Legible Bio

About Legible Bio

Making biotech more legible www.legible.bio (https://www.legible.bio?utm_medium=podcast)

Publisher

Shoumik Dabir

Category

science · technology

Language

en

Explicit

No

First episode

17 Nov 2025

Latest episode

10 Oct 2026

Latest episodes

7 episodes in the feed.

1. 

   10 Oct 2026

   Embryo selection and the science of creating future people

   Watch on YouTube here (https://youtu.be/ZbHHxGvXSkw)Embryo selection is one of the most interesting technologies out there. If you could choose your kid’s height, would you? What about intelligence? Or more saliently, the risk of key diseases that your kid might be predisposed to? And how do we even know the tech is real? I discuss all this and more with Jonathan Anomaly, whose company Herasight (https://www.herasight.com/) is imputing polygenic risk scores for embryos based on fairly accessible inputs. The quagmire of ethical and scientific questions all this presents, I think, is ultimately tractable and offers reason for optimism. 00:00 - From Academia to Herasight 07:12 - Is Embryo Selection Controversial 11:31 - Polygenic Scores Explained 21:14 - Why Insurance Hasn’t Covered It 28:18 - Who Uses Screening and Why 32:35 - IVF Limits and Future Tech 36:52 - Selection vs Editing and Gattaca Fears 42:07 - Ethical Boundaries 43:01 - Breakthrough Imputation Proof 48:49 - Winning Clinics Over 51:18 - Ethics Backlash Explained 55:28 - Preference Cascade Theory 59:19 - Blank Slate Debate 01:03:09 - Pleiotropy Tradeoffs 01:08:29 - Autism Risk Predictor 01:13:37 - Repro Tech And Birth Rates 01:20:17 - Relationships And Family Futures 01:24:25 -Books And Optimistic Wrap This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.legible.bio (https://www.legible.bio?utm_medium=podcast&utm_campaign=CTA_1)

2. 

   1 Oct 2026

   Read + Write MRIs with Benjamin Anderson

   Discussing all things bioelectricity with Benjamin (https://www.consciousrepository.com/) from Aion Bio (http://aion.bio)Watch on YouTube (https://youtu.be/PFvChSPYpg8?si=fEpf9LPwQ2FkNfBa), follow on X (https://x.com/LegibleBio) Michael Levin’s latest paper - 0:34 Benjamin’s journey to bioelectricity - 3:37 How MRI works - 11:52 Longitudinal imaging - 17:11 MRI vs. ultrasound - 26:15 Making MRI more accessible - 28:57 Bioelectricity and the medbed - 36:39 Building in St. Louis - 57:39 This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.legible.bio (https://www.legible.bio?utm_medium=podcast&utm_campaign=CTA_1)

3. 

   30 Jan 2026

   Ep 5: Creative Destruction in Biotech with Shelby Newsad

   Shelby Newsad (https://shelbyann.substack.com/) is an early stage venture investor at Compound (https://www.compound.vc/). I’ve long admired her thesis work (https://www.abiohackerfuture.com/) in publicly sharing how biotech could unfold over the next decade. In this conversation, we talk about everything from decentralized clinical trials to incumbent vs startup advantages in biotech. Hope you enjoy! Watch on X (https://x.com/LegibleBio/status/2017025005222068309?s=20), YouTube (https://www.youtube.com/watch?v=i68Kx9Js9ao), or Spotify (https://open.spotify.com/episode/0QrxTMn5VTFG9MJBxJoVdl?si=uYKBYCqXR42RN8T8SqCURg) Chapters 07:21 Platform vs Product 14:25 Creative Destruction in Biotech 23:54 Decentralized Science and Crypto 30:35 Careful with Gray Label Peptides 35:34 Accelerating Human Clinical Trials 45:36 The Role of Virtual Cell Models 50:01 The Evolution of Bio-Manufacturing 53:34 Consumer Biotech: The Next Frontier 58:51 Implications of Looksmaxxing Resources mentioned Compound Research Day: Rapid in vivo Iteration (https://luma.com/8iq6lndd) Everything Is Tuberculosis: The History and Persistence of Our Deadliest Infection by John Green (https://www.amazon.com/Everything-Tuberculosis-Persistence-Deadliest-Infection/dp/0525556575) This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.legible.bio (https://www.legible.bio?utm_medium=podcast&utm_campaign=CTA_1)

4. 

   10 Dec 2025

   Ep 4: Bioelectricity with anabology

   This was an amazing conversation—I learned a lot and hope you do too. Watch on YouTube here (https://www.youtube.com/watch?v=WXQoFqvq77Y). More on RJ/ anabology here (https://anabology.com/). More on Aion Biosciences here (https://www.aion.bio/). Also check out skin.food (https://skin.food/) (would personally recommend!) Some resources mentioned: literature.bio (https://literature.bio/) - RJ’s website where he recommends reading the works of Sidney Fox and Ray Peat Chapters 00:00 - Background and Bioelectricity 10:19 - Gilbert Ling 28:27 - Raymond Damidian 45:23 - What is Structured Water? 49:32 - Are Small Molecule Approaches a Dead End? 59:30 - Building Aion Biosciences in St Louis. MO 01:05:12 - Consciousness and Origin of Life 01:11:46 - Cosmetics Sidequest (skin.food) This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.legible.bio (https://www.legible.bio?utm_medium=podcast&utm_campaign=CTA_1)

5. 

