Straight Shot is the GLP-1 podcast for patients who want the real information, not the watered-down version. Dr. Clete Barrick is dual board-certified in internal medicine and obesity medicine, has treated more than 5,000 patients on GLP-1s, and has personally lost 100 lbs on tirzepatide. Each week he breaks down one focused topic: how these medications work, how to optimize your results, what your doctor isn't telling you, and what the science actually says. No guests. No fluff. No corporate script. Just the straight shot, from a doctor who lives it. New episodes weekly. Visit barrickhealth.com for physician-led weight loss care.
Publisher
Dr. Clete Barrick
Category
health & fitness · health & fitness · health & fitness
Let Dr. Barrick know what you think of the episode and send any questions his way too! Is your GLP-1 making your hair fall out? This episode covers hair loss and what to do about it, burning skin on high doses, injection-site reactions, Ozempic face, loose skin and body contouring surgery, psoriasis, hidradenitis and skin cancer. Ending with a verdict, built from a full literature review. Dr. Clete Barrick is board-certified in internal medicine and obesity medicine. Straight Shot Season 2 ...
2 Nov 2026
GLP-1s & the Immune System
Let Dr. Barrick know what you think of the episode and send any questions his way too! Does a GLP-1 weaken your immune system? This episode covers infections, COVID, sepsis, shingles, surgery, inflammation, autoimmune disease, allergic reactions, transplant medicines, HIV and vaccines. Ending with a verdict, built from a full literature review. Dr. Clete Barrick is board-certified in internal medicine and obesity medicine. Straight Shot Season 2 goes through the body one system at a time. ...
26 Oct 2026
GLP-1s & the Endocrine System
Let Dr. Barrick know what you think of the episode and send any questions his way too! Every GLP-1 carries a black box warning about thyroid cancer. Should it worry you? This episode covers the thyroid cancer data, why screening ultrasounds backfire, your thyroid pill, prediabetes, low blood sugar on insulin and other diabetes medicines, type 1 diabetes, ketoacidosis, bariatric surgery, your adrenal glands and genetic causes of obesity. Ending with a verdict, built from a full literature revi...
19 Oct 2026
GLP-1s & the Respiratory System
Let Dr. Barrick know what you think of the episode and send any questions his way too! Zepbound is now FDA-approved for sleep apnea. Can you finally put the CPAP away? This episode covers what GLP-1s do for sleep apnea, why the sleep study should come before the shot, what happens if you stop, and the evidence on asthma, COPD, lung function, lung cancer and breathing side effects. Ending with a verdict, built from a full literature review. Dr. Clete Barrick is board-certified in internal me...
12 Oct 2026
GLP-1s & the Musculoskeletal System
What do GLP-1s do to your bones, muscles and joints? Today we cover muscle loss, bone density, fractures, knee arthritis, joint replacement, gout and tendons, plus a verdict, built from a full literature review. Dr. Clete Barrick, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is your musculoskeletal system. The GLP-1 Bible, preorder now: https://barrickhealth.com/glp1-bible Free first visit with Dr...
6 Oct 2026
GLP-1s & the Reproductive System
What do GLP-1s do to your reproductive health? Today we cover birth control, pregnancy, polycystic ovary syndrome (PCOS), menopause and testosterone, plus a verdict, built from a full literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is reproductive health, for women and men. The GLP-1 Bible, preorder now: barrickhealth.com/glp1-bible Free first visit with Dr. B...
28 Sept 2026
GLP-1s & the Gut
What do GLP-1s do to your gut? Today we cover the everyday side effects, the rare ones, what helps, and a verdict, built from a full literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is the gut. In this episode: - The everyday side effects: nausea in 44% at 2.4 mg of Wegovy, vomiting or constipation in about 1 in 4, almost all mild and tied to dose increases - T...
21 Sept 2026
GLP-1s & the Brain
What do GLP-1s do to your brain? Today we cover brain benefits, harms, and a verdict, built from a full literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is the brain. In this episode: - How a GLP-1 reaches your brain: semaglutide does not cross the blood-brain barrier, so its strongest effects are on appetite and reward and its weakest are on memory - Stroke: 1...
13 Sept 2026
GLP-1s & The Kidneys
What do GLP-1s do to your kidneys? Today we cover the benefits, harms, and a verdict, built from a full literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is the kidney. In this episode: - FLOW, the only trial in this class built to test the kidney: semaglutide cut kidney failure, 50% filtration loss, or kidney and heart death 24% in 3,533 people with type 2 diab...
