Unstoppable Brain with Dr. Kyra Bobinet

About Unstoppable Brain with Dr. Kyra Bobinet

You have the goals, the checklists, and the ambition. Yet, there is a pesky gap between the person you are and the version of yourself that you aspire to be. If you’ve ever felt like you’re fighting an invisible headwind in your health, your habits, or your career, it’s not a character flaw. It’s a brain trap. Welcome to Unstoppable Brain, a sanctuary of clarity in an era of ruptured attention and optimization burnout. Hosted by Kyra Bobinet, MD-MPH— physician and behavior researcher, trained at Harvard, UCSF, Stanford, and CEO of Fresh Tri—this show marks the end of the "performative" era and the beginning of the Iterative Mindset. Each week, we cool the friction of being human and empower you through stories and practical science: • The Trend-Check: We cut through the noise of wellness fads and click-bait science. Dr. Bobinet, with her sharp-witted co-host, pressure-tests the latest trends and peer-reviewed papers, debunking the junk and translating real science into a clear, actionable roadmap for your week. • The Master Class: We go behind the scenes interviewing world-class innovators, clinicians, and creators who have abandoned the performance trap to iterate their way through profound struggle and into lives of purpose. • The Science of You: Drawing on Dr. Bobinet’s decades of work—from wilderness therapy with incarcerated youth to leading health innovation for 30 million people—we explore what unlocks your potential through the lens of the brain, the habenula (your brain’s master switch for all you do or feel), and how the Iterative Mindset is the ultimate protective factor against getting stuck. Stop fighting your brain. Start leading it. Whether you are navigating a high-stakes career pivot, reclaiming your vitality, or simply looking to find your footing in an overstimulating world, Unstoppable Brain provides the hard science and relatable storytelling to help you become truly unstoppable.

Publisher

Kyra Bobinet

Category

health & fitness · health & fitness · health & fitness

Language

en

Explicit

No

First episode

26 Mar 2026

Latest episode

21 Oct 2026

Latest episodes

8 episodes in the feed.

1. 

   21 Oct 2026

   Steve Ramirez: How Memory Shapes Grief, Addiction & Who You Are

   What if your memories aren't recordings of the past, but edits you rewrite every time you recall them? On this episode of Unstoppable Brain, Dr. Kyra Bobinet sits down with Steve Ramirez, neuroscientist and associate professor of psychological and brain sciences at Boston University and author of How to Change a Brain. Steve is known for pioneering research on manipulating memories in the brain, which he started with his late lab partner and friend, Xu Liu. Steve talks openly about losing Xu at 37, the drinking that followed, and the intervention by his wife and childhood best friends that saved his life. He explains how recovery taught him that "the opposite of addiction is connection," and how building new positive memories helped him grow a life around his grief. They also get into the science: why every recall changes a memory a little, how psychedelic-assisted therapy may hold the memory "file" open longer for editing, what engrams are, why lost memories may still be in the brain (the library is intact, but the librarian is on strike), and how short-form content and the attention economy are affecting our memory and decisions. If you've been through loss, are working on changing a habit, or just want to understand how your brain builds who you are, this conversation is for you. What you'll learn • Why a single memory can move you to tears or euphoria in seconds, and affect your whole body • How grief works like a fixed bubble that a bigger life can grow around • Why Steve says the opposite of addiction is connection, and what finally helped him get sober • How recalling a memory is like hitting "Save As" on a Word file, and why every recall changes it • How psychedelic-assisted therapy may help people work with memories that are "too hot to touch" • The ethics of memory manipulation, from clinical healing to social media ads • What an engram is, and why memory works like a 3D web or a symphony instead of one spot in the brain • Why the brain may use memories mainly to predict the future • How "lost" memories in Alzheimer's, addiction and childhood amnesia have been restored in research • How short-form content affects attention and memory, and the "fast food" way to think about it • Why flawed memory is a reason to give each other more grace and curiosity in arguments Time Stamps 00:30 Welcome and introduction to Dr. Steve Ramirez 01:30 Why scientists talk in jargon 03:00 The main message of How to Change a Brain 04:15 Honoring Xu Liu, Steve's late lab partner 05:00 Death as a teacher: Kyra's story of losing a friend 06:45 We all become memories 08:30 How Xu's legacy lives on in the science 09:30 Using grief to help others 10:30 Trauma, PTSD and the hippocampus 12:45 "One plus one equals three": the partnership with Xu 14:45 Losing Xu and the slide into drinking 17:30 The intervention that saved his life 18:00 Recovery Elevator and "the opposite of addiction is connection” 19:30 COVID drinking as collective grief 21:00 Emotion and memory: Antonio Damasio 21:45 Growing your life around grief 23:15 Seeing life "in 4K with sober eyes” 24:15 Building positive memories after loss 26:30 Therapy, language and naming feelings 27:00 Psychedelic-assisted therapy and "too hot" memories 29:00 Eternal Sunshine and the ethics of erasing memories 29:30 Recalling a memory is like hitting "Save As” 32:00 Ethical vs. manipulative uses of memory science 33:45 Myth or fact: do memories change every time we recall them? 36:00 Memory as the brain's best prediction 37:45 What is an engram? 40:15 Can you lose your sense of self without a hippocampus? 41:45 Are we the same person over time? 43:45 What is the "DNA of...

