BaladoCritique - club de lecture médical

About BaladoCritique - club de lecture médical

BaladoCritique – club de lecture médical | médecine interne | EBM

Publisher

Dr Luc Lanthier et collaborateurs

Category

education

Language

fr

Explicit

No

First episode

19 Nov 2017

Latest episode

29 Oct 2026

Latest episodes

71 episodes in the feed.

1. 29 Oct 2026

   BC 081 – Atorvastatine, événements cardiovasculaires et survie sans invalidité chez les personnes âgées (étude STAREE)

   Dans cette 81e baladodiffusion, les Drs Luc Lanthier et Pierre-Nicolas Perron discutent du traitement de la dyslipidémie chez les personnes âgées avec l’étude STAREE, en plus de réviser la littérature médicale de septembre 2026. Quiz clinique (1 min 19), présentation principale (1 min 40), critique (19 min 50), retour sur le cas clinique (26 min 28), autres articles (28 min 48), réponse au quiz clinique (31 min 04). Référence principale : Zoungas S, Wolfe R, Moran C, Nicholls SJ, Cloud GC, Reid CM, et al; STAREE Investigators. Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults. N Engl J Med. 2026;395(13):1259-1272. PubMed PMID: 42670961 (https://pubmed.ncbi.nlm.nih.gov/42670961/). Articles associés : Mortensen MB. Statins in Older Adults – Evidence at Last. N Engl J Med. 2026;395(13):1327-8. PubMed PMID: 42814932 (https://pubmed.ncbi.nlm.nih.gov/42814932/). Gencer B, Marston NA, Im K, Cannon CP, Sever P, Keech A, et al. Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta-analysis of randomised controlled trials. Lancet. 2020;396(10263):1637-43. PubMed PMID: 33186535 (https://pubmed.ncbi.nlm.nih.gov/33186535/). Mortensen MB, Nordestgaard BG. Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70-100 years: a contemporary primary prevention cohort. Lancet. 2020;396(10263):1644-52. PubMed PMID: 33186534 (https://pubmed.ncbi.nlm.nih.gov/33186534/). Cholesterol Treatment Trialists Collaboration. Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials. Lancet. 2019;393(10170):407-15. PubMed PMID: 30712900 (https://pubmed.ncbi.nlm.nih.gov/30712900/). Orkaby AR, Driver JA, Ho YL, Lu B, Costa L, Honerlaw J, et al. Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older. JAMA. 2020;324(1):68-78. PubMed PMID: 32633800 (https://pubmed.ncbi.nlm.nih.gov/32633800/). Yourman LC, Cenzer IS, Boscardin WJ, Nguyen BT, Smith AK, Schonberg MA, et al. Evaluation of Time to Benefit of Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years: A Meta-analysis. JAMA Intern Med. 2021;181(2):179-85. PubMed PMID: 33196766 (https://pubmed.ncbi.nlm.nih.gov/33196766/). Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe Smet al; PROSPER study group. PROspective Study of Pravastatin in the Elderly at Risk. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet. 2002;360(9346):1623-30. PubMed PMID: 12457784 (https://pubmed.ncbi.nlm.nih.gov/12457784/). Blumenthal RS, Morris PB, Gaudino M, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153(17):e1154-e1276. PubMed PMID: 41824552 (https://pubmed.ncbi.nlm.nih.gov/41824552/). Bonnet F, Poulizac P, Rousselot N, Couffinhal T, Galli G, Berdai D, et al. Discontinuation of statins for primary prevention of atherosclerotic cardiovascular disease in adults aged 75 years or older (SAGA/SITE): a multicentre, open-label, pragmatic, non-inferiority randomised trial. Lancet Healthy Longev. 2026;7(7):100884. PubMed PMID: 42580354 (https://pubmed.ncbi.nlm.nih.gov/42580354/). https://deprescribing.org/wp-content/uploads/2025/10/Statin-Deprescribing-Algorithm.pdf (https://deprescribing.org/wp-content/uploads/2025/10/Statin-Deprescribing-Algorithm.pdf) Table de survie actuarielle (Canada) : https://www150.statcan.gc.ca/n1/pub/84-537-x/84-537-x2024001-fra.htm (https://www150.statcan.gc.ca/n1/pub/84-537-x/84-537-x2024001-fra.htm) Autres articles d’intérêt récent : Kim D, Lee YS, Shim J, Yu HT, Park J, Park JK, et al. Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk. N Engl J Med. 2026;395(12):1155-65. PubMed PMID: 42663303 (https://pubmed.ncbi.nlm.nih.gov/42663303/). Silvain J, Choi KH, Monguillon V, Kang D, Cayla G, Kim W, et al. Discontinuation of beta-blockers in stable patients with previous myocardial infarction, preserved left ventricular ejection fraction, and no heart failure: a pooled analysis of individual patient data. Lancet. 2026;408(10560):1093-102. PubMed PMID: 42669300 (https://pubmed.ncbi.nlm.nih.gov/42669300/). Guides de pratique : Mills NL, Newby LK, Zaman S, Almahmeed WA, Bucciarelli-Ducci C, Colvin MM, et al. Fifth Universal Definition of Myocardial Infarction (2026). J Am Coll Cardiol. 2026;88(11):1314-68. PubMed PMID: 42663357 (https://pubmed.ncbi.nlm.nih.gov/42663357/). Thompson A, Fleischmann KE, Smilowitz NR, de Las Fuentes L, Mukherjee D, et al. 2026 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;154(13):e413-e504. PubMed PMID: 42804570 (https://pubmed.ncbi.nlm.nih.gov/42804570/). Fischer M, Vaughn BP, Peery AF, Kelly CR. AGA Clinical Practice Update on Management of Clostridioides difficile Infection in Adults: Expert Review. Clin Gastroenterol Hepatol. 2026;24(9):2359-69. PubMed PMID: 42383946 (https://pubmed.ncbi.nlm.nih.gov/42383946/). Référence du quiz clinique : https://ourworldindata.org/deadliest-animals (https://ourworldindata.org/deadliest-animals) https://en.wikipedia.org/wiki/List_of_animals_deadliest_to_humans (https://en.wikipedia.org/wiki/List_of_animals_deadliest_to_humans)

