Interested in learning more about glycobiology? You’ve come to the right place. Welcome to GlycanHub, the first podcast to explore health, disease and longevity through the lens of glycobiology.Glycans have been described as the third alphabet of biology alongside nucleic acid and proteins. Using this alphabet, our cells are able to communicate and interact with each other in health and disease. Meaning that once we truly understand the glycan language, we will gain a better understanding of ourselves.Every episode features an interview with a scientist or expert giving us a glimpse into what glycobiology research has uncovered about the human body to date and the potential applications of these findings in the medicine of tomorrow.Make sure to subscribe so you don’t miss out on new GlycanHub episodes.
The Role of Glycans in the Medicine of Tomorrow: Insights from 11 Leading Scientists
Is the future of medicine sweetened by the study of glycans? As GlycanHub rounds off its season, we've brought back the insights of 11 eminent scientists spanning from neuroscience to nanotechnology. Each guest delves into their vision of how glycans could shape medical advancements in their respective fields. Join Rina, our host, for a grand finale that paints a holistic picture of the promising horizon glycobiology is steering us towards. Answers to the question: What role do you think glyc...
9 Aug 2023
Should You Stop Eating Red Meat? Glycans, Inflammation, and Cancer with Prof. Vered Padler-Karavani
Could your steak dinner be tricking your immune system? In this episode we shed light on the connection between specific foods and colorectal cancer. Explore xeno-autoantigens, grasp the nuances of immunotherapy, and question the reliability of animal-derived heart valves. Vered Padler-Karavani is the principal investigator in the Department of Cell Research and Immunology at Tel Aviv University. Her research combines glycobiology, immunology, bio-nanotechnology, cancer research and xenotrans...
19 Jul 2023
Rebranding Menopause: Glycans, Hormones and Inflammation with Dr. Louise Newson
Does menopause hold implications beyond reproductive health? This episode reveals that the shift in hormonal balance affects inflammatory patterns, mediated by complex carbohydrates called glycans. We unravel the overlooked role of perimenopause in chronic disease onset and debunk common myths. Exploring hormone replacement therapy, we discuss its wider health impact, beyond mere symptom management. Louise Newson, a distinguished GP and Menopause Specialist, is the founder of the Balance App,...
5 Jul 2023
Navigating the COVID-19 Pandemic: Glycans, Biological Age and Inflammation with Prof. Gordan Lauc
In an era defined by COVID-19, understanding the intricacies of our immune response and the profound role our lifestyle choices play in shaping our resilience or vulnerability to future pandemics is of great importance. In this episode, we unravel the influence of glycans, complex carbohydrates instrumental in immune response regulation, on our understanding of COVID-19 susceptibility and severity. We explore the role of lifestyle in disease prevention, particularly focusing on diet and obesi...
14 Jun 2023
Glycans and Neurodegenerative Diseases: A New Perspective on Alzheimer's with Prof. Ronald Schnaar
The longer lifespans we enjoy come shadowed by age-related diseases, notably Alzheimer's. This episode shines a light on the often-overlooked glycans, complex carbohydrates that play a pivotal role in healthy brain function. Our understanding of Alzheimer's causation has evolved, moving beyond just 'trash accumulation' to include problems with 'trash clearance.' Discover the potential of glycans in healing spinal cord injuries, the hurdles in identifying early biomarkers and delivering drugs ...
31 May 2023
Molecular Human and the Multi-Omics Revolution: with Dr. Karsten Suhre and Dr. Anna Halama
Are you ready to journey through the intricate layers of Omics, a rapidly developing field that's reshaping our understanding of biological systems? From genomics to proteomics and metabolomics, the multi-omics approach intertwines these layers, offering a rich, multidimensional view of human biology. Today's conversation unravels the fascinating complexity within our bodies, spotlighting the current advancements in multi-omics research and its transformative potential in disease diagnosis an...
17 May 2023
Glycans and Cardiovascular Disease: Understanding Modifiable Risk Factors and the Power of Lifestyle Choices with Prof. Samia Mora
It is a widely known fact that cardiovascular diseases are the leading cause of mortality and morbidity in both men and women, which puts an urgency on gaining a better understanding of them. One interesting lens to look at CVDs is through glycans. However, in order to do so, we need to uncover the answer to which came first, the chicken or the egg? Do glycans change in response to the disease? Or are they actively involved in disease development? To figure this out, we welcomed Prof. S...
3 May 2023
The Past, Present and Future of Congenital Disorders of Glycosylation with Prof. Hudson Freeze
Glycosylation, a biological process vital to life, is likely something you’ve never heard of before. It involves the addition of sugar molecules, known as glycans, to proteins and lipids which enable a number of crucial physiological functions, from immune regulation to cell-to-cell communication. This episode explores what happens when genetic mutations disrupt the glycosylation pathway as well as the detective work and collaboration required to diagnose and treat the resulting conditions. H...
