Veteran journalist, investor, and Second Opinion Media founder Chrissy Farr talks with the CEOs and founders who've been in the trenches long enough to know that healthcare doesn't move at startup speed. These aren't the entrepreneurs chasing quick exits—they're the "lifers" who understand that building in healthcare requires endless pivots, regulatory navigation, and decade-long timelines. No hype, just honest conversations about what it really takes. Each episode explores healthcare innovation, startup strategy, medical technology and AI, health system transformation, and investment insights from operators who've navigated regulatory challenges, clinical trials, reimbursement complexities, and the unique dynamics of the healthcare industry.
"Second Opinion" with Christina Farr, Ash Zenooz MD & Luba Greenwood JD
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Podcast Overview
Veteran journalist, investor, and Second Opinion Media founder Chrissy Farr talks with the CEOs and founders who've been in the trenches long enough to know that healthcare doesn't move at startup speed. These aren't the entrepreneurs chasing quick exits—they're the "lifers" who understand that building in healthcare requires endless pivots, regulatory navigation, and decade-long timelines. No hype, just honest conversations about what it really takes. Each episode explores healthcare innovation, startup strategy, medical technology and AI, health system transformation, and investment insights from operators who've navigated regulatory challenges, clinical trials, reimbursement complexities, and the unique dynamics of the healthcare industry.
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Publishing Since
6/17/2024
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Recent Episodes
July 31, 2026
Matthew Rothstein, VP of Engineering at Akido, on building the first AI native health system
Matthew Rothstein, VP of Engineering at Akido, joins Christina Farr to talk about what changes when a technology company becomes a health system. He built a credit card, sold it to Goldman Sachs, helped launch the Apple Card, and now works on the AI foundation for a bi-coastal network of nearly 100 clinics and a street medicine program in LA and San Francisco. They get into his case for open weights models over commercial frontier models in medical imaging, why he thinks an AI answer is information rather than care, and whether benchmarking AI against a panel of clinical experts is a fair test when most patients never get access to that panel.—SPONSOR:Akido is a technology company re-engineering healthcare around AI. Its AI-native health system frees physicians from the cognitive heavy lifting of medicine and partners on the investigation and discovery, so doctors can focus on judgment and care. This stretches a limited physician supply to reach far more people. Akido operates a national network of more than 1,000 providers across 26 specialties and six markets. Founded in 2015 out of USC's Digital Health Lab, its Series B was led by Oak HC/FT. For more information, visit www.akido.com—LINKS: Aikido: https://www.akido.com/ Chrissy Farr on YouTube: https://www.youtube.com/@LiferswithChristinaFarr Chrissy Farr on Instagram: https://www.instagram.com/cfarr/ Subscribe to the Second Opinion Newsletter: https://secondopinion.media/ Chrissy’s Book: The Storyteller's Advantage: https://www.chrissyfarr.com/books —FOLLOW:Matthew:https://www.linkedin.com/in/marothstein Chrissy:https://www.linkedin.com/in/christinafarr/ https://x.com/chrissyfarr Second Opinion Media:https://www.instagram.com/second.opinion.media/ https://x.com/second_op_media —TIMESTAMPS:(00:00) Lead In(00:37) Intro(01:23) From NIH to fintech(03:12) Life inside Goldman(04:38) Fintech vs health tech(07:26) AI aha moment(09:51) How genAI changes teams(12:31) Staying relevant by building(14:27) Rebuilding healthcare systems(17:38) Why care delivery wins(20:34) Designing for clinicians(22:37) Prioritizing impactful AI(23:36) Scaling complex care(24:33) Open models explained(27:28) Data access and privacy(30:01) Synthetic data and twins(32:52) ChatGPT triage reality check(36:42) Doctors plus AI tools(39:28) General vs specialized models(42:35) Reimbursement and value based care(45:14) AI reshapes engineering teams(49:13) Empathy in care delivery(50:46) Akido rebrand and AI native system(51:41) Wrap
July 30, 2026
The 80-year-old mistake at the heart of US healthcare | Mark Bertolini, Oscar Health
