Anaesthesia Study Notes
Primary Exam Notes (OneNote) - https://1drv.ms/o/c/2894d6aaca6619c7/IgDHGWbKqtaUIIAopwAAAAAAAZYTq_fLgFvlOeHTwA2kZV0 [Updated 28/1/26]
Final Exam Notes (OneNote) - https://1drv.ms/o/c/2894d6aaca6619c7/IgDHGWbKqtaUIIAoEgEAAAAAAeZV7B7eJYvP-ybrJg1oIys
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Link to my OneNote - scanned 1 page summaries and flashcards
KEY POINTS:
Presentation 24-72h post-injury - risk during major trauma and surgery (esp long bones)
Pathophysiology:
Fat from marrow into lungs = pulmonary hypertension, RV strain, hypoxia
SIRS from fatty acids = myocardial depression, ARDS, DIC
Prevention = early immobilisation/reduction and operative management
Dx of exclusion but classic triad of GURDS = confusion, respiratory distress and petechiae
Petechiae only present in 50% but pathognomonic
Mx = exclude other Dx (PE, anaphylaxis) --> treat fracture (no cement)
A) ETT (req in 40%)
B) FiO2 1.0, ARDS-ventilation
C) fluids, pressors, inotropes, coags correct (DIC)
D/E) normal sugar/temp
ICU post-op, resolves <7 days
9 Oct 2022
Cardiovascular effects of Central Neuraxial Blockade - Cardiovascular Physiology
Explain the cardiovascular effects of central neuraxial blockade
2019B08 62.6%
2013C12 56.0%
2013A12 38.0%
8 Oct 2022
Effects of IPPV on Cardiac Output - Cardiovascular Physiology
Explain the effects of intermittent positive pressure ventilation on cardiac output
2021B01 56.5%
2019A01 54.7%
2014A05 37.6%
2013B01 19.7%
Discuss the potential adverse effects of suxamethonium.
Describe how suxamethonium and non-depolarising neuromuscular blocking agents produce their adverse cardiovascular effects.
Outline the possible reasons for prolonged paralysis induced by an intravenous dose of 1 mg/kg of suxamethonium.
22 Apr 2022
Suxamethonium (1/2 - General Pharmacology) - Neuromuscular Pharmacology
Pharmacology - Dose, Onset (Mechanism of Action - Accommodation, Phase II Block), Offset, Side Effect (Summary)
Describe how suxamethonium produces neuromuscular blockade. What is the mechanism of recovery of neuromuscular function and what mechanisms may be involved in Phase II block?
4 Apr 2022
Factors affecting PaCO2 - Respiratory Physiology
Describe the factors influencing CO2 tension in blood.
2 Apr 2022
CNS effects of raised FiCO2 - Respiratory Physiology
Outline the central nervous system effects of an awake person breathing air containing CO2.
17 Mar 2022
Perfusion Limitation vs Diffusion Limitation - Respiratory Physiology
Explain the difference between perfusion limitation and diffusion imitation in the transfer of gas between alveolus and pulmonary capillary. Outline the factors that determine whether a gas is perfusion or diffusion limited.
6 Mar 2022
Pulmonary vs Systemic Circulation - Respiratory Physiology
Briefly outline the differences between the pulmonary circulation and the systemic circulation.
4 Mar 2022
Response to Hypoxaemia - Respiratory Physiology
Describe the response to hypoxaemia in both the awake and anaesthetised patient.
2 Mar 2022
CO2 Carriage in Blood - Respiratory Physiology
Describe the ways in which CO2 is carried in the blood
28 Feb 2022
PaCO2 vs ETCO2 - Respiratory Physiology
Discuss possible causes for the PaCO2 differing from the ETCO2 in an anaesthetised, intubated patient on IPPV.
28 Feb 2022
Venous Admixture - Respiratory Physiology
Define “Venous Admixture”. Briefly explain how venous admixture influences arterial oxygen tension and how an increase in inspired oxygen concentration may affect this.
27 Feb 2022
Time Constants - Respiratory Physiology
Explain the concept of time constants and relate these to “fast” and “slow ” alveoli
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