Inflammatory Content is a podcast about immunology and biomedical sciences more broadly. UC San Diego immunologist Dr. Kellen Cavagnero PhD reviews the latest high-impact original articles and discusses all things science with leading researchers in the field. Inflammatory Content has been featured in Nature and received sponsorship from the NIH.
In this episode of Inflammatory Content, Dr. Kellen Cavagnero explores the debilitating skin disease hidradenitis suppurativa (HS) and takes a deep dive into a recent Immunity paper that comprehensively examines the role of tertiary lymphoid structures in HS pathogenesis. HS has long defied simple classification, with prevailing disease models emphasizing hair follicle dysfunction, aberrant wound healing, or chronic inflammation. This work adds a new dimension by implicating autoimmunity as a central contributor to HS pathogenesis, further underscoring the complexity of the disease.
Relevant Links:
• Paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC12404358/
• Commentary: https://pmc.ncbi.nlm.nih.gov/articles/PMC11790253/
If you enjoy Inflammatory Content and want to help me keep the conversations going, consider supporting the podcast! You can write a review, share this episode with friends and colleagues, or make a donation to help keep the show ad-free and thriving. Your contributions, big or small, go directly toward covering production costs and allow me to bring you even more Inflammatory Content. You can donate directly here: https://venmo.com/Kellen-Cavagnero.
I’d love to hear from you! Feel free to reach out with questions, feedback, or topic suggestions via email at kcavagnero@gmail.com, on X @KellenCavagnero, or connect with me on LinkedIn.
Stay curious and keep exploring at www.inflammatorycontent.com
20 Aug 2025
#27: A Surprising New Role for Neutrophils in Wound Healing
In this episode of Inflammatory Content, Dr. Kellen Cavagnero breaks down a new Nature paper showing that a subset of skin neutrophils doesn’t just fight bacteria—they also build extracellular matrix (ECM). After injury, these neutrophils rapidly assemble rings of ECM around the wound that strengthen the barrier and limit bacterial entry. This program depends on TGF-β signaling within neutrophils; when that pathway is disabled, the rings fail to form and bacteria penetrate more easily.
Relevant Links:
• Paper: https://pubmed.ncbi.nlm.nih.gov/40108463/
• Commentary: https://www.nature.com/articles/s41577-025-01170-5
If you enjoy Inflammatory Content and want to help me keep the conversations going, consider supporting the podcast! You can write a review, share this episode with friends and colleagues, or make a donation to help keep the show ad-free and thriving. Your contributions, big or small, go directly toward covering production costs and allow me to bring you even more Inflammatory Content. You can donate directly here: https://venmo.com/Kellen-Cavagnero.
I’d love to hear from you! Feel free to reach out with questions, feedback, or topic suggestions via email at kcavagnero@gmail.com, on X @KellenCavagnero, or connect with me on LinkedIn.
Stay curious and keep exploring at www.inflammatorycontent.com
5 Jul 2025
#26: Spatial Proteomics Uncovers a Lifesaving Treatment for Severe Skin Drug Reactions
Host Kellen Cavagnero discusses a Nature study by Thierry Nordman on spatial proteomics, which identifies a JAK inhibitor treatment for toxic epidermal necrolysis, a severe skin reaction, in this interview episode.
Reach and audience
Public platform figures. Ratings count people who left a rating, not total listeners.
Apple Podcasts (US)
5.0 / 5
11 ratings
Spotify
5.0 / 5
14 ratings
Podcast Authority Score: 29 / 100
A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.
Quality
37
Social presence
0
YouTube
0
Engagement
51
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