Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas.
Proteomics in Proximity
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Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas.
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Recent Episodes
June 16, 2026
Hype to Evidence: What FDA, XPRIZE and ARPA-H Are Teaching Us About Longevity
<p>Welcome to the Olink® Proteomics in Proximity podcast! <br> </p><p>Below are some useful resources mentioned in this episode: </p><p> </p><p>Reagan-Udall Foundation at FDA Gerotherapeutics in Aging Event Recording available: Affecting the Aging Trajectory: Regulatory Constructs for Gerotherapeutic Drug, Biologic and Device Development</p><p><a href="https://reaganudall.org/news-and-events/events/affecting-aging-trajectory-regulatory-constructs-gerotherapeutic-drug">https://reaganudall.org/news-and-events/events/affecting-aging-trajectory-regulatory-constructs-gerotherapeutic-drug</a></p><p> </p><p><strong>UK Biobank Pharma Proteomics Project (UKB-PPP)</strong>, one of the world’s largest scientific studies of blood protein biomarkers conducted to date, <a href="https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies">https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies</a> </p><p> </p><p><strong>UK Biobank Pharma Proteomics Project Full Cohort Study: Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Study</strong></p><p><a href="https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx">https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx</a></p><p><strong>Organ Ageing and Ageing Clock Publications leveraging Olink Proteomics:</strong></p><p>Oh, H.SH et al. (2025). Plasma proteomics links brain and immune system aging with healthspan and longevity. Nat Med 31, 2703–2711. <a href="https://doi.org/10.1038/s41591-025-03798-1">https://doi.org/10.1038/s41591-025-03798-1</a></p><p>Goeminne et al (2024). Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems Cell Metabolism, 37, 205-222.e6</p><p>Argentieri, M.A et al. (2024). Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med <strong>30</strong>, 2450–2460. <a href="https://doi.org/10.1038/s41591-024-03164-7">https://doi.org/10.1038/s41591-024-03164-7</a></p><p><strong>Additional publication of interest: </strong></p><p><a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F38015820%2F&data=05%7C02%7Csarantis.chlamydas%40olink.com%7Cf9c2242b26e9451de90708dc2d5f9fe6%7C0bc012cfb3e946bd95a6cecc37315bb1%7C1%7C0%7C638435135933758045%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=t%2FLhxWspYWLcFpU1uq1OnYhdn0PAQFJHvDE3yITWHWI%3D&reserved=0">Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens. </a>Kardell O (2023). J Proteome Res. 2024 Jan 5;23(1):117-129. <a href="https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00473">https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00473</a></p><p><strong>Subscribe to the podcast on your favorite player or app:</strong></p><p>Apple Podcasts: <a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtube.com%2Fredirect%3Fevent%3Dvideo_description%26redir_token%3DQUFFLUhqbmw0SE1vbnFIcng0SUM1RnozZ0hQdVEyRnB6Z3xBQ3Jtc0trZk4wVUFsT09NNUhJMzdwRmx0Q01TclNGWjRvYVZjUEpDN0Vwak9ONDVvSWFOdU1wTHZJUkF1c052VlBEaHBUdGVkTW1vLVM1OTB6YTM0UG50U09MUkJjQ1hlMGI3aUhaM0oyZ2ZjRU5TeEFvc2d3OA%26q%3Dhttps%253A%252F%252Fapple.co%252F3T0YbSm%26v%3DQJbH-2z9Hww&data=05%7C01%7Cbrianne.petritis%40olink.com%7C429494ad0f7948f7a92f08db5254c2c6%7C0bc012cfb3e946bd95a6cecc37315bb1%7C1%7C0%7C638194296212967642%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=RLG5GbmFPHhN47yP%2Blu%2FAHBZ2jHfJp8NFS2eZIFO9%2FQ%3D&reserved=0">https://apple.co/3T0YbSm</a> <br> </p><p>Spotify Podcasts: <a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtube.com%2Fredirect%3Fevent%3Dvideo_description%26redir_token%3DQUFFLUhqbFhtTW1DMktyXzlzWGdEVzNnbXdsOTRUOFNZUXxBQ3Jtc0ttUWtROXJiSEIwR0JWTmd2bXRKVjMySUNkS09MU2JSMjhqTHppanlkQzhhUmRPTkU3WlRwUmkyTE9Qdk15RHhlbEU1VTRBM2FGSDBTYllLQnFNUmxpdWk0STVHMGdXQm8zMWtyYmVuNkdSclp4VnhLSQ%26q%3Dhttps%253A%252F%252Fopen.spotify.com%252Fshow%252F2sZ2wxOqI4b4vSngkajLs8%253Fsi%253Dd957d55c8db046f7%26v%3DQJbH-2z9Hww&data=05%7C01%7Cbrianne.petritis%40olink.com%7C429494ad0f7948f7a92f08db5254c2c6%7C0bc012cfb3e946bd95a6cecc37315bb1%7C1%7C0%7C638194296212967642%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=wcxGyPE9BvcWgBP8SNmtL2yJXxI6Iqn31uFErVuReR8%3D&reserved=0">https://open.spotify.com/show/2sZ2wxO...