HemaSphere is the official online, open access journal of the European Hematology Association (EHA). HemaSphere publishes exciting basic, translational, and clinical research in hematology. We are pleased to introduce our new podcast series where our host and guest speakers exchange ideas about select HemaSphere publications. Spend some time with us and enjoy casual and insightful discussions about hematology research. Listen to the stories behind the papers. HemaSphere is always accessible; our full range of open access publications is available at www.hemaspherejournal.com.
Why More Mitochondrial DNA Mutations Can Mean a Better Outcome - Dr Ilaria Pagani
This episode explores how chronic myeloid leukemia has been transformed by imatinib and other TKIs, while also showing why major clinical challenges remain for the patients who do not respond well or want to stop therapy. Host Scientific Editor Dr Charles de Bock talks with Dr. Ilaria Pagani about her recent HemaSphere paper on mitochondrial DNA mutations, oxidative phosphorylation, and treatment response in CML, and why mitochondria may be an overlooked source of biomarkers and new targets. We discuss the biology of relapse, why some patients can achieve treatment-free remission, and how mitochondrial metabolism may help explain differences between poor responders and super responders. The conversation also touches on patient advocacy, quality of life, and the need for more collaborative, metabolism-focused research.
Read the article in full, open access: https://hsphere.pub/448 (https://hsphere.pub/448)
You've read the paper, now hear the story.
17 Jun 2026
Why Inflammatory Signaling Holds the Key to Durable MDS Therapies - Dr Manja Wobus, Dr Katja Sockel
In this episode, host Dr Charles de Bock delves into groundbreaking preclinical research exploring the potential of tasquinimod to restore blood cell production and modify the bone marrow microenvironment in MDS with Dr Manja Wobus and Dr Katja Sockel. Join us as we unpack the mechanisms, animal studies, and future clinical prospects for this promising therapy.
Read the accompanying article published in HemaSphere https://bit.ly/3OjuuiS (https://bit.ly/3OjuuiS)
i4MDS, EHA's Specialized Working Group information https://hsphere.pub/5d4 (https://hsphere.pub/5d4)
7 May 2026
p53 in Cancer: Dual Threat - Dr Isabelle Plo, Dr Barbara Monte-Mór
Discover the latest insights into the multifaceted role of p53 in normal hematopoiesis and its critical involvement in myeloproliferative neoplasms (MPNs). This episode features Dr. Isabelle Plo and Dr. Barbara Monte-Mór sharing their expertise on TP53 mutations, molecular mechanisms driving leukemic transformation, and emerging therapeutic strategies targeting p53.
Article: https://bit.ly/4sZbo01 (https://bit.ly/4sZbo01)
Comments, Suggestions or Feedback? Please take a few minutes and let us know: https://wkf.ms/4pDYjYb
Who has been a guest on HemaSphere Podcast
Names identified in recent episode analyses. Showing up to five guests.
Tim Mocking
Francesca Fioredda
Eleni Papadaki
Dr Francesca Tiso
Dr Florentien in 't Hout
Reach and audience
Public platform figures. Ratings count people who left a rating, not total listeners.
YouTube views
3,470
Score snapshot 15 Sept 2025
Spotify
5.0 / 5
3 ratings
Podcast Authority Score: 31 / 100
A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.
Quality
19
Social presence
0
YouTube
74
Engagement
32
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