Go beyond the headlines with Harlan M. Krumholz, MD, SM, FACC, Editor-in-Chief of JACC, as he shares reflections on the science, ideas, and issues shaping cardiovascular medicine today.
Celebrating A Journey of 2 Years: Dr. Harlan Krumholz Reflecting on His Time as Editor-in-Chief of JACC | JACC
Two years into his role as Editor-in-Chief, Dr. Harlan Krumholz looks back on the journey that's shaped JACC, staying true to its mission while evolving to better serve authors and readers around the world. He shares what's driven the journal's growth into a truly international platform and offers a glimpse of where he sees JACC heading next, as it continues to advance cardiovascular science and care on a global scale.
20 Oct 2025
Editor's Page: October 28, 2025 | JACC
Dr. Harlan Krumholz reflects on the profound impact of experiencing a patient’s death for the first time, describing how medical training often leaves clinicians unprepared for the emotional and communicative challenges that follow. Over time, he developed a compassionate framework for speaking with grieving families—honoring the deceased, reassuring them about suffering, releasing them from guilt, and recognizing the love present—to help shape how loss is experienced and remembered. He urges physicians to share their own stories of patient loss, emphasizing that medicine is not only about prolonging life but also about caring deeply and meaningfully when life ends.
13 Oct 2025
Editor's Page: October 21, 2025 | JACC
In this week's Editor's Page, Dr. Harlan Krumholz introduces Dr. Milton Packer’s adipokine hypothesis, which proposes that dysfunctional visceral fat and the adipokines it secretes are central to the development of heart failure with preserved ejection fraction (HFpEF). This framework suggests that the benefits of therapies like GLP-1 receptor agonists and SGLT2 inhibitors may stem partly from restoring balance in adipose–cardiac signaling, offering a biologically grounded model for a condition long marked by therapeutic frustration. While the hypothesis is ambitious and unproven, it provides a coherent structure for future research and exemplifies how bold, integrative thinking can advance medical understanding.
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