Singapore's premier podcast on the biotech ecosystem. The show notes and transcripts can be found on nucleatesingapore.substack.com. Subscribe and follow us to keep your finger on the pulse of Singapore’s biotech ecosystem. For feedback and suggestions, feel free to reach out to the team at singapore@nucleate.org
Nucleate Singapore Pulse
Claim This Podcastby Nucleate Singapore
30 episodes
Updated Bi-weekly
Accepts GuestsHas SponsorsLocation 🇸🇬
39
Podcast Authority
BetaPoorBased on show quality, social media presence, reviews, charts, and more
Quality54
Social0
YouTube0
Engagement60
Podcast Overview
Singapore's premier podcast on the biotech ecosystem. The show notes and transcripts can be found on nucleatesingapore.substack.com. Subscribe and follow us to keep your finger on the pulse of Singapore’s biotech ecosystem. For feedback and suggestions, feel free to reach out to the team at singapore@nucleate.org
Language
🇺🇲
Publishing Since
7/1/2023
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39
Podcast Authority
BetaPoorBased on show quality, social media presence, reviews, charts, and more
Quality54
Social0
YouTube0
Engagement60
7
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10
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excellent
Episode Length
34 minutes
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23 episodes over 2.0 years
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Every 32 days
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Recent Episodes
June 17, 2026
Rewriting human aging with Physics and AI with Dr. Peter Fedichev of Gero (Part 2)
<p>Dr. Peter Fedichev is the co-founder and CEO of <strong>GERO</strong>, a Singapore-based biotech startup that uses physics-informed AI and massive human health datasets to discover drugs aimed at slowing down aging and treating age-related diseases.</p><p>In the 2nd part of this episode, Peter explains how Gero builds generative models of human health to predict disease trajectories and identify shared biological drivers across multiple chronic conditions. He discusses why metabolic dysfunction and inflammation represent promising intervention points, how partnerships with pharma companies like Chugai accelerate translation, and why companion dogs could become the proving ground for longevity therapeutics.</p><p>Peter also shares his perspective on AI-driven drug discovery, arguing that target identification, not molecule generation, will create the greatest value. He outlines Gero’s open-source approach, fundraising journey, and vision for a future where therapies can meaningfully slow the aging process itself.</p><p><br></p><p>Host: John Joson Ng</p><p>Editors: Dillon Chew, Chi Dam, Vasilina Gedzun</p><p><br></p><p>00:00 Gero Roadmap Overview</p><p>00:35 Predicting Disease Trajectories</p><p>03:03 Super Targets Strategy</p><p>05:07 Ozempic Market Wakeup</p><p>07:28 Binary Strategy With Pharma</p><p>10:11 Gerosense Wearable Aging API</p><p>11:58 Crossdisciplinary Lab Workflow</p><p>14:09 ProtoBind Diff Explained</p><p>17:16 Open Source Business Logic</p><p>21:10 Chugai Partnership Begins</p><p>23:57 AI Push In Big Pharma</p><p>27:09 Funding Gero Early</p><p>31:38 Differentiating From Calico and Altos</p><p>35:56 Longevity Roadmap Dogs To Humans</p><p>42:36 Next Milestones For Gero</p><p>43:45 Personal Motivation To Fight Aging</p>
June 17, 2026
Rewriting human aging with Physics and AI with Dr. Peter Fedichev of Gero (Part 1)
<p>Dr. Peter Fedichev is the co-founder and CEO of <strong>GERO</strong>, a Singapore-based biotech startup that uses physics-informed AI and massive human health datasets to discover drugs aimed at slowing down aging and treating age-related diseases.</p><p>In this episode, explains his transition from a decade in theoretical physics to longevity biotech, motivated by applying physics tools to complex living systems and discoveries like the naked mole rat’s lack of mortality acceleration. He contrasts biology’s case-control, fact-collecting culture with physics’ search for universal variables, arguing aging is a universal, chronic-process problem well suited to physics-style modeling. Peter describes Gero’s approach as building predictive, generative AI models from large-scale medical records and omics data to capture the “equations of motion” of health over time. He critiques hallmark-of-aging narratives and emphasizes “functional decline” (functional span) over healthspan, noting very old people can be disease-free yet severely impaired. Using thermodynamics as an analogy, he argues aging involves entropy-like, stochastic damage that is hard to reverse but potentially possible to slow or stop by targeting fundamental control variables.