Profane, insane, and 100% primo science, Petri Dish is a no-BS podcast that explores the wildest subjects in modern science with clarity and evil joy.
Hosted by Sean Allen, a Nanoparticle/Immunology Researcher, and Nathan Allen, his "screenwriter" brother, Petri Dish fuses hard science with a freewheeling and madcap conversational style.
Cannabinoids, Plague, Cats, the dreaded Candiru, and the even more dreaded Covid-19: all these and more are dissected with intellect and irreverence, dropping every week.
So reject ignorance. Join the Scientific Revolution. Join Petri Dish.
Ep. 185 How to Make a Drug Pt 2: Libraries and Design
On this second episode about drug discovery, we discuss small molecule drug libraries and the challenges behind rational design! Don't know what that means? Tune in to find out!
References:
https://www.frontiersin.org/articles/10.3389/fcell.2019.00107/full (https://www.frontiersin.org/articles/10.3389/fcell.2019.00107/full)
https://next.cancer.gov/discoveryresources/resources_ndl.htm (https://next.cancer.gov/discoveryresources/resources_ndl.htm)
https://www.molbiolcell.org/doi/10.1091/mbc.E22-08-0377 (https://www.molbiolcell.org/doi/10.1091/mbc.E22-08-0377)
https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treatment-certain-patients-duchenne-muscular-dystrophy (https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treatment-certain-patients-duchenne-muscular-dystrophy)
https://www.goodrx.com/health-topic/gene-therapy/crispr-therapeutics-vertex-exa-cel (https://www.goodrx.com/health-topic/gene-therapy/crispr-therapeutics-vertex-exa-cel)
https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/crispr-timeline (https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/crispr-timeline)
14 Aug 2023
Ep. 184 How to Make a Drug Pt 1: A Target
Hey everyone! Today's episode is about getting into the nitty gritty of drug discovery. We often benefit from the research and development that goes into the creation of drugs we use to treat illnesses without really understanding what goes into that process. In this first part, we will discuss how you conceptually begin the process.
References:
https://www.nature.com/articles/nrd2399 (https://www.nature.com/articles/nrd2399)
https://www.fda.gov/vaccines-blood-biologics/zolgensma (https://www.fda.gov/vaccines-blood-biologics/zolgensma)
https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0806-1 (https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0806-1)
https://www.ncbi.nlm.nih.gov/books/NBK519062/ (https://www.ncbi.nlm.nih.gov/books/NBK519062/)
https://www.sciencedirect.com/science/article/pii/B9780128191828000338 (https://www.sciencedirect.com/science/article/pii/B9780128191828000338)
https://www.sciencedirect.com/science/article/pii/0006291X89926788?via%3Dihub (https://www.sciencedirect.com/science/article/pii/0006291X89926788?via%3Dihub)
https://www.nature.com/articles/362841a0 (https://www.nature.com/articles/362841a0)
https://www.sciencedirect.com/science/article/pii/S0305737220300554 (https://www.sciencedirect.com/science/article/pii/S0305737220300554)
7 Aug 2023
Ep. 183 Influenza Pt 4: Vaccines and Pandemics
Sorry for the COVID-related break in episodes everyone! In our return, we complete our series on influenza by discussing past epidemics and pandemics to understand how influenza has repeatedly led to large scale medical events. Then we will finish by discussing the current and future state of influenza vaccines!
References:
https://www.nejm.org/doi/full/10.1056/nejmp058281 (https://www.nejm.org/doi/full/10.1056/nejmp058281)
https://www.nature.com/articles/nature08157 (https://www.nature.com/articles/nature08157)
https://pubmed.ncbi.nlm.nih.gov/16208372/ (https://pubmed.ncbi.nlm.nih.gov/16208372/)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578040/ (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578040/)
https://www.who.int/news-room/spotlight/history-of-vaccination/history-of-influenza-vaccination (https://www.who.int/news-room/spotlight/history-of-vaccination/history-of-influenza-vaccination)
https://www.scripps.edu/news-and-events/press-room/2020/20200623-wilson-universalflu.html (https://www.scripps.edu/news-and-events/press-room/2020/20200623-wilson-universalflu.html)
https://www.cdc.gov/flu/season/faq-flu-season-2022-2023.htm (https://www.cdc.gov/flu/season/faq-flu-season-2022-2023.htm)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159335/ (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159335/)
https://www.nature.com/articles/nrmicro.2017.118 (https://www.nature.com/articles/nrmicro.2017.118)
https://www.sciencedirect.com/science/article/abs/pii/0042682278901538 (https://www.sciencedirect.com/science/article/abs/pii/0042682278901538)
https://www.cdc.gov/flu/prevent/flushot.htm (https://www.cdc.gov/flu/prevent/flushot.htm)
https://www.science.org/content/article/innovative-universal-flu-vaccine-shows-promises-it-first-clinical-test (https://www.science.org/content/article/innovative-universal-flu-vaccine-shows-promises-it-first-clinical-test)
https://www.science.org/doi/10.1126/science.aaz5143 (https://www.science.org/doi/10.1126/science.aaz5143)
https://www.nih.gov/news-events/nih-research-matters/using-mrna-technology-universal-flu-vaccine (https://www.nih.gov/news-events/nih-research-matters/using-mrna-technology-universal-flu-vaccine)
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