Dive deeper into wellness than ever before. Host, Dov, joins leading experts and innovators in wellness, fitness and biohacking to discover the roots of the causes of modern health challenges. Join Dov as he explores innovative ways to optimize performance, address wellness issues and live your best life.
Root of the Cause Radio
Claim This Podcastby Root of the Cause Radio
4.8(28 reviews)
31 episodes
Updated Weekly
Accepts GuestsHas SponsorsLocation 🇺🇸
28
Podcast Authority
BetaPoorBased on show quality, social media presence, reviews, charts, and more
Quality25
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Podcast Overview
Dive deeper into wellness than ever before. Host, Dov, joins leading experts and innovators in wellness, fitness and biohacking to discover the roots of the causes of modern health challenges. Join Dov as he explores innovative ways to optimize performance, address wellness issues and live your best life.
Language
🇺🇲
Publishing Since
1/20/2020
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Recent Episodes
May 7, 2026
Mistletoe Therapy for Cancer: The Treatment Most Oncologists Ignore I Dr. Mark Hancock
<p>Dr. Mark Hancock is the leading authority on mistletoe therapy in the US today. In this episode, he joins me for a powerful conversation exploring cutting-edge approaches in integrative cancer therapy you won’t hear about in conventional settings. We break down the science behind mistletoe treatment—its mechanisms, immune effects, and clinical use across subcutaneous, IV, intratumoral, and intraperitoneal delivery—along with real-world case insights.</p><p>We also dive into ferroptosis, an emerging iron-dependent cancer cell death pathway gaining attention in oncology, plus the strategic use of repurposed drugs, targeted supplements, and often-overlooked blood biomarkers that can reveal deeper insights into cancer progression and treatment response.</p><p>2:50–Dr. Hancock’s backstory: discovery of anthroposophic medicine and mistletoe</p><p>4:30–UK rotations and meeting the legendary Dr. Morris Orange and seeing mistletoe in inpatient oncology</p><p>6:12–Dr. Orange’s pioneering work: high‑dose fever‑inducing mistletoe and intratumoral injections</p><p>9:55–Mistletoe mechanism of action: lectins, dendritic cells, cytokines, NK/T/B cells, apoptosis, viscotoxins, and host‑tree complexity</p><p>14:12–Host trees and formulations: 13+ host species, varying lectin/viscotoxin profiles, and the “art” of selecting mistletoe</p><p>17:30–Clinical protocols: mixing high‑lectin and endotoxin‑rich products (e.g., Abnoba + Iscador) and weekly cycling strategies</p><p>17:50–Teaching mistletoe: Hancock’s apprenticeship program and in‑depth training for providers who want to use mistletoe</p><p>18:33–Routes of administration: SubQ as the foundation, IV as the main adjunct, with intratumoral and intraperitoneal use in select cases</p><p>23:32–Germany vs. US: advanced procedural mistletoe (e.g., pancreatic injections) and leading integrative German centers (Havelhöhe, Filderklinik, Witten/Herdecke)</p><p>30:10 Case study: stage IIIC triple‑negative breast cancer—large tumor, patient refusing chemo/radiation, opting for intratumoral mistletoe</p><p>35:05–“Cold” tumors and prostate cancer: immune deserts, checkpoint inhibitor limits, and clinical responses to mistletoe</p><p>41:47–NSAIDs, COX‑2 inhibitors: how they blunt fever/skin reactions and can negate mistletoe’s desired immune effect</p><p>47:10–Titrating mistletoe: using the “mosquito‑bite” SubQ reaction and fever pattern to adjust dose and frequency</p><p>50:08–Ferroptosis 101: iron‑driven cell death, artemisinin/artesunate, IV vitamin C, and sequencing with mistletoe for immunogenic benefit</p><p>56:45-How selective is ferroptosis towards cancer cells? Potential dark side of ferroptosis</p><p>1:01:00–Biomarkers for ferroptosis and terrain: ferritin, ESR vs. CRP, LDH, and deciding when a patient is ready for treatment</p><p>1:21:26-Dr. Hancock's top 4 favorite supplements for cancer and why</p><p>1:24:55–Theoretical metabolic risks with Metformin/Berberine. LDH as glycolysis vs. tissue‑breakdown marker, Warburg effect context. Potential for guiding use of DCA/Metformin/Berberine</p><p>1:36:12-Dr. Hancock's top 3 favorite repurposed drugs and why</p><p>1:42:11-Clinical pearls regarding ferroptosis and autophagy that NO ONE talks about</p><p>1:47:12-Dr. Hancock's 3 favorite blood biomarkers</p><p>1:54:20-Dr. Hancock’s mistletoe training via PAAM and his apprenticeship</p><p>https://anthroposophicmedicine.org/mistletoe-course</p><p>https://humanizingmedicine.com/</p><p>https://mistletoetherapy.com/team/mark-hancock-md-mph/</p>
