Welcome to the SELF Principle Podcast with Dr. Sean Hashmi—a board-certified nephrologist and obesity medicine specialist helping you live longer through evidence-based medicine. SELF stands for Sleep, Exercise, Love, and Food—the four pillars of lasting health. Each episode breaks down complex medical research into practical strategies for metabolic health, kidney protection, and longevity. No fads. No hype. Just science you can trust. Dr. Hashmi's YouTube channel has helped over 110,000 people take control of their health. Now he's bringing that same evidence-based approach to your ears.
Sean Hashmi, MD
Claim This Podcastby Sean Hashmi, MD
5.0(3 reviews)
76 episodes
Updated Daily
Accepts GuestsHas Sponsors
Podcast Overview
Welcome to the SELF Principle Podcast with Dr. Sean Hashmi—a board-certified nephrologist and obesity medicine specialist helping you live longer through evidence-based medicine. SELF stands for Sleep, Exercise, Love, and Food—the four pillars of lasting health. Each episode breaks down complex medical research into practical strategies for metabolic health, kidney protection, and longevity. No fads. No hype. Just science you can trust. Dr. Hashmi's YouTube channel has helped over 110,000 people take control of their health. Now he's bringing that same evidence-based approach to your ears.
Language
🇺🇲
Publishing Since
4/29/2025
1 verified contact email on file for Sean Hashmi, MD
Pitch yourself as a guest, propose sponsorships, or reach out directly to the host.
Recent Episodes
July 26, 2026
This Sign Means Your Kidneys Are Already Damaged
<p>Your kidneys can lose more than half their function and never once make you feel sick. Nephrologist Dr. Sean Hashmi walks through the real warning signs of kidney disease, including the ones almost everyone misses because they blame them on something else.</p><p>Fewer than one in 20 people with early kidney disease are aware they have it, because kidneys are built with so much spare filtering capacity that blood tests can look normal while damage quietly continues underneath. </p><p>Dr. Hashmi covers the eight warning signs to watch for as a cluster, from swelling and foamy urine to washed-out fatigue and itchy skin, the visible signs on your ankles, eyes, and nails and why they show up late, and the sign people miss completely: rising blood pressure. He also explains why diabetes and high blood pressure cause about half of all kidney disease with zero symptoms, and the two simple tests, a blood test for creatinine and a urine albumin-to-creatinine ratio, that catch kidney damage years before any symptom appears.</p><p><br></p><p>References:<br>Gong J, Vaduganathan M, Wadhera RK. Chronic kidney disease prevalence and awareness among US adults. JAMA Cardiol. 2026;11(1):77-81.<br>Romagnani P, Agarwal R, Chan JCN, et al. Chronic kidney disease. Nat Rev Dis Primers. 2025;11(1):8.<br>Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V. Chronic kidney disease. Lancet. 2021;398(10299):786-802.<br>KDIGO CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S):S117-S314.</p><p><br></p><p>Want the evidence-based breakdowns in writing? Sign up for the free weekly newsletter at selfprinciple.org/newsletter.</p><p><br></p><p>The information in this content is for educational purposes only and does not constitute medical advice. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. The views expressed here are my own and do not represent the views of my employer or any affiliated institution.</p><p><br></p><p>Practice kindness and gratitude.</p><p>Dr.Sean</p>
July 20, 2026
Do Proton Pump Inhibitors Cause Kidney Disease?
