by American College of Cardiology
The American College of Cardiology offers select interviews and summaries of cardiology’s most interesting research areas from ACCEL’s renowned library, hosted by ACCEL Editor-in-Chief Alison L. Bailey, MD, FACC, FAACPVR.
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🇺🇲
Publishing Since
7/14/2022
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April 29, 2025
<div class="OutlineElement Ltr SCXW181444702 BCX0"> <p class="Paragraph SCXW181444702 BCX0"><span class= "TextRun SCXW181444702 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW181444702 BCX0">Patients with peripheral artery disease (PAD) often experience significant walking difficulties, and there are limited therapies available to improve their mobility.</span> <span class= "NormalTextRun SCXW181444702 BCX0">I</span><span class= "NormalTextRun SCXW181444702 BCX0">nvestigation</span> <span class= "NormalTextRun SCXW181444702 BCX0">made through the</span> <span class="NormalTextRun SCXW181444702 BCX0">STRIDE</span> <span class="NormalTextRun SCXW181444702 BCX0">(</span><span class= "NormalTextRun SCXW181444702 BCX0">Effects of</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW181444702 BCX0">Semaglutide</span> <span class="NormalTextRun SCXW181444702 BCX0">on Functional Capacity in Patients</span> <span class= "NormalTextRun SCXW181444702 BCX0">With</span> <span class= "NormalTextRun SCXW181444702 BCX0">Type 2 Diabetes and Peripheral Arterial Disease</span><span class= "NormalTextRun SCXW181444702 BCX0">)</span> <span class= "NormalTextRun SCXW181444702 BCX0">t</span><span class= "NormalTextRun SCXW181444702 BCX0">rial</span> <span class= "NormalTextRun SCXW181444702 BCX0">focused on</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW181444702 BCX0">semaglutide</span><span class="NormalTextRun SCXW181444702 BCX0">, a drug known for promoting weight loss, reducing inflammation, and lowering the risk of heart attack or stroke, to determine if it could enhance the functional abilities of PAD patients.</span></span><span class="EOP SCXW181444702 BCX0" data-ccp-props= "{"201341983":0,"335557856":16777215,"335559739":0,"335559740":240}"> </span></p> </div> <div class="OutlineElement Ltr SCXW181444702 BCX0"> <p class="Paragraph SCXW181444702 BCX0"><span class= "EOP SCXW181444702 BCX0" data-ccp-props= "{"201341983":0,"335557856":16777215,"335559739":0,"335559740":240}"> </span><span class="TextRun SCXW181444702 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW181444702 BCX0">In this interview,</span> <span class="NormalTextRun SCXW181444702 BCX0">Drs. Alison Bailey and</span> <span class= "NormalTextRun SCXW181444702 BCX0">Marc</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW181444702 BCX0">Bonaca</span> <span class="NormalTextRun SCXW181444702 BCX0">discuss how the</span> <span class= "NormalTextRun SCXW181444702 BCX0">STRIDE</span> <span class= "NormalTextRun SCXW181444702 BCX0">trial data supports the use of</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW181444702 BCX0">semaglutide</span> <span class="NormalTextRun SCXW181444702 BCX0">for individuals with PAD and</span> <span class="NormalTextRun SCXW181444702 BCX0">type 2 diabetes,</span> <span class= "NormalTextRun SCXW181444702 BCX0">highlight</span><span class= "NormalTextRun SCXW181444702 BCX0">ing</span> <span class= "NormalTextRun SCXW181444702 BCX0">its cardiometabolic, cardiovascular, and kidney benefits, as well as its ability to improve function, symptoms, and overall quality of life</span><span class= "NormalTextRun SCXW181444702 BCX0">.