2. 28 Sept 2026

   BC 080 – Rivaroxaban puis aspirine vs aspirine seule après une arthroplastie totale de la hanche ou du genou (étude EPCAT-III)

   Dans cette 80e baladodiffusion, les Drs Mathieu Labossière et Alexandre Mutchmore discutent de thromboprophylaxie en chirurgie orthopédique, en plus de réviser la littérature médicale d’août 2026. Quiz clinique (2 min 05), présentation principale (2 min 38), critique (21 min 51), retour sur le cas clinique (31 min 27), autres articles (32 min 50), réponse au quiz clinique (36 min 19). Référence principale : Shivakumar S, Matino D, Zukor D, Kahn SR, Vincent G, Mundi R, et al. Rivaroxaban Then Aspirin vs. Aspirin Alone after Total Hip or Knee Arthroplasty. N Engl J Med. 2026. Epub 2026/07/12. doi: 10.1056/NEJMoa2603649. PubMed PMID: 42437501 (https://pubmed.ncbi.nlm.nih.gov/42437501/). Articles associés : The Pulmonary Embolism Prevention (PEP) Trial Collaborative Group. Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Lancet 2000;355:1295-302. PubMed PMID: 10776741 (https://pubmed.ncbi.nlm.nih.gov/10776741/). Anderson DR, Dunbar MJ, Bohm ER, et al. Aspirin versus low-molecular-weight heparin for extended venous thromboembolism prophylaxis after total hip arthroplasty: a randomized trial. Ann Intern Med. 2013;158(11):800-6. PubMed PMID: 23732713 (https://pubmed.ncbi.nlm.nih.gov/23732713/). Anderson DR, Dunbar M, Murnaghan J, Kahn SR, Gross P, Forsythe M, et al. Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty. N Engl J Med. 2018;378(8):699-707. PubMed PMID: 29466159 (https://pubmed.ncbi.nlm.nih.gov/29466159/). Anderson DR, Morgano GP, Bennett C, Dentali F, Francis CS, Garcia DA et al. American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients. Blood Adv 2019;3(23):3898–3944. PubMed PMID: 31794602 (https://pubmed.ncbi.nlm.nih.gov/31794602/). Sidhu VS, Kelly TL, Pratt N, Graves SE, Buchbinder R, Adie S et al. Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial. JAMA. 2022;328(8):719-727. PubMed PMID: 35997730 (https://pubmed.ncbi.nlm.nih.gov/35997730/). Autres articles d’intérêt récent : Heerspink HJL, Neuen BL, Agarwal R, Cherney DZI, Lam CSP, Tuttle KR, et al. Finerenone in Persons with Chronic Kidney Disease without Diabetes. N Engl J Med. 2026;395(6):533-45. PubMed PMID: 42246672 (https://pubmed.ncbi.nlm.nih.gov/42246672/). Colson AE, Kumar PN, Ruane PJ, Chetchotisakd P, Ratanasuwan W, Liberty A, et al. Switch to once-weekly, single-tablet islatravir-lenacapavir from daily standard of care for HIV-1 (ISLEND-2): a multicentre, randomised, open-label, active-controlled, phase 3 non-inferiority trial. Lancet. 2026;408(10557):821-32. PubMed PMID: 42586113 (https://pubmed.ncbi.nlm.nih.gov/42586113/). Stone JH, Buttgereit F, Saraux A, Schmidt WA, Dejaco C, Spiera R, et al. Phase 3 Trial of Secukinumab in Polymyalgia Rheumatica. N Engl J Med. 2026;395(7):637-47. PubMed PMID: 42234540 (https://pubmed.ncbi.nlm.nih.gov/42234540/). Akerboom B, Martens ESL, Stals MAM, Brouwer RE, Coppens M, Costantino G, et al. YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism in Patients With Cancer: A Randomized Clinical Trial. JAMA. 2026;336(8):655-63. PubMed PMID: 42437322 (https://pubmed.ncbi.nlm.nih.gov/42437322/). Guides de pratique : Prabhakaran S, Gonzalez NR, Zachrison KS, Adeoye O, Alexandrov AW, Ansari SA, et al. 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2026;57(8):e316-e436. PubMed PMID: 41582814 (https://pubmed.ncbi.nlm.nih.gov/41582814/). Walsh MN, Kober L, Sliwa K, Adamo M, Agarwal A, Banerjee A, et al. AHA/ACC/ESC/WHF Expert Consensus Document: Second Universal Definition of Heart Failure (2026). Circulation. 2026;154(7):e279-e93. PubMed PMID: 42366997 (https://pubmed.ncbi.nlm.nih.gov/42366997/). Référence du quiz clinique : Vaglio A, Peyronel F, Bajema IM, Pegoraro F. Retroperitoneal fibrosis. Lancet. 2026;408(10555):649-664. PubMed PMID: 41905382 (https://pubmed.ncbi.nlm.nih.gov/41905382/).

