Rare Kidney Disease Show

About Rare Kidney Disease Show

Welcome to the new Rare Kidney Disease Show part of the RKD Scientific Network sponsored by Travere Therapeutics. The Rare Kidney Disease Show is your primary source for cutting-edge insights, expert perspectives, and pivotal updates in nephrology. Led by our panel of experts, explore the advances in glomerular nephropathies through compelling conversations, challenging case studies, and discussions tackling hot topics. Join us as we strive to provide you with the ultimate resource to support your clinical practice and advance patient care.

Publisher

Travere Therapeutics

Category

education · health & fitness

Language

en

Explicit

No

First episode

20 Mar 2024

Latest episode

20 Aug 2026

Latest episodes

10 episodes in the feed.

1. 

   20 Aug 2026

   Evolving Management of FSGS: Proteinuria and Clinical Data with Drs. Daniel Gale and Gaia Coppock

   Welcome to Travere Therapeutics’ Rare Kidney Disease Show podcast, where rare kidney disease gets a spotlight. Host Dr. Chris Gisler, Senior Medical Director at Travere Therapeutics, is joined by Dr. Daniel Gale and Dr. Gaia Coppock for a practical and evidence-driven conversation on FSGS, proteinuria, and what registry and clinical data mean for clinical decision-making. In this episode, Dr. Gaia Coppock reflects on how the heterogeneous nature of focal segmental glomerulosclerosis (FSGS) has historically been challenging for clinicians and highlights we are working towards a new era of research, diagnosis, and therapeutics. From there, the discussion focuses on FSGS as a podocytopathy, outlining different triggering events that converge on podocyte injury and shared downstream pathways. Dr. Daniel Gale goes on to discuss how RaDaR, PARASOL, and other real-world datasets have helped clarify the relationship between proteinuria remission and long-term kidney outcomes. The conversation also explores the Phase 3 DUPLEX study. Dr. Coppock reviews the study design and key findings, including reductions in proteinuria, data on complete remission, safety profiles, and the challenges of interpreting estimated glomerular filtration rate (eGFR) slope in a complex and heterogeneous condition like FSGS. Together, experts reflect on where FSGS care is heading, underscoring the importance of targeting lower proteinuria thresholds, improving diagnostic precision, and adopting multi-targeted approaches. Speakers: Dr. Chris Gisler is a medical director at Travere Therapeutics and an adult Nephrologist Dr. Daniel Gale, MBBS, PhD (Professor of Nephrology, University College London. Director, RaDaR/Rare Renal Registry) Dr. Gaia Coppock, MD (Assistant Professor of Clinical Medicine, Renal-Electrolyte and Hypertension. University of Pennsylvania/Penn Medicine) Key Takeaways: FSGS is a heterogeneous pattern of injury, not a single condition. FSGS can arise from multiple causes, which has historically made diagnosis, treatment, and clinical trial design difficult Proteinuria is one of the most important clinical signals in FSGS. RaDaR and PARASOL have helped validate what clinicians have long suspected: lower proteinuria targets matter, and proteinuria can serve as a meaningful predictor of disease activity and response DUPLEX <helped clarify how proteinuria reduction in a clinical trial can be interpreted in FSGS>, especially in a condition where eGFR slope can be difficult to assess because of heterogeneity, hyperfiltration, and variability in kidney function The future of FSGS care depends on pushing to achieve the lowest proteinuria targets possible while becoming more precise in diagnosis and treatment Key Quotes: “Proteinuria really represents a very strong biomarker of disease activity, rather than simply a readout of how much damage has occurred in the kidney.” (6:08) “I think that clinicians should push harder with FSGS. You know, don't stop until you've exhausted all options and really push to get to the lowest proteinuria target possible.” (25:59) "I think the use of FSGS as a disease label is now really established to be doing more harm than good for many patients. It's the start of the diagnostic journey, not the end of it.” (26:27) Disclaimer: Guest speakers of the Rare Kidney Disease Show may be paid consultants of Travere Therapeutics. This podcast episode was recorded on June 9, 2026. Please always consult updated sources for the latest information, as information discussed may have changed since the recording date.

2. 

