一支穿云箭，千菌万码来相见！大家好，我是张禅跑。
尿液为什么是黄色的？血红素是怎么一步步被代谢，最终变成尿胆素并排出体外的？胆红素如果不能有效清除，会对身体造成什么样的影响？肠道微生物在血红素代谢中扮演了怎样不可替代的角色？什么是BilR酶，它是如何被发现并确认具有胆红素还原功能的？BilR在不同细菌和人群中分布如何？是否和疾病有关？新生儿为什么更容易发生黄疸？炎症性肠病患者是否存在胆红素代谢功能缺陷？为什么说这项研究填补了一个“百年未解”的科学空白？
今天介绍的文章是：BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen （BilR是一个将胆红素还原为尿胆原的肠道微生物酶）。在2024年1月发表于Nature Microbiology 《自然·微生物学》。
第一作者： Brantley Hall
通讯作者：Brantley Hall；江晓芳
通讯单位：马里兰大学；美国国立卫生研究院NIH
原文链接：https://www.nature.com/articles/s41564-023-01549-x (https://www.nature.com/articles/s41564-023-01549-x)
感谢您的收听！您还可以在小宇宙、QQ音乐、苹果播客、Spotify、Apple Podcasts、Youtube等平台找到我。您可以在小宇宙和Spotify评论，以及微信公众号私信给我留言提出宝贵意见！您还可以在爱发电平台搜索“千菌万码”以及在微信公众号“千菌万码”给我打赏，或者通过shownote单集简介末尾的支持链接进行订阅支持！谢谢大家！
支持这个播客：https://podcasters.spotify.com/pod/show/szhangjerry/support (https://podcasters.spotify.com/pod/show/szhangjerry/support)
Support this podcast: https://podcasters.spotify.com/pod/show/szhangjerry/support (https://podcasters.spotify.com/pod/show/szhangjerry/support)
18 Sept 2024
EP17: “天生痛风圣体”的人类，有肠道菌群默默守护！
一支穿云箭，千菌万码来相见！大家好，我是张禅跑。
痛风的根源是什么？为什么近年来中国高尿酸血症的患病率如此迅速攀升，已经成为继“三高”之后的“第四高”？人类为何在进化中失去了尿酸酶基因，导致我们成为“天生痛风圣体”？现有的降尿酸药物有哪些副作用，为什么需要探索新的降尿酸途径？肠道菌群如何在尿酸代谢中发挥了重要作用，能够帮助我们有效降低尿酸水平？斯坦福大学的最新研究如何揭示肠道细菌降解尿酸的潜在机制？中山大学的研究如何发现肠道细菌可以通过刺激宿主促进尿酸排泄？高尿酸血症和痛风患者如何通过饮食管理、体重管理和生活方式调整来有效控制症状？
今天介绍的文章1：一个广泛分布的基因簇弥补了灵长类动物中尿酸酶缺失的影响（A widely distributed gene cluster compensates for uricase loss in hominids）。在2023年8月发表于《细胞》Cell。
第一作者： Yuanyuan Liu
通讯作者：Dylan Dodd
通讯单位：斯坦福大学医学院
原文链接：https://www.cell.com/cell/fulltext/S0092-8674(23)00687-6 (https://www.cell.com/cell/fulltext/S0092-8674(23)00687-6)
今天介绍的文章2：由模糊另枝菌产生的马尿酸促进肠道尿酸排泄，从而缓解高尿酸血症（Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia）。在2024年2月发表于《细胞·宿主与微生物》Cell Host & Microbe。
第一作者： 许潆兮、刘鲁笛、朱江源
通讯作者：柳雁
通讯单位：中山大学公共卫生学院广东省营养膳食与健康重点实验室
原文链接：https://www.cell.com/cell-host-microbe/abstract/S1931-3128(24)00036-2 (https://www.cell.com/cell-host-microbe/abstract/S1931-3128(24)00036-2)
今天的分享就到这里了。感谢您的收听！您可以在小宇宙、QQ音乐、苹果播客、Spotify、Apple Podcasts、Google Podcasts等平台找到我。您可以在小宇宙APP和微信公众号私信给我留言提出宝贵意见！您还可以在爱发电平台搜索“千菌万码”以及在微信公众号“千菌万码”给我打赏，或者通过shownote单集简介末尾的支持链接进行订阅支持！谢谢大家！
支持这个播客：https://anchor.fm/szhangjerry/support (https://anchor.fm/szhangjerry/support)
Support this podcast: https://anchor.fm/szhangjerry/support (https://anchor.fm/szhangjerry/support)
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Support this podcast: https://podcasters.spotify.com/pod/show/szhangjerry/support (https://podcasters.spotify.com/pod/show/szhangjerry/support)
27 Aug 2024
SP16: Game On: How Borderlands 3 is Advancing Gut Microbiota Research
Microbial Matters, a podcast introducing latest microbiome research. Hi, I’m Jerry Zhang, a chemical biologist studying human microbiome. In this Podcast, I’m going to share with you newest advances in microbiome research, especially those related to human health.
Sarrazin-Gendron, R. et al. Improving microbial phylogeny with citizen science within a mass-market video game. Nat. Biotechnol. 1–9 (2024) doi:10.1038/s41587-024-02175-6.
Have you played Borderlands 3? Did you know that the in-game arcade mini-game, Borderlands Science, holds a hidden scientific treasure? Why is a podcast about gut microbiota talking about Borderlands 3? How are scientists using the mini-game Borderlands Science to tackle research challenges in gut microbiota? Why is sequence alignment so tough for AI but manageable for gamers? What are citizen science games? Which fields benefit from these games? How do video games and science come together? What is MMOS, and what are its goals and achievements?
Tune in to find out the surprising connection between gaming and gut microbiota research, and explore the fascinating world of citizen science games with us!
What Borderlands Science looks like:
https://raw.githubusercontent.com/ZJerryZ/Microbial_Matters_SP16/main/BLS.png (https://raw.githubusercontent.com/ZJerryZ/Microbial_Matters_SP16/main/BLS.png)
How to align two nucleotide sequences:
https://raw.githubusercontent.com/ZJerryZ/Microbial_Matters_SP16/main/alignment-EN.png (https://raw.githubusercontent.com/ZJerryZ/Microbial_Matters_SP16/main/alignment-EN.png)
Link to the original article: https://www.nature.com/articles/s41587-024-02175-6 (https://www.nature.com/articles/s41587-024-02175-6)
Support this podcast: https://anchor.fm/szhangjerry/support (https://anchor.fm/szhangjerry/support)
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Support this podcast: https://podcasters.spotify.com/pod/show/szhangjerry/support (https://podcasters.spotify.com/pod/show/szhangjerry/support)
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