Mark Bertolini, CEO of Oscar Health, has run healthcare from every seat: CEO of Aetna, co-CEO of Bridgewater, and now head of the insurer he calls a pirate ship among Spanish galleons. He and Chrissy trace how an 80-year-old wartime workaround became the employer-sponsored system nobody is incentivized to fix, and what replaces it: one risk pool, a portable bucket of your own money, and a plan you keep for life. Along the way: the ICHRA mechanism, the $32 shower chair, the system priced at $468, and the personal story behind his hospice reform at Aetna.—SPONSOR:Oscar Health, Inc. is on a mission to give people greater power over their healthcare by building a more consumer-driven healthcare system. By leveraging technology to place individuals at the center of their healthcare experience, Oscar is transforming the industry into one that is proactive, personal, and transparent. Through its insurance subsidiary, Oscar Insurance, the company provides individual market health plans, innovative digital tools, and support for models such as ICHRA, helping people make more informed decisions with greater choice and coverage tailored to their needs. Dive into our conversation on Oscar's blog: https://www.hioscar.com/blog/future-of-healthcare-conversation-mark-bertolini?utm_source=lifers_youtube-organic&utm_campaign=all_null_christina-farr-mark-bertolini&utm_medium=national_all_null&utm_term=future-of-healthcare-blog —LINKS: Oscar Health: https://www.hioscar.com/ Lucie Health Marketplace: https://www.luciehealth.com/ Chrissy Farr on YouTube: https://www.youtube.com/@LiferswithChristinaFarr Chrissy Farr on Instagram: https://www.instagram.com/cfarr/ Subscribe to the Second Opinion Newsletter: https://secondopinion.media/ Chrissy’s Book: The Storyteller's Advantage: https://www.chrissyfarr.com/books —FOLLOW:Mark:https://www.linkedin.com/in/markbertolini Chrissy:https://www.linkedin.com/in/christinafarr/ https://x.com/chrissyfarr Second Opinion Media:https://www.instagram.com/second.opinion.media/ https://x.com/second_op_media —TIMESTAMPS:(00:00) Preview(00:25) Why employer loyalty doesn't exist anymore(02:12) How World War II built the system we have(03:02) Three economic models pushed together(04:47) The $23,000 question at CNBC(06:23) Conflating financing and investment(08:18) The three employer-sponsored insurance markets(09:57) Pooling every American and giving them their own bucket(11:09) The churn problem and lifetime value(14:32) Squaring the morbidity curve(16:48) What ICHRA is and why Oscar is betting on it(18:45) Curated pricing, the Lucie Health marketplace(21:53) What the system refuses to curate(23:23) Rewriting the hospice program(26:22) Dignitas and how we talk about dying(28:25) Why CEOs haven't dropped healthcare yet(31:03) Machiavelli and the tenure problem(32:43) Which employers tip first(34:14) Growing up in Detroit(34:51) Never count anyone else's money(37:22) From the Ford assembly line to accounting(39:05) Why spreadsheets give the illusion of certainty(40:45) Choosing Oscar(43:38) Reasons to believe(46:14) Wrap
July 21, 2026
Lauren Makler, Cofertility, on making egg freezing free
Christina Farr interviews Lauren Makler, Co-Founder & CEO of Cofertility, about making egg freezing accessible and creating a fairer fertility system.
77 total episodes available with 57 transcripts
Recent guests on "Second Opinion" with Christina Farr, Ash Zenooz MD & Luba Greenwood JD
Guests from recent episodes — sign up to see every guest that has ever appeared on this show.
Lauren Makler
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Amit Phull
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Keaton Bedell
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Joe DeVivo
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Paul Meyer
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Neil Hockstein
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Aretha Rochester
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Yusuf Sherwani
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Aartik Sarma
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Venkatesh Murthy
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Paul Sufka
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Sandeep Palakodeti
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Frequently asked questions
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- What is "Second Opinion" with Christina Farr, Ash Zenooz MD & Luba Greenwood JD?
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This podcast updates daily.
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Yes, this podcast regularly features guests.
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