Gyno Gurus Podcast
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Podcast Overview
<p><span>Alexandra MacLean, WHNP-BC, and Peter Mandel, MD, FACOG, are women’s health clinicians and co-hosts dedicated to translating medical evidence into clear, practical guidance. Their conversations help listeners understand their bodies, ask better questions, and make confident decisions—without the jargon. </span></p>
Language
🇺🇲
Publishing Since
9/20/2025
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Recent Episodes
May 28, 2026
PCOS IS EXTINCT!!!
In this episode of the Gyno Gurus Podcast, we break down the emerging concept of PMOS (Polyendocrine Metabolic Ovarian Syndrome) and why many experts believe the term “PCOS” may no longer fully capture what’s really happening in the body. We explore how genetics, epigenetics, insulin resistance, brain signaling, ovarian dysfunction, and androgen excess may all converge through different pathways to create the same clinical syndrome. From LH dysfunction and theca cell overstimulation to fasting insulin, AMH, and lipid abnormalities, this episode takes a deeper look into the true pathophysiology behind “PMOS.” Whether you’re struggling with irregular cycles, infertility, or metabolic dysfunction — understanding the why behind the condition changes everything. Chapters: 00:00 PCOS is No More 05:52 Pathophysiology of PMOS 10:09 Understanding the Underlying Causes 12:13 PCOS vs PMOS, Does it Really Matter? 14:09 Markers of PMOS: LH/FSH Ratio, AMH, Fasting Insulin Levels, Dyslipidemia 19:58 Final Thoughts In this episode we discuss: • Epigenetics and fetal programming • How PMOS may begin in the womb and brain • LH dysregulation and ovarian signaling • Theca cells and androgen overload • Insulin resistance and hyperinsulinemia • The “ovary-first” theory • LH vs FSH ratios • AMH and metabolic markers • Different pathways leading to the same syndrome If you enjoyed this episode, make sure to like, subscribe, and share with someone navigating PCOS/PMOS. #PCOS #PMOS #InsulinResistance #Hormones #Fertility #WomensHealth #Endocrinology #Infertility #HormonalHealth #MetabolicHealth #GynoGurusPodcast
March 28, 2026
PCOS Explained (Part 1): What It Is, How It's Diagnosed, & Why It's Misunderstood
If you’ve ever been told you have PCOS—or think you might—you’re not alone… but you may not have gotten the full picture. In Part 1 of this PCOS series, we break down what PCOS actually is (and what it isn’t), why it’s called a syndrome, and how it’s diagnosed in real clinical practice. We also dive into common symptoms, ultrasound criteria, and the metabolic connections that are often overlooked. This episode is designed to give you a clear, evidence-based foundation—so you can better understand your body and advocate for the care you deserve. 🧠 What we cover: What PCOS (Polycystic Ovarian Syndrome) really means The difference between a disease vs a syndrome (and why it matters) Diagnostic criteria (including Rotterdam criteria) How ultrasound findings factor into diagnosis Common symptoms of PCOS The link between Vitamin D & metabolic dysfunction What may actually cause PCOS The critical role of your provider in making the diagnosis Chapters: 00:00 Introduction 01:30 PCOS = Polycystic Ovarian Syndrome 01:50 Disease vs Syndrome 04:33 How do we Diagnose PCOS? 05:22 Ultrasound Criteria for Diagnosis 08:15 PCOS Symptoms 10:02 Vitamin D Levels and Metabolic Dysfunction 12:12 What Causes PCOS? 16:02 Provider Role in Diagnosis 20:50 Next Week's Episode 📌 Who this is for: Women diagnosed with PCOS Anyone struggling with irregular cycles, acne, or hormonal symptoms Clinicians who want a clearer framework for diagnosing PCOS 🔔 Don’t forget: Subscribe for Part 2 + more evidence-based women’s health content from the Gyno Gurus Podcast 🧬 Disclaimer: This content is for educational purposes only and is not medical advice. Always consult your healthcare provider for personalized care.
January 29, 2026
Fact or Fiction - PMS, Is It All In Your Head?
Is PMS really “all in your head”? 🤔 In this Fact or Fiction episode of the Gyno Gurus Women’s Health Podcast, we break down one of the most dismissive myths in women’s health—and replace it with actual physiology. We dive into what’s really driving PMS and PMDD, from hormonal signaling and progesterone sensitivity to neurotransmitters like serotonin. We also explore evidence-based treatments (including SSRIs) and emerging options like low-dose naltrexone (LDN)—what’s backed by science, what’s overstated, and what deserves more research. If you’ve ever been told PMS is “just stress” or “in your head,” this episode is for you. 👇 Chapters below so you can jump right to what matters most to you. Chapters: 00:00 Intro 00:34 PMS - It's All in Your Head?! 02:18 - Causes & Treatments of PMS & PMDD 06:44 - Progesterone & PMS 09:50 - SSRIs as a Treatment for PMS 10:58 - Our Final Assessment on PMS & PMDD 11:28 - Low Dose Naltrexone for PMS 🎧 Listen on Spotify & Apple Podcasts 📺 Watch on YouTube 📌 Subscribe for evidence-based women’s health, minus the myths Educational purposes only. Not medical advice.
12 total episodes available
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Frequently asked questions
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- What is Gyno Gurus Podcast?
<p><span>Alexandra MacLean, WHNP-BC, and Peter Mandel, MD, FACOG, are women’s health clinicians and co-hosts dedicated to translating medical evidence into clear, practical guidance. Their conversations help listeners understand their bodies, ask better questions, and make confident decisions—without the jargon. </span></p> - How often does this podcast release new episodes?
This podcast updates daily.
- Where can I listen to this podcast?
This podcast is available on 4 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
- Does this podcast accept guests?
No, this podcast does not typically feature guests.
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