Origins, Breakthroughs, and The Future of Genomics with Dr. Jerry Lanchbury PhD
Former Myriad CSO and genetics trailblazer Dr. Jerry Lanchbury joins Kian to chart the field’s evolution—from manual lab work and the first PCR runs to today’s embryo ranking software and whole‑genome newborn programs. Along the way, we unpack gene‑patent battles, polygenic risk scores, and the growing role patients play in steering reproductive medicine.
19 Jun 2025
Genetics, Drug Discovery, and the Future of Medicine | Dr. Veera Rajagopal
Physician-scientist Dr. Veera Rajagopal discusses how human genetics propels drug discovery, covering genome sequencing and AI's impact on genetic research in this interview.
13 Jun 2025
Genetics, Identity, and the Science of Who We Are | Professor Robert Plomin
Professor Robert Plomin discusses how genetics shape intelligence, personality, and mental health, challenging assumptions about parenting's influence and highlighting the role of randomness in development in an interview with Kian.
25 Apr 2025
Fatherhood, Excellence, and the Age of AI Doctors | Anthony Pompliano
In this episode of High Alchemy, Anthony Pompliano and Kian Sadeghi sit down for a wide-ranging conversation on parenting, ambition, innovation, and the accelerating future shaped by AI. From life-or-death moments in NYC to the constant pursuit of excellence, they dive into what it means to lead, build, and stay ahead in a world that's changing faster than ever. They discuss fatherhood, performance indicators, AI in healthcare, investing, and the future of medicine - with stories, insights, and bold takes throughout.
27 Mar 2025
AGI, Biotech, and China vs. The Internet | Balaji Srinivasan
Balaji Srinivasan has built, invested in, and predicted some of the biggest shifts in tech. From Counsyl to crypto to Network States, he’s always ahead of the curve. Now, he’s sitting down with Nucleus Founder/CEO Kian Sadeghi to break down what’s coming next.
In this episode, Balaji and Kian dive into the future of health, AI, and governance. Why did Balaji focus on Mendelian diseases? What does inflation have to do with longevity? And is universal healthcare really enough? They tackle regulation, crypto, biotech, and the AI revolution. Plus, Balaji drops a wild prediction that might just blow your mind.
22 Feb 2025
Startup Wins, Brutal Lessons, and BIG Moves | Matt Lanter (President of Nucleus)
Matt Lanter helped build OpenStore, the startup backed by Founders Fund that’s snapping up Shopify brands at lightning speed. Now, he’s making another big bet. This time on Nucleus Genomics, a startup backed with $30M to make DNA testing personal.Why the switch? What did he see coming?In this episode, Matt and Kian dive into the wild world of startups - big wins, brutal lessons, and the real cost of building something from scratch. Matt spills on his worst funding blunder, the best (and worst) advice in Silicon Valley, the moment he knew he had to join Nucleus, and the next big move he’s betting on.
4 Feb 2025
He Became the 'Sperm King' After This Crazy Accident | Khaled Kteily (CEO of Legacy)
Khaled Kteily didn’t plan to become the "Sperm King," but one life-changing moment set him on this unexpected journey.
After spilling four hot drinks on his lap (yes, really), Khaled discovered just how uncomfortable and outdated sperm freezing was - and decided to do something about it.
He founded Legacy, the at-home sperm testing and freezing company that’s breaking taboos and changing the game for men’s fertility.
In this episode, Khaled and Kian tackle questions most people are too SHY to ask: Should men freeze their sperm early? Why and how should people calculate their sperm quality? Do saunas and TRT mess with fertility? And why is fertility still treated like it’s only a woman’s problem?
This is the rawest, no-filter conversation about male fertility you didn’t know you needed.
15 Jan 2025
Will AI Replace Doctors? | Dr Jared Pelo (CMO of Bionic Health)
After facing the shortcomings of the US healthcare system and experiencing a profound loss, he set out to create Bionic Health - a platform using AI to empower people to take control of their health. With a background in medicine and experience at companies like Microsoft and Nuance, Jared is dedicated to making healthcare more accessible and effective for everyone.
In this episode, Jared and Kian dive into pressing questions: Can AI replace doctors? How can it improve diagnoses? Is the healthcare system ready for these changes? They also explore underrated lab tests, the challenges of insurance, and what it will take to truly fix healthcare.
Reach and audience
Public platform figures. Ratings count people who left a rating, not total listeners.
YouTube views
11,680
Score snapshot 15 Sept 2025
Spotify
5.0 / 5
5 ratings
Podcast Authority Score: 31 / 100
A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.
Quality
19
Social presence
0
YouTube
76
Engagement
32
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