3. 23 Aug 2026

   BC 079 – Daraxonrasib ou chimiothérapie dans le cancer du pancréas métastatique déjà traité (étude RASolute 302)

   Dans cette 79e baladodiffusion, les Drs Luc Lanthier et Giulia Pool discutent d’une nouveauté thérapeutique en cancer du pancréas, en plus de réviser la littérature médicale de mai, juin et juillet 2026. Quiz clinique (2 min 05), présentation principale (2 min 35), critique (22 min 32), retour sur le cas clinique (28 min 04), autres articles (29 min 32), réponse au quiz clinique (36 min 35). Référence principale : O’Reilly EM, Wainberg ZA, Hendifar AE, Borad MJ, Pietrantonio F, Pant S, et al. Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer. N Engl J Med. 2026;395(4):325-37. PubMed PMID: 42223072 (https://pubmed.ncbi.nlm.nih.gov/42223072/). Articles associés : Teede HJ, Khomami MB, Morman R, Laven JSE, Joham AE, Costello MF, et al. Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process. Lancet. 2026;407(10545):2329-39. PubMed PMID: 42119588 (https://pubmed.ncbi.nlm.nih.gov/42119588/). Stoop TF, Javed AA, Oba A, Koerkamp BG, Seufferlein T, Wilmink JW, et al. Pancreatic cancer. Lancet. 2025;405(10485):1182-202. PubMed PMID: 40187844 (https://pubmed.ncbi.nlm.nih.gov/40187844/). Der CJ, Yeh JJ. Advances in RAS Therapeutics for Pancreatic Cancer. N Engl J Med. 2026;394(18):1857-1861. PubMed PMID: 42090797 (https://pubmed.ncbi.nlm.nih.gov/42090797/). Wolpin BM, Park W, Garrido-Laguna I, Spira A, Starodub A, Sommerhalder D, et al. Daraxonrasib in Previously Treated Advanced RAS-Mutated Pancreatic Cancer. N Engl J Med. 2026;394(18):1790-802. PubMed PMID: 42090791 (https://pubmed.ncbi.nlm.nih.gov/42090791/). Sivakumar S. Breaking the RAS Barrier in Pancreatic Cancer. N Engl J Med. 2026;395(4):400-1. PubMed PMID: 42485631 (https://pubmed.ncbi.nlm.nih.gov/42485631/). Aronchik I, Kar S, Zhuang Y, Ahler E, Lai LP, Seshadri V, et al. Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer. Nat Med. 2026;32(8):2865-77. PubMed PMID: 42581230 (https://pubmed.ncbi.nlm.nih.gov/42581230/). Autres articles d’intérêt récent : Rosenfield K, Klok FA, Piazza G, Sharp ASP, Ni Ainle F, Jaff MR, et al. Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism. N Engl J Med. 2026;394(20):1979-90. PubMed PMID: 41910345 (https://pubmed.ncbi.nlm.nih.gov/41910345/). Cummings JL, Atri A, Sano M, Zetterberg H, Scheltens P, Knop FK, et al. Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer’s disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials. Lancet. 2026;407(10544):2167-79. PubMed PMID: 41865758 (https://pubmed.ncbi.nlm.nih.gov/41865758/). Hayden FG, Shinkai M, Clark TW, Luetkemeyer AF, Sax PE, Hanage WP, et al. Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts. N Engl J Med. 2026;394(19):1905-15. PubMed PMID: 42127390 (https://pubmed.ncbi.nlm.nih.gov/42127390/). Houston BL, McIsaac DI, Breau RH, Kanji S, Greenstreet P, Andrews M, et al. Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery. N Engl J Med. 2026;394(24):2419-28. PubMed PMID: 42267805 (https://pubmed.ncbi.nlm.nih.gov/42267805/). Hou J, Lim SG, Buti M, Yuen MF, Gane E, Lampertico P, et al. Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection. N Engl J Med. 2026;394(24):2395-406. PubMed PMID: 42206582 (https://pubmed.ncbi.nlm.nih.gov/42206582/). Wazni OM, Chun KRJ, Nair DG, Anic A, Duytschaever M, Chrispin J, et al; AVANT GUARD Study Investigators. Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation. N Engl J Med. 2026;394(24):2407-2418. PubMed PMID: 42041224 (https://pubmed.ncbi.nlm.nih.gov/42041224/). Doshi SK, Kar S, Nair DG, Waggoner T, Agarwal H, Moussavian M, et al. Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation. N Engl J Med. 2026;394(21):2083-94. PubMed PMID: 41910347 (https://pubmed.ncbi.nlm.nih.gov/41910347/). Staphylococcus aureus Network Adaptive Platform Trial G, Lee TC, Barina LA, Walls G, Goodman AL, Yahav D, et al. Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia. N Engl J Med. 2026;394(23):2329-39. PubMed PMID: 42308484 (https://pubmed.ncbi.nlm.nih.gov/42308484/). Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group. Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial. Lancet. 2026;408(10550):141-152. PubMed PMID: 42309115 (https://pubmed.ncbi.nlm.nih.gov/42309115/). Nathan SD, Smith P, Deng C, King CS, De Salvo M, Weigt SS, et al. Phase 3 Trials of Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis. N Engl J Med. 2026;395(2):115-26. PubMed PMID: 42149993 (https://pubmed.ncbi.nlm.nih.gov/42149993/). Guides de pratique : Smolen JS, Edwards CJ, Konzett V, Laskou F, Aletaha D, Caporali R, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2025 update. Ann Rheum Dis. 2026;85(6):991-1009. PubMed PMID: 41826212 (https://pubmed.ncbi.nlm.nih.gov/41826212/). Peery AF, Strate LL, Stollman N, Mankaney G, Chang JW, Grover S. ACG Clinical Guideline: Colonic Diverticulitis. Am J Gastroenterol. 2026;121(7):1549-61. PubMed PMID: 42390126 (https://pubmed.ncbi.nlm.nih.gov/42390126/). Writing Committee M, Ndumele CE, Rodriguez F, Dixon DL, Khan SS, Mukherjee D, et al. 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;154(4):e50-e158. PubMed PMID: 42263157 (https://pubmed.ncbi.nlm.nih.gov/42263157/). Références du quiz clinique : Richert Q, Miller N, Cameron S, Barr B, Nkosi J, Sharma A. Updates on Rhabdomyolysis: A Clinically Oriented Narrative Review. Chest. 2026;170(1):128-36. PubMed PMID: 41619932 (https://pubmed.ncbi.nlm.nih.gov/41619932/). Cabral BMI, Edding SN, Portocarrero JP, Lerma EV. Rhabdomyolysis. Dis Mon. 2020;66(8):101015. PubMed PMID: 32532456 (https://pubmed.ncbi.nlm.nih.gov/32532456/).

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