</a> <br> </p><p>Google Podcasts: <a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtube.com%2Fredirect%3Fevent%3Dvideo_description%26redir_token%3DQUFFLUhqbUJvQTBEd2RObjZhUUV5aTBRRTgwWnM0NzJkUXxBQ3Jtc0tsbzdvVDJVX3hJcERNNTdSUWk4aF90UkN5dnFZOEx5N3M1cXhsWDhBMkw3WGNVVlRFdzlPZTVfU1JEbFZ5X0hINllKMnhGbUJ1aWJxSEVhMkQ4XzY5T1hNMWx1QkFPNDFDVk56eVJpa2FtM2tIME40aw%26q%3Dhttps%253A%252F%252Fpodcasts.google.com%252Ffeed%252FaHR0cHM6Ly9mZWVkcy50cmFuc2lzdG9yLmZtL3Byb3Rlb21pY3MtaW4tcHJveGltaXR5%26v%3DQJbH-2z9Hww&data=05%7C01%7Cbrianne.petritis%40olink.com%7C429494ad0f7948f7a92f08db5254c2c6%7C0bc012cfb3e946bd95a6cecc37315bb1%7C1%7C0%7C638194296212967642%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=SV7UhWVw%2FXMgk%2FkZstx3GZdfMO7b5TD130ygPDGbpfE%3D&reserved=0">https://podcasts.google.com/feed/aHR0...</a> <br> </p><p>Amazon Music: <a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtube.com%2Fredirect%3Fevent%3Dvideo_description%26redir_token%3DQUFFLUhqbFBWalpPajl5em9CSHZod200aVFQNXBUNllxZ3xBQ3Jtc0ttbERHdC1vRnNzYko5QjBkck1VQnlGNHF5WW0tU2hVSmF1bGJrdHlvUU5SU0F4SnhWbThRYXA1Q3lQbkh6WWpBUTFibmQ5N2N5aDFzNWxUcmlxX20xa2x0dlJiS2E3Z3ExNHFSWDV0YmJCaThHejVDTQ%26q%3Dhttps%253A%252F%252Fmusic.amazon.com%252Fpodcasts%252Fd97ace94-f02b-4b37-9532-799548ef2840%26v%3DQJbH-2z9Hww&data=05%7C01%7Cbrianne.petritis%40olink.com%7C429494ad0f7948f7a92f08db5254c2c6%7C0bc012cfb3e946bd95a6cecc37315bb1%7C1%7C0%7C638194296212967642%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=VuXCqaZq6y1wyNNy2IFn%2Fkkx1GyNmOUIddRKxuHWkPE%3D&reserved=0">https://music.amazon.com/podcasts/d97...</a> <br> </p><p>Podcast Addict: <a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtube.com%2Fredirect%3Fevent%3Dvideo_description%26redir_token%3DQUFFLUhqa2NjQ3V2VTZDVnplM2xvbEpjdzR6b01PRmtqQXxBQ3Jtc0ttZV9fbWJaNE5MTkk3UndLS1BEbUUxdUwyWVBqazBqVXZRbDlXZ3Bzc3BEb0xTMHNVSkthZnAyUl9jYVZnMUdnOFN6cjRmcUxtZ0E5ZlR1YXp0dkgwdHVSX2Rsd3FidEZ3S001OGtaUi1WY2l2NndOQQ%26q%3Dhttps%253A%252F%252Fpodcastaddict.com%252Fpodcast%252F4098296%26v%3DQJbH-2z9Hww&data=05%7C01%7Cbrianne.petritis%40olink.com%7C429494ad0f7948f7a92f08db5254c2c6%7C0bc012cfb3e946bd95a6cecc37315bb1%7C1%7C0%7C638194296212967642%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=HF6t7us6WQGS20%2F8n4d4HSxmOXDGq9jD8Iem0nK0OIw%3D&reserved=0">https://podcastaddict.com/podcast/409...</a> <br> </p><p>Deezer: <a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtube.com%2Fredirect%3Fevent%3Dvideo_description%26redir_token%3DQUFFLUhqbVlXUnpCalZla0Z1SEtQbkVhTDdNMmNWWmw5Z3xBQ3Jtc0ttRXNKRFRBV2tDLWZ3VklIYXgyQThTVGp0..."></a></p>
June 9, 2026
When Proteins Tell Time: Biological Aging with Tony Wyss-Coray
<p>Welcome to the Olink® Proteomics in Proximity podcast! </p><p>Below are some useful resources mentioned in this episode: <br>UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date. <a href="https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies">https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies</a> </p><p>Research articles and news<br>UK Biobank Pharma Proteomics Project Full Cohort Study: Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Study<br><a href="https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx">https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx</a></p><p>Parabiosis <br>Conboy et al (2005) Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433: 