Modified
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Podcast Overview
<p><b>Join me as we dig into a heaped serving of GMO crops through the lens of science, history, and culture. From the Victorian origins of plant genetics through to the genetically modified world we live in today. I’m Dr. Orlando de Lange and I’ll be your guide as we explore true stories that just might change how you think about the past, present and future of food. </b></p>
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🇺🇲
Publishing Since
8/4/2025
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Recent Episodes
April 18, 2026
CRISPR changes the world and unlocks GMO 2.0
What is CRISPR-Cas9 and how is it going to revolutionize the world of GMO crops? References de Lange, O., Binder, A. and Lahaye, T. (2014), From dead leaf, to new life: TAL effectors as tools for synthetic biology. Plant J → Review article on TAL effectors by yours truly Ishino Y, Shinagawa H, Makino K, Amemura M, Nakata A. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J Bacteriol. 1987 → Paper first describing CRISPR in 1987 Interview with the 2020 Nobel Prize laureate in chemistry, Emmanuelle Charpentier, recorded in Stockholm on 12 December 2022. Martin Jinek et al.,A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity.Science337,816-821(2012). —> First paper describing use of CRISPR as a programmable DNA endonuclease Updates on Global Regulatory Landscape for Gene-Edited Crops By Clement Dionglay, January 24, 2024 https://www.isaaa.org/blog/entry/default.asp?BlogDate=1/24/2024 -> Update on regulation of gene editing. https://sanatech-seed.com/en/221226-2/ → Article from Sanatech describing the gene-edited, High GABA tomato.
April 4, 2026
The colorful world of GMOs
From glowing petunias to purple tomatoes - this episode is a roundup of some of the lesser known GMO crops that are nonetheless out there in our world. Key references Glowing plants I Bought a Glowing Plant. It Led Me Down a Rabbit Hole. Scientific American. 2024 Glowing Plant US Patent www.light.bio - to buy your own glowing plant. Blue Roses https://www.suntoryapplause.com/ https://www.suntory.com/sic/story/bluerose/ Wikipedia article - https://en.wikipedia.org/wiki/Blue_rose Pink Pineapples https://www.pinkglowpineapple.com/ US Patent Purple tomatoes Martin C, Butelli E. The Purple Tomato Story; From Laboratory Bench to the Consumer. ACS Food Sci Technol. 2024 GM Purple Tomato Gets Approval in the United States. ISAAA. 2024 https://www.norfolkhealthyproduce.com/ Rainbow Papaya https://en.wikipedia.org/wiki/Dennis_Gonsalves Arctic apples https://www.tandfonline.com/doi/pdf/10.1080/02648725.1998.10647966 https://en.wikipedia.org/wiki/Arctic_Apples#Commercialization GMO poplar trees https://www.livingcarbon.com/ For the First Time, Genetically Modified Trees Have Been Planted in a U.S. Forest. New York Times. 2023 Wang G, Dong Y, Liu X, Yao G, Yu X, Yang M. The Current Status and Development of Insect-Resistant Genetically Engineered Poplar in China. Front Plant Sci. 2018 Tao, Y.; Chiu, L.-W.; Hoyle, J.W.; Dewhirst, R.A.; Richey, C.; Rasmussen, K.; Du, J.; Mellor, P.; Kuiper, J.; Tucker, D.; et al. Enhanced Photosynthetic Efficiency for Increased Carbon Assimilation and Woody Biomass Production in Engineered Hybrid Poplar. Forests 2023
March 22, 2026
Your Questions Answered - Part 2
From glowing fish to feminizing tofu - the second and final installment of me answering your questions about GMO. References relevant to Question 1 - Soy Phytoestrogens Article on use of the term “Soy boy” Messina, M., Mejia, S. B., Cassidy, A., Duncan, A., Kurzer, M., Nagato, C., … Barnes, S. (2022). Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data. Critical Reviews in Food Science and Nutrition, 62(21), 5824–5885. Povey AC, Clyma J-A, McNamee R, et al; Participating Centres of Chaps-UK. Phytoestrogen intake and other dietary risk factors for low motile sperm count and poor sperm morphology. Andrology. 2020;8:1805–1814. References relevant to Question 2 - GMO animals Wikipedia article on GloFish - provides a good summary of the history. https://en.wikipedia.org/wiki/GloFish 2003 discussion forum - discussing merits of brand new GloFish product. Bratspies, Rebecca. (2005). Glowing in the Dark: How America's First Transgenic Animal Escaped Regulation. CAPITOL ALERT ‘Glowing fish’ exempt from proposed ban on gene-edited pets in California By Kate Wolffe Updated February 5, 2026 2:20 PM Wikipedia article on AquaAdvantage Salmon 2024 AquaBounty press release announcing sell off of assets. References relevant to Question 3 - Health impacts of GMOs Shen, C., Yin, XC., Jiao, BY. et al. Evaluation of adverse effects/events of genetically modified food consumption: a systematic review of animal and human studies. Environ Sci Eur 34, 8 (2022). https://doi.org/10.1186/s12302-021-00578-9
17 total episodes available
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- What is Modified?
<p><b>Join me as we dig into a heaped serving of GMO crops through the lens of science, history, and culture. From the Victorian origins of plant genetics through to the genetically modified world we live in today. I’m Dr. Orlando de Lange and I’ll be your guide as we explore true stories that just might change how you think about the past, present and future of food. </b></p> - How often does this podcast release new episodes?
This podcast updates daily.
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This podcast is available on 4 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
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Information about guest appearances is not available.
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