   10 Apr 2026

   Rewriting Kidney Care with Endothelin and Proteinuria

   Welcome to Travere Therapeutics’s Rare Kidney Disease podcast, where rare kidney disease gets a spotlight. Host Chris Gisler brings together two leading voices in nephrology, Dr. Donald Kohan and Dr. Yelena Drexler, for an energetic conversation about why proteinuria matters so much in diseases like FSGS and IgA nephropathy. What starts as a discussion of proteinuria as a lab value soon deepens: what is it, why does it mean more than just numbers, and how does it actually drive kidney injury? Dr. Donald Kohan breaks down the biology of endothelin, showing its role at every stage of glomerulonephritis. At the same time, Dr. Yelena Drexler links research to real patient care and shares the practical impact of proteinuria on outcomes. Whether you’re a clinician, researcher, or patient advocate, this episode delivers clear takeaways—from the latest studies shaping proteinuria targets to the call for multi-pathway, biology-informed treatment strategies. Speakers: Dr. Chris Gisler is a medical director at Travere Therapeutics and an adult Nephrologist Dr. Donald Kohan is a Professor of Medicine, Division of Nephrology & Hypertension at the University of Utah Dr. Yelena Drexler is an Associate Professor of Clinical Medicine, Division of Nephrology & Hypertension at the University of Miami Disclaimer: Guest speakers of the Rare Kidney Disease Show may be paid consultants of Travere Therapeutics. This podcast episode was recorded on March 6, 2026. Please always consult updated sources for the latest information, as information discussed may have changed since the recording date.

3. 

   2 Sept 2025

   Insights from the SPARTAN Study with Drs. Jonathan Barratt and Shikha Wadhwani

   In this episode, Drs. Jonathan Barratt and Shikha Wadhwani discuss findings from the SPARTAN study, a Phase 2 open-label, single-arm trial evaluating sparsentan in 12 treatment-naïve patients with IgA nephropathy. The conversation explores the trial’s design, including assessments of proteinuria reduction and urinary biomarkers to better understand sparsentan’s mechanism of action. Results from SPARTAN demonstrate a 69% mean reduction in proteinuria at 24 weeks, alongside biomarker trends consistent with decreased glomerular inflammation. Dr. Barratt notes that no new safety signals emerged, with hypotension observed at a rate consistent with prior studies and no adverse hepatic events reported. Together, the experts reflect on how these data support the biological plausibility of sparsentan’s anti-inflammatory properties and may inform the development of biomarker-guided strategies in IgA nephropathy, including ongoing evaluation of sparsentan in the PROTECT trial. Key Takeaways: SPARTAN demonstrated a robust mean reduction in proteinuria (~69%) in treatment-naïve patients with IgA nephropathy after 24 weeks of sparsentan therapy. Biomarker analysis revealed reductions in markers of macrophage activation, complement activity, and inflammatory cytokines, supporting the hypothesis of a potential anti-inflammatory effect. No new safety signals were observed; hypotension rates were consistent with earlier trials, and no clinically significant changes in hepatic function were reported. These findings contribute to our mechanistic understanding of sparsentan and provide a framework for future investigation of biomarkers from samples from larger studies such as PROTECT. Speakers: Dr. Jonathan Barratt, PhD, FRCP. Professor of Renal Medicine at the University of Leicester, where he leads the IgA Nephropathy Research Programme. He is internationally recognized for his leadership in translational and clinical research in glomerular diseases, particularly IgA nephropathy. Dr. Barratt directs the UK’s Rare Disease Group for the UK National Registry of Rare Kidney Diseases (RaDaR). Dr. Shikha Wadhwani, MD, MS, FASN. Associate Professor of Medicine in the Division of Nephrology and Vice Chair of Clinical Research in the Department of Medicine at University of Texas Medical Branch. She is also the inaugural Associate Research Officer for clinical research, overseeing clinical trials across all 5 schools at UTMB. She is the founding member of the International Society of Glomerular Disease (ISGD) and is steering a global effort aimed at supporting the growth and success of physician-trialists. In her spare time, Dr. Wadhwani co-hosts a podcast called Kidney Compass: Navigating Clinical Trials. Disclaimer: Guest speakers of the Rare Kidney Disease Show may be paid consultants of Travere Therapeutics. This podcast episode was recorded on July 25, 2025. Please always consult updated sources for the latest information, as information discussed may have changed since the recording date.

4. 

   27 May 2025

   From Podocyte to Patient: The Pathophysiology of FSGS

   Doctors Tobias Huber and Chris Gisler examine the pathophysiology of FSGS, focusing on how podocyte injury causes glomerular filtration barrier breakdown and proteinuria, while also exploring endothelin 1 and angiotensin II's roles in worsening podocyte dysfunction; this is an interview.

5. 