760-764. <a href="https://www.nature.com/articles/nature03260">https://www.nature.com/articles/nature03260</a></p><p>Villeda et al. (2011). The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90–94 <a href="https://www.nature.com/articles/nature03260">https://doi.org/10.1038/nature10357</a></p><p>Organ Aging/Ageing Clock Publications leveraging Olink Proteomics<br>Oh, H.SH et al. (2025). Plasma proteomics links brain and immune system aging with healthspan and longevity. Nat Med 31, 2703–2711. <a href="https://doi.org/10.1038/s41591-025-03798-1">https://doi.org/10.1038/s41591-025-03798-1</a><br>Goeminne et al (2025). Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems Cell Metabolism, 37, 205-222.e6<br><a href="https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00401-7">https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00401-7</a><br>Argentieri, M.A et al. (2024). Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med <strong>30</strong>, 2450–2460.<a href="https://doi.org/10.1038/s41591-024-03164-7"> https://doi.org/10.1038/s41591-024-03164-7</a></p><p>Young blood factors infused into young mice<br>Villeda et al (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. 20:659-663. <a href="https://www.nature.com/articles/nm.3569">https://www.nature.com/articles/nm.3569</a></p><p>Single cell work with Stephen Quake<br>Pálovics et al (2022). Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature 603:309-314. <br><a href="https://www.nature.com/articles/s41586-022-04461-2">https://www.nature.com/articles/s41586-022-04461-2</a></p><p>Andrew Yang, Gladstone Institute labeling of hundreds of endogenous plasma proteins<br>Yang et al (2020). Physiological blood-brain transport is impaired with age by a shift in transcytosis. Nature 583: 425-430. <br><a href="https://www.nature.com/articles/s41586-020-2453-z">https://www.nature.com/articles/s41586-020-2453-z</a></p><p>Eric Topol episode with Tony on Ground Truths<br><a href="https://erictopol.substack.com/p/tony-wyss-coray-the-science-of-aging">https://erictopol.substack.com/p/tony-wyss-coray-the-science-of-aging</a></p><p>Mike Snyder’s team (Stanford) and the concept of Ageotypes<br>Ahadi S et al. (2020). Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nature Medicine. 2020;26:83–90. <a href="https://www.nature.com/articles/s41591-019-0719-5">https://www.nature.com/articles/s41591-019-0719-5</a></p><p>Preprint ahead of Nature Medicine paper Tony references coming out weeks after podcast episode<br>Ding et al (2026; preprint). Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease. bioRxiv <br><a href="https://www.biorxiv.org/content/10.64898/2026.02.10.704909v1">https://www.biorxiv.org/content/10.64898/2026.02.10.704909v1</a></p><p>Vero Biosciences: Founded with Tony where a consumer can have blood measured, which organs show accelerated aging with clinician input into potential interventions. <a href="https://www.verobioscience.com/">https://www.verobioscience.com/</a></p><p>Teal Rise: Founded with Tony, partnering with Olink that has collected a large database to drive model building across diseases and prediction. <a href="https://tealrise.com/">https://tealrise.com/</a></p><p>Heike A. Bischoff-Ferrari and the Do-Health Trial:<br>Bischoff-Ferrari et al (2025). Individual and additive effects of vitamin D, omega-3, and exercise on DNA methylation clocks of biological aging in older adults in the Do-Health trial. Nature Aging. 