   17 Nov 2025

   Ep 2: Evolution of Biotech with Keith Robison

   Watch on YouTube here (https://youtu.be/zu9P5T6GJPY?si=WVwau4TF-rs1gSFa) Chapters00:00 (https://www.youtube.com/watch?v=zu9P5T6GJPY) Evolution of Biotech: Past and Present05:29 (https://www.youtube.com/watch?v=zu9P5T6GJPY&t=329s) Understanding Sequencing: Basics and Importance10:07 (https://www.youtube.com/watch?v=zu9P5T6GJPY&t=607s) The Drug Development Process: Then and Now17:18 (https://www.youtube.com/watch?v=zu9P5T6GJPY&t=1038s) The Shift from Small Molecules to Biologics22:11 (https://www.youtube.com/watch?v=zu9P5T6GJPY&t=1331s) Chance and Unpredictability in Drug Discovery26:35 (https://www.youtube.com/watch?v=zu9P5T6GJPY&t=1595s) Sequencing Technologies: DNA, RNA, and Proteins44:12 (https://www.youtube.com/watch?v=zu9P5T6GJPY&t=2652s) Exciting Innovations in Sequencing53:53 (https://www.youtube.com/watch?v=zu9P5T6GJPY&t=3233s) Synthetic Biology and Ginkgo’s Vision01:01:49 (https://www.youtube.com/watch?v=zu9P5T6GJPY&t=3709s) Automation in Biotechnology01:10:33 (https://www.youtube.com/watch?v=zu9P5T6GJPY&t=4233s) Recommended Reads for Biotech EnthusiastsResources mentioned * Keith’s blog (https://omicsomics.blogspot.com/): * The Billion Dollar Molecule (https://www.amazon.com/Billion-Dollar-Molecule-Companys-Perfect/dp/0671510576) by Barry Werth * For Blood or Money (https://www.amazon.com/Blood-Money-Billionaires-Biotech-Blockbuster/dp/0393540952) by Nathan Vardi * The Coming Plague (https://www.amazon.com/Coming-Plague-Emerging-Diseases-Balance/dp/0140250913) by Laurie Garrett * Plenty of Room at the Bottom (https://web.pa.msu.edu/people/yang/RFeynman_plentySpace.pdf) by Richard Feynman This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.legible.bio (https://www.legible.bio?utm_medium=podcast&utm_campaign=CTA_1)

6. 

   17 Nov 2025

   Ep 1: Democratizing DNA sequencing with Ana Cornell

   Watch on YouTube here (https://youtu.be/VOPSZL8mn6Q?si=_wsMzj4BMn3vp1e8) Learn more about what Ana’s building here (https://www.acorngenetics.com/) ChaptersChapters00:00 Circus to Genetics05:14 Building a Sequencer13:26 The Future of Sequencing: Decentralization and Accessibility18:31 Challenges in Manufacturing and Scaling21:21 Sequencing in Breweries23:47 Building a Platform Company29:54 Misunderstandings about Sequencing35:09 What Does It Mean Go Fast in Biotech?39:36 The Biotech Race: US vs. China47:22 Family and Startups54:33 The Role of Personality Types in Leadership This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.legible.bio (https://www.legible.bio?utm_medium=podcast&utm_campaign=CTA_1)

7. 

   17 Nov 2025

   Ep 0: Biotech theses with Andrew Hui

   Also watch on YouTube (https://youtu.be/wXSuQQup5-c?si=BMIwsRRzlWW8E6bP) 00:36 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=36s) Journey into Biotech: From Education to Industry03:23 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=203s) Investing in Biotech: Early Experiences and Lessons Learned06:11 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=371s) Starting a Biotech Company: The Initial Steps09:14 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=554s) Developing Technology in Biomanufacturing11:55 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=715s) Challenges of Venture Capital in Biotech14:45 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=885s) Reflections on Business Strategy and Acquisitions17:39 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=1059s) Exploring the Mining Industry: Insights and Parallels20:39 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=1239s) Comparing Mining and Biotech: Investment Strategies23:10 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=1390s) Final Thoughts on Mining and Biotech Investments26:32 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=1592s) Exploring Emerging Markets and Biotech29:29 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=1769s) The Distressed Biotech IP Thesis32:51 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=1971s) Danaher and the Power of Operational Efficiency36:45 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=2205s) The Challenges of Venture Capital in Biotech41:29 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=2489s) The Role of CROs in Biotech45:34 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=2734s) Critique of the Biotech Industry55:21 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=3321s) The Importance of Biosecurity in Biotech01:05:29 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=3929s) Biosecurity and Monitoring Layers01:07:28 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=4048s) Ginkgo Biosecurity: The Bio Radar Concept01:11:50 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=4310s) The Role of Sequencing in Biosecurity01:17:56 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=4676s) China’s National Priority in Sequencing Technology01:23:32 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=5012s) The Future of Drug Development and Sequencing01:32:19 (https://www.youtube.com/watch?v=wXSuQQup5-c&t=5539s) Short Read vs Long Read Sequencing This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.legible.bio (https://www.legible.bio?utm_medium=podcast&utm_campaign=CTA_1)

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Guest appearances

Books guests

Based on episode analysis; this does not confirm that the show is currently accepting guests.