January 22, 2026
Killing Cancer with Sulforaphane featuring Dr. Jed Fahey and Dr. Brian Cornblatt
<p>In this episode, we’re thrilled to welcome Dr. Jed Fahey—one of the planet’s foremost experts in phytochemicals and sulforaphane (SFN) research. Retired from Johns Hopkins but still a powerhouse in the field, Dr. Fahey is here to deliver a true masterclass on all things SFN, particularly its game-changing potential against cancer. Joining Dr. Fahey is Dr. Brian Cornblatt, his protégé, who’ll provide frontline insights from the clinical studies behind Avmacol - the SFN supplement he designed.</p><p>[2:50] From Mars to Broccoli. Dr. Fahey recounts his journey from researching "Life on Mars" to sulforaphane research at Johns Hopkins.</p><p>[7:00] "He Had Me at Hello." Dr. Cornblatt recalls meeting Dr. Fahey at a Johns Hopkins journal club, where they bonded over research.</p><p>[11:25] Dismantling the NRF2 Myth. Dr. Fahey and Dr. Cornblatt debunk fears that sulforaphane protects tumors.</p><p>[21:10] Taming the "Red Devil." Sulforaphane shields the heart from toxic chemotherapy while making tumors more vulnerable to treatment.</p><p>[35:35] The Glutathione Paradox. A transient depletion in glutathione leads to a genetic rebound that supercharges cellular defenses.</p><p>[41:00] NRF2 101</p><p>[43:30] Matrix Metalloproteinases (MMPs) and NK-kB and SFN’s inhibitory effects on their pro-cancer pathways.</p><p>[47:09] Starving the Tumor. Sulforaphane cuts off a tumor's blood supply (HIF-1/VEGF) and flips the "kill switch" on silenced suppressor genes via HDAC inhibition.</p><p>[49:30] Sulforaphane’s antibacterial effects against H. pylori help reduce the risk of stomach malignancies.</p><p>[54:20] The 150-Mutation Trap. Why single-target drugs fail against complex tumors and why multi-modal plant compounds are necessary.</p><p>[58:35] Killing the “Root of the Cause”. Targeting the drug-resistant "cancer stem cells" that cause relapses by stripping away their ability to self-renew.</p><p>[1:03:40] Similarities between indolent cancers (slow-dividing cancers) and cancer stem cells.</p><p>[1:07:47] Why the bladder is the "ideal" target for SFN.</p><p>[1:17:50] Dr. Fahey and Dr. Cornblatt reveal their daily habits, from eating homegrown sprouts to using genomics for precision.</p><p>[1:22:00] Suppositories. Bypassing the digestive tract to deliver protective compounds directly to the colon, prostate and cervix.</p><p>[1:28:37] Reclaiming Research. How clinicians can use "N of 1" trials to bypass the NIH funding void to help prove phytochemical efficacy.</p><p>[1:31:34] Dr. Brian Cornblatt’s New Project. Revolutionizing healthcare with the first hospital-based, preventive clinic on the planet. Collecting 8 gigs of diagnostic data, including the patients full genome, with the help of AI.</p><p>[1:34:35] Ending Amputations. A breakthrough Bahamas protocol combining plasma rays, exosomes, and specialized blood flow supplements to save diabetic limbs from decay.</p><p>[1:36:00] Eradicating Cancer. A look at AI-driven clinics and the "Tzar" blood test detecting cancer at Stage 0, way before any advanced image detection, with 91% sensitivity (soon to be 95%).</p><p><strong>Resources:</strong></p><p><a href="http://jedfahey.com/" rel="noopener noreferrer" target="_blank">Dr. Jed Fahey’s website</a>, <a href="https://quantumlongevity.ai/" rel="noopener noreferrer" target="_blank">Dr. Brian Cornblatt’s new project</a>, <a href="https://clinicaltrials.gov/study/NCT03934905" rel="noopener noreferrer" target="_blank">Doxorubicin plus SFN clinical trial</a>, <a href="https://www.nature.com/articles/s41598-017-12855-w" rel="noopener noreferrer" target="_blank">HIF1 Inhibition</a>, <a href="https://www.sciencedirect.com/science/article/abs/pii/S1756464615003606" rel="noopener noreferrer" target="_blank">HDAC Inhibition</a>, <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4133889/" rel="noopener noreferrer" target="_blank">MMP/NFKB</a>, <a href="https://www.sciencedirect.com/science/article/pii/S109727650600147X?utm_source=chatgpt.com"...
June 24, 2025
Debunking Dr. Paul Saladino's Misinformation on Sulforaphane
The host debunks Dr. Paul Saladino's misinformation regarding the phytochemical sulforaphane, citing studies to counter Saladino's claims about its perils and highlight its benefits; this is a solo episode.
31 total episodes available
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