</span></span><span class= "EOP SCXW181444702 BCX0" data-ccp-props= "{"201341983":0,"335559739":0,"335559740":240}"> </span></p> </div> <div class="OutlineElement Ltr SCXW181444702 BCX0"> <p class="Paragraph SCXW181444702 BCX0"><span class= "EOP SCXW181444702 BCX0" data-ccp-props= "{"201341983":0,"335559739":0,"335559740":240}"> </span><a class="Hyperlink SCXW181444702 BCX0" href= "https://itunes.apple.com/us/podcast/eagles-eye-view-your-weekly-cv-update-from-acc-org/id1274635046" target="_blank" rel="noreferrer noopener"><span class= "TextRun Underlined SCXW181444702 BCX0" lang="EN-US" xml:lang= "EN-US" data-contrast="none"><span class= "NormalTextRun SCXW181444702 BCX0" data-ccp-charstyle= "Hyperlink">Subscribe on Apple</span></span></a> <span class= "TextRun Underlined SCXW181444702 BCX0" lang="EN-US" xml:lang= "EN-US" data-contrast="none"><span class= "NormalTextRun SCXW181444702 BCX0" data-ccp-charstyle= "Hyperlink">Podcasts</span></span> <span class= "TextRun SCXW181444702 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW181444702 BCX0">| </span></span><a class= "Hyperlink SCXW181444702 BCX0" href= "http://www.acc.org/education-and-meetings/products-and-resources/accel-audio" target="_blank" rel="noreferrer noopener"><span class= "TextRun Underlined SCXW181444702 BCX0" lang="EN-US" xml:lang= "EN-US" data-contrast="none"><span class= "NormalTextRun SCXW181444702 BCX0" data-ccp-charstyle= "Hyperlink">Subscribe to ACCEL</span></span></a><span class= "EOP SCXW181444702 BCX0" data-ccp-props= "{"201341983":0,"335559739":0,"335559740":240}"> </span></p> </div>
April 22, 2025
<div class="OutlineElement Ltr SCXW214520747 BCX0"> <p class="Paragraph SCXW214520747 BCX0"><span class= "TextRun SCXW214520747 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW214520747 BCX0">Transcatheter</span> <span class="NormalTextRun SCXW214520747 BCX0">a</span><span class= "NormalTextRun SCXW214520747 BCX0">ortic</span> <span class= "NormalTextRun SCXW214520747 BCX0">v</span><span class= "NormalTextRun SCXW214520747 BCX0">alve</span> <span class= "NormalTextRun SCXW214520747 BCX0">r</span><span class= "NormalTextRun SCXW214520747 BCX0">eplacement (TAVR) has</span> <span class="NormalTextRun SCXW214520747 BCX0">emerged</span> <span class="NormalTextRun SCXW214520747 BCX0">as the preferred treatment for aortic stenosis. However, there is a lack of long-term outcome data for low-risk patients. The 5-year results from the</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW214520747 BCX0">Evolut</span> <span class="NormalTextRun SCXW214520747 BCX0">Low-Risk randomized trial address this gap</span><span class= "NormalTextRun SCXW214520747 BCX0">,</span> <span class= "NormalTextRun SCXW214520747 BCX0">offering compelling evidence with no significant negative signals regarding TAVR's clinical outcomes and valve performance.</span></span><span class= "EOP SCXW214520747 BCX0" data-ccp-props= "{"201341983":0,"335557856":16777215,"335559739":0,"335559740":240}"> </span></p> </div> <div class="OutlineElement Ltr SCXW214520747 BCX0"> <p class="Paragraph SCXW214520747 BCX0"><span class= "TextRun SCXW214520747 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW214520747 BCX0">In this episode, Dr</span><span class= "NormalTextRun SCXW214520747 BCX0">s</span><span class= "NormalTextRun SCXW214520747 BCX0">.</span> <span class= "NormalTextRun SCXW214520747 BCX0">Richard A. Chazal</span> <span class="NormalTextRun SCXW214520747 BCX0">and</span> <span class="NormalTextRun SCXW214520747 BCX0">Michael J. Reardon delve into the 5-year results from the</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW214520747 BCX0">Evolut</span> <span class="NormalTextRun SCXW214520747 BCX0">Low-Risk randomized trial</span><span class="NormalTextRun SCXW214520747 BCX0">, offering</span> <span class= "NormalTextRun SCXW214520747 BCX0">valuable insights</span> <span class="NormalTextRun SCXW214520747 BCX0">about the future of TAVR and its impact on patient care.