Take ownership of your long-term health and fitness with Metabolic Edge. Hosted by Dr. Andrew Appleton- distinguished Internal Medicine Specialist and Assistant Professor at Western University, and Tommy Caldwell, bestselling author & high-performance coach, this podcast uncovers the root causes of lifestyle-driven diseases that plague our communities. From heart disease to cancer to neurological disorders , our health is intricately linked to our cardiometabolic health. Learn how to optimize yours so you can live long and strong.
Key Topics Covered
The Next Frontier in Weight Loss: GLP-1s & Myostatin Inhibitors
The Muscle Loss Problem: While GLP-1 receptor agonists (like Tirzepatide) are highly effective for weight loss, roughly 25% to 30% of the weight lost is actually lean body mass (muscle).
The Pharmaceutical Solution: A recent Phase II clinical trial paired a GLP-1 drug with a myostatin inhibitor (which blocks the protein that caps muscle growth), successfully promoting lean mass development while shedding fat.
The Practical Alternative: The hosts emphasize that resistance training and adequate protein intake achieve these exact same muscle-preserving results naturally, though large-scale studies on this are rarely funded because "you can't package and sell" exercise.
The "Enhanced Games" & Tech-Bro Gladiators
A critique of the upcoming "Enhanced Games"—an Olympic-style event where performance-enhancing drugs are openly allowed.
Using baseball's historic steroid era (e.g., Mark McGwire and Sammy Sosa) as an example, they discuss how performance enhancers amplify raw power margins without actually replacing foundational athletic coordination.
A humorous look at the logical extreme of this trend: transitioning from myostatin inhibitors to full-blown CRISPR genetic engineering, drawing parallels to the movie Gattaca.
The Rise of "Wellness Burnout"
Wellness Maxing: The multi-billion-dollar wellness industry has created a exhausting "firehose" of protocols, leaving people overwhelmed by red-light masks, cold plunges, complex morning supplement "stacks," and hyper-optimized mattress coolers.
The Power of Subtraction: The hosts advocate for simplifying your health routine rather than adding to it. They recommend automating simple meal choices, hitting a baseline of 20 minutes of daily exercise, and finding community-based, accountable activities like pickleball to naturally reduce stress and fight social isolation.
10 Jun 2026
Ep.58: The truth about peptides
Andrew and Tommy return from a long hiatus to discuss the rising popularity of peptides for weight loss, muscle gain, and various other health hacks.
19 Jul 2025
Ep.57- Using your brain to control your diet
What does the latest psychological research say about controlling your poorest eating habits? What simple strategies can you use to begin taking control of your diet? Tommy and Andrew answer these questions in the latest episode.
Follow this link (https://docs.google.com/forms/d/e/1FAIpQLSfJKEDhX5M6mNkX8T0MDINVoccwSo5W84zsINAdUNGxWHGmGQ/viewform) to apply for our medically integrated 12-week Immersion Weight Loss Program
Reach and audience
Public platform figures. Ratings count people who left a rating, not total listeners.
Spotify
4.7 / 5
15 ratings
Podcast Authority Score: 51 / 100
A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.
Quality
69
Social presence
0
YouTube
0
Engagement
82
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