2. 

   2 Jul 2026

   Dr. Kyra Answers Your Questions About Habits, Cravings, and Change

   Why do we know exactly what we should do, then still fail to do it? In this season finale of Unstoppable Brain, Dr. Kyra Bobinet answers viewer questions with special guest Isabella Allen.Together, they explore the neuroscience behind the “know-do gap,” why motivation breaks down, how the habenula acts as the brain’s behavioral brake, and why habits, addiction, procrastination, stress, and self-sabotage are all connected. Dr. Kyra explains why your brain may stop you from taking action, how doom scrolling and snoozing can become addictive loops, and why relying on panic and deadlines can wear you down over time. She also breaks down the surprising connection between GLP-1s, cravings, addiction, the vagus nerve, acetylcholine, genetics, trauma, and behavior change. This episode is a practical and science-backed Q&A for anyone who wants to understand why change feels so hard, and how to work with the brain instead of fighting it.Learn how to close the gap between what you know you should do and what you actually do. What You’ll Learn • Why there’s a gap between knowing what to do and actually doing it • How the habenula acts as the “brake” on behavior • Why your phone can hijack your morning routine • How stress and panic become a productivity trap • Why self-compassion helps the “doer” follow through • How the habenula helps you stop wasting effort and start iterating • The possible connection between GLP-1s, cravings, and addiction • How the vagus nerve may relate to behavior change • Why trauma, genetics, and environment can shape motivation • What Dr. Kyra learned from season one of Unstoppable Brain Chapters 00:30 Intro: A Season Finale Q&A 00:47 Why Do We Know What To Do But Still Don’t Do It? 01:06 The Know-Do Gap Explained 02:05 What Is the Habenula? 03:00 Why Your Brain Hits the Brakes 04:41 How to Stop Morning Doom Scrolling 06:02 Why Deadlines and Panic Drive Productivity 07:35 The Planner vs. The Doer 08:41 How Rewards Help You Take Action 09:49 Is There Anything Positive About the Habenula? 10:45 What Rats Teach Us About Failure and Iteration 12:45 GLP-1s, Addiction, and Cravings 13:50 How GLP-1s May Quiet the Habenula 17:13 The Vagus Nerve and the Habenula 18:23 Acetylcholine, Calm, and Habit Change 20:18 Are Brain Behaviors Learned or Genetic? 21:25 Trauma, Epigenetics, and a Sensitive Habenula 24:00 Dr. Kyra’s Biggest Takeaway From Season One 25:16 Closing Thoughts and Season Two Tease

3. 