<p>Do heartburn pills like omeprazole really damage your kidneys? Nephrologist Dr. Sean Hashmi breaks down what the actual research found, how big the risk really is, and who carries it versus who barely does.</p><p>Large observational studies do show a higher rate of chronic kidney disease in people who take proton pump inhibitors daily for years, roughly 26 to 50 percent higher depending on the study. But that number is smaller than it sounds once it's anchored in real numbers, and every one of these studies is observational, meaning it cannot prove the pill itself is the cause rather than the reasons someone was prescribed it in the first place. Dr. Hashmi explains the research trap called confounding by indication, the one kidney injury from these drugs that is not a myth, and why dose and time, not the single pill, are what actually drive the risk. He also covers the safe, planned way to taper off a proton pump inhibitor without acid rebound, and who genuinely needs to stay on one.</p><p><br></p><p>References:<br>Lazarus B, et al. Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern Med. 2016;176(2):238-246.<br>Ang SP, et al. Association between proton pump inhibitor use and risk of incident chronic kidney disease. Biomedicines. 2024;12(7):1414.<br>Rajan P, et al. The association between proton pump inhibitor use and the risk of adverse kidney outcomes. Therap Adv Gastroenterol. 2022;15:17562848221074183.<br>Praga M, González E. Acute interstitial nephritis. Kidney Int. 2010;77(11):956-961.</p><p><br></p><p>Want the evidence-based breakdowns in writing? Sign up for the free weekly newsletter at selfprinciple.org/newsletter.</p><p><br></p><p>The information in this content is for educational purposes only and does not constitute medical advice. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. The views expressed here are my own and do not represent the views of my employer or any affiliated institution. Never start, stop, or change the dose of any prescription medication without consulting your physician.</p><p><br></p><p>Practice kindness and gratitude.</p><p>Dr.Sean</p>
July 19, 2026
Can Kidney Disease Be Reversed? Here's What Really Happens
<p>Can kidney disease be reversed? A five-year study in PLOS Medicine found that about one in five people with kidney disease saw their numbers return to the normal range. Nephrologist Dr. Sean Hashmi explains what that finding actually means, and why it is different from the "reverse it naturally" promises flooding your feed.</p><p>You cannot regrow kidney filters that have scarred or died, and chronic kidney disease has no cure. But the two numbers that define kidney health, your filtering score and the protein in your urine, can genuinely improve. Dr. Hashmi walks through the four things the evidence says actually move those numbers: controlling blood pressure and blood sugar, the two medication classes proven in the DAPA-CKD and EMPA-KIDNEY trials to slow kidney decline, treating fixable underlying causes, and a plant-predominant, low-salt eating pattern. He also flags the supplement claims that can push potassium or phosphorus to dangerous levels, and addresses the popular claim that blood pressure medications harm the kidneys.</p><p><br></p><p>References:<br>Shardlow A, et al. Chronic kidney disease in primary care: outcomes after five years. PLoS Med. 2016;13(9):e1002128.<br>Heerspink HJL, et al. Dapagliflozin in patients with chronic kidney disease. N Engl J Med. 2020;383(15):1436-1446.<br>The EMPA-KIDNEY Collaborative Group. Empagliflozin in patients with chronic kidney disease. N Engl J Med. 2023;388(2):117-127.<br>Kalantar-Zadeh K, et al. Chronic kidney disease. Lancet. 2021;398(10299):786-802.</p><p>Want the evidence-based breakdowns in writing? Sign up for the free weekly newsletter at selfprinciple.org/newsletter.</p><p><br></p><p>The information in this content is for educational purposes only and does not constitute medical advice. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. The views expressed here are my own and do not represent the views of my employer or any affiliated institution. Never start, stop, or change the dose of any prescription medication without consulting your physician.</p><p><br></p><p>Practice kindness and gratitude.</p><p>Dr. Sean</p>
76 total episodes available
Similar Podcasts
Discover related shows you might enjoy
Deep-dive analytics for Sean Hashmi, MD
Frequently asked questions
Have a different question and can't find the answer you're looking for? Reach out to our support team by sending us an email and we'll get back to you as soon as we can.
- What is Sean Hashmi, MD?
- How often does this podcast release new episodes?
This podcast updates daily.
- Where can I listen to this podcast?
This podcast is available on 4 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
- Does this podcast accept guests?
No, this podcast does not typically feature guests.
Legal Disclaimer
Pod Engine is not affiliated with, endorsed by, or officially connected with any of the podcasts displayed on this platform. We operate independently as a podcast discovery and analytics service.
All podcast artwork, thumbnails, and content displayed on this page are the property of their respective owners and are protected by applicable copyright laws. This includes, but is not limited to, podcast cover art, episode artwork, show descriptions, episode titles, transcripts, audio snippets, and any other content originating from the podcast creators or their licensors.
We display this content under fair use principles and/or implied license for the purpose of podcast discovery, information, and commentary. We make no claim of ownership over any podcast content, artwork, or related materials shown on this platform. All trademarks, service marks, and trade names are the property of their respective owners.
While we strive to ensure all content usage is properly authorized, if you are a rights holder and believe your content is being used inappropriately or without proper authorization, please contact us immediately at hey@podengine.ai for prompt review and appropriate action, which may include content removal or proper attribution.
By accessing and using this platform, you acknowledge and agree to respect all applicable copyright laws and intellectual property rights of content owners. Any unauthorized reproduction, distribution, or commercial use of the content displayed on this platform is strictly prohibited.