</span></span><span class= "EOP SCXW214520747 BCX0" data-ccp-props= "{"201341983":0,"335557856":16777215,"335559739":0,"335559740":240}"> </span></p> </div> <div class="OutlineElement Ltr SCXW214520747 BCX0"> <p class="Paragraph SCXW214520747 BCX0"><span class= "TextRun SCXW214520747 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW214520747 BCX0">Related References</span><span class= "NormalTextRun SCXW214520747 BCX0">:</span></span><span class= "EOP SCXW214520747 BCX0" data-ccp-props= "{"201341983":0,"335559739":0,"335559740":240}"> </span></p> </div> <div class="OutlineElement Ltr SCXW214520747 BCX0"> <p class="Paragraph SCXW214520747 BCX0"><span class= "TextRun SCXW214520747 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW214520747 BCX0">1.</span> <span class= "NormalTextRun SCXW214520747 BCX0">Popma JJ, Deeb GM, Yakubov SJ</span><span class="NormalTextRun SCXW214520747 BCX0">, et al</span><span class="NormalTextRun SCXW214520747 BCX0">;</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW214520747 BCX0">Evolut</span> <span class="NormalTextRun SCXW214520747 BCX0">Low Risk Trial Investigators. Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients. N Engl J Med. 2019 May 2;380(18):1706-1715.</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW214520747 BCX0">doi</span><span class="NormalTextRun SCXW214520747 BCX0">: 10.1056/NEJMoa1816885.</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW214520747 BCX0">Epub</span> <span class="NormalTextRun SCXW214520747 BCX0">2019 Mar 16. PMID: 30883053.</span></span><span class="EOP SCXW214520747 BCX0" data-ccp-props= "{"201341983":0,"335559685":720,"335559739":0,"335559740":240}"> </span></p> </div> <div class="OutlineElement Ltr SCXW214520747 BCX0"> <p class="Paragraph SCXW214520747 BCX0"><a class= "Hyperlink SCXW214520747 BCX0" href= "https://itunes.apple.com/us/podcast/eagles-eye-view-your-weekly-cv-update-from-acc-org/id1274635046" target="_blank" rel="noreferrer noopener"><span class= "TextRun Underlined SCXW214520747 BCX0" lang="EN-US" xml:lang= "EN-US" data-contrast="none"><span class= "NormalTextRun SCXW214520747 BCX0" data-ccp-charstyle= "Hyperlink">Subscribe on Apple</span></span></a> <span class= "TextRun Underlined SCXW214520747 BCX0" lang="EN-US" xml:lang= "EN-US" data-contrast="none"><span class= "NormalTextRun SCXW214520747 BCX0" data-ccp-charstyle= "Hyperlink">Podcasts|</span></span> <a class= "Hyperlink SCXW214520747 BCX0" href= "http://www.acc.org/education-and-meetings/products-and-resources/accel-audio" target="_blank" rel="noreferrer noopener"><span class= "TextRun Underlined SCXW214520747 BCX0" lang="EN-US" xml:lang= "EN-US" data-contrast="none"><span class= "NormalTextRun SCXW214520747 BCX0" data-ccp-charstyle= "Hyperlink">Subscribe to ACCEL</span></span></a><span class= "EOP SCXW214520747 BCX0" data-ccp-props= "{"201341983":0,"335559739":0,"335559740":240}"> </span></p> </div>
April 15, 2025
