Generation Health

About Generation Health

Generation Health is a bi-weekly podcast dedicated to helping you live a longer, healthier life. Brothers Joey DiMatteo (PharmD, CCN) and Dante DiMatteo (PharmD) continue the legacy of their father, Joe DiMatteo, by cutting through the clickbait to deliver balanced, data-backed analysis on diet, exercise, supplementation, and pharmacology. Alongside host Tyler Andrews—who brings the audience's questions to the table—they provide the clear, evidence-based insights you need to make informed decisions about your health.

Publisher

Dante DiMatteo

Category

health & fitness · health & fitness

Language

en

Explicit

No

First episode

7 Mar 2023

Latest episode

21 Sept 2026

Latest episodes

103 episodes in the feed.

1. 

   21 Sept 2026

   PCOS is gone. PMOS is here.

   PCOS (Polycystic Ovary Syndrome) has, for millions of women, been the catch-all explanation for a host of symptoms like irregular periods, weight gain, acne, facial hair growth, and painful ovarian cysts. While our understanding has grown, the name often served as a distraction, and kept women from understanding the underlying cause. This led to people treating the immediate symptom without correcting the core problem. When The Lancet formally renamed PCOS to Polyendocrine Metabolic Ovarian Syndrome (PMOS), it signaled a massive shift in how clinicians are educating patients: this disease is simply too big for its old name. Joey DiMatteo (PharmD, CCN) breaks down why this rebrand matters far beyond medical terminology. By reframing the condition around metabolic and hormonal complexity, this update shifts the focus from quick symptom management to root-cause treatment. The goal is long-term health rather than just fixing what's broken today. Don't get stuck in the PMOS spiral - Treat it at the source. IN THIS EPISODE, YOU'LL LEARN: • Why is PCOS being renamed to PMOS? • Why erratic periods, weight gain, and acne can all signal one problem. • How to stop the driver of PMOS • Why a birth control prescriptions often misses the full diagnostic picture. • Why follow-through on secondary bloodwork like A1c is vital for systemic health. We love questions. Comment below or email us: questions@askjoedimatteo.com CONNECT: Products - https://askjoedimatteo.com/youtube Questions - questions@askjoedimatteo.com Facebook -  https://facebook.com/askjoedimatteo Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 00:21 - Lancet: PCOS is now PMOS 00:53 - Why is the name changing? 03:24 - What PMOS really means 05:41 - The metabolic health is the core. 10:04 - Complex Hormone Interplay in PMOS 12:26 - Is there a cure for PMOS? 15:03 - Insulin Resistance 16:48 - How medications factor in 17:52 - Takeaway: Control the Source 21:00 - Show Outro SHOW NOTES: 1) PMOS - The New Name for PCOS (Lancet): https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00717-8/fulltext DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

2. 

