by Zhenrun Jerry Zhang
一支穿云箭，千菌万码来相见！千菌万码是一档介绍最新肠道菌群研究的播客。Microbial Matters, a podcast introducing latest microbiome research.
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🇺🇲
Publishing Since
5/22/2022
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September 18, 2024
<p>一支穿云箭，千菌万码来相见！大家好，我是张禅跑。</p> <p>痛风的根源是什么？为什么近年来中国高尿酸血症的患病率如此迅速攀升，已经成为继“三高”之后的“第四高”？人类为何在进化中失去了尿酸酶基因，导致我们成为“天生痛风圣体”？现有的降尿酸药物有哪些副作用，为什么需要探索新的降尿酸途径？肠道菌群如何在尿酸代谢中发挥了重要作用，能够帮助我们有效降低尿酸水平？斯坦福大学的最新研究如何揭示肠道细菌降解尿酸的潜在机制？中山大学的研究如何发现肠道细菌可以通过刺激宿主促进尿酸排泄？高尿酸血症和痛风患者如何通过饮食管理、体重管理和生活方式调整来有效控制症状？</p> <p><br></p> <p>今天介绍的文章1：一个广泛分布的基因簇弥补了灵长类动物中尿酸酶缺失的影响（A widely distributed gene cluster compensates for uricase loss in hominids）。在2023年8月发表于《细胞》Cell。</p> <p>第一作者： Yuanyuan Liu</p> <p>通讯作者：Dylan Dodd</p> <p>通讯单位：斯坦福大学医学院</p> <p>原文链接：<a href="https://www.cell.com/cell/fulltext/S0092-8674(23)00687-6">https://www.cell.com/cell/fulltext/S0092-8674(23)00687-6</a></p> <p><br></p> <p>今天介绍的文章2：由模糊另枝菌产生的马尿酸促进肠道尿酸排泄，从而缓解高尿酸血症（Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia）。在2024年2月发表于《细胞·宿主与微生物》Cell Host & Microbe。</p> <p>第一作者： 许潆兮、刘鲁笛、朱江源</p> <p>通讯作者：柳雁</p> <p>通讯单位：中山大学公共卫生学院广东省营养膳食与健康重点实验室</p> <p>原文链接：<a href="https://www.cell.com/cell-host-microbe/abstract/S1931-3128(24)00036-2">https://www.cell.com/cell-host-microbe/abstract/S1931-3128(24)00036-2</a></p> <p><br></p> <p>今天的分享就到这里了。感谢您的收听！您可以在小宇宙、QQ音乐、苹果播客、Spotify、Apple Podcasts、Google Podcasts等平台找到我。您可以在小宇宙APP和微信公众号私信给我留言提出宝贵意见！您还可以在爱发电平台搜索“千菌万码”以及在微信公众号“千菌万码”给我打赏，或者通过shownote单集简介末尾的支持链接进行订阅支持！谢谢大家！</p> <p>支持这个播客：<a href="https://anchor.fm/szhangjerry/support">https://anchor.fm/szhangjerry/support</a></p> <p>Support this podcast: <a href="https://anchor.fm/szhangjerry/support">https://anchor.fm/szhangjerry/support</a></p> --- Support this podcast: <a href="https://podcasters.spotify.com/pod/show/szhangjerry/support" rel="payment">https://podcasters.spotify.com/pod/show/szhangjerry/support</a>
August 27, 2024
<p>Microbial Matters, a podcast introducing latest microbiome research. Hi, I’m Jerry Zhang, a chemical biologist studying human microbiome. In this Podcast, I’m going to share with you newest advances in microbiome research, especially those related to human health.</p> <p><br></p> <p>Sarrazin-Gendron, R. <em>et al.</em> Improving microbial phylogeny with citizen science within a mass-market video game. <em>Nat. Biotechnol.</em> 1–9 (2024) doi:10.1038/s41587-024-02175-6.</p> <p><br></p> <p>Have you played Borderlands 3? Did you know that the in-game arcade mini-game, Borderlands Science, holds a hidden scientific treasure? Why is a podcast about gut microbiota talking about Borderlands 3? How are scientists using the mini-game Borderlands Science to tackle research challenges in gut microbiota? Why is sequence alignment so tough for AI but manageable for gamers? What are citizen science games? Which fields benefit from these games? How do video games and science come together? What is MMOS, and what are its goals and achievements?</p> <p>Tune in to find out the surprising connection between gaming and gut microbiota research, and explore the fascinating world of citizen science games with us!</p> <p>What Borderlands Science looks like:</p> <p><a href="https://raw.githubusercontent.com/ZJerryZ/Microbial_Matters_SP16/main/BLS.png">https://raw.githubusercontent.com/ZJerryZ/Microbial_Matters_SP16/main/BLS.png</a></p> <p>How to align two nucleotide sequences:</p> <p><a href="https://raw.githubusercontent.com/ZJerryZ/Microbial_Matters_SP16/main/alignment-EN.png">https://raw.githubusercontent.com/ZJerryZ/Microbial_Matters_SP16/main/alignment-EN.png</a></p> <p><br></p> <p>Link to the original article: <a href="https://www.nature.com/articles/s41587-024-02175-6">https://www.nature.com/articles/s41587-024-02175-6</a></p> <p>Support this podcast: <a href="https://anchor.fm/szhangjerry/support">https://anchor.fm/szhangjerry/support</a></p> --- Support this podcast: <a href="https://podcasters.spotify.com/pod/show/szhangjerry/support" rel="payment">https://podcasters.spotify.com/pod/show/szhangjerry/support</a>
July 31, 2024
<p>一支穿云箭，千菌万码来相见！大家好，我是张禅跑。</p> <p>今天介绍的文章是：Improving microbial phylogeny with citizen science within a mass-market video game （通过大众市场电子游戏中的公众科学改进微生物种系发生学）。在2024年4月发表于《自然·生物技术》。</p> <p>第一作者： Roman Sarrazin-Gendron</p> <p>通讯作者：Jérôme Waldispühl </p> <p>通讯单位：McGill University 麦吉尔大学</p> <p>你玩过《无主之地3》这款游戏吗？游戏中的内置街机小游戏“无主之地·科学”竟然另有乾坤？为什么一个讲肠道菌群的播客会提到《无主之地3》这款游戏？科学家们是如何利用“无主之地·科学”小游戏来解决肠道菌群科研问题的？为什么序列比对的任务对人工智能来说困难重重，而游戏玩家可以更好地完成？公众科学游戏是什么？你知道有哪些领域受益于公众科学游戏吗？电子游戏与科学结合有哪些具体的结合方式？MMOS是一个什么样的组织？它的目标和成就是什么？</p> <p><br></p> <p>今天的分享就到这里了。感谢您的收听！您可以在小宇宙和Spotify评论，或者微信公众号私信给我留言提出宝贵意见！您还可以在爱发电平台搜索“千菌万码”以及在微信公众号“千菌万码”给我打赏，或者通过shownote单集简介末尾的支持链接进行订阅支持！谢谢大家！</p> <p><br></p> --- Support this podcast: <a href="https://podcasters.spotify.com/pod/show/szhangjerry/support" rel="payment">https://podcasters.spotify.com/pod/show/szhangjerry/support</a>
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