   18 Jun 2026

   Marcus Buckingham: Why Love Is the Most Powerful Force in Business

   What happens when businesses start treating people like resources instead of human beings?  In this episode of Unstoppable Brain, Dr. Kyra Bobinet sits down with bestselling author and performance researcher Marcus Buckingham to explore the business case for love. Drawing from his new book, Design Love In, Marcus explains why love is far more than a soft idea. It is a measurable force that shapes employee engagement, customer loyalty, resilience, productivity, and long-term business value. Marcus shares why people need “red threads” in their workday, how leaders can create stronger connections with remote teams, and why weekly check-ins can have a major impact on performance. He also examines the growing role of artificial intelligence in the workplace and asks a crucial question: Can AI help humans flourish, or are companies using it in ways that damage the customer experience? You’ll learn: • Why love is a serious business metric • How to identify the work that gives you energy • Why employees need at least 20% “red threads” in their day • How leaders can build connection across remote teams • The five feelings that create loving experiences • Why AI struggles to replace genuine human care • How to handle difficult leadership decisions with compassion Marcus Buckingham is a leading authority on human strengths and performance. He is the bestselling author of First, Break All the Rules, Love + Work, and Design Love In. Subscribe to Unstoppable Brain for more conversations that turn neuroscience into practical strategies for behavior change and a better life. 00:00 Cold Open 00:45 Introducing Marcus Buckingham 02:07 Why Love Is the Most Powerful Force in Business 05:31 Why Business Leaders Avoid the Word “Love” 06:40 What Marcus Learned After Selling His Company 09:40 Love Is Oxygen 10:14 Finding Your Red Threads at Work 12:39 How Love Changes Your Brain 13:34 Why You Need 20% Red Threads in Your Day 17:10 You Can’t Love What You Can’t See 18:15 The Weekly Check-In Every Manager Should Use 20:45 How Remote Teams Build Real Connection 23:20 The Five Feelings That Create Love 25:03 Control, Harmony, and Significance 28:07 Why People Need the Warmth of Others 29:44 Growth, Learning, and Loyalty 34:49 What Love Really Means 36:44 When Firing Someone Can Be an Act of Love 39:31 Can Humans Love AI? 42:03 Can AI Love Humans? 43:25 Is AI Damaging the Customer Experience? 48:27 Will AI Crush Human Connection? 52:08 The Data Behind the Business Case for Love 57:00 Why Business Schools Overlook Love 58:00 Love, Motivation, and the Habenula 01:07:00 How to Fire Someone Lovingly 01:11:50 Final Takeaways

4. 

   4 Jun 2026

   Dr. Joe Kvedar: Can AI Fix Healthcare Before the System Breaks?

   Traditional healthcare is struggling to keep up with the needs of patients. Telemedicine, wearable devices, AI, and digital health tools have created new ways to monitor our health and access care. Yet many patients still face long wait times, confusing systems, and limited access when they need an in-person appointment. In this episode of Unstoppable Brain, Dr. Kyra Bobinet speaks with Dr. Joseph Kvedar, a professor of dermatology at Harvard Medical School, president of the American Telemedicine Association, and author of The Internet of Healthy Things and The New Mobile Age. Dr. Kvedar has spent decades studying the future of healthcare. He saw the rise of telemedicine and wearable technology long before either became mainstream. In this conversation, he explains where digital health has delivered on its promise, where the healthcare system has fallen short, and why some problems still require a human doctor in the room. The discussion covers the limits of AI in healthcare, the growth of telemedicine, the role of wearable devices such as Apple Watch and Oura Ring, the risks of private equity in medicine, and the growing complexity patients face when trying to get care. Dr. Kvedar also shares his prediction for the next major shift in healthcare: digital twins. A digital version of your body could one day help doctors test treatments, predict your response to medications, and create more personalized care. In this episode, you’ll learn: Why traditional healthcare still feels broken Where telemedicine improves the patient experience Why AI still has major limits in medicine How wearable technology gives doctors a fuller picture of your health Why motivation matters more than tracking alone How private equity can change the patient experience Why digital twins could shape the future of personalized medicine How innovators stay committed when their ideas are years ahead of the market Subscribe to Unstoppable Brain for practical conversations about neuroscience, behavior change, personal growth, and the tools that can help you build the life you want. Chapters 00:00 Why traditional healthcare still feels broken 00:15 Welcome to Unstoppable Brain 01:23 Predicting the rise of digital health 03:51 The early vision for a digital health assistant 05:00 The rise of wearables and the Oura Ring 05:40 Why healthcare can’t “move fast and break things” 08:17 The risks of AI tools without clinical research 10:50 Where AI performs well, and where it fails 13:37 Why digital health is having a major moment 14:33 Wearables give a continuous picture of your health 16:23 Has personalized medicine gone too far? 18:03 Longevity trends, hype, and scientific evidence 21:25 Why telemedicine pioneers felt like outsiders 23:02 Has digital health made care harder to navigate? 24:31 How patient portals improve access 26:28 The biggest failure of digital healthcare 30:17 Retail healthcare, Amazon, Ro, Hims, and Hers 32:16 Why patients choose telemedicine 34:15 The risks of private equity in healthcare 38:23 Why patients feel powerless inside the system 41:48 Why in-person healthcare still struggles 44:48 The digital side of healthcare is working 45:42 Why AI still can’t replace a physical exam 48:03 Wearables, motivation, and lasting behavior change 52:00 Advice for people challenging conventional thinking 55:35 The future of digital health 56:11 How digital twins could transform medicine

5. 

