I didn’t see that coming
Claim This Podcastby Brendan Bouffler
Podcast Overview
<p>New po this is a podcast for people interested in or suffering from optic neuritis and associated illnesses - but from a patient's prospect. When I started my journey with optic neuritis, there were very few resources on the Internet that could describe to me what I could expect both from the disease and the treatment and how it would feel. So this podcast is designed to fill that app. </p> <p></p> <p>I'm helped in each episode by my friend and collaborator Dr. Joanna Gould, who has a PhD neurology and helps explain some of the more difficult scientific topics.</p> <p></p> <p>They certainly isn't medical advice, but it's a medical experience that hopefully you can benefit from.</p> <p></p> <p>Contact us at boof@sighup.net. </p>
Language
🇺🇲
Publishing Since
3/11/2026
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Recent Episodes
May 22, 2026
Promiscuous, sheep, and more about monoclonal antibodies
Brendan, Joanna, and immunologist Dr. Paul Ibbett continue their deep dive into biologics, the immune system, and Brendan's treatment journey. What's covered Demyelination explained — and why Brendan's optic-nerve-only damage points away from MS How the brain and immune system talk to each other (featuring a spawning salmon and a very over-enthusiastic ram) A new vagus-nerve implant that acts like a "snooze button" on TNF-alpha Why biologics cost so much — manufacturing in giant bioreactors, ~$1bn per approved drug, and the NHS vs. private cost question (Brendan paid £3,000 per Rituximab infusion privately) Bispecific antibodies — the next frontier, especially in cancer The future: sequencing patient immune systems and using AI/ML to pick the right drug Could biologics ever be injected directly into the CSF? Possibly, but not without certainty about the target
May 15, 2026
Monoclonal antibodies and Chinese mice
Brendan and Joanna are joined by immunologist Dr. Paul Ibbett to unpack the biologic therapies Brendan is using for his optic neuritis. What's covered Biologics vs. monoclonal antibodies, and how they're manufactured in Chinese hamster ovary cell lines Why ~90% of drugs fail, and how AI/ML is improving antibody design The blood-brain barrier and why it makes neurology so hard to treat The immune system as a "spider's web" — B cells, T cells, and TNF-alpha Brendan's journey: Rituximab didn't work, now on infliximab (a TNF-alpha blocker), with steroids tapering How inflammation damages the optic nerve, and a possible Behçet's disease diagnosis
May 8, 2026
The time I just said no
Last week we covered a lot of exotic tests and the exotic tests list continue. But there was also a time when I just flat out said no to a test because I thought it was silly. And the logic behind it was silly too.
12 total episodes available
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- What is I didn’t see that coming?
<p>New po this is a podcast for people interested in or suffering from optic neuritis and associated illnesses - but from a patient's prospect. When I started my journey with optic neuritis, there were very few resources on the Internet that could describe to me what I could expect both from the disease and the treatment and how it would feel. So this podcast is designed to fill that app. </p> <p></p> <p>I'm helped in each episode by my friend and collaborator Dr. Joanna Gould, who has a PhD neurology and helps explain some of the more difficult scientific topics.</p> <p></p> <p>They certainly isn't medical advice, but it's a medical experience that hopefully you can benefit from.</p> <p></p> <p>Contact us at boof@sighup.net. </p> - How often does this podcast release new episodes?
This podcast updates daily.
- Where can I listen to this podcast?
This podcast is available on 4 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
- Does this podcast accept guests?
Yes, this podcast regularly features guests.
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