   28 Mar 2025

   Intro to FSGS - Dr. Howard Trachtman

   Title:  Intro to FSGS Episode Description: In this episode of the Rare Kidney Disease Show, Howard Trachtman, Adjunct Professor of Pediatrics at the University of Michigan, and Chris Gisler, medical director at Travere Therapeutics, explore the complexities of FSGS, covering its pathophysiology, classifications, and clinical presentation. They discuss key drivers of kidney failure, challenges in diagnosis and management, and the unmet need for safe and effective treatments. Listeners will gain insights into the patient journey, role of precision medicine, disease heterogeneity, and the future of clinical trial design. The episode concludes with how PARASOL is shaping advancements in FSGS research and clinical trials. Key Takeaways: Evolving Classification of FSGS – Once defined primarily by histopathology, FSGS is now recognized as a heterogeneous disorder with distinct genetic, immune, and metabolic etiologies. This shift has critical implications for diagnosis and treatment. FSGS and the Role of Podocyte Injury – Podocyte loss is a key driver of FSGS progression, with genetic, immune, and metabolic insults leading to irreversible damage. Understanding this mechanism is crucial for developing targeted therapies. Challenges in Treatment and Therapeutic Gaps – Current treatment strategies rely on empiric use of steroids and calcineurin inhibitors, with variable efficacy and significant side effects. A more targeted approach is needed to improve patient outcomes. Speakers: Howard Trachtman is the Adjunct Professor of Pediatrics at the University of Michigan. Chris Gisler is a medical director at Travere Therapeutics and a former community nephrologist practicing in Pittsburgh.

6. 

   16 Jan 2025

   ASN Update - Sparsentan Redefining IgAN Treatment

   In this episode of the Rare Kidney Disease Show, a panel of nephrology experts explore the latest data on sparsentan, as presented at ASN Kidney Week 2024. Dr. Hiddo Heerspink presents a post hoc analysis of the PROTECT trial comprised of patients who achieved complete proteinuria remission. Dr. Chee Kay Cheung shares interim data from the SPARTAN study on sparsentan therapy in treatment-naïve patients with IgA nephropathy. Lastly, Dr. Bruce Hendry discusses combination treatment of sparsentan with SGLT2i in the SPARTACUS study. These discussions are introduced by Dr. Edgar Lerma, who offers his insights into the possible clinical implications of these data.

7. 

   16 Aug 2024

   Rethinking IgAN: A Different Perspective from Community Nephrologists : 4

   Luis Velez, MD is a board-certified community nephrologist in San Antonio, TX with expertise in hypertension and glomerular disorders. Jessica Coleman, MD is a board-certified community nephrologist practicing between Savanah, GA and Charleston, SC with expertise in hypertension and glomerular disorders. In this episode, Drs Velez and Coleman discuss management of IgAN patients from the viewpoint of community nephrologists. They discuss the evolution in their management of IgAN, highlighting the availability of new data such as RaDaR as a key driver of change. With greater awareness of the role of proteinuria, they advocate for early and aggressive treatment to avoid long term complications of IgAN. Key Quotes: “RaDaR taught me that the traditional way of looking at IgA nephropathy is wrong. We realized this is a disease state that absolutely can progress and can progress more rapidly than what we initially appreciated and certainly at a younger age in these patients. (02:25) “When we look at patients with proteinuria, even just 0.5 g/d, a third of patients under 40 are going to progress to end stage kidney disease in ten years [RaDaR].” (04:30) “With the RaDaR data, we see levels of proteinuria 0.5 -0.8 g/d still being significant markers for disease progression.” (08:56) Key Takeaways: IgAN is not a benign disease Proteinuria is the most important prognostic indicator of disease progression in IgA Nephropathy HCPs should be targeting lower proteinuria goals to achieve complete remission <0.3 g/d The updated KDIGO Guidelines should support clinicians’ decisions to target complete remission

8. 