   21 May 2026

   Liz Tran: AQ, Adaptability, and the Future of Human Success

   What helps people thrive when everything keeps changing? In this episode of Unstoppable Brain, Liz Tran joins Dr. Kyra Bobinet for a deep conversation about adaptability, behavior change, and the skill set people need to survive in an unpredictable world. Liz explains why IQ and EQ no longer tell the full story, and why “AQ” or Agility Quotient may be the defining trait of modern leadership. Drawing from years coaching fast-growing tech CEOs, she breaks down the habits, mindsets, and emotional skills that help people navigate uncertainty without losing themselves. They discuss the neuroscience behind resistance to change, the importance of anchors and routines, how to recover faster after setbacks, and why discomfort is often the clearest sign of growth. The conversation also explores how personality shapes adaptability, the danger of perfectionism, why human connection matters more in an AI-driven world, and how learning to operate in uncertainty can transform your work, relationships, and identity.If you’ve felt overwhelmed by constant change, this episode offers a practical framework for staying grounded while continuing to grow. Topics Covered: What “AQ” means and why it matters Why successful founders constantly reinvent themselves The difference between IQ, EQ, and AQ How adaptability impacts leadership and performance The neuroscience of fear, failure, and resistance to change The four pillars of agility: Anchors, Bets, Classroom, and Discomfort Why routines and grounding habits matter How to recover faster after setbacks The danger of perfectionism and overplanning Human connection in an AI-driven world The four AQ archetypes and how they operate Why discomfort is a signal of growth How to build resilience during uncertainty Chapter Timestamps 00:00 Why adaptability matters more than ever 00:45 The founders who kept reinventing themselves 03:00 Why agility became the defining trait of success 05:00 The problem with fixed identities 08:00 Childhood pain, ambition, and achievement 12:00 Beginner’s mind and unlearning old patterns 14:40 Why AQ can grow over time 15:00 The neuroscience of resistance to change 18:00 Why people repeat the same mistakes 19:00 The importance of anchors and stability 21:00 Meditation, routines, and emotional grounding 24:00 Energy audits and managing depletion 29:00 The three types of anchors 31:30 Bets and learning to operate in uncertainty 35:00 Recovery rate vs. success rate 37:00 Why human connection matters more than ever 41:00 The AQ archetypes explained 44:00 The Astronaut vs. the Neurosurgeon 47:00 The Novelist vs. the Firefighter 51:00 Why life should feel like a classroom 55:00 Discomfort as a signal of growth 57:00 Fear, neuroscience, and adaptability

6. 

   7 May 2026

   Dr. Eva Selhub: The Truth About Resilience (It’s Not What You Think)

   What if stress isn’t the problem, but how your brain responds to it is? In this episode of Unstoppable Brain, Dr. Kyra Bobinet sits down with physician and resilience expert Eva Selhub to break down what’s actually happening in your brain when you feel overwhelmed, burned out, or stuck in unhealthy patterns. Dr. Selhub shares how stress rewires your brain, why resilience is often misunderstood, and how small daily shifts can help you regain control. You’ll learn: Why resilience is not about pushing harder How stress creates addictive behavior loops What your brain is doing when you feel overwhelmed Why modern life is keeping you stuck in survival mode How nature, connection, and awareness reset your system Simple practices to reduce stress and restore balance This conversation blends neuroscience, behavior change, and real-world experience to give you a clear path forward. ⏱️ Timestamps 00:00 – Why Dr. Eva Selhub almost left medicine 00:18 – Burnout, dopamine, and modern stress 01:33 – Building a career around “non-traditional” medicine 03:00 – The moment that changed everything 05:34 – Save lives vs help people live 06:21 – Compounding trauma and burnout 07:56 – What resilience actually means 11:13 – Why resilience is misunderstood 13:33 – The real definition of resilience 17:27 – Thriving vs surviving 18:25 – Hormesis and stress adaptation 20:13 – Neuroplasticity, good vs bad habits 22:55 – How your brain creates coping behaviors 26:46 – The hidden cost of stress loops 29:04 – Why modern life keeps you overwhelmed 31:11 – Phone addiction and dopamine cycles 35:01 – The missing piece: connection and love 37:54 – Why mindset matters more than biology alone 40:16 – Finding self-love through nature 43:30 – Why modern identity increases stress 46:18 – High achievers and burnout 47:51 – The “love response” explained 52:31 – Nature, healing, and connection 57:37 – Daily habits to build resilience 01:00:08 – Final thoughts and where to find Dr. Selhub

7. 