   7 Sept 2026

   Why TRT is Failing Men

   Testosterone and TRT are having a moment. Public sentiment has radically shifted, often seeing it as an obvious primary intervention for men. Men's health clinics and online stores have made it easy to access. Even the US military is expanding access by checking testosterone levels for all service members 30 years old and older. But is TRT really the best answer for men who are tired or gaining weight? Dante DiMatteo (PharmD) uses a pile of peer-reviewed studies and clinical experience to provide a balanced, fair, and honest answer to the question so many middle-aged men are facing: Why don't I feel like I used to? IN THIS EPISODE, YOU'LL LEARN: • Are online TRT clinics following best practices? • Why automatic testosterone screening is a bad idea. • What is a real Low-T score? • What is the process for diagnosing Low-T? • What factors impact testosterone production? • What do testosterone levels actually signal? We love questions. Comment below or email us: questions@askjoedimatteo.com CONNECT: Products - https://askjoedimatteo.com/youtube Questions - questions@askjoedimatteo.com Facebook -  https://facebook.com/askjoedimatteo Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 00:51 - New Department of War policy on Testosterone 02:38 - Information comes with a catch 03:54 - When is testosterone screening worthwhile? 04:42 - Testosterone is a proxy. 05:51 - Online TRT Clinics vs Guidelines 06:12 - Study findings 06:55 - What 90% of TRT Sites got right 07:26 - What does a real diagnosis look like? 08:31 - One-third of retests return to normal 10:00 - Medications that can lower testosterone 11:25 - What number is actually low? 13:36 - Pete Hegseth's Official Announcement 16:08 - Why TRT seems to work 18:21 - Is TRT dangerous? 20:00 - How does TRT impact fertility? 20:57 - Reasonable TRT results 25:09 - What's most likely causing Testosterone decline 27:28 - TRT will help specific men 28:19 - Where to do before TRT 30:18 - Summary SHOW NOTES: 1) Online Clinic Discrepancies (Study): https://academic.oup.com/jcem/article/111/6/1651/8414025 2) Sec Hegseth Announcement (Video): https://x.com/SecWar/status/2077425458430230838?s=20 3) Testosterone in Healthy Man (Study): https://doi.org/10.1111/j.1365-2265.2012.04432.x 4) Aging Men Testosterone & Function (Study): https://doi.org/10.1530/EJE%2D12%2D0890 5) Endocrine Society Statement: https://www.endocrine.org/news-and-advocacy/news-room/2026/statement-on-testosterone-replacement-therapy 6) Mood & Agression in men on High-dose Testosterone (Study): https://doi.org/10.1001/archpsyc.57.2.133 7) TRAVERSE (Study): https://doi.org/10.1056/NEJMoa2215025 8) Testosterone May Improve Mood & Sexual Function (Study): https://doi.org/10.1136/bmj.i989 DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

3. 

   24 Aug 2026

   Sleep Aids: A to Zzz

   Not all sleep aids are created equal. With dozens of options available ranging from natural supplements to prescription medications, finding the solution that will get you to sleep, keep you asleep, and not have unwanted side effects can be a challenge. That's why pharmacist and nutritionist Joey DiMatteo is making it easy by ranking them! He discusses the ones that work, the ones don't, and how to choose based on the particular challenge you're facing. After that, Dante DiMatteo (PharmD) goes over a study directly linking strength in older women to longevity. There are a host of reasons women over 60 should do resistance training, but a 33% reduced risk of mortality has to be one of the best! IN THIS EPISODE, YOU'LL LEARN: • Which sleep aids work best. • How to find the root of your sleep disturbance. • Which prescription sleep aids a pharmacist would never take. • When it's time for a sleep study. • What single factor reduces risk of mortality by 33% in women 63+. We love questions. Comment below or email us: questions@askjoedimatteo.com CONNECT: Products - https://askjoedimatteo.com/youtube Questions - questions@askjoedimatteo.com Facebook -  https://facebook.com/askjoedimatteo Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowYTM Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a Rumble - https://rumble.com/user/GenerationHealth YouTube Podcast - https://www.youtube.com/@GenerationHealthShow YouTube Clips - https://www.youtube.com/@askjoedimatteo Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life! CHAPTERS: 00:00 - Show Intro 00:40 - How we rank sleep aids 01:32 - Alcohol 02:31 - Anti-psychotics (Seroquel) 03:12 - Over-the-counter options 04:14 - Z-drugs (Ambien, Lunesta, Sonata) 05:20 - Benzodiazepine 06:20 - Trazodone 07:31 - Melatonin 09:22 - Supplement Blends 11:31 - Doxepin (low dose) & Ramelteon 12:28 - Dayvigo & Belsomra (orexin receptor antagonist) 13:34 - The only A+ intervention: CBT-I 15:01 - Ranking Recap 15:44 - Takeaway: Find the root problem first. 16:39 - Muscular Strength & Mortality in women 63-99 17:12 - How the study was designed 18:24 - Findings of the study 21:34 - Grip strength is a proxy, not a goal. 23:18 - Takeaway: Exercise is safe & effective 24:54 - Show Outro SHOW NOTES: 1) Muscular Strength & Mortality (Study): • https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845052 DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Reach and audience

Public platform figures. Ratings count people who left a rating, not total listeners.

YouTube views

445,260

Score snapshot 15 Sept 2025

Apple Podcasts (US)

5.0 / 5

14 ratings

Spotify

5.0 / 5

1 ratings

Podcast Authority Score: 69 / 100

A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.

Quality

74

Social presence

0

YouTube

86

Engagement

77