The new Agilent - Imperial College London podcast series focuses on Agilent's ongoing relationship with Imperial College London and discuss some of the most interesting researches carried out in the Agilent Measurement suite sited at White City campus in London (UK).

Exploring Analytical Science
Claim This Podcastby Agilent Technologies LDA UK Limited
Podcast Overview
The new Agilent - Imperial College London podcast series focuses on Agilent's ongoing relationship with Imperial College London and discuss some of the most interesting researches carried out in the Agilent Measurement suite sited at White City campus in London (UK).
Language
🇺🇲
Publishing Since
6/1/2021
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Recent Episodes

June 1, 2021
Episode 7: A panel discussion about cutting edge analytical capabilities for advancing science
In this episode, as the final episode of the series, we did a deeper dive into the the role of technological and digital advances in analytical instrumentation and how these developments made possible to move science forward. For Research Use Only. Not for use in diagnostic procedures. DE44320.2799189815

June 1, 2021
Episode 6: Analysis of the complex component parts of Mergo™: an oligonucleotide-based drug delivery system for the treatment of immune and genetic diseases
As interest in oligonucleotide therapeutics increases, there is an ever-growing need for analytical techniques that can properly analyse and quantitate these complex biomolecules. Mass spectrometry (MS) is required to analyse impurities, degradants, and other biological/chemical modifications and is the method of choice for the analysis of synthetic oligonucleotides. Sixfold Bioscience, in collaboration with the National Measurement Laboratory (NML) have been using the Agilent AdvancedBio 6545XT LC/Q-TOF to develop a method to analyse complex oligonucleotides of various lengths with volatile ion pair reagents. This method is used for quality control of oligonucleotides that are subsequently assembled into Mergos™ for use in in vivo applications. In addition to the analytical capabilities currently being utilised by Sixfold, the Agilent 1290 Infinity II Preparative system is also being used for oligonucleotide purification. Both reverse-phase (C18) and anion-exchange (IEX) chromatography is regularly carried out to assist in Sixfold's purification workflow. As a result of this work, and as an extension to the work currently being carried out by the Tate group at Imperial College, a Metabolomics group is in the process of being formed at the Molecular Sciences Research Hub. This group will aim to solve challenges related to the analysis of biomolecules and will take advantage of the combined know-how and expertise of scientists at Imperial College, Sixfold Bioscience and Agilent. Dr James Rushworth, Research Associate at Sixfold Bioscience. For Research Use Only. Not for use in diagnostic procedures. DE44320.2788078704

June 1, 2021
Episode 5: Identification of Common Cutting Agents in Latent Fingerprints
Drugs of abuse have a detrimental effect on both society and the individual. Cutting agents are often added to drugs of abuse for a variety of reasons such as increasing the effect of the drug; this can enhance the user's response but can also seriously increase health risks. Contaminants can be introduced to drugs of abuse unintentionally, for example, metal contamination from synthesis apparatus and/or experimental procedures, leaching of materials from storage (containers and 'laboratory' environment) and biological microorganisms. Cutting agents and contaminants are of extreme importance in determining routes of distribution and relationships between drug batches. Dr Trevor Ferris, Manager of the Agilent Measurement Suite, Department of Chemistry, Imperial College London. For Forensics Use. RA44295.4940509259
7 total episodes available
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