6 Sept 2026
GLP-1s & the Heart
What do GLP-1s do to your heart? Today we cover cardiac benefits, harms, and a verdict, built from a full literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is the heart. In this episode: - Heart-safety trials the Food and Drug Administration (the FDA) required showed protection instead: heart attacks, strokes, and cardiovascular deaths down 14% across ten trials...
30 Aug 2026
GLP-1s and Your Liver: Benefits, Risks, Verdict
What do GLP-1s do to your liver? We cover the benefits, harms, and a verdict, all built from a 94-source literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, founder of Barrick Health, 5,000+ GLP-1 patients, 95 lbs lost on tirzepatide, opens Season 2 of Straight Shot: every organ, one episode at a time, starting with the liver. In this episode: - Fatty liver by its new names, metabolic dysfunction-associated steatotic liver disease (MASLD)...
18 May 2026
ECO 2026: 5 Studies That Will Change How You Use GLP-1s
Twelve thousand researchers. Hundreds of presentations. Five studies that matter. Dr. Clete Barrick breaks down the most important GLP-1 research presented at the European Congress on Obesity 2026 in Istanbul, and what each finding means for patients on Ozempic, Wegovy, Mounjaro, and Zepbound right now. He covers the new higher-dose Wegovy data (7.2 mg), the maintenance dosing trial Zepbound patients have been waiting for, what happens when you switch from an injection to an oral pill, the re...
3 May 2026
Foundayo vs. Oral Wegovy: Which GLP-1 Pill Should You Actually Take?
There are now two FDA-approved GLP-1 pills for weight loss, and they are not the same drug. Dr. Clete Barrick (board-certified in internal medicine and obesity medicine) breaks down the side-by-side: the chemistry, the dosing rules, the weight loss data, the side effects, the cost, and which patient profile fits each pill. What you'll learn: - Why Foundayo (orforglipron) and oral Wegovy (semaglutide 25 mg) are pharmacologically different drugs, not just two brands of the same thing - The mor...
26 Apr 2026
The "Hidden" GLP-1 Side Effects Study: What Every Headline Got Wrong
A new study in Nature Health used AI to scan over 400,000 Reddit posts from 67,000 GLP-1 users and uncovered side effects that aren't on the label. Fox News, CNN, and Medscape ran the same headline: "hidden side effects doctors are missing." Dr. Clete Barrick, board-certified in internal medicine and obesity medicine, prescribes these medications every day and takes tirzepatide himself. In this episode, he walks through what the University of Pennsylvania researchers actually found, why the m...
11 Apr 2026
Semaglutide vs. Tirzepatide: A Doctor's Honest Comparison
Semaglutide or tirzepatide? Ozempic or Mounjaro? It's the most asked question in GLP-1 medicine, and Dr. Clete Barrick has prescribed both to over 5,000 patients. In this episode, he covers the real differences between single and dual agonist medications, the head-to-head SURMOUNT-5 trial results, side effect profiles (including the birth control interaction most providers miss), who actually does better on which medication, and why the best GLP-1 is the one you can afford to stay on. He also...
7 Apr 2026
How GLP-1s Actually Work (in Plain English)
Your body already makes GLP-1 every time you eat. The problem? Natural GLP-1 lasts about two minutes before an enzyme destroys it. Semaglutide and tirzepatide are engineered to do the same job, just louder and longer. Dr. Clete Barrick breaks down how these medications work at three job sites: your pancreas, your stomach, and (most importantly) your brain. He explains the difference between homeostatic hunger and hedonic hunger, why GLP-1s quiet "food noise" through the brain's reward circuit...
6 Apr 2026
Episode 1: Welcome to Straight Shot
Dr. Clete Barrick is dual board-certified in internal medicine and obesity medicine, has treated thousands of GLP-1 patients going on five years, and has personally lost over 80 pounds on tirzepatide. In this premiere episode of Straight Shot, he tells the full story: how a Navy physician couldn't outrun his own biology, what changed when the food noise went quiet, and why he built this show. He also breaks down the problem he sees every day: patients being mismanaged on GLP-1s by providers r...
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Apple Podcasts (US)
5.0 / 5
1 ratings
Spotify
5.0 / 5
1 ratings
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