Deciphering the science behind what makes us human, one video and one article at a time. Visit YouTube or my website to find out more. <br/><br/><a href="https://neuroeverything.substack.com?utm_medium=podcast">neuroeverything.substack.com</a>
NeuroEverything Podcast
Claim This Podcastby Hesham Mashhour
5 episodes
Updated Weekly
Accepts GuestsHas Sponsors
Podcast Overview
Deciphering the science behind what makes us human, one video and one article at a time. Visit YouTube or my website to find out more. <br/><br/><a href="https://neuroeverything.substack.com?utm_medium=podcast">neuroeverything.substack.com</a>
Language
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Publishing Since
7/11/2024
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Recent Episodes
October 17, 2024
Substack Exclusive: A Flickering Light Can Clear Alzheimer's Amyloid Plaques
<p>Scientists have discovered that exposing mice with Alzheimer's disease to a 40Hz flickering light can significantly improve Alzheimer's symptoms.</p><p>The exact mechanism remains unclear, it seems that being exposed to an hour of a 40Hz flickering light can clear amyloid plaques in the brain.</p><p><strong>D54D2 is a monoclonal antibody of β-amyloid and allows us to visualise the plaques in these 6-month-old 5XFAD mice. Clearance of amyloid plaques was achieved with both a 40Hz and 80Hz flicker, but was most pronounced at 40Hz.</strong></p><p>So, how does a flicker light achieve this effect?</p><p>Gene expression.</p><p>A flicker light is able to alter the expression of genes that code for Aquaporin-4 (AQP-4) transporters. It seems that the clearance of amyloid plaques takes place through these cell membrane transporters. We already know from previous research that AQP-4, which is mostly a transporter of water molecules across the cell membrane, is also essential in clearing accumulated amyloid and tau aggregates from the brain. So, everything seems to check out really.</p><p>Sound too good to be true?</p><p>Here’s a map showing differentially expressed genes showing the genes that are overexpressed and underexpressed in different types of neuronal cells.</p><p>This also lines up with some really old research from 2006 where a 10Hz flicker was used in elderly human subjects and was found to improve memory.</p><p><p>To receive new consider becoming a free subscriber. It’s free and it’s the smart thing to do.</p></p><p><strong>Citations:</strong></p><p>Murdock, M.H., Yang, CY., Sun, N. et al. Multisensory gamma stimulation promotes glymphatic clearance of amyloid. Nature 627, 149–156 (2024). https://doi.org/10.1038/s41586-024-07132-6</p><p>Williams, J., Ramaswamy, D. & Oulhaj, A. 10 Hz flicker improves recognition memory in older people. BMC Neurosci 7, 21 (2006). https://doi.org/10.1186/1471-2202-7-21 #alzheimer #alzheimersresearch #flickering #science</p> <br/><br/>Get full access to NeuroEverything at <a href="https://neuroeverything.substack.com/subscribe?utm_medium=podcast&utm_campaign=CTA_4">neuroeverything.substack.com/subscribe</a>
August 1, 2024
Creatine Does More Than Build Muscles, It Helps Treat Depression
<p>Creatine is one of the most popular sports supplements used by athletes around the world. It effectively helps build muscle mass and is safe to use.</p><p>However, scientists are starting to suspect that creatine may prove to be as beneficial for the brain as it is for skeletal muscles, if not more so. We now have multiple studies that suggest creatine may help protect the brain from the harms of sleep deprivation and neurodegenerative disease, improve cognition, and it may even improve mood and help treat depression.</p><p>I summarise the evidence on creatine and its role in the treatment of depression. I'll explain why creatine can treat depression and improve mental health by improving brain metabolism, and suggest a regimen for those of you who might want to try supplementing with creatine.</p><p>Subscribe to my channel on <a target="_blank" href="https://www.youtube.com/channel/UCpGGGC5gcs2lLpuJSM-_6qQ">YouTube</a>.</p><p>Or — even better — subscribe to my Substack to receive updates straight into your inbox whenever I have something to say. It’s your support that allows me to continue creating high-quality scientific content for free.</p><p>Because in the dark times we live in today… science must triumph.</p><p>Thank you.</p> <br/><br/>Get full access to NeuroEverything at <a href="https://neuroeverything.substack.com/subscribe?utm_medium=podcast&utm_campaign=CTA_4">neuroeverything.substack.com/subscribe</a>
July 25, 2024
Clara Immerwahr: A Great Chemist Undone
<p>The history of science is full of stories of great female scientists that were reduced and stifled by those around them. Clara Immerwahr was the first German woman to receive a PhD in chemistry.</p><p>A brilliant scientist in her own right, Clara's life and career were cut short after her marriage to the renowned chemist and Nobel Prize recipient Fritz Haber.</p><p>In this video, we discuss Clara's overlooked contributions and the challenges she faced. This is very much a story of lost potential, but it serves as a reminder to all that we must do all we can to protect the rights and freedoms of women, as they become increasingly challenged.</p><p>Long Live Clara & Every Female Scientist... Past, Present, and Future.</p> <br/><br/>Get full access to NeuroEverything at <a href="https://neuroeverything.substack.com/subscribe?utm_medium=podcast&utm_campaign=CTA_4">neuroeverything.substack.com/subscribe</a>
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