundbites, allowing some of the most interesting players in technology to share their insider expertise and explain the challenges they face in building the future. Hosted by Alice Lloyd George.
30: Noor Siddiqui —Predicting Your Future Child’s Health Just Got Easier
On today's episode I speak with Noor Siddiqui, the founder of Orchid (https://www.orchidhealth.com/), a company that quantifies the genetic risks of your future children. We discuss the plunge in genome sequencing costs and why Orchid's ability to predict polygenic diseases impacts so many families compared to predicting single-gene diseases.
Noor reveals what it was like starting a company remotely during COVID, how her mother's own rare disease motivated her and what genetic privilege means. We discuss her path from doing a Thiel fellowship to teaching a crypto class at Stanford to doing genomics and AI research with Sebastian Thrun. Finally, we get into our contrarian views and why biology advances seem to provoke the strongest pushback.
Full transcript on Medium. This episode was produced by Daniel Bouza.
28 Dec 2020
29: Kevin Caldwell — A Bio Bank for the Future
In the last Flux episode of 2020, Alice talks with Kevin Caldwell, founder and CEO of Ossium Health, a company building the first bank of on-demand bone marrow stem cells and developing therapeutics to treat leukemia, blood cancer, and other diseases.
Kevin discusses how he navigated his many career options and how his time with grandparents shaped his values. After graduating law school and getting degrees in physics and economics, working at McKinsey and at hedge funds, Kevin realized he wanted to have more impact and switched to life sciences.
We discuss the history of stem cell therapy and why the potential for living drugs is so exciting. Kevin shares why no-one has used bone marrow from deceased donors, and how Ossium is building the first major procurement network to enable donor and recipient matches at scale. He gets into the business model, views on the future, and the advantages of raising from both life science and traditional tech investors.
Full transcript on Medium. This episode was produced by Daniel Bouza.
23 Oct 2020
28: Adam Arrigo—The Show Must Go Beyond
Flux fandom. In today's episode Alice talks with Adam Arrigo, co-founder and CEO of Wave (https://wavexr.com/), a live virtual concert company.
Adam has been pushing the frontier of music his whole life, from touring as a musician to designing Rockband the game at Harmonix. In 2016 Adam and Aaron Lemke founded Wave. Along the way the company has evolved and worked with artists including Imogen Heap, Kill the Noise, Tokimonsta, Galantis, Rezz, John Legend and the Weeknd. Today Wave distributes imaginative, interactive shows across platforms, from MMO games to Twitch, Youtube and TikTok. Wave just closed a Series B with Justin Bieber and J Balvin investing.
Adam gets into how the core insights around design and interactivity from the early days of VR are critical to the product today, and how he's reimagining the medium of concerts from the ground up. He explains how the pandemic has created a challenge for artists but also an opportunity for Wave to serve them.
Adam discusses business models and monetization, from virtual goods to tipping. We cover trends in Asia such as the VTuber phenomenon, how companies like Riot and Epic in the U.S. are pushing the industry forward, and the new crop of creative virtual IP startups.
Adam shares how the metaverse can be a beautiful and liberating place and gives advice to founders at the frontier—on how to build something that defies classification and how to find a team of passionate Avengers who align with your vision of the future.
Full transcript on Medium. This episode was produced by Dan Bouza.
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