“Give It to Me Straight, Doc” delivers expert medical insight, honest conversations, and trusted information straight from the doctors you rely on. Each episode breaks down today’s health topics into clear, practical guidance you can actually use.
Publisher
Tampa General Hospital & USF Health Morsani College of Medicine
Why 90% of New Drugs Fail Before Reaching Patients | Give It To Me Straight, Doc
Why can it cost up to $2 billion to develop a new medicine when 90% of drug candidates still fail? In this episode of Give It to Me Straight, Doc, Anjalee Khemlani goes behind the scenes of the pharmaceutical industry with Goldman Sachs Research’s Salveen Richter, Novavax veteran John Trizzino, and Nasha Fitter, co-founder of Citizen Health and the FOXG1 Research Foundation.
They explain how pharmaceutical companies decide which diseases to pursue, why COVID vaccines moved faster than most treatments, how policy and pricing shape research, and why failed trials are such a major part of drug development. Nasha also shares her personal fight to find a treatment for her daughter’s ultra-rare FOXG1 syndrome and why patients don’t just need more drugs. They need drugs that work.
Have questions about your health care and not sure where to turn? We give you unfiltered insight into how health care really works.
This program is for informational purposes only and is not a substitute for professional medical advice.
Presented by Tampa General Hospital and USF Health.
25 Aug 2026
Why Hospital Bills Are So Expensive and How to Pay Less | Give It To Me Straight, Doc
Why can a hospital bed cost as much as a car, and could paying cash actually be cheaper than using insurance? Hospital leaders Michael Maron and Jose Lozano explain what drives the cost of care, from 24/7 staffing and multimillion-dollar technology to the hidden expenses behind every hospital visit. They also share how to compare hospitals, find the right specialist, evaluate hospital rankings, ask about financial assistance, and better understand your costs before the bill arrives.
Have questions about your health care and not sure where to turn? We give you unfiltered insight into how health care really works.
This program is for informational purposes only and is not a substitute for professional medical advice.
Presented by Tampa General Hospital and USF Health.
25 Aug 2026
What Happens When You Stop Ozempic or Other GLP-1s? | Give It To Me Straight, Doc
GLP-1 medications like Ozempic, Wegovy, Mounjaro and Zepbound have transformed weight loss. But what happens when patients want to stop taking them? Does the weight return, and are these medications meant to be lifelong?
On this episode of Give It to Me Straight, Doc, host Anjalee Khemlani speaks with Sean Duffy, co-founder and CEO of Omada Health; Dr. Shantanu Gaur, co-founder and CEO of Allurion; and Jared Holz, health care sector strategist at Mizuho.
They discuss why GLP-1s are not a silver bullet, the challenges of side effects and muscle loss, why some patients stop treatment, and the support needed to achieve lasting results. The conversation also explores non-surgical alternatives, the next generation of pills and longer-lasting injections, and research into possible uses involving addiction, inflammation and Alzheimer’s disease.
Have questions about your health care and not sure where to turn? We give you unfiltered insight into how health care really works.
This program is for informational purposes only and is not a substitute for professional medical advice.
Presented by Tampa General Hospital and USF Health.
12 Aug 2026
The Truth About Longevity: Peptides, Supplements and Wellness Myths | Give It To Me Straight, Doc
#healthcare #healthandwellness #doctor
Can the latest wellness trends actually help you live longer, or are they simply expensive quick fixes?
In this episode of Give It to Me Straight, Doc, host Anjalee Khemlani examines the growing longevity industry and the products being marketed as shortcuts to better health. The conversation explores supplements, peptides, GLP-1 medications, nutrition, exercise and the influence social media has on the choices consumers make.
The experts also break down the risks of questionable wellness products, why online popularity should not be mistaken for medical credibility and how to separate legitimate science from persuasive marketing. Ultimately, the discussion reveals that the real foundation of lasting wellness may be much less exciting, but far more effective: consistent sleep, exercise, healthy eating and sustainable daily habits.
Presented by Tampa General Hospital and USF Health.
3 Aug 2026
America’s Aging Crisis: Who Will Take Care of Us? | Give It To Me Straight, Doc
America is getting older, but is the health care system prepared for what comes next?
In this episode of Give It To Me Straight, Doc., host Anjalee Khemlani speaks with health care and aging experts about the growing pressure facing older adults and the family members caring for them. They break down caregiver burnout, the rising cost of in-home care, the hidden economic toll on families and why millions of Americans may soon be forced to choose between their careers and caring for an aging parent.