   23 Apr 2026

   Anne-Laure Le Cunff: How to Stop Chasing Goals and Start Changing Your Life

   What if the problem isn’t your discipline… but your approach? In this episode of Unstoppable Brain, Dr. Kyra Bobinet sits down with neuroscientist and author Anne-Laure Le Cunff to break down a smarter way to change your life. After a health scare forced her to rethink everything, Anne-Laure walked away from a successful career at Google and rebuilt her life using what she calls the “experimental mindset.” Instead of chasing big goals, she focuses on small, repeatable experiments that help you learn what actually works for you. This conversation covers: Why announcing goals can make you less likely to succeed How to use “tiny experiments” to create real change The danger of tying your self-worth to productivity How to handle criticism and build resilience Why imperfection and learning in public accelerate growth The difference between legacy and generativity If you’ve ever felt stuck, overwhelmed, or unsure of your next move, this episode gives you a practical framework to move forward. ⏱️ TIMESTAMPS00:00 – The health scare that changed everything 01:45 – From Google to neuroscience: a non-linear path 03:10 – The “life quake” moment 06:00 – Fear, family, and leaving a stable career 09:30 – Finding community during uncertainty 12:00 – Learning in public and facing criticism 16:30 – Dealing with negative feedback and self-doubt 19:00 – Journaling, relationships, and emotional resilience 23:30 – Why perfection is the wrong goal 27:00 – Separating self-worth from productivity 30:30 – The experimental mindset explained 33:40 – Why goals fail (and what works instead) 36:00 – Tiny experiments vs big goals 40:00 – How to track progress without self-judgment 44:00 – Confidence, language, and reframing failure 49:00 – Legacy vs generativity 52:30 – How to make an impact right now 54:30 – Apprentice → Artisan → Architect framework 58:30 – Scaling your work without burning out 1:02:00 – Letting go of control and trusting your team 1:05:00 – How to improve as a creator (powerful closing insight)

8. 

   26 Mar 2026

   Nir Eyal: Why You Keep Quitting (And How to Finally Stay Consistent)

   Why do you keep quitting on your goals, even when you know exactly what to do? In the first episode of Unstoppable Brain, Dr. Kyra Bobinet sits down with behavioral expert and bestselling author Nir Eyal to break down the real reason people fail, and it has nothing to do with discipline, talent, or outside circumstances. The problem is belief. Nir explains why most people never follow through, even after reading the right books, hiring coaches, or learning proven systems. He introduces the Motivation Triangle, a framework that reveals the missing piece behind behavior change, and shows how limiting beliefs quietly sabotage your progress. You’ll also hear: Why quitting, not failure, is the real problem How belief drives consistency more than willpower The hidden mental patterns behind weight loss, habits, and performance Why pain, discomfort, and resistance don’t mean stop How to rewire limiting beliefs into ones that drive action The science behind attention, motivation, and persistence This conversation blends neuroscience, psychology, and real-life experience into a clear system you can apply immediately. If you’ve ever said: “I know what to do, I just don’t do it” This episode explains why. Connect with Nir: https://www.nirandfar.com/ (https://www.nirandfar.com/) Order Beyond Belief: https://www.amazon.com/Beyond-Belief-Science-Backed-Limiting-Breakthrough/dp/0593852036 (https://www.amazon.com/Beyond-Belief-Science-Backed-Limiting-Breakthrough/dp/0593852036) ⏱️ TIMESTAMPS 00:00 Why people fail their goals 00:24 Meet Nir Eyal 01:30 Why this book matters more than his others 03:30 The real problem with behavior change 06:00 The Motivation Triangle explained 07:00 Why belief is the missing piece 09:00 Emotional eating and behavior patterns 11:00 Why consistency beats the “perfect plan” 13:00 The real reason people quit 14:30 Breaking limiting beliefs 16:00 Pain, avoidance, and behavior loops 18:00 The power of attention and the brain 22:00 Chronic pain and belief systems 26:00 Why suffering is optional 31:00 The rat experiment that changes everything 34:00 How belief drives endurance 37:00 Controlling attention like a superpower 41:00 Reframing relationships and perception 46:00 The Byron Katie method explained 52:00 Labels, identity, and self-limiting beliefs

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Apple Podcasts (US)

5.0 / 5

4 ratings