</p><p><br></p><p>Host: John Joson Ng</p><p>Editors: Dillon Chew, Chi Dam, Vasilina Gedzun</p><p><br></p><p>00:00 Meet Peter Fedichev</p><p>00:23 From Physics to Biology</p><p>02:30 Non Aging Animals Spark</p><p>04:27 Physics Lens on Aging</p><p>06:21 Why Gero Exists</p><p>09:46 Modeling Health Dynamics</p><p>10:49 Beyond Lifespan Healthspan</p><p>12:43 Functional Decline Focus</p><p>16:07 Thermodynamics Meets AI</p><p>18:56 Entropy Limits Reversal</p><p>22:02 Temperature and Lifespan</p><p>25:12 Modeling to Speed Drugs</p><p>27:20 Closing Why Aging First</p>
May 14, 2026
Advancing Precision Microbiome Innovation with Dr. Boon Chong Goh of ArrowBiome
<p>Dr. Boon Chong Goh is the co-founder and CTO of <strong>ArrowBiome</strong>, a Singapore-based biotech startup developing precision microbiome solutions through its lysin engineering platform.</p><p><br></p><p>Spun out from the Singapore-MIT Alliance for Research and Technology and NTU Lee Kong Chian School of Medicine, <strong>ArrowBiome</strong> develops proprietary and patented platform technologies that enable highly selective bacterial targeting and killing. With “arrow-like” precision, the company is advancing microbiome solutions across applications including body odour, acne, other bacteria-associated skin conditions, gut health, and antimicrobial resistance.</p><p><br></p><p>In this episode, Boon Chong shares how his journey from physics, protein structure, and molecular simulations led him into antimicrobial resistance research and eventually entrepreneurship. He discusses why lysins are powerful tools for precision microbiome control, how ArrowBiome moved from academic research to commercialization, and why the company strategically entered skincare and personal care before tackling more complex antimicrobial challenges. He also reflects on startup fundraising, Singapore’s biotech ecosystem, scaling production, global expansion, and the personal shift from scientist to entrepreneur.</p><p><br></p><p>Host: Shamieraah Jamal</p><p>Editors: Chi Dam, Shamieraah Jamal, Dillon Chew</p><p><br></p><p><strong>Timestamp</strong>:</p><p>00:00 Introduction to Dr. Boon Chong Goh</p><p>00:54 Journey From Physics to Antimicrobial Research</p><p>01:36 Why Lysins Became the Focus</p><p>04:24 Why Lysin Technology Matters for AMR</p><p>05:25 Funding Early Antimicrobial Projects</p><p>07:19 From Research Scientist to Entrepreneur</p><p>09:19 From CEO to CTO</p><p>14:10 Building ArrowBiome in Singapore</p><p>15:48 Why Singapore for Deep Tech and Cosmeceuticals</p><p>17:28 ArcherZyme and SmartArrow</p><p>19:19 Why Start with Cosmeceuticals</p><p>21:15 Regulatory Pathways and Clinical Testing</p><p>22:01 Measuring Success in Acne and Body Odor</p><p>23:23 Microbiome Differences Across Populations</p><p>24:51 Scaling Fermentation</p><p>25:37 B2B Partnerships and Global Clients</p><p>26:33 Formulation Partnerships with CHAKS</p><p>27:49 Singapore Startup Ecosystem and Partnerships</p><p>29:01 Winning Gold at In-Cosmetics Asia</p><p>31:06 Belgium Subsidiary and Global Expansion</p><p>32:20 What Next for ArrowBiome</p><p>33:20 M&A Strategy and Exit Planning</p><p>34:22 Advice for Researcher-Entrepreneurs</p><p>36:31 From Scientist to Strategic Founder</p>
30 total episodes available
Recent guests on Nucleate Singapore Pulse
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Dr Goh Wei Jiang
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Ritika Khetawat
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This podcast updates bi-weekly.
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This podcast is available on 7 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
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Yes, this podcast regularly features guests.
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