The conversation also explores the roles of hospice and palliative care, whether technology and AI can help close the caregiving gap and what families should begin planning for before a health crisis happens.
Presented by Tampa General Hospital and USF Health.
30 Jun 2026
Why Health Care Feels Broken, Explained by Doctors | Give It To Me Straight, Doc
Why does health care feel so hard to navigate?
In this episode of Give It To Me Straight, Doc, host Anjalee Khemlani sits down with Dr. Jason Wilson of Tampa General Hospital , Morsani College of Medicine, and USF Health to break down some of the biggest frustrations patients face in today’s health care system.
From long ER wait times and crowded emergency departments to urgent care, primary care access, specialist referrals, insurance hurdles, prior authorizations and direct-to-consumer health care, this conversation explains what is really happening behind the scenes when patients try to get care.
Dr. Wilson shares why the emergency room can take so long, when patients should consider urgent care, how doctors think through testing and treatment, and why the system can feel confusing even for the people working inside it.
The episode also explores how health care is changing outside the traditional doctor’s office, including telehealth, retail care, online health platforms and the growing number of ways patients are trying to access care faster.
If you have ever felt stuck waiting, confused by insurance, unsure where to go for care, or overwhelmed by the health care system, this episode gives you a clearer look at how it works and what patients should know before making their next medical decision.
Presented by Tampa General Hospital and USF Health.
5 Jun 2026
Is Online Health Care the New Doctor's Office? | Give It To Me Straight, Doc
Health care is changing fast, and more patients are turning to online platforms, telehealth visits, cash-pay options, prescription marketplaces and direct-to-consumer care to get what they need faster.
In this episode of Give It To Me Straight, Doc, host Anjalee Khemlani breaks down the rise of direct-to-consumer health care and what it means for patients, doctors, pharmacies and the future of medicine. From Amazon One Medical and Sesame to GoodRx, GLP-1 weight loss medications, online prescriptions, pharmacy access, insurance frustrations and price transparency, this conversation looks at how health care is starting to feel more like e-commerce.
As more people search for care online, compare prescription prices, pay cash for certain services and use telehealth as part of their medical journey, the traditional doctor’s office is no longer the only front door to health care. But what does that mean for privacy, quality, access and affordability?
Presented by Tampa General Hospital and USF Health Morsani College of Medicine.
7 May 2026
Insurance: The Truth From Industry Experts | Give It To Me Straight, Doc
In this episode of Give It To Me Straight, Doc, we’re talking about one of the most confusing parts of health care: insurance.
What goes on behind the scenes when creating the perfect health plan? Our experts explain what to look for, what to ask, and how to better understand your plan. If insurance has ever felt overwhelming, this conversation helps make the process a little easier to navigate.
2 Apr 2026
The Truth About Pharmacy (What No One Tells You)
Prescription drug prices remain one of the most confusing and frustrating parts of the healthcare system. In this episode of Tampa General Hospital’s newest streaming series, host Anjalee Khemlani sits down with former Walgreens CEO Tim Wentworth, along with independent pharmacy owners, to break down the hidden forces shaping what patients pay at the pharmacy counter.
The conversation dives into the powerful role of Pharmacy Benefit Managers (PBMs) — the middlemen that negotiate drug prices between insurers, pharmacies, and pharmaceutical companies — and how their practices can impact prescription costs, pharmacy reimbursements, and patient access to medications.
2 Mar 2026
AI in Health Care – Smarter Care Everywhere
In this episode of Tampa General Hospital’s newest streaming series, host Anjalee Khemlani sits down with AI and medical experts to discuss the growing role of artificial intelligence in modern health care. The conversation helps consumers stay informed on the latest advancements and explains how patients can protect themselves as insurers begin using AI-driven tools.
12 Feb 2026
What's Wrong With Health Care in America?
In the debut episode of Tampa General Hospital’s newest podcast, host Anjalee Khemlani sits down with Dr. Mark Moseley, President of USF Tampa General Physicians and Executive Vice President of Tampa General Hospital, to discuss the rising cost of health care in the U.S. and how patients can take a more informed, proactive approach to their care while building stronger relationships with their physicians.
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Apple Podcasts (US)
5.0 / 5
3 ratings
Spotify
5.0 / 5
1 ratings
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