<div class="OutlineElement Ltr SCXW42806501 BCX0"> <p class="Paragraph SCXW42806501 BCX0"><span class= "TextRun SCXW42806501 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW42806501 BCX0">Fluid restriction is often recommended for heart failure (HF) patients to prevent congestion, but its benefits and safety are unclear. The FRESH-UP</span> <span class="NormalTextRun SCXW42806501 BCX0">study</span> <span class="NormalTextRun SCXW42806501 BCX0">is the first to</span> <span class="NormalTextRun SCXW42806501 BCX0">show that strict fluid restriction does not improve health status for chronic, symptomatic HF patients and may increase thirst distress without reducing mortality, hospitalization, acute kidney injury, or medication needs.</span></span><span class= "EOP SCXW42806501 BCX0" data-ccp-props= "{"335557856":16777215}"> </span></p> </div> <div class="OutlineElement Ltr SCXW42806501 BCX0"> <p class="Paragraph SCXW42806501 BCX0"><span class= "TextRun SCXW42806501 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW42806501 BCX0">In this interview, Roland RJ van</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW42806501 BCX0">Kimmenade</span><span class="NormalTextRun SCXW42806501 BCX0">, MD and Alison L. Bailey, MD, FACC discuss</span> <span class= "NormalTextRun SCXW42806501 BCX0">the impacts of the FRESH-UP study</span> <span class= "NormalTextRun SCXW42806501 BCX0">and</span> <span class= "NormalTextRun SCXW42806501 BCX0">how liberal fluid intake is safe for chronic HF patients</span><span class= "NormalTextRun SCXW42806501 BCX0">,</span> <span class= "NormalTextRun SCXW42806501 BCX0">even</span> <span class= "NormalTextRun SCXW42806501 BCX0">enhanc</span><span class= "NormalTextRun SCXW42806501 BCX0">ing</span> <span class= "NormalTextRun SCXW42806501 BCX0">their well-being.</span> <span class="NormalTextRun SCXW42806501 BCX0">Providers are encouraged</span> <span class="NormalTextRun SCXW42806501 BCX0">to reconsider universal fluid restrictions and adopt a more individualized approach.</span></span><span class= "EOP SCXW42806501 BCX0" data-ccp-props= "{"335557856":16777215}"> </span></p> </div> <div class="OutlineElement Ltr SCXW42806501 BCX0"> <p class="Paragraph SCXW42806501 BCX0"><span class= "EOP SCXW42806501 BCX0" data-ccp-props= "{}"> </span><span class="TextRun SCXW42806501 BCX0" lang= "EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW42806501 BCX0">RELATED REFERENCES:</span></span><span class="EOP SCXW42806501 BCX0" data-ccp-props="{}"> </span></p> </div> <div class="ListContainerWrapper SCXW42806501 BCX0"> <ol class="NumberListStyle1 SCXW42806501 BCX0" role="list" start= "1"> <li class="OutlineElement Ltr SCXW42806501 BCX0" role="listitem" data-leveltext="%1." data-font="Times New Roman" data-listid="1" data-list-defn-props= "{"335552541":0,"335559685":720,"335559991":360,"469769242":[65533,0],"469777803":"left","469777804":"%1.","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"> <p class="Paragraph SCXW42806501 BCX0"><span class= "TextRun SCXW42806501 BCX0" lang="DA-DK" xml:lang="DA-DK" data-contrast="auto"><span class= "NormalTextRun SCXW42806501 BCX0">Herrmann JJ,</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW42806501 BCX0">Brunner</span><span class="NormalTextRun SCXW42806501 BCX0">-La</span> <span class= "NormalTextRun SpellingErrorV2Themed SCXW42806501 BCX0">Rocca</span> <span class="NormalTextRun SCXW42806501 BCX0">HP, Baltussen LE, et al.</span></span> <span class="TextRun SCXW42806501 BCX0" lang= "EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW42806501 BCX0">Liberal Fluid Intake Versus Fluid Restriction in Chronic Heart Failure: A Randomized Clinical Trial. Nat Med</span> <span class= "NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW42806501 BCX0"> 2025;Mar</span> <span class= "NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW42806501 BCX0"> 30:[</span><span class= "NormalTextRun SpellingErrorV2Themed SCXW42806501 BCX0">Epub</span> <span class="NormalTextRun SCXW42806501 BCX0">ahead of print].</span></span><span class="EOP SCXW42806501 BCX0" data-ccp-props="{}"> </span></p> </li> </ol> </div>
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