NEXT BREAKTHROUGH: The Biomedical Innovation Brainstorm
Claim This Podcastby Francesca Chen
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Podcast Overview
<p>This is where ideas for biomedical innovation are brainstormed and born.</p><p><br /></p><p>In this extraordinarily important field, it is vital to ask the right questions- as the resulting solutions will aim to go on and solve some of the greatest medical issues.</p><p><br /></p><p>Do you want to create this change? Because that next breakthrough starts here.</p><p><br /></p><p>We invite guest researchers from the many niche areas of this field not only to pry at existing problems they face in their innovative work, but we then take this information, and here is our core element, look into the cracks, and derive ideas for the creation of new devices to target these problems. </p><p><br /></p><p>My name is Francesca Chen, and as your host, I’m a student fascinated in the potential of the near future of biomedical innovation- one that the ideas cultivated directly in this podcast could go on to impact. </p><p><br /></p><p>This is the real lab behind the innovation, alive with real ideas that could go on to change real people's lives. </p><p><br /></p><p>With NEXT BREAKTHROUGH, you could be the one to change them. </p><p><br /></p><p>Follow to be the first to know when the new episode drops. In the meantime, check out our podcast trailer! </p>
Language
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Publishing Since
6/24/2025
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Recent Episodes
December 15, 2025
Drosophila melanogaster: Neuroscience, Sensory Processing Behind Taste and Scent, Optogenetics, Nutrient Sensing, the Connectome
<p>“One of the things that's really sort of changed fly neuroscience recently is the connectome.”</p><p><br /></p><p>This connectome, Dr. Gordon says, is “like this map of all the connections between all the different neurons in the fly brain.” It completely revolutionized the way scientists do things like genome sequencing, where it would take years to sequence one single animal. </p><p>Now, this can be done in a day. </p><p>He says, “If something like the technology for studying connectomes could be scalable in a similar way, and we could then easily get connectome information from other species, for example, the species of insects or other larger species, etc.”</p><p><br /></p><p>Hello everyone, welcome to Next Breakthrough! My name is Francesca Chen, and I have a surprise for everyone today in this month’s episode. </p><p>I interviewed Dr. Michael Gordon, a Professor and PI in the Department of Zoology at UBC, whose team looks at a very unique animal in their research: the Drosophila melanogaster. A fruit fly. Intrigued? I was as well when I initially read through Dr. Gordon’s research, and thus wanted to bring his thoughts to share with you all. As the topic of this episode suggests, we will cover a wide variety and depth of aspects today, including fly models and genetics, neuroscience, sensory processing in terms of taste and scent, optogenetics, nutrient sensing, linking things back to human health, the connectome, and more in much more detail. Although some things discussed do not directly related to biomedicine per say, remember that biomedicine is really influenced and impacted by a broad scope of areas, and it can be through profound research from one of these areas that ties to something more central, as Dr. Gordon explains today. The episode gives us a broader view of the stretch and connectedness that are human biomedical sciences. It is all very interesting, so definitely go ahead and enjoy this unique episode. (I would also recommend you guys research a bit about the Human Connectome Project when you finish listening!) </p><p>Without further ado, here is Dr. Mike Gordon. </p>
November 15, 2025
HIV & Antiretroviral Drugs and Therapy: Mitochondrial Toxicity, Mitochondrial DNA Depletion, Telomer e Length, Pregnancy & Preterm Delivery
<p>One of the limitations Dr. Hélène Côté recognizes in this field of research is the complexity behind the intaking of these antiretroviral drugs in individuals, where causation is not always clear. If this can be done, she says, on a scale which allows answering of questions with more granularity, she would be able to close in on what antiretroviral drug does what, and figure out a link between the drug and its affects. </p><p><br /></p><p>Welcome back, everyone, to Next Breakthrough, our hub of biomedical innovation brainstorm! My name is Francesca Chen, and I’m very excited to introduce to you all Dr. Hélène Côté. In this episode, Dr. Hélène Côté, a PI and professor in the Department of Pathology and Laboratory Medicine at UBC talks about her team’s research in HIV medication. Our discussion tracks the journey of antiretroviral drugs’ introduction- from initial adverse affects-to now, and current improvements of patients’ lives, to more internal aspects such as mitochondrial toxicity and antiretroviral impacts on mtDNA depletion, the relationship of these drugs to telomere length, how these drugs influence pregnancy and preterm delivery, and much more. Ending off is a reflection on how the fight against HIV has progressed in the past years, current challenges researchers like Dr. Côté and her team face, and anticipated progression in the future. There’s lots of densely packed intriguing insights in our conversation, so let’s dive right in! And as always, please consider following this podcast to increase the size of your biomedical brain. And without further ado, here is Dr. Hélène Côté.</p>
October 14, 2025
Type 1 Diabetes & Stem Cell Therapy, Macroencapsulation Devices, CRISPR/Gene Editing, Yamanaka Factors, Hypoimmune Cells
<p>The elimination of life-long immunosuppressant drugs begins with being able to able to avoid the immune system's attack. </p><p>Avoiding the immune system’s attack, as Dr. Zhao explains, lies in the generating of hypoimmune cells, and the tweaking of certain genes in order to “mask” the molecular ID of these cells when they are in the body....</p><p><br></p><p>Welcome back, innovators! My name is Francesca Chen, your host for Next Breakthrough. In this episode we interviewed Dr. Jia Zhao, a post doc in the Kieffer Lab, which is part of the Department of Cellular and Physiological Sciences at UBC. The Kieffer Lab delves into the treatment of Type 1 diabetes, focussing on a combination of insulin producing cells and macroencapsulation devices, and genetic engineering. In this episode, we discussed stem cell therapy, donor alleles, pancreatic pregenital cells, Beta cells (you will learn what all these are soon!) macroencapsulation, CRISPR and gene editing, hypoimmune cells, and more. We ended off by addressing the efforts need to make these emerging diabetes therapies more accessible and less expensive to a larger population. There are lots of fascinating components embedded in our interview- as always, should you find anything you want to look into on your own time, please do- I would recommend looking into the Yamanaka factors Dr. Zhao and I talk about a little later in the interview.</p><p>Without further ado, here is Dr. Jia Zhao! </p>
7 total episodes available
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- What is NEXT BREAKTHROUGH: The Biomedical Innovation Brainstorm?
<p>This is where ideas for biomedical innovation are brainstormed and born.</p><p><br /></p><p>In this extraordinarily important field, it is vital to ask the right questions- as the resulting solutions will aim to go on and solve some of the greatest medical issues.</p><p><br /></p><p>Do you want to create this change? Because that next breakthrough starts here.</p><p><br /></p><p>We invite guest researchers from the many niche areas of this field not only to pry at existing problems they face in their innovative work, but we then take this information, and here is our core element, look into the cracks, and derive ideas for the creation of new devices to target these problems. </p><p><br /></p><p>My name is Francesca Chen, and as your host, I’m a student fascinated in the potential of the near future of biomedical innovation- one that the ideas cultivated directly in this podcast could go on to impact. </p><p><br /></p><p>This is the real lab behind the innovation, alive with real ideas that could go on to change real people's lives. </p><p><br /></p><p>With NEXT BREAKTHROUGH, you could be the one to change them. </p><p><br /></p><p>Follow to be the first to know when the new episode drops. In the meantime, check out our podcast trailer! </p> - How often does this podcast release new episodes?
This podcast updates daily.
- Where can I listen to this podcast?
This podcast is available on 4 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
- Does this podcast accept guests?
Yes, this podcast regularly features guests.
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