5: 376-385. <br><a href="https://www.nature.com/articles/s43587-024-00793-y">https://www.nature.com/articles/s43587-024-00793-y</a></p><p>Subscribe to the podcast on your favorite player or app:<br>Apple Podcasts:<a href="https://apple.co/3T0YbSm"> https://apple.co/3T0YbSm</a> </p><p>Spotify Podcasts: <a href="https://open.spotify.com/show/2sZ2wxOqI4b4vSngkajLs8">https://open.spotify.com/show/2sZ2wxOqI4b4vSngkajLs8</a></p><p>Amazon Music: <a href="https://music.amazon.com/podcasts/d97ace94-f02b-4b37-9532-799548ef2840/proteomics-in-proximity">https://music.amazon.com/podcasts/d97ace94-f02b-4b37-9532-799548ef2840/proteomics-in-proximity</a></p><p>Podcast Addict: <a href="https://podcastaddict.com/podcast/proteomics-in-proximity/4098296">https://podcastaddict.com/podcast/proteomics-in-proximity/4098296</a></p><p>Deezer: <a href="https://www.deezer.com/us/show/5178787">https://www.deezer.com/us/show/5178787</a></p><p>Proteomics in Proximity refers to the principle underlying Olink technology called the Proximity Extension Assay (PEA). More information about the assay and how it works can be found here: <a href="https://bit.ly/3Rt7YiY">https://bit.ly/3Rt7YiY</a> </p><p>Host: Cindy Lawley<br>Co-host: Sarantis Chlamydas<br>Executive Producer: Cindy Lawley<br>Editor: Fredrik Hamfelt, Phosworks<br>Project Manager: Eva Kellerman, Phosworks</p><p>For any questions regarding information Olink Proteomics, please email us at info@olink.com or visit our website: <a href="https://www.olink.com/">https://www.olink.com/</a></p>
September 9, 2025
From self-driving cars to self-caring people
<p>Welcome to the Olink® Proteomics in Proximity podcast! </p><p> </p><p>Below are some useful resources mentioned in this episode: </p><p> </p><p><strong>Olink tools and software</strong></p><p>· Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: <a href="https://olink.com/products-services/exploreht/">https://olink.com/products-services/exploreht/</a> </p><p> </p><p><strong>UK Biobank Pharma Proteomics Project (UKB-PPP)</strong>, one of the world’s largest scientific studies of blood protein biomarkers conducted to date, <a href="https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies">https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies</a> </p><p> </p><p>World Health Organization (2003). <a href="https://iris.who.int/handle/10665/42682">Adherence to long-term therapies: evidence for action</a> (PDF). </p><p>Geneva: World Health Organisation. <a href="https://en.wikipedia.org/wiki/ISBN_(identifier)">ISBN</a> <a href="https://en.wikipedia.org/wiki/Special:BookSources/978-92-4-154599-0">978-92-4-154599-0</a></p><p> </p><p><strong>Research articles and news</strong></p><p>· <strong>Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Study</strong></p><p><a href="https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx">https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx</a></p><p>· <a href="https://www.nature.com/articles/s41591-025-03798-1#auth-Hamilton_Se_Hwee-Oh-Aff1-Aff2-Aff3">Hamilton Se-Hwee Oh</a> et al 2025. Plasma proteomics links brain and immune system aging with healthspan and longevity<a href="https://www.nature.com/articles/s41591-025-03798-1">https://www.nature.com/articles/s41591-025-03798-1</a>. <a href="https://www.nature.com/nm">Nature Medicine</a> (2025)</p><p>· Song, Y., Abuduaini, B., Yang, X. et al. Identification of inflammatory protein biomarkers for predicting the different subtype of adult with tuberculosis: an Olink proteomic study. Inflamm. Res. <strong>74</strong>, 60 (2025). https://doi.org/10.1007/s00011-025-02020-9</p><p>· <a href="https://onlinelibrary.wiley.com/authored-by/Qureshi/Ferhan">Ferhan Qureshi</a> et al 2023. Analytical validation of a multi-protein, serum-based assay for disease activity assessments in multiple sclerosis. Proteomics clinical application 2023</p><p>· Dhindsa, R.S., Burren, O.S., Sun, B.B. et al. Rare variant associations with plasma protein levels in the UK Biobank. 2023 Nature, DOI: 10.1038/s41586-023-06547-x</p><p><a href="https://www.nature.com/articles/s41586-023-06547-x">https://www.nature.com/articles/s41586-023-06547-x</a></p><p>· Sun, B.B., Chiou, J., Traylor, M. et al. 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