   24 Jun 2024

   The Role of Endothelin in IgAN, ft. Dr. Donald Kohan : 3

   Overview: In this episode, Donald Kohan discusses the role of the endothelin system in chronic kidney disease, specifically focusing on IgA nephropathy. Endothelin 1 is a potent vasoactive molecule produced in various cell types, including the kidney, where it plays a crucial role in regulating renal function. Endothelin acts on endothelin A and B receptors in the kidney, contributing to pathophysiologic effects such as proteinuria, fibrosis, and inflammation. The interaction between the endothelin and angiotensin systems in the kidney leads to various pathophysiological effects, including heparinase production, glycocalyx degradation, and proteinuria. In IgA nephropathy, endothelin affects different renal cell types, leading to inflammation, mesangial cell injury, podocyte dysfunction, and vascular constriction. Inhibiting endothelin receptors along with renin angiotensin system inhibitors can have significant effects on kidney health in CKD patients. Studies have shown that blocking both endothelin A and angiotensin receptors has a more nephroprotective effect in IgA nephropathy compared to blocking angiotensin receptors alone. Drugs like sparsentan have shown positive outcomes in preserving kidney function and reducing proteinuria in patients with IgA nephropathy. The PROTECT study demonstrated the superiority of sparsentan over Irbesartan in Key Quotes: "Endothelin 1 is a really unusual molecule. It's highly stable because it has 2 interchain disulfide bonds that resist degradation. It's extremely potent having about 10 fold higher potency than any other known vasoactive factor." "An important point, however, is that angiotensin and ET one cause their effects through different pathways. Angiotensin, for example, stimulates transient calcium release, which causes more short term contraction other effects. While endothelin 1 stimulates more sustained calcium release, which then elicits longer lasting pathophysiologic effects." "Importantly, sparsentan, a combined ETA and angiotensin type 1 receptor blocker reduces proteinuria and improves kidney function to a greater extent than AT1 receptor blockade in patients with IgA nephropathy." Key Takeaways: Endothelin-1 acts via ETA receptors to cause vasoconstriction, fibrosis, cell proliferation and other effects that promote chronic kidney disease. The endothelin and renin-angiotensin systems interact, forming a vicious cycle that worsens kidney injury. In IgA nephropathy models, combined ETA + angiotensin receptor blockade with sparsentan reduced proteinuria and kidney injury more than angiotensin blockade alone. The PROTECT trial in IgA nephropathy patients showed sparsentan significantly lowered proteinuria and stabilized eGFR compared to an angiotensin receptor blocker.

9. 

   24 Apr 2024

   Unmet Needs in IgAN: Burden of Disease & Long-Term Impact on Patients ft. Dr. Jonathan Barratt : 2

   Overview: In this episode of the Rare Kidney Disease Show, Professor Jonathan Barratt discusses the need to take a long-term approach when managing IgA nephropathy patients. He presents data from the UK National Registry of Rare Kidney Diseases (RaDaR). During this recording you will hear Professor Barratt discussing the continued risk of progression to end stage renal disease even in patients with proteinuria of less than 1g/day, the current threshold of high risk as per KDIGO guidelines. The data from the UK has been reinforced by recent database studies and these will also be discussed by Professor Barratt. Key Quotes: "If you have IgA Nephropathy and you're diagnosed as a child, half of those children have developed kidney failure at 20 years." "We need to be thinking, what is it like for that patient in front of us being 50 or 60, not necessarily what's going to happen in the next five or ten years." "If we don't think the longer term, we're going to under-treat and not serve our patients well." Key Takeaways: IgA nephropathy patients often have decades of life ahead of them, so physicians should focus on minimizing lifetime risk of kidney failure rather than short-term outcomes (00:02:11) RaDaR data shows high rates of kidney failure among IgA nephropathy patients in the UK, even those diagnosed and treated as children (00:04:05) Per the RaDaR publication, an eGFR decline of <1 ml/min per 1.73 m2 per year must be the target if patients are to avoid kidney failure (00:06:48) In the UK, 1 in 4 IgA nephropathy patients with 0.5-1 g/day proteinuria reach ESRD within 10 years (00:08:23) Recent US database searches confirm high rates of CKD progression and kidney failure in IgA nephropathy patients, even those with lower proteinuria levels (00:13:20)

10. 

    20 Mar 2024

    Getting Ahead of IgAN: A New Treatment Paradigm for Disease Control ft. Dr. Brad Rovin : 1

    Overview: In this episode of the Rare Kidney Disease Show, Dr. Rovin, Professor of Internal Medicine and Pathology at Ohio State University and chair of the RKD Scientific Network and Podcast, discusses advances in the management of IgAN through a patient case study. “IgAN progresses more often than we thought and progresses even in patients with low levels of proteinuria.” “We continue to strive for greater improvements.” “Approaching IgAN with targeted therapies can affect different aspects of IgAN pathogenesis.” Key Takeaways: Understanding the Underlying IgAN pathophysiology: Highlight the 4-Hit Hypothesis and the intricate disease mechanism (4:27) IgAN Case Study Introduction (6:57) Treatment Initiation (8:26) Management of Progression: Question the outcomes of initial intervention for this patient (9:50) Foundational Therapy: Optimization for improved outcomes (10:24) Maintenance Options: Explore available therapies to sustain treatment effectiveness (11:05) Postulated Algorithm: Discover an algorithm for inflammation management and proteinuria reduction (11:49) Closing Remarks: Gain insight into future episodes (14:10)

Reach and audience

Public platform figures. Ratings count people who left a rating, not total listeners.

Apple Podcasts (US)

5.0 / 5

6 ratings

Spotify

5.0 / 5

2 ratings

Podcast Authority Score: 13 / 100

A composite of feed quality, social presence, YouTube performance and engagement. Read the methodology.

Quality

2

Social presence

0

YouTube

0

Engagement

60

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Guest appearances

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