Weekly Pep Talk

About Weekly Pep Talk

Welcome to Weekly Pep Talk — where GLP-1s, peptides, and longevity get real and judgment-free. Hosted by Prime Longevity Protocol, each episode covers semaglutide, tirzepatide, peptide therapy, biohacking, weight loss, metabolic health, and wellness optimization. Real talk for Warriors who refuse to settle for average. No shame. No gatekeeping. Just real people chasing real results. New episodes every week. Come optimize with us. 🧬 Nothing discussed is medical advice. Always consult your healthcare provider.

Publisher

Prime Longevity Protocol

Category

health & fitness

Language

en

Explicit

No

First episode

28 Apr 2026

Latest episode

19 Oct 2026

Latest episodes

20 of 30 episodes have a transcript.

1. 

   19 Oct 2026

   Hair Transplant Day 10 Results + Hair Growth Peptides & FLGR-242 | Mike Sheffer & Max Plasencia

   Mike Sheffer shares his early hair transplant recovery and what he experienced during the first 10 days after the procedure. In Episode 29 of Weekly Pep-Talk, Mike and Max Plasencia discuss hair loss, DHT, minoxidil, finasteride, GHK-Cu, BPC-157, TB-500, nutrition, inflammation, and the peptides and topicals Mike personally used during recovery. The conversation then shifts to an early FLGR-242 case discussion, where they review changes in body weight and lean mass before breaking down myostatin inhibition, muscle-building limits, training, nutrition, and why younger lifters should be cautious with performance-enhancing compounds. Educational discussion only. Not medical advice. Buy Peptides online at Prime Longevity Peptides: Enter code:welcome20 for 20% off your first order:⁠⁠https://primelongevitypeptides.com⁠⁠ (https://primelongevitypeptides.com) Join Our Facebook Community Group: GLP & Peptide Warriors: Science-Backed &Supported (https://bit.ly/42QGewT) Instagram ⁠prime_longevity_protocol (https://www.instagram.com/prime_longevity_protocol/)Email - info@primelongevityprotocol.com (mailto:info@primelongevityprotocol.com) FREE Skool: https://www.skool.com/mikes-pep-talk-... (https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbUtReGJzUjUwNXAzandkX0g3YTZORFJGTzd5UXxBQ3Jtc0trMzFESzhLQnNhZnpUd3J5eVdkSnRaaVkzT1JkSndjemg1RHVTNFp1SXExMG5EdU1FRk1NMzFOZzZuRy11bUFibVZLRVo0Ukd4dTJNZE1HZEZFeDBQLUlTeXJIZk1qNTUxSndBV1FZOUdYanRMbmlvbw&q=https%3A%2F%2Fwww.skool.com%2Fmikes-pep-talk-7413%2Fabout%3Fref%3Dbfd5515888694ea7bfc87cb403a75aa8&v=cK5EoZC4sgs) SPOTIFY: https://open.spotify.com/show/2ADXM9h... (https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqa1BhXzBIVE9kbjZqaG5XYmdkWC00cEs5Tmh6Z3xBQ3Jtc0ttcFlfQ3VkTDFvSzd0VVZRZUtjMXh2YXM5cmMtSjlTSU05eG45dFJodENFNk8tQVkxaGJsZk9YcVJEUi0zbUtYek1xSEttRVJJT2pPdE9fVkhTOWs3Q28zMTdGT0J5aFRVcGFtMUlxWjFlRVRoOFZRbw&q=https%3A%2F%2Fopen.spotify.com%2Fshow%2F2ADXM9hhNpBj1uwLI7Hc8C%3Fsi%3D12c3f1f39c84481e&v=cK5EoZC4sgs)

2. 

   5 Oct 2026

   MOTS-c Human vs Mouse, PNC-27 & Next-Gen Peptides | Mike Sheffer & Max Plasencia | Ep.28

   What is the difference between human and mouse-sequence MOTS-c, and could the sequence you're using affect how you respond? In Episode 28 of Weekly Pep-Talk, Mike Sheffer and Max Plasencia dive deep into MOTS-c, mitochondrial function, peptide reactions, next-generation amylin compounds, PNC-27/PNC-28, and growth hormone peptide combinations. The conversation starts with MOTS-c and why the hosts believe it has become such an interesting compound for mitochondrial health, AMPK activation, energy production, glucose utilization and exercise-related performance. They then explain the distinction they discuss between the mouse sequence and human reference sequence, including the difference at position 14. Pasted text Mike and Max also discuss why some people report reactions to MOTS-c, their experiences with histamine reactions, and the potential relationship they speculate about between quercetin and peptide reactions. They emphasize that their observations are not based on a controlled study. Pasted text The episode then moves into Eli Lilly's amylin-focused compounds, including the discussion around cagrilintide and a newer amylin receptor agonist. They compare mechanisms, discuss gastric side effects, dose-response concepts from clinical trials, and why the hosts believe amylin-based approaches could become an important part of future weight-management strategies. Pasted text Mike and Max also revisit PNC-27 and PNC-28, including their discussion of p53, MDM2/HDM2 and early laboratory and animal research. Importantly, they acknowledge that this is a highly experimental area and repeatedly frame these compounds as research-only rather than established cancer treatments. Pasted text Finally, they answer a viewer question about combining Tesamorelin, Ipamorelin and CJC-1295, explaining how they view the different pathways, CJC variations and potential approaches to cycling these compounds.

