Inside PX42 is the official podcast of PX42 Consulting, hosted by CEO Charles Skamser alongside PX42 executives, AI Agent engineers, and leading industry experts. Each episode dives deep into the strategies, technologies, and real-world applications shaping the future of the intelligent enterprise. From designing and deploying AI Agents to unlocking business value through automation, decision intelligence, and enterprise-scale transformation, Inside PX42 delivers candid insights and forward-looking conversations to help leaders harness the full potential of AI-driven organizations.
Inside PX42: Driving the Intelligent Enterprise with AI Agents
Claim This Podcastby PX42 Consulting
14 episodes
Updated Daily
Accepts GuestsHas Sponsors
Podcast Overview
Inside PX42 is the official podcast of PX42 Consulting, hosted by CEO Charles Skamser alongside PX42 executives, AI Agent engineers, and leading industry experts. Each episode dives deep into the strategies, technologies, and real-world applications shaping the future of the intelligent enterprise. From designing and deploying AI Agents to unlocking business value through automation, decision intelligence, and enterprise-scale transformation, Inside PX42 delivers candid insights and forward-looking conversations to help leaders harness the full potential of AI-driven organizations.
Language
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Publishing Since
9/5/2025
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Recent Episodes
July 29, 2026
From AI Reckoning to AI Payback: Why Enterprise AI Is Entering Its Accountability Phase
In this episode of Inside PX42, CEO Charles Skamser is joined by AI strategy consultant Catherine Spencer and systems expert Edward Hamilton to discuss the massive shift from AI experimentation to operational accountability. Based on the recent Intelligent AI Agents Weekly briefings—"The Enterprise AI Reckoning Has Begun" and "The AI Bill Comes Due"—the team breaks down why pilots, copilots, and AI theater are no longer enough. They introduce the Enterprise AI Payback Framework and explore how organizations must manage token economics, model orchestration, and digital labor safely inside production workflows. Key Topics Discussed: Why the Enterprise AI Reckoning Has Begun: Moving from activity-based metrics to true capability. The AI Bill Comes Due: Hyperscaler capex, Alphabet's historic cash burn, and the rising cost of physical infrastructure. The Enterprise AI Payback Framework: Evaluating AI through the lenses of business outcome, operating discipline, cost visibility, governance, and trust. Model Strategy as an Executive Discipline: Optimizing the cost-to-outcome frontier and leveraging in-house or domain-specific models. AI Agents as Digital Workers: Managing agent sprawl, security risks (including the Hugging Face breach), and the necessity of an AI Agent Operating System (AgentOS™). The Monday-Morning Playbook: Running a ruthless portfolio review to classify initiatives into production, scale, redesign, or stop candidates.
July 7, 2026
How to Create Real Business and Financial Outcomes at Scale in the Face of the AI ROI Crisis
Charles Skamser, Catherine Spencer, and Edward Hamilton deliver a masterclass in enterprise AI economics. They dismantle the 'bear case' of Ed Zitron and the 'tokenmaxxing' critique of Alex Karp by detailing PX42’s 12-layer AI AgentOS™ architecture, secure microVM runtimes, zero-copy data fabrics, and precise multi-model routing. Featuring full, CFO-visible ROI calculations for customer service, claims leakage, and fraud triage.
June 1, 2026
Why Enterprises Need an Agent OS for Digital Labor
The hosts explain why the chatbot era is giving way to governed agentic AI, and why boards are demanding safe, measurable, and cost-controlled autonomous workflows. They break down PX42’s ten-layer reference architecture for digital labor, from orchestration and identity to observability, evidence, and policy enforcement.
14 total episodes available
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Frequently asked questions
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- What is Inside PX42: Driving the Intelligent Enterprise with AI Agents?
- How often does this podcast release new episodes?
This podcast updates daily.
- Where can I listen to this podcast?
This podcast is available on 4 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
- Does this podcast accept guests?
Yes, this podcast regularly features guests.
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