29 Mar 2023
Understanding Biological Age and its Clinical Applications with Dr Peter Joshi
The concept of biological age might sound like a new notion, but it’s something researchers have been looking at for 35 years. A person’s biological age can tell us more about them than chronological age because it includes genetics, lifestyle and environmental factors. Since it’s such an individualised metric, it’s important to find a reliable way of measuring it. In the episode, Rina and her guest Dr Peter Joshi describe 11 different biological ageing clocks, the research behind them and wh...
15 Mar 2023
The Link between IgG Glycans, Aging, and Disease: A Discussion with Dr. Olga Zaytseva on Glycosylation Regulation
How much control do we have over our health? The study of epigenetics made us aware of the remarkable malleability of our phenotype, prompting closer investigation on how lifestyle and environment impact our health and longevity. In this context, glycans - a class of historically understudied biological polymers may hold the key to a better understanding of the interplay between genetic and epigenetic factors contributing to disease development. Olga Zaytseva is a post-doctoral researcher at ...
1 Mar 2023
Glycans and the Immune System: Understanding Immune Regulation with Prof. Salomé Pinho
Glycans have a great capacity to fine-tune the inflammatory response and often determine how successfully the immune system distinguishes between friend and foe. While cancer cells build a glycan shield to hide from immune surveillance, pathogens can mimic our glycans in order to evade immune detection and perpetuate infection. Salomé Pinho is the Immunology, Cancer and GlycoMedicine Group leader at the Institute for Research and Innovation in Health at the University of Porto, her research f...
29 Nov 2022
Sex Drugs and Medical Research with Dr Alka Patel and Dr Julija Jurić
Is it enough to conduct medical research only on white men? Why are women more affected by autoimmune diseases? Do menopause and pregnancy trigger different ailments? Is there such a thing as a male and a female hormone? In this episode of The Age of You - a sweet secret to longevity, we discuss male-centric medicine and the effects created by the exclusion of women in medical research. Our guests are DR Alka Patel, a TEDx speaker, GP, lifestyle doctor, longevity coach, author, ...
18 Oct 2022
Living WELL through menopause with Suzanne Parkes
Menopause is no laughing matter, but having humour about it might be the key to breaking down the stigma. In order to celebrate World Menopause Day, we’re bringing you an uplifting interview with Suzzane Parkes - a person near and dear to all of us in GlycanAge. Suzanne is a consultant that spent her career in the fitness industry and has always prioritized a holistic approach to her health. Suzanne is passionate about sharing her menopause journey in order to prevent future gener...
17 Jun 2022
Proactive cancer treatments - why are we targeting the last, instead of the first cell? with Dr. Azra Raza
Despite the buzz around novel cancer therapies, the harsh reality is that most only extend life expectancy by a few months. Dr Azra Raza, a Professor of Medicine, and the Director of the MDS Centre at Columbia University, has a different approach. Azra argues that the key to defeating cancer lies in early detection, and she has dedicated over 35 years of her career to collecting samples and researching myelodysplastic syndromes (MDS) with the goal of catching cancer at its earliest stage. Lis...
11 Mar 2022
Glycans and Menopause with Dr. Louise Newson, Prof. Tim Spector and Prof. Gordan Lauc
Why do women age faster during menopause? Should menopause be rebranded as a hormone deficiency? Is it ever too late to start HRT? Listen to this episode to find out the answers to these questions and many more! Meet the guests: Doctor Louise Newson is the Founder of Newson Health Menopause & Wellbeing Centre as well as Balance App and The Menopause Charity. She’s a renowned menopause specialist and is dedicated to helping women of all ages understand that menopause does...
25 Feb 2022
Importance of yoga, nutrition, and chronic illness with Anastasis Tzanis
t’s not often you get to listen to inspirational yet grounded people. However, today we bring you just that. Meet Anastasis Tzanis — A yoga and breathing instructor, and a nutritional therapist. He shared his struggles with IBS, the effects of yoga, and his experience with GlycanAge. Find out why he doesn’t believe in the one-solution-fits-all approach and why he’s not a fan of restrictive diets. As he and Rina discuss trends in the alternative health industry, Anastasis shares his tips on ho...
10 Feb 2022
Role of Glycans in Longevity with Prof. Gordan Lauc
Dear listener, are you interested in learning how to live healthier and take advantage of the latest scientific research? If the answer is yes, you’ll love our first episode in which we dive into understanding longevity. Tune in as our host Rina interviews Professor Gordan Lauc on the importance of glycans and how these sugars will shape the future of medicine. Other topics we discuss in the episode are - chronic illness, interesting research into the best diet, modern medicine and more...
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