3. 

   28 Sept 2026

   RETA Update: FDA battle continues, New Reta addition, MK677, PCOS & Q&A

   MK-677, Retatrutide, growth hormone, peptide sourcing, testing, PE-22-28 and PCOS — this episode of Weekly Pep-Talk covers a wide-ranging Q&A on some of the most talked-about compounds and developments in the peptide and performance space. Mike Sheffer and Max Plasencia break down what they know about MK-677, including why it isn't technically a peptide, how it relates to ghrelin and growth hormone release, and why interest in it has expanded beyond traditional bodybuilding circles. The conversation also dives into the latest Eli Lilly and retatrutide discussion, including the potential implications of how retatrutide could be classified, pharmaceutical exclusivity, compounding, market access and the broader peptide industry. They also discuss what could come next for GLP-1 and amylin-based therapies, including the potential role of amylin receptor agonists for people who have reached plateaus or are considering transitioning away from GLP-based compounds. Another major topic is growth hormone availability and peptide sourcing, including concerns around overseas HGH, certificates of analysis (COAs), batch testing, chain of custody and the difference between testing a representative sample versus relying on third-party documentation. Mike and Max also discuss PE-22-28, neuroplasticity, cognitive effects, Semax, Selank and Dihexa, followed by a discussion around PCOS, insulin resistance, inflammation and mitochondrial health. 🔬 Topics Covered * MK-677 / Ibutamoren * MK-677 and growth hormone * Ghrelin receptor agonists * Growth hormone and aging * Retatrutide * Eli Lilly and retatrutide * GLP-1 and weight-loss compounds * Amylin receptor agonists * Cagrilintide discussion * Growth hormone availability * HGH sourcing and testing * Peptide COAs * Batch testing and chain of custody * U.S. vs overseas peptide manufacturing * PE-22-28 * TREK1 and neuroplasticity * Dihexa * Semax and Selank * PCOS and insulin resistance * Mitochondrial health * BPC-157 and KPV discussion * Peptide industry updates * Weekly Pep-Talk Buy Peptides online at Prime Longevity Peptides: Enter code:welcome20 for 20% off your first order:⁠⁠https://primelongevitypeptides.com⁠⁠ (https://primelongevitypeptides.com) Join Our Facebook Community Group: GLP & Peptide Warriors: Science-Backed &Supported (https://bit.ly/42QGewT) Instagram ⁠prime_longevity_protocol⁠ (https://www.instagram.com/prime_longevity_protocol/) Email - info@primelongevityprotocol.com (mailto:info@primelongevityprotocol.com) INSTAGRAM: mikesheffer_ FREE Skool: https://www.skool.com/mikes-pep-talk-... (https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbUtReGJzUjUwNXAzandkX0g3YTZORFJGTzd5UXxBQ3Jtc0trMzFESzhLQnNhZnpUd3J5eVdkSnRaaVkzT1JkSndjemg1RHVTNFp1SXExMG5EdU1FRk1NMzFOZzZuRy11bUFibVZLRVo0Ukd4dTJNZE1HZEZFeDBQLUlTeXJIZk1qNTUxSndBV1FZOUdYanRMbmlvbw&q=https%3A%2F%2Fwww.skool.com%2Fmikes-pep-talk-7413%2Fabout%3Fref%3Dbfd5515888694ea7bfc87cb403a75aa8&v=cK5EoZC4sgs) SPOTIFY: https://open.spotify.com/show/2ADXM9h... (https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqa1BhXzBIVE9kbjZqaG5XYmdkWC00cEs5Tmh6Z3xBQ3Jtc0ttcFlfQ3VkTDFvSzd0VVZRZUtjMXh2YXM5cmMtSjlTSU05eG45dFJodENFNk8tQVkxaGJsZk9YcVJEUi0zbUtYek1xSEttRVJJT2pPdE9fVkhTOWs3Q28zMTdGT0J5aFRVcGFtMUlxWjFlRVRoOFZRbw&q=https%3A%2F%2Fopen.spotify.com%2Fshow%2F2ADXM9hhNpBj1uwLI7Hc8C%3Fsi%3D12c3f1f39c84481e&v=cK5EoZC4sgs)

Inside a recent episode

Your Blood Work Is Missing This! Triglycerides, A1C, VIP & Peptides | Mike Sheffer & Max Plasencia

Published 10 Aug 2026 · Transcript excerpt

[…] If your triglycerides are normal, like in my case, and I just recently had some blood work done and my HDL came down a bit, while my LDL stayed high as it's always been. Right. So my HDL to LDL ratio decreased and I got a slight bump in the triglycerides. OK, now we have to take a serious look at, you know, diet and exercise. So it's important to not look at just one marker. You have to take the totality of them all. And also, what is your diet like? You know, if someone says, look, my HDL is is, you know, In range, my LDL is super high. I'm a carnivore. Okay, makes sense. You eat a lot of saturated fats from meat. […]

Reach and audience

Public platform figures. Ratings count people who left a rating, not total listeners.

Apple Podcasts (US)

5.0 / 5

2 ratings

Spotify

5.0 / 5

4 ratings

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