A weekly podcast breaking down the latest peer-reviewed research in head and neck surgery and oncology. Perfect for busy clinicians.
Head and Neck Oncology Journal Club
Claim This Podcastby Krishnakumar Thankappan
5.0(2 reviews)
21 episodes
Updated Daily
Accepts GuestsHas Sponsors
Podcast Overview
A weekly podcast breaking down the latest peer-reviewed research in head and neck surgery and oncology. Perfect for busy clinicians.
Language
🇺🇲
Publishing Since
12/3/2025
1 verified contact email on file for Head and Neck Oncology Journal Club
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Recent Episodes
July 4, 2026
The METRO PLUS Trial: Metronomic Chemotherapy Added to Paclitaxel-Carboplatin in Advanced HNSCC
<p><strong>Can a $180-a-year regimen close the access gap in advanced head and neck cancer?</strong></p><p>In this episode we cover METRO PLUS (Kapoor et al., JCO Global Oncology 2026), a single-center, open-label, phase III trial from Varanasi testing whether adding triple oral metronomic chemotherapy — erlotinib, celecoxib, and weekly methotrexate — to paclitaxel-carboplatin improves survival in platinum-sensitive, unresectable advanced HNSCC.</p><p>238 patients, randomized 1:1, in a young, oral-cavity-predominant cohort. The combination doubled median overall survival (10 v 5 months; HR 0.54) and progression-free survival (6 v 2 months; HR 0.38), lifted the 6-month OS rate to 68.6% versus 36.5%, and did all of this without increasing grade 3-5 toxicity. Quality of life favored the combination across multiple domains.</p><p>Paper: <a href="https://doi.org/10.1200/GO-25-00721">https://doi.org/10.1200/GO-25-00721</a></p>
June 28, 2026
Thyroglossal Duct Cyst Excision: Sistrunk Procedure
<p>Audio companion to our surgical video on the Sistrunk procedure for thyroglossal duct cyst. Embryology, why simple excision recurs, and a concise step-by-step of the operation — incision, subplatysmal flaps, strap separation, central hyoid skeletonisation and resection, en bloc specimen delivery, and layered closure. Watch the dissection: <a href="https://www.youtube.com/watch?v=cki1r1fIAw8">https://www.youtube.com/watch?v=cki1r1fIAw8</a></p>
June 28, 2026
Neoadjuvant Chemoimmunotherapy vs Immunotherapy Alone in HNSCC
<p><strong>A 23-study, 751-patient meta-analysis asks a practical question: when you give neoadjuvant immunotherapy before surgery in resectable head and neck cancer, does adding chemotherapy actually help?</strong></p><p>Baratz and colleagues (Mayo Clinic, JAMA Otolaryngology–Head & Neck Surgery, March 2026) pooled the prospective phase 1 and 2 data across three regimens — chemoimmunotherapy, single-agent immunotherapy, and dual-agent immunotherapy — in mostly HPV-negative, locally advanced disease.</p><p><strong>What we cover:</strong></p><ul><li>The headline response gap: major-plus-complete pathologic response of <strong>66% with chemoimmunotherapy vs 18% dual-agent vs 6% single-agent</strong></li><li>Complete pathologic response (~38% vs 5% vs 3%) and why radiographic complete responses appeared only in the chemoimmunotherapy arm</li><li>The counterintuitive safety finding — more grade 3–5 events with single-agent immunotherapy (29%) than chemoimmunotherapy (17%) — and why the authors won't draw conclusions from it</li><li>The crucial caveat: these are pooled single-arm trials, not a randomized head-to-head</li><li>Who the likely target population is for a future phase 3 trial: HPV-negative, T3/T4 oral cavity disease</li></ul><p><strong>Bottom line:</strong> A large, consistent signal that neoadjuvant chemoimmunotherapy outperforms immunotherapy alone on pathologic response — strong enough to justify a phase 3 comparison, not strong enough to settle it.</p><p><strong>Source paper</strong><br> Baratz HQ, Hidalgo C, Price DL, et al. Neoadjuvant Immunotherapy and Chemoimmunotherapy Regimens in Head and Neck Cancer: A Systematic Review and Meta-Analysis. JAMA Otolaryngol Head Neck Surg. Published online March 12, 2026. doi:10.1001/jamaoto.2026.0080<br> <a href="https://doi.org/10.1001/jamaoto.2026.0080">https://doi.org/10.1001/jamaoto.2026.0080</a></p><p>More episodes: hnoncology-journalclub.netlify.app</p>
21 total episodes available
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Frequently asked questions
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- What is Head and Neck Oncology Journal Club?
- How often does this podcast release new episodes?
This podcast updates daily.
- Where can I listen to this podcast?
This podcast is available on 4 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
- Does this podcast accept guests?
Information about guest appearances is not available.
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