From First Principles
Hosted by Lester Nare and Krishna Choudhary · Krishna Choudhary and Lester Nare
5.0from 802 ratings
- 75
- Episodes
- 41
- Transcribed
- 802
- Ratings
- Daily
- Cadence
- 2025
- First episode
About From First Principles
From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.
- Publisher
- Krishna Choudhary and Lester Nare
- Category
- science
- Language
- en
- Explicit
- No
- First episode
- 1 Aug 2025
- Latest episode
- 7 Oct 2026
Latest episodes
41 of 75 episodes have a transcript.
7 Oct 2026TRANSCRIPT
Nobel Prize in Chemistry 2026 Explained: Mirror Molecules (EP 63)
6 Oct 2026TRANSCRIPT
Nobel Prize in Physics 2026 Explained: IceCube & Neutrinos
5 Oct 2026TRANSCRIPT
Nobel Prize in Medicine 2026 Explained: Optogenetics (EP 61)
Inside a recent episode
Nobel Prize in Chemistry 2026 Explained: Mirror Molecules (EP 63)
Published 7 Oct 2026 · Transcript excerpt
[…] If two mirror images interact differently with the body, then the manufacturer needs to understand which form is being made, how much of it is being made, and how we can actually create asymmetric synthesis where we can build a preference of one over another, right? Understanding these nonlinear effects helps researchers interpret experiments, identify active species, and decide how to actually improve selectivity. So this year's Nobel Prizes the work that they've done is very much important for drug development at large. This is, it's so interesting. I think, you know, I've talked about this previously, you know, my dad has worked in stage one drug discovery for quite some time. […]
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Public platform figures. Ratings count people who left a rating, not total listeners.
- Apple Podcasts (US)
- 4.9 / 5
- 185 ratings
- Spotify
- 5.0 / 5
- 617 ratings
Contact From First Principles
- Guest appearances
- Does not typically book guests
Based on episode analysis; this does not confirm that the show is currently accepting guests.
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Questions about From First Principles
Who hosts From First Principles?
Lester Nare and Krishna Choudhary host the show. Published by Krishna Choudhary and Lester Nare.
How often do new episodes come out?
The show publishes daily, based on its RSS feed.
Does From First Principles take guests?
The show does not typically feature guests, based on episode analyses.
Where can I read transcripts?
41 of 75 episodes have a transcript on Pod Engine. Full transcripts are available with a Pod Engine plan.
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