Last Humans in the Loop

About Last Humans in the Loop

A weekly conversation about AI, technology, startups, and the future from people who've actually built the systems everyone uses. Chris Slowe CTO'd Reddit through hypergrowth and its IPO. Marty Weiner was a founding engineer at Pinterest and Reddit's first CTO. Zach Weinersmith is the creator of Saturday Morning Breakfast Cereal and the NYTimes bestselling author of books exploring the future of science and technology. Each week we debate the biggest stories, explain the technology behind them, and occasionally wander into philosophy, history, and whatever weird rabbit hole AI sends us down.

Publisher

Chris Slowe, Marty Weiner, Zach Weinersmith

Category

news · technology

Language

en

Explicit

No

First episode

6 Jul 2026

Latest episode

8 Oct 2026

Latest episodes

8 of 15 episodes have a transcript.

1. 

   8 Oct 2026TRANSCRIPT

   Would You Give AI Your Passwords?

   Chris Slowe, Marty Weiner, and Zach Weinersmith discuss AI advancements, from password management to scientific breakthroughs, in this interview.

2. 

   30 Sept 2026TRANSCRIPT

   Is This the Best AI Model Right Now?

   Chris Slowe, Marty Weiner, and Zach Weinersmith interview industry experts on the latest AI models, their capabilities, and emerging trends.

3. 

   23 Sept 2026TRANSCRIPT

   HAVE YOU TRIED JEV YET??

   Chris Slowe, Marty Weiner, and Zach Weinersmith interview industry experts on AI advancements, including recursive self-improvement, faster decision-making, and potential risks.

4. 

   16 Sept 2026TRANSCRIPT

   AI POLITICAL FALLOUT UNDERWAY, CALLS TO SLOW AI, ANTHROPIC IPO, AI GEN PHOTOSHOP, MATH FALLOUT

   Chris Slowe, Marty Weiner, and Zach Weinersmith discuss AI's political fallout, the potential for AI-generated photoshops, and the future of mathematics in this interview.

5. 

   9 Sept 2026TRANSCRIPT

   ASTRAPALOOZA! Let's explore all the ways people are using ChatGPT6

   Chris Slowe, Marty Weiner, and Zach Weinersmith explore ChatGPT 6's groundbreaking capabilities, from decompiling code to creating art and solving complex math problems, in this interview.

6. 

   2 Sept 2026TRANSCRIPT

   "How is AI changing math?" with Math Professor Jonathan Wise

   Host Chris Slowe interviews Math Professor Jonathan Wise about how AI is revolutionizing mathematical discovery and the future of the field.

7. 

   2 Sept 2026TRANSCRIPT

   Are you marketing to AI yet?, Humans talking like AI now, Live AI made TV shows, China exports surge

   Chris Slowe, Marty Weiner, and Zach Weinersmith discuss AI's impact on marketing, language, and technology, interviewing industry experts on the latest advancements.

8. 

   26 Aug 2026TRANSCRIPT

   Laptop AI = 6 Month Old Frontier Models, AI Cancer Vaccines, Test Scores Down, Bomber Drones + AI

   Chris Slowe, Marty Weiner, and Zach Weinersmith explore AI's rapid advancements, from laptop models to cancer vaccines and autonomous drones, in this interview.

9. 

   20 Aug 2026

   Study: AI Use Makes You Look Lazy, RAM $$$ Up 7x, Open Weight Music AI, Security Flaw in Major LLMs

   Chris Slowe, Marty Weiner, and Zach Weinersmith discuss AI's impact on perception, the rising cost of AI infrastructure, and new developments in AI music and security in this interview.

10. 

    13 Aug 2026

    AI doing real science, EU: AI needs watermarks, Jeff Dean leaves Google, Riemann Hypothesis Progress

    Chris Slowe, Marty Weiner, and Zach Weinersmith interview industry experts on AI's scientific breakthroughs, regulatory challenges, and its impact on creative work and technology.

11. 

    5 Aug 2026

    The AI Productivity Paradox, New LLM Architecture, AlphaFold Shutting Down, 10 Math Breakthroughs

    Chris Slowe, Marty Weiner, and Zach Weinersmith discuss the AI productivity paradox, new LLM architectures, and significant math breakthroughs in this interview.

12. 

    29 Jul 2026

    OpenAI v Hugging Face Update, Opus 5, Anthropic v Open Weights, Startup Surge, Qualcomm Robot Fail

    Chris Slowe, Marty Weiner, and Zach Weinersmith discuss OpenAI's model breach, the debate over open-weight models, and the latest AI advancements and controversies.

13. 

    22 Jul 2026

    The AI Moat is Gone, AI Solves ANOTHER Big Math Problem, Open AI vs Closed AI, AI Takes Hollywood

    03:06 NVIDIA's Robotics AI & Cosmos Models 08:28 Open-Weight AI Is Catching Up 13:07 Are AI Moats Disappearing? 16:16 How Distillation Makes Copying Models Faster + Cheaper 19:22 Hugging Face Hack & AI Cybersecurity 23:20 Can Governments Regulate Open AI? 29:20 The Explosion of Specialized AI Models 32:03 AI Solves Another Major Math Problem 40:20 Hollywood's AI Future (George Lucas, Netflix & VFX) 55:02 Linus Torvalds on AI and Linux 56:22 Is LinkedIn Already Full of AI? 58:08 AI, Copyright & The Future of Creativity

14. 

    15 Jul 2026

    Inside Claude's "Mind", AI Solves 50-Year Math Problem, Apple sues OpenAI, Recreating Voices with AI

    01:20 Apple sues OpenAI 06:40 GPT-5.6 First Impressions 08:00 Live Demo — GPT-5.6 builds a 3D cannon in Blender 14:40 Inside Claude's Mind — Anthropic's "Global Workspace" discovery 29:15 AI Solves 50-Year-Old Math Problems 43:30 AI, Productivity & The Future of Work — Why recessions may accelerate automation 1:08:00 Cloning Kermit the Frog with Eleven Labs

15. 

    6 Jul 2026

    Anthropic’s Fable 5, OpenAI’s Jalapeño Chip, Midjourney Medical Scans & AI Decoding Ancient Scrolls

    00:00 Introductions 02:00 Anthropic's Fable 5 & ChatGPT 5.6 & federal new government regulation 25:00 OpenAI's Jalapeño AI chip 35:00 Midjourney enters medical imaging 44:00 AI voices & Hollywood 58:00 AI decodes ancient scrolls

Inside a recent episode

Would You Give AI Your Passwords?

Published 8 Oct 2026 · Transcript excerpt

[…] I am always a little afraid to... yield that kind of power to the do you think though do you think this is like when it was 1994 and you were like i don't i can't use a credit card on the internet it's full of you know scary people and like you know maybe that was true in 1994 so you know the question is can this be made safe i mean i would be pretty freaked out if something reset my own password for me overnight uh You know, it also could be a pressure thing. I mean, startups will start using this stuff because they've got to go faster, leaner, better. And so they may be pushed into it. And real quick on the decisions API, this is sort of like we reported in the last couple of